DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02

AUTHORS

Cristel V. Camacho, Pavlina K. Todorova, Molly C. Gillam, Nozomi Tomimatsu, Carlos R Gil del Alcazar, Mariya Ilcheva, Bipasha Mukherjee, Brian McEllin, Vamsidhara Vemireddy, Kimmo Hatanpaa, Michael D. Story, Amyn A. Habib, Vundavalli V. Murty, Robert Bachoo, Sandeep Burma

ABSTRACT

Glioblastomas (GBM) are highly radioresistant and lethal brain tumors. Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are a risk factor for the development of GBM. In this study, we systematically examined the contribution of IR-induced DSBs to GBM development using transgenic mouse models harboring brain-targeted deletions of key tumor suppressors frequently lost in GBM, namely Ink4a, Ink4b, Arf and/or PTEN. Using low linear energy transfer (LET) X-rays to generate simple breaks or high LET HZE particles (Fe ions) to generate complex breaks, we found that DSBs induce high-grade gliomas in these mice which, otherwise, do not develop gliomas spontaneously. Loss of Ink4a and Arf was sufficient to trigger IR-induced glioma development but additional loss of Ink4b significantly increased tumor incidence. We analyzed IR-induced tumors for copy number alterations to identify oncogenic changes that were generated and selected for as a consequence of stochastic DSB events. We found Met amplification to be the most significant oncogenic event in these radiation-induced gliomas. Importantly, Met activation resulted in the expression of Sox2, a GBM cancer stem cell marker, and was obligatory for tumor formation. In sum, these results indicate that radiation-induced DSBs cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation. More... »

