Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

P Rajbhandari, K A Schalper, N M Solodin, S J Ellison-Zelski, K Ping Lu, D L Rimm, E T Alarid

ABSTRACT

Estrogen receptor-alpha (ERα) is an important biomarker used to classify and direct therapy decisions in breast cancer (BC). Both ERα protein and its transcript, ESR1, are used to predict response to tamoxifen therapy, yet certain tumors have discordant levels of ERα protein and ESR1, which is currently unexplained. Cellular ERα protein levels can be controlled post-translationally by the ubiquitin-proteasome pathway through a mechanism that depends on phosphorylation at residue S118. Phospho-S118 (pS118-ERα) is a substrate for the peptidyl prolyl isomerase, Pin1, which mediates cis-trans isomerization of the pS118-P119 bond to enhance ERα transcriptional function. Here, we demonstrate that Pin1 can increase ERα protein without affecting ESR1 transcript levels by inhibiting proteasome-dependent receptor degradation. Pin1 disrupts ERα ubiquitination by interfering with receptor interactions with the E3 ligase, E6AP, which also is shown to bind pS118-ERα. Quantitative in situ assessments of ERα protein, ESR1, and Pin1 in human tumors from a retrospective cohort show that Pin1 levels correlate with ERα protein but not to ESR1 levels. These data show that ERα protein is post-translationally regulated by Pin1 in a proportion of breast carcinomas. As Pin1 impacts both ERα protein levels and transactivation function, these data implicate Pin1 as a potential surrogate marker for predicting outcome of ERα-positive BC. More... »

PAGES

1438

References to SciGraph publications

  • 2002-10. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response in NATURE
  • 2002-11. Automated subcellular localization and quantification of protein expression in tissue microarrays in NATURE MEDICINE
  • 2012-08. Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells in ONCOGENE
  • 1997-12. Contribution of enhanced transcriptional activation by ER to [12Val] K-Ras mediated NIH3T3 cell transformation in ONCOGENE
  • 2012-06. Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis in ONCOGENE
  • 2005-05. Phosphorylation-specific prolyl isomerization: is there an underlying theme? in NATURE CELL BIOLOGY
  • 2001-09. Pin1 regulates turnover and subcellular localization of β-catenin by inhibiting its interaction with APC in NATURE CELL BIOLOGY
  • 2012-02. Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis in BREAST CANCER RESEARCH AND TREATMENT
  • 2010-05. Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα-induced granulocytic differentiation through c-Jun in AML in LEUKEMIA
  • 2003-04. The prolyl isomerase Pin1 in breast development and cancer in BREAST CANCER RESEARCH
  • 2003-03. How the ubiquitin–proteasome system controls transcription in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-11. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-10. Prolyl cis-trans isomerization as a molecular timer in NATURE CHEMICAL BIOLOGY
  • 1999-06. The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2013.78

    DOI

    http://dx.doi.org/10.1038/onc.2013.78

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052577931

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23542176


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