Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07

AUTHORS

H Schoeneberger, K Belz, B Schenk, S Fulda

ABSTRACT

Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (GSH) depletion by buthionine sulfoximine (BSO) primes ALL cells for apoptosis induced by the Smac mimetic BV6 that antagonizes IAP proteins. Similarly, BSO cooperates with BV6 to induce cell death in patient-derived primary leukemic samples, underscoring the clinical relevance. In contrast, BSO does not sensitize non-malignant lymphohematopoietic cells from healthy donors toward BV6, pointing to some tumor selectivity. Mechanistically, both agents cooperate to stimulate reactive oxygen species (ROS) production, which is required for BSO/BV6-induced cell death, as ROS inhibitors (that is, N-acetylcysteine, MnTBAP, Trolox) significantly rescue cell death. Further, BSO and BV6 cooperate to trigger lipid peroxidation, which is necessary for cell death, as genetic or pharmacological blockage of lipid peroxidation by GSH peroxidase 4 (GPX4) overexpression or α-tocopherol significantly inhibits BSO/BV6-mediated cell death. Consistently, GPX4 knockdown or GPX4 inhibitor RSL3 enhances lipid peroxidation and cell death by BSO/BV6 cotreatment. The discovery of redox regulation of Smac mimetic-induced cell death has important implications for developing rational Smac mimetic-based combination therapies. More... »

PAGES

4032-4043

References to SciGraph publications

  • 2001. Antileukemic Effects of Buthionine Sulfoximine (BSO) (NSC 326231) in Vivo: A Pilot Study in Acute Myeloblastic Leukemia in ACUTE LEUKEMIAS VIII
  • 2009-07. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? in NATURE REVIEWS DRUG DISCOVERY
  • 2014-07. Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities in LEUKEMIA
  • 2006-08. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy in ONCOGENE
  • 2009-10. Apoptosis and glutathione: beyond an antioxidant in CELL DEATH & DIFFERENTIATION
  • 2012-05. RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis in LEUKEMIA
  • 2013-12. Modulation of oxidative stress as an anticancer strategy in NATURE REVIEWS DRUG DISCOVERY
  • 2013-11. Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis in CELL DEATH & DISEASE
  • 2012-08. Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process in CELL DEATH & DIFFERENTIATION
  • 2013-07. RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex in ONCOGENE
  • 2004-07. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells in CELL DEATH & DIFFERENTIATION
  • 2012-02. Targeting IAP proteins for therapeutic intervention in cancer in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2014.338