PAGES

1064

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2014.29

DOI

http://dx.doi.org/10.1038/onc.2014.29

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052829396

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24632607


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p15", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Amplification", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-met", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation, Ionizing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Camacho", 
        "givenName": "Cristel V.", 
        "id": "sg:person.015142321177.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015142321177.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todorova", 
        "givenName": "Pavlina K.", 
        "id": "sg:person.01213225677.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213225677.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gillam", 
        "givenName": "Molly C.", 
        "id": "sg:person.013714340461.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013714340461.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomimatsu", 
        "givenName": "Nozomi", 
        "id": "sg:person.0653541155.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653541155.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "del Alcazar", 
        "givenName": "Carlos R Gil", 
        "id": "sg:person.010136473501.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010136473501.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ilcheva", 
        "givenName": "Mariya", 
        "id": "sg:person.01110057250.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110057250.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukherjee", 
        "givenName": "Bipasha", 
        "id": "sg:person.01057036426.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057036426.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McEllin", 
        "givenName": "Brian", 
        "id": "sg:person.01125151626.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125151626.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vemireddy", 
        "givenName": "Vamsidhara", 
        "id": "sg:person.01315211551.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315211551.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hatanpaa", 
        "givenName": "Kimmo", 
        "id": "sg:person.01053241133.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053241133.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Story", 
        "givenName": "Michael D.", 
        "id": "sg:person.01073537512.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073537512.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VA North Texas Health Care System", 
          "id": "https://www.grid.ac/institutes/grid.422201.7", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX", 
            "VA North Texas Health Care System, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Habib", 
        "givenName": "Amyn A.", 
        "id": "sg:person.01173330633.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173330633.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Columbia University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murty", 
        "givenName": "Vundavalli V.", 
        "id": "sg:person.014031477642.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014031477642.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachoo", 
        "givenName": "Robert", 
        "id": "sg:person.01345142471.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345142471.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Southwestern Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.267313.2", 
          "name": [
            "Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burma", 
        "givenName": "Sandeep", 
        "id": "sg:person.01142321463.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142321463.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1046/j.1460-9568.1999.00699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001028012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001430701", 
          "https://doi.org/10.1007/s00401-007-0243-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002993405", 
          "https://doi.org/10.1038/nrm3012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002993405", 
          "https://doi.org/10.1038/nrm3012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)60815-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004307527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2010.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004602874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-7-58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007405477", 
          "https://doi.org/10.1186/1476-4598-7-58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012534742", 
          "https://doi.org/10.1038/nature06084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.21142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013218301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013378737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35092584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014622173", 
          "https://doi.org/10.1038/35092584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35092584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014622173", 
          "https://doi.org/10.1038/35092584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1596707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016912267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018991915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019948611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgq153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020295586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022817678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1141478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023671304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870120111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024082356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024286683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-3019(03)00137-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028653382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-3019(03)00137-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028653382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2013.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029137897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009117107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031469929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219747110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031529544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032551105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032551105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.12.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033185893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.11.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033302817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.26445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033916366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0710052104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034562854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2013.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035788552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036425682", 
          "https://doi.org/10.1038/85798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/85798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036425682", 
          "https://doi.org/10.1038/85798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199111073251902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036678878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2008.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037641129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00017-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037695027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrfmmm.2010.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037848792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2008.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038191281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039570773", 
          "https://doi.org/10.1038/nature07385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-002-0672-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041873101", 
          "https://doi.org/10.1007/s00247-002-0672-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042631734", 
          "https://doi.org/10.1038/nrc2391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1016912108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043613463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.6853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046019796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2011.474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046554846", 
          "https://doi.org/10.1038/onc.2011.474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djr093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047452054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2007.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047954116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.4.1563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047977012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048356671", 
          "https://doi.org/10.1038/nrc3205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2009.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049147418", 
          "https://doi.org/10.1038/nrneurol.2009.96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrneurol.2009.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049147418", 
          "https://doi.org/10.1038/nrneurol.2009.96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn3060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051238833", 
          "https://doi.org/10.1038/nrn3060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1142946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr1393.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068195385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3538.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078552833", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-02", 
    "datePublishedReg": "2015-02-01", 
    "description": "Glioblastomas (GBM) are highly radioresistant and lethal brain tumors. Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are a risk factor for the development of GBM. In this study, we systematically examined the contribution of IR-induced DSBs to GBM development using transgenic mouse models harboring brain-targeted deletions of key tumor suppressors frequently lost in GBM, namely Ink4a, Ink4b, Arf and/or PTEN. Using low linear energy transfer (LET) X-rays to generate simple breaks or high LET HZE particles (Fe ions) to generate complex breaks, we found that DSBs induce high-grade gliomas in these mice which, otherwise, do not develop gliomas spontaneously. Loss of Ink4a and Arf was sufficient to trigger IR-induced glioma development but additional loss of Ink4b significantly increased tumor incidence. We analyzed IR-induced tumors for copy number alterations to identify oncogenic changes that were generated and selected for as a consequence of stochastic DSB events. We found Met amplification to be the most significant oncogenic event in these radiation-induced gliomas. Importantly, Met activation resulted in the expression of Sox2, a GBM cancer stem cell marker, and was obligatory for tumor formation. In sum, these results indicate that radiation-induced DSBs cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2014.29", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2480880", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7051101", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2562268", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3822533", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2682810", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683864", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification", 
    "pagination": "1064", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fba45ef208e8bc901df4bb240eb23278dd3ac162b222cce4e1ddbd604be19da4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24632607"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2014.29"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052829396"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2014.29", 
      "https://app.dimensions.ai/details/publication/pub.1052829396"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000437.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc201429"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.29'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.29'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.29'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2014.29'


 

This table displays all metadata directly associated to this object as RDF triples.