    DOI

    http://dx.doi.org/10.1038/onc.2014.338

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000381322

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25381820


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomimetic Materials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Buthionine Sulfoximine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glutathione", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Jurkat Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipid Peroxidation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondrial Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligopeptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schoeneberger", 
            "givenName": "H", 
            "id": "sg:person.01002113507.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002113507.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belz", 
            "givenName": "K", 
            "id": "sg:person.0677111136.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677111136.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schenk", 
            "givenName": "B", 
            "id": "sg:person.01160717352.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160717352.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulda", 
            "givenName": "S", 
            "id": "sg:person.01331656400.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331656400.85"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-0409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000530949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2007.1957", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000616792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0891-5849(98)00261-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001817534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbbm.2005.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001825124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbbm.2005.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001825124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminhematol.2008.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004382182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2011.09.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004702619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2011.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004938709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-08-173310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005009325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005425492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005500014", 
              "https://doi.org/10.1038/nrd4002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra023001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005718906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008093277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-1055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010680926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.1997.0341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010756605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-18156-6_44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011084186", 
              "https://doi.org/10.1007/978-3-642-18156-6_44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-18156-6_44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011084186", 
              "https://doi.org/10.1007/978-3-642-18156-6_44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-09-114314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013445919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.300012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015516776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2012.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016341290", 
              "https://doi.org/10.1038/cdd.2012.10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2013.457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017272218", 
              "https://doi.org/10.1038/cddis.2013.457"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017656268", 
              "https://doi.org/10.1038/nrd2803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017656268", 
              "https://doi.org/10.1038/nrd2803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m112.398966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022580968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m807061200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022994431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023241051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023605394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/08941930600674702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024141801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3627", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025792112", 
              "https://doi.org/10.1038/nrd3627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1998.2931", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026252168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2190001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027549159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2190001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027549159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fonc.2014.00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030888937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032826025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2141.2009.07603.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033060993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0601945103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033702987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033978648", 
              "https://doi.org/10.1038/sj.cdd.4401431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033978648", 
              "https://doi.org/10.1038/sj.cdd.4401431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/89.23.1789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034878122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035415055", 
              "https://doi.org/10.1038/cdd.2009.107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035415055", 
              "https://doi.org/10.1038/cdd.2009.107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035804358", 
              "https://doi.org/10.1038/leu.2014.56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2014.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035804358", 
              "https://doi.org/10.1038/leu.2014.56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.10.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036164945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.03.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036616855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-0227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040456727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2013-05-500918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041648123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood.v97.2.393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042164381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042639867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.12.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042741198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046914764", 
              "https://doi.org/10.1038/sj.onc.1209608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046914764", 
              "https://doi.org/10.1038/sj.onc.1209608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3280199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047640070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3280199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047640070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2008.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048140866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2011.353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049850273", 
              "https://doi.org/10.1038/leu.2011.353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pbc.22541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050159697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pbc.22541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050159697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbagen.2012.11.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052828668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2012.337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053056645", 
              "https://doi.org/10.1038/onc.2012.337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.03.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053704255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2009.2743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059231080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2011.4258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059231688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/1.3.203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059448733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074566086", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076809784", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079423863", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081580668", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082646861", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-07", 
        "datePublishedReg": "2015-07-01", 
        "description": "Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (GSH) depletion by buthionine sulfoximine (BSO) primes ALL cells for apoptosis induced by the Smac mimetic BV6 that antagonizes IAP proteins. Similarly, BSO cooperates with BV6 to induce cell death in patient-derived primary leukemic samples, underscoring the clinical relevance. In contrast, BSO does not sensitize non-malignant lymphohematopoietic cells from healthy donors toward BV6, pointing to some tumor selectivity. Mechanistically, both agents cooperate to stimulate reactive oxygen species (ROS) production, which is required for BSO/BV6-induced cell death, as ROS inhibitors (that is, N-acetylcysteine, MnTBAP, Trolox) significantly rescue cell death. Further, BSO and BV6 cooperate to trigger lipid peroxidation, which is necessary for cell death, as genetic or pharmacological blockage of lipid peroxidation by GSH peroxidase 4 (GPX4) overexpression or \u03b1-tocopherol significantly inhibits BSO/BV6-mediated cell death. Consistently, GPX4 knockdown or GPX4 inhibitor RSL3 enhances lipid peroxidation and cell death by BSO/BV6 cotreatment. The discovery of redox regulation of Smac mimetic-induced cell death has important implications for developing rational Smac mimetic-based combination therapies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2014.338", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "31", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death", 
        "pagination": "4032-4043", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "01d10b3bdab6a1617ce94aea9784c8f78c8fea81e805a4956ab9de019d0e1cf2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25381820"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2014.338"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000381322"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2014.338", 
          "https://app.dimensions.ai/details/publication/pub.1000381322"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000421.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/onc/journal/v34/n31/full/onc2014338a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.338'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.338'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.338'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.338'


     

    This table displays all metadata directly associated to this object as RDF triples.

    334 TRIPLES      21 PREDICATES      103 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2014.338 schema:about N0a19e4c996b84d838fd20a0e4ae4767f
    2 N1aca00539d234d7c9a5a668534caea4d
    3 N21046e812aaf45c89134dfcccdbd9694
    4 N32eabc253c0b4281b784868de44966b1
    5 N39c20b579c33453b8862bb48f6056262
    6 N5eaa5e7b3f784d3fb7276a8fe273ed6d
    7 N852546e2e3794626b434d566224de1fa
    8 N9b5a0140cf8b4ed99ad073bc40b267b0
    9 Na2fdda381cd84e67974bfef6e1193261
    10 Na4a209d966f94426a99cf7c2733be29d
    11 Nc1aacc55c6e24de490164b9eea6ee80a
    12 Ne68a5903f66e4db0bdcfb6122708b3fe
    13 Ne7dbd426d8614f9eb46dd82512f3a4c4
    14 Nfac0746e0bea4accad37d4b519100f15
    15 Nfe471b638d0d4617883008a42cf58d9d
    16 anzsrc-for:06
    17 anzsrc-for:0601
    18 schema:author Na810ee068d30408d914bbbfadf416602
    19 schema:citation sg:pub.10.1007/978-3-642-18156-6_44
    20 sg:pub.10.1038/cdd.2009.107
    21 sg:pub.10.1038/cdd.2012.10
    22 sg:pub.10.1038/cddis.2013.457
    23 sg:pub.10.1038/leu.2011.353
    24 sg:pub.10.1038/leu.2014.56
    25 sg:pub.10.1038/nrd2803
    26 sg:pub.10.1038/nrd3627
    27 sg:pub.10.1038/nrd4002
    28 sg:pub.10.1038/onc.2012.337
    29 sg:pub.10.1038/sj.cdd.4401431
    30 sg:pub.10.1038/sj.onc.1209608
    31 https://app.dimensions.ai/details/publication/pub.1074566086
    32 https://app.dimensions.ai/details/publication/pub.1076809784
    33 https://app.dimensions.ai/details/publication/pub.1079423863
    34 https://app.dimensions.ai/details/publication/pub.1081580668
    35 https://app.dimensions.ai/details/publication/pub.1082646861
    36 https://doi.org/10.1002/ijc.24064
    37 https://doi.org/10.1002/pbc.22541
    38 https://doi.org/10.1006/abbi.1997.0341
    39 https://doi.org/10.1006/abio.1998.2931
    40 https://doi.org/10.1016/j.bbagen.2012.11.020
    41 https://doi.org/10.1016/j.ccr.2007.08.029
    42 https://doi.org/10.1016/j.cell.2007.10.030
    43 https://doi.org/10.1016/j.cell.2007.10.037
    44 https://doi.org/10.1016/j.cell.2009.03.015
    45 https://doi.org/10.1016/j.cell.2012.03.042
    46 https://doi.org/10.1016/j.cell.2013.12.010
    47 https://doi.org/10.1016/j.chembiol.2008.02.010
    48 https://doi.org/10.1016/j.cmet.2008.07.005
    49 https://doi.org/10.1016/j.freeradbiomed.2011.09.030
    50 https://doi.org/10.1016/j.immuni.2012.01.012
    51 https://doi.org/10.1016/j.jbbm.2005.10.003
    52 https://doi.org/10.1016/j.molcel.2011.06.011
    53 https://doi.org/10.1016/s0891-5849(98)00261-5
    54 https://doi.org/10.1042/bj2190001
    55 https://doi.org/10.1042/bj3280199
    56 https://doi.org/10.1053/j.seminhematol.2008.09.007
    57 https://doi.org/10.1056/nejmra023001
    58 https://doi.org/10.1073/pnas.0601945103
    59 https://doi.org/10.1074/jbc.m111.300012
    60 https://doi.org/10.1074/jbc.m112.398966
    61 https://doi.org/10.1074/jbc.m807061200
    62 https://doi.org/10.1080/08941930600674702
    63 https://doi.org/10.1089/ars.2007.1957
    64 https://doi.org/10.1089/ars.2009.2743
    65 https://doi.org/10.1089/ars.2011.4258
    66 https://doi.org/10.1093/carcin/1.3.203
    67 https://doi.org/10.1093/jnci/89.23.1789
    68 https://doi.org/10.1111/j.1365-2141.2009.07603.x
    69 https://doi.org/10.1158/0008-5472.can-06-0409
    70 https://doi.org/10.1158/1078-0432.ccr-03-0642
    71 https://doi.org/10.1158/1078-0432.ccr-12-1055
    72 https://doi.org/10.1158/1078-0432.ccr-13-0227
    73 https://doi.org/10.1182/blood-2007-09-114314
    74 https://doi.org/10.1182/blood-2008-08-173310
    75 https://doi.org/10.1182/blood-2013-05-500918
    76 https://doi.org/10.1182/blood.v97.2.393
    77 https://doi.org/10.3389/fonc.2014.00003
    78 schema:datePublished 2015-07
    79 schema:datePublishedReg 2015-07-01
    80 schema:description Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (GSH) depletion by buthionine sulfoximine (BSO) primes ALL cells for apoptosis induced by the Smac mimetic BV6 that antagonizes IAP proteins. Similarly, BSO cooperates with BV6 to induce cell death in patient-derived primary leukemic samples, underscoring the clinical relevance. In contrast, BSO does not sensitize non-malignant lymphohematopoietic cells from healthy donors toward BV6, pointing to some tumor selectivity. Mechanistically, both agents cooperate to stimulate reactive oxygen species (ROS) production, which is required for BSO/BV6-induced cell death, as ROS inhibitors (that is, N-acetylcysteine, MnTBAP, Trolox) significantly rescue cell death. Further, BSO and BV6 cooperate to trigger lipid peroxidation, which is necessary for cell death, as genetic or pharmacological blockage of lipid peroxidation by GSH peroxidase 4 (GPX4) overexpression or α-tocopherol significantly inhibits BSO/BV6-mediated cell death. Consistently, GPX4 knockdown or GPX4 inhibitor RSL3 enhances lipid peroxidation and cell death by BSO/BV6 cotreatment. The discovery of redox regulation of Smac mimetic-induced cell death has important implications for developing rational Smac mimetic-based combination therapies.