406 TRIPLES      21 PREDICATES      93 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2014.29 schema:about N0fb70094aeb841a3b8a4478a5f1d697e
2 N4565be1536824f30b348ed6df507e611
3 N4f358acc3f564afa972c878521a5061b
4 N4f958552610a4edebd8897239aad4584
5 N53f9bf552cc948b498737474b84f8fb6
6 N7a171a2e98ed487c8033f32dd22fbf35
7 N8a086670a2ef4a65b023236e305c1184
8 N9c2bd10e3fee401ba19453b0df00a010
9 Nc13fe41026cf4709a198511990b8b3c5
10 Nd8fc47c583c848a59d24528cf6db7e98
11 Ne5947a0ae1ae4db3be2af4ec26f40d5c
12 Nec1124e69cd24bc0a7dbc01834fd6bf4
13 Nefae411fa0274dadb584e97247adb307
14 Nfae5ffa5eda942e1a4e49a67d6ad2103
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N040d714a1a3c4bae8e41df44b9fa8010
18 schema:citation sg:pub.10.1007/s00247-002-0672-0
19 sg:pub.10.1007/s00401-007-0243-4
20 sg:pub.10.1038/35092584
21 sg:pub.10.1038/85798
22 sg:pub.10.1038/nature06084
23 sg:pub.10.1038/nature07385
24 sg:pub.10.1038/nrc2391
25 sg:pub.10.1038/nrc3205
26 sg:pub.10.1038/nrm3012
27 sg:pub.10.1038/nrn3060
28 sg:pub.10.1038/nrneurol.2009.96
29 sg:pub.10.1038/onc.2011.474
30 sg:pub.10.1186/1476-4598-7-58
31 https://app.dimensions.ai/details/publication/pub.1078552833
32 https://doi.org/10.1002/cncr.23741
33 https://doi.org/10.1002/gcc.2870120111
34 https://doi.org/10.1002/glia.21142
35 https://doi.org/10.1002/ijc.26445
36 https://doi.org/10.1006/bbrc.1997.6853
37 https://doi.org/10.1016/j.bbcan.2007.07.006
38 https://doi.org/10.1016/j.ccr.2009.11.022
39 https://doi.org/10.1016/j.dnarep.2008.01.010
40 https://doi.org/10.1016/j.dnarep.2008.06.016
41 https://doi.org/10.1016/j.dnarep.2013.08.009
42 https://doi.org/10.1016/j.dnarep.2013.10.004
43 https://doi.org/10.1016/j.ijrobp.2007.12.018
44 https://doi.org/10.1016/j.jocn.2010.05.010
45 https://doi.org/10.1016/j.mrfmmm.2010.12.010
46 https://doi.org/10.1016/s0090-3019(03)00137-x
47 https://doi.org/10.1016/s0140-6736(12)60815-0
48 https://doi.org/10.1016/s1535-6108(02)00017-x
49 https://doi.org/10.1046/j.1460-9568.1999.00699.x
50 https://doi.org/10.1056/nejm199111073251902
51 https://doi.org/10.1073/pnas.0710052104
52 https://doi.org/10.1073/pnas.1009117107
53 https://doi.org/10.1073/pnas.1016912108
54 https://doi.org/10.1073/pnas.1219747110
55 https://doi.org/10.1073/pnas.96.4.1563
56 https://doi.org/10.1093/carcin/bgq153
57 https://doi.org/10.1093/jnci/djr093
58 https://doi.org/10.1101/gad.1596707
59 https://doi.org/10.1126/science.1141478
60 https://doi.org/10.1126/science.1142946
61 https://doi.org/10.1158/0008-5472.can-05-1946
62 https://doi.org/10.1158/0008-5472.can-05-4181
63 https://doi.org/10.1158/0008-5472.can-08-4853
64 https://doi.org/10.1158/0008-5472.can-11-3490
65 https://doi.org/10.1158/0008-5472.can-11-3760
66 https://doi.org/10.1667/rr1393.1
67 https://doi.org/10.1667/rr3538.1
68 schema:datePublished 2015-02
69 schema:datePublishedReg 2015-02-01
70 schema:description Glioblastomas (GBM) are highly radioresistant and lethal brain tumors. Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are a risk factor for the development of GBM. In this study, we systematically examined the contribution of IR-induced DSBs to GBM development using transgenic mouse models harboring brain-targeted deletions of key tumor suppressors frequently lost in GBM, namely Ink4a, Ink4b, Arf and/or PTEN. Using low linear energy transfer (LET) X-rays to generate simple breaks or high LET HZE particles (Fe ions) to generate complex breaks, we found that DSBs induce high-grade gliomas in these mice which, otherwise, do not develop gliomas spontaneously. Loss of Ink4a and Arf was sufficient to trigger IR-induced glioma development but additional loss of Ink4b significantly increased tumor incidence. We analyzed IR-induced tumors for copy number alterations to identify oncogenic changes that were generated and selected for as a consequence of stochastic DSB events. We found Met amplification to be the most significant oncogenic event in these radiation-induced gliomas. Importantly, Met activation resulted in the expression of Sox2, a GBM cancer stem cell marker, and was obligatory for tumor formation. In sum, these results indicate that radiation-induced DSBs cooperate with loss of Ink4 and Arf tumor suppressors to generate high-grade gliomas that are commonly driven by Met amplification and activation.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N762c5d85f09b4c42b7e1f4ee1c519c01
75 Nf44bc25510c343afa0ee5b2166cb38e6
76 sg:journal.1097543
77 schema:name DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification
78 schema:pagination 1064
79 schema:productId N43d8772f98344baa82b2b1dbe83ab319
80 Nb9a60a70a6834c58a4e29155829f9071
81 Nc234cc0f3719441795220903fbf8618e
82 Nd9979b33f30d48df98a9ace23d9f9ad2
83 Ne8f29ea6582449258cff6485ae7c5e8f
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052829396
85 https://doi.org/10.1038/onc.2014.29
86 schema:sdDatePublished 2019-04-10T20:36
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N4ca18cfb55aa4b61b282a02b460b0ba9
89 schema:url https://www.nature.com/articles/onc201429
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N040d714a1a3c4bae8e41df44b9fa8010 rdf:first sg:person.015142321177.91
94 rdf:rest N5b927448980e419280699f110db5efe7
95 N08f0952af5244236a0e0b48a136ed5b1 rdf:first sg:person.0653541155.98
96 rdf:rest N284599a577b84158977024fe1f740291
97 N0fb70094aeb841a3b8a4478a5f1d697e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name DNA Breaks, Double-Stranded
99 rdf:type schema:DefinedTerm