    81 schema:genre research_article
    82 schema:inLanguage en
    83 schema:isAccessibleForFree false
    84 schema:isPartOf N226f3678c5b24faea8ff37e3ee159586
    85 Na9943f066648433eb7946afe55a281d9
    86 sg:journal.1097543
    87 schema:name Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death
    88 schema:pagination 4032-4043
    89 schema:productId N43364b95bc724e9a959bb8f85a4fb29a
    90 N58f0fd85655d4896ab5d8932f9cc6bb7
    91 N7b62741628e04331834e529208198e86
    92 N7ff479b0ba034a20bf368bc29a4606b0
    93 Na1cf83dab5434c35b420f336940bedb3
    94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000381322
    95 https://doi.org/10.1038/onc.2014.338
    96 schema:sdDatePublished 2019-04-10T13:55
    97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    98 schema:sdPublisher N9a5fa065939847e78ec9f2a966e96bbb
    99 schema:url http://www.nature.com/onc/journal/v34/n31/full/onc2014338a.html
    100 sgo:license sg:explorer/license/
    101 sgo:sdDataset articles
    102 rdf:type schema:ScholarlyArticle
    103 N0a19e4c996b84d838fd20a0e4ae4767f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Reactive Oxygen Species
    105 rdf:type schema:DefinedTerm
    106 N1aca00539d234d7c9a5a668534caea4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Buthionine Sulfoximine
    108 rdf:type schema:DefinedTerm
    109 N21046e812aaf45c89134dfcccdbd9694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    110 schema:name Apoptosis
    111 rdf:type schema:DefinedTerm
    112 N226f3678c5b24faea8ff37e3ee159586 schema:issueNumber 31
    113 rdf:type schema:PublicationIssue
    114 N32eabc253c0b4281b784868de44966b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Biomimetic Materials
    116 rdf:type schema:DefinedTerm
    117 N39c20b579c33453b8862bb48f6056262 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Humans
    119 rdf:type schema:DefinedTerm
    120 N43364b95bc724e9a959bb8f85a4fb29a schema:name dimensions_id
    121 schema:value pub.1000381322
    122 rdf:type schema:PropertyValue
    123 N58f0fd85655d4896ab5d8932f9cc6bb7 schema:name doi
    124 schema:value 10.1038/onc.2014.338
    125 rdf:type schema:PropertyValue
    126 N5eaa5e7b3f784d3fb7276a8fe273ed6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Drug Synergism
    128 rdf:type schema:DefinedTerm
    129 N721b161dabe440d8871b80deaf4885cd rdf:first sg:person.01331656400.85
    130 rdf:rest rdf:nil
    131 N7b62741628e04331834e529208198e86 schema:name nlm_unique_id
    132 schema:value 8711562
    133 rdf:type schema:PropertyValue
    134 N7ff479b0ba034a20bf368bc29a4606b0 schema:name readcube_id
    135 schema:value 01d10b3bdab6a1617ce94aea9784c8f78c8fea81e805a4956ab9de019d0e1cf2
    136 rdf:type schema:PropertyValue
    137 N852546e2e3794626b434d566224de1fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
    139 rdf:type schema:DefinedTerm
    140 N9a5fa065939847e78ec9f2a966e96bbb schema:name Springer Nature - SN SciGraph project
    141 rdf:type schema:Organization
    142 N9b5a0140cf8b4ed99ad073bc40b267b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Oligopeptides
    144 rdf:type schema:DefinedTerm
    145 N9d671a5f1f5b4f18b5d9f1939b5ef605 rdf:first sg:person.01160717352.50
    146 rdf:rest N721b161dabe440d8871b80deaf4885cd
    147 Na1cf83dab5434c35b420f336940bedb3 schema:name pubmed_id
    148 schema:value 25381820
    149 rdf:type schema:PropertyValue
    150 Na2fdda381cd84e67974bfef6e1193261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Glutathione
    152 rdf:type schema:DefinedTerm
    153 Na4a209d966f94426a99cf7c2733be29d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Cells, Cultured
    155 rdf:type schema:DefinedTerm
    156 Na810ee068d30408d914bbbfadf416602 rdf:first sg:person.01002113507.47
    157 rdf:rest Nfb6ace70912644ad959f5e9f8b5bdb84
    158 Na9943f066648433eb7946afe55a281d9 schema:volumeNumber 34
    159 rdf:type schema:PublicationVolume
    160 Nc1aacc55c6e24de490164b9eea6ee80a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Child
    162 rdf:type schema:DefinedTerm
    163 Ne68a5903f66e4db0bdcfb6122708b3fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Intracellular Signaling Peptides and Proteins
    165 rdf:type schema:DefinedTerm
    166 Ne7dbd426d8614f9eb46dd82512f3a4c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Jurkat Cells
    168 rdf:type schema:DefinedTerm
    169 Nfac0746e0bea4accad37d4b519100f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Lipid Peroxidation
    171 rdf:type schema:DefinedTerm
    172 Nfb6ace70912644ad959f5e9f8b5bdb84 rdf:first sg:person.0677111136.44
    173 rdf:rest N9d671a5f1f5b4f18b5d9f1939b5ef605
    174 Nfe471b638d0d4617883008a42cf58d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Mitochondrial Proteins