100 N1616f2017bad47c6bab1f83b6295b90d rdf:first sg:person.01173330633.42
101 rdf:rest N8896bffc74b044f1a2877da4515b24da
102 N1b666f753bfa48e78d0365821d2988cb rdf:first sg:person.01142321463.18
103 rdf:rest rdf:nil
104 N284599a577b84158977024fe1f740291 rdf:first sg:person.010136473501.93
105 rdf:rest Na84add63e2e3464abd7a310286f7a1ee
106 N2e024214c41a42ed9171f31fa8459df2 rdf:first sg:person.01345142471.27
107 rdf:rest N1b666f753bfa48e78d0365821d2988cb
108 N43d8772f98344baa82b2b1dbe83ab319 schema:name pubmed_id
109 schema:value 24632607
110 rdf:type schema:PropertyValue
111 N4565be1536824f30b348ed6df507e611 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Gene Amplification
113 rdf:type schema:DefinedTerm
114 N4ca18cfb55aa4b61b282a02b460b0ba9 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N4f358acc3f564afa972c878521a5061b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Gene Deletion
118 rdf:type schema:DefinedTerm
119 N4f958552610a4edebd8897239aad4584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mice, Inbred C57BL
121 rdf:type schema:DefinedTerm
122 N53f9bf552cc948b498737474b84f8fb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Brain Neoplasms
124 rdf:type schema:DefinedTerm
125 N5b927448980e419280699f110db5efe7 rdf:first sg:person.01213225677.39
126 rdf:rest N85d03522ac9a4f1dbe676f1539a57626
127 N6d1c0e19eb3742159f5cd83fb360b144 rdf:first sg:person.01057036426.11
128 rdf:rest N8370492af3ed4259b63ceacb9fafb111
129 N762c5d85f09b4c42b7e1f4ee1c519c01 schema:issueNumber 8
130 rdf:type schema:PublicationIssue
131 N7a171a2e98ed487c8033f32dd22fbf35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proto-Oncogene Proteins c-met
133 rdf:type schema:DefinedTerm
134 N8370492af3ed4259b63ceacb9fafb111 rdf:first sg:person.01125151626.31
135 rdf:rest Ne114408a25784c369f16fa808b1ae1b0
136 N85d03522ac9a4f1dbe676f1539a57626 rdf:first sg:person.013714340461.09
137 rdf:rest N08f0952af5244236a0e0b48a136ed5b1
138 N8896bffc74b044f1a2877da4515b24da rdf:first sg:person.014031477642.39
139 rdf:rest N2e024214c41a42ed9171f31fa8459df2
140 N8a086670a2ef4a65b023236e305c1184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mice, Knockout
142 rdf:type schema:DefinedTerm
143 N9c2bd10e3fee401ba19453b0df00a010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N9de56f93ccb440ee912fcd6a36c222b3 rdf:first sg:person.01073537512.86
147 rdf:rest N1616f2017bad47c6bab1f83b6295b90d
148 Na84add63e2e3464abd7a310286f7a1ee rdf:first sg:person.01110057250.04
149 rdf:rest N6d1c0e19eb3742159f5cd83fb360b144
150 Nb9a60a70a6834c58a4e29155829f9071 schema:name doi
151 schema:value 10.1038/onc.2014.29
152 rdf:type schema:PropertyValue
153 Nc13fe41026cf4709a198511990b8b3c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cyclin-Dependent Kinase Inhibitor p16
155 rdf:type schema:DefinedTerm
156 Nc234cc0f3719441795220903fbf8618e schema:name readcube_id
157 schema:value fba45ef208e8bc901df4bb240eb23278dd3ac162b222cce4e1ddbd604be19da4
158 rdf:type schema:PropertyValue
159 Nd8fc47c583c848a59d24528cf6db7e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cyclin-Dependent Kinase Inhibitor p15
161 rdf:type schema:DefinedTerm
162 Nd9979b33f30d48df98a9ace23d9f9ad2 schema:name nlm_unique_id
163 schema:value 8711562
164 rdf:type schema:PropertyValue
165 Nddd5e09ecf484eec9171798a98afc388 rdf:first sg:person.01053241133.39
166 rdf:rest N9de56f93ccb440ee912fcd6a36c222b3
167 Ne114408a25784c369f16fa808b1ae1b0 rdf:first sg:person.01315211551.99
168 rdf:rest Nddd5e09ecf484eec9171798a98afc388
169 Ne5947a0ae1ae4db3be2af4ec26f40d5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Glioblastoma
171 rdf:type schema:DefinedTerm
172 Ne8f29ea6582449258cff6485ae7c5e8f schema:name dimensions_id
173 schema:value pub.1052829396
174 rdf:type schema:PropertyValue
175 Nec1124e69cd24bc0a7dbc01834fd6bf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Radiation, Ionizing
177 rdf:type schema:DefinedTerm
178 Nefae411fa0274dadb584e97247adb307 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Mice
180 rdf:type schema:DefinedTerm
181 Nf44bc25510c343afa0ee5b2166cb38e6 schema:volumeNumber 34
182 rdf:type schema:PublicationVolume
183 Nfae5ffa5eda942e1a4e49a67d6ad2103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Mice, Nude
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
190 schema:name Oncology and Carcinogenesis
191 rdf:type schema:DefinedTerm
192 sg:grant.2480880 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
193 rdf:type schema:MonetaryGrant
194 sg:grant.2562268 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
195 rdf:type schema:MonetaryGrant
196 sg:grant.2682810 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
197 rdf:type schema:MonetaryGrant
198 sg:grant.2683864 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
199 rdf:type schema:MonetaryGrant
200 sg:grant.3822533 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
201 rdf:type schema:MonetaryGrant
202 sg:grant.7051101 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2014.29
203 rdf:type schema:MonetaryGrant
204 sg:journal.1097543 schema:issn 0950-9232
205 1476-5594
206 schema:name Oncogene
207 rdf:type schema:Periodical
208 sg:person.010136473501.93 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
209 schema:familyName del Alcazar
210 schema:givenName Carlos R Gil
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010136473501.93
212 rdf:type schema:Person
213 sg:person.01053241133.39 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
214 schema:familyName Hatanpaa
215 schema:givenName Kimmo
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053241133.39
217 rdf:type schema:Person
218 sg:person.01057036426.11 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
219 schema:familyName Mukherjee
220 schema:givenName Bipasha
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057036426.11
222 rdf:type schema:Person
223 sg:person.01073537512.86 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
224 schema:familyName Story
225 schema:givenName Michael D.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073537512.86
227 rdf:type schema:Person
228 sg:person.01110057250.04 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
229 schema:familyName Ilcheva
230 schema:givenName Mariya
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110057250.04
232 rdf:type schema:Person
233 sg:person.01125151626.31 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
234 schema:familyName McEllin
235 schema:givenName Brian
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125151626.31
237 rdf:type schema:Person
238 sg:person.01142321463.18 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
239 schema:familyName Burma
240 schema:givenName Sandeep
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142321463.18
242 rdf:type schema:Person
243 sg:person.01173330633.42 schema:affiliation https://www.grid.ac/institutes/grid.422201.7
244 schema:familyName Habib
245 schema:givenName Amyn A.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173330633.42
247 rdf:type schema:Person
248 sg:person.01213225677.39 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
249 schema:familyName Todorova
250 schema:givenName Pavlina K.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213225677.39
252 rdf:type schema:Person
253 sg:person.01315211551.99 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
254 schema:familyName Vemireddy
255 schema:givenName Vamsidhara
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315211551.99
257 rdf:type schema:Person
258 sg:person.01345142471.27 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
259 schema:familyName Bachoo
260 schema:givenName Robert
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345142471.27
262 rdf:type schema:Person
263 sg:person.013714340461.09 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
264 schema:familyName Gillam
265 schema:givenName Molly C.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013714340461.09
267 rdf:type schema:Person
268 sg:person.014031477642.39 schema:affiliation https://www.grid.ac/institutes/grid.239585.0
269 schema:familyName Murty
270 schema:givenName Vundavalli V.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014031477642.39
272 rdf:type schema:Person
273 sg:person.015142321177.91 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
274 schema:familyName Camacho
275 schema:givenName Cristel V.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015142321177.91
277 rdf:type schema:Person
278 sg:person.0653541155.98 schema:affiliation https://www.grid.ac/institutes/grid.267313.2
279 schema:familyName Tomimatsu
280 schema:givenName Nozomi
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653541155.98
282 rdf:type schema:Person
283 sg:pub.10.1007/s00247-002-0672-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041873101
284 https://doi.org/10.1007/s00247-002-0672-0
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s00401-007-0243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001430701
287 https://doi.org/10.1007/s00401-007-0243-4
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/35092584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014622173
290 https://doi.org/10.1038/35092584
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/85798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036425682
293 https://doi.org/10.1038/85798
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nature06084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012534742
296 https://doi.org/10.1038/nature06084
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
299 https://doi.org/10.1038/nature07385
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nrc2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042631734
302 https://doi.org/10.1038/nrc2391
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nrc3205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048356671
305 https://doi.org/10.1038/nrc3205
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nrm3012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002993405
308 https://doi.org/10.1038/nrm3012
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nrn3060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051238833
311 https://doi.org/10.1038/nrn3060
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nrneurol.2009.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049147418
314 https://doi.org/10.1038/nrneurol.2009.96
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/onc.2011.474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046554846
317 https://doi.org/10.1038/onc.2011.474
318 rdf:type schema:CreativeWork
319 sg:pub.10.1186/1476-4598-7-58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007405477
320 https://doi.org/10.1186/1476-4598-7-58
321 rdf:type schema:CreativeWork
322 https://app.dimensions.ai/details/publication/pub.1078552833 schema:CreativeWork