    176 rdf:type schema:DefinedTerm
    177 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Biological Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Biochemistry and Cell Biology
    182 rdf:type schema:DefinedTerm
    183 sg:journal.1097543 schema:issn 0950-9232
    184 1476-5594
    185 schema:name Oncogene
    186 rdf:type schema:Periodical
    187 sg:person.01002113507.47 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    188 schema:familyName Schoeneberger
    189 schema:givenName H
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002113507.47
    191 rdf:type schema:Person
    192 sg:person.01160717352.50 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    193 schema:familyName Schenk
    194 schema:givenName B
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160717352.50
    196 rdf:type schema:Person
    197 sg:person.01331656400.85 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    198 schema:familyName Fulda
    199 schema:givenName S
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331656400.85
    201 rdf:type schema:Person
    202 sg:person.0677111136.44 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    203 schema:familyName Belz
    204 schema:givenName K
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677111136.44
    206 rdf:type schema:Person
    207 sg:pub.10.1007/978-3-642-18156-6_44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011084186
    208 https://doi.org/10.1007/978-3-642-18156-6_44
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/cdd.2009.107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035415055
    211 https://doi.org/10.1038/cdd.2009.107
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/cdd.2012.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016341290
    214 https://doi.org/10.1038/cdd.2012.10
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/cddis.2013.457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017272218
    217 https://doi.org/10.1038/cddis.2013.457
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/leu.2011.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049850273
    220 https://doi.org/10.1038/leu.2011.353
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/leu.2014.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035804358
    223 https://doi.org/10.1038/leu.2014.56
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/nrd2803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017656268
    226 https://doi.org/10.1038/nrd2803
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nrd3627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025792112
    229 https://doi.org/10.1038/nrd3627
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nrd4002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005500014
    232 https://doi.org/10.1038/nrd4002
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/onc.2012.337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053056645
    235 https://doi.org/10.1038/onc.2012.337
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/sj.cdd.4401431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033978648
    238 https://doi.org/10.1038/sj.cdd.4401431
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/sj.onc.1209608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046914764
    241 https://doi.org/10.1038/sj.onc.1209608
    242 rdf:type schema:CreativeWork
    243 https://app.dimensions.ai/details/publication/pub.1074566086 schema:CreativeWork
    244 https://app.dimensions.ai/details/publication/pub.1076809784 schema:CreativeWork
    245 https://app.dimensions.ai/details/publication/pub.1079423863 schema:CreativeWork
    246 https://app.dimensions.ai/details/publication/pub.1081580668 schema:CreativeWork
    247 https://app.dimensions.ai/details/publication/pub.1082646861 schema:CreativeWork
    248 https://doi.org/10.1002/ijc.24064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042639867
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1002/pbc.22541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050159697
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1006/abbi.1997.0341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010756605
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1006/abio.1998.2931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026252168
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.bbagen.2012.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052828668
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.ccr.2007.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008093277
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.cell.2007.10.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036164945
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.cell.2007.10.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032826025