323 https://doi.org/10.1002/cncr.23741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032551105
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1002/gcc.2870120111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024082356
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1002/glia.21142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013218301
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1002/ijc.26445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033916366
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1006/bbrc.1997.6853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046019796
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.bbcan.2007.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047954116
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.ccr.2009.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033302817
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.dnarep.2008.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037641129
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.dnarep.2008.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038191281
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.dnarep.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035788552
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.dnarep.2013.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029137897
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.ijrobp.2007.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033185893
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.jocn.2010.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004602874
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/j.mrfmmm.2010.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037848792
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1016/s0090-3019(03)00137-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028653382
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1016/s0140-6736(12)60815-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004307527
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/s1535-6108(02)00017-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037695027
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1046/j.1460-9568.1999.00699.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001028012
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1056/nejm199111073251902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036678878
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1073/pnas.0710052104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034562854
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1073/pnas.1009117107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031469929
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1073/pnas.1016912108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043613463
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1073/pnas.1219747110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031529544
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1073/pnas.96.4.1563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047977012
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1093/carcin/bgq153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020295586
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1093/jnci/djr093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047452054
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1101/gad.1596707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016912267
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1126/science.1141478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023671304
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1126/science.1142946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456066
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/0008-5472.can-05-1946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019948611
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/0008-5472.can-05-4181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018991915
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1158/0008-5472.can-08-4853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022817678
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1158/0008-5472.can-11-3490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013378737
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1158/0008-5472.can-11-3760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024286683
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1667/rr1393.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068195385
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1667/rr3538.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196633
394 rdf:type schema:CreativeWork
395 https://www.grid.ac/institutes/grid.239585.0 schema:alternateName Columbia University Medical Center
396 schema:name Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.267313.2 schema:alternateName The University of Texas Southwestern Medical Center
399 schema:name Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX
400 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX
401 Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.422201.7 schema:alternateName VA North Texas Health Care System
404 schema:name Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX
405 VA North Texas Health Care System, Dallas, TX
406 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...