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.cell.2009.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053704255
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.cell.2012.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036616855
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.cell.2013.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042741198
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.chembiol.2008.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048140866
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.cmet.2008.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023605394
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.freeradbiomed.2011.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004702619
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.immuni.2012.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005425492
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.jbbm.2005.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001825124
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.molcel.2011.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004938709
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/s0891-5849(98)00261-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001817534
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1042/bj2190001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027549159
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1042/bj3280199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047640070
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1053/j.seminhematol.2008.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004382182
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1056/nejmra023001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005718906
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1073/pnas.0601945103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033702987
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1074/jbc.m111.300012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015516776
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1074/jbc.m112.398966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022580968
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1074/jbc.m807061200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022994431
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1080/08941930600674702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024141801
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1089/ars.2007.1957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000616792
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1089/ars.2009.2743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231080
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1089/ars.2011.4258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231688
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1093/carcin/1.3.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059448733
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1093/jnci/89.23.1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034878122
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/j.1365-2141.2009.07603.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033060993
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1158/0008-5472.can-06-0409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000530949
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1158/1078-0432.ccr-03-0642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023241051
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1158/1078-0432.ccr-12-1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010680926
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1158/1078-0432.ccr-13-0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040456727
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1182/blood-2007-09-114314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013445919
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1182/blood-2008-08-173310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005009325
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1182/blood-2013-05-500918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041648123
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1182/blood.v97.2.393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042164381
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.3389/fonc.2014.00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030888937
    331 rdf:type schema:CreativeWork
    332 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
    333 schema:name Institute for Experimental Cancer Research in Pediatrics, Goethe-University, Frankfurt, Germany
    334 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...