PRC2-independent chromatin compaction and transcriptional repression in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

C Vallot, A Hérault, S Boyle, W A Bickmore, F Radvanyi

ABSTRACT

The silencing of large chromosomal regions by epigenetic mechanisms has been reported to occur frequently in cancer. Epigenetic marks, such as histone methylation and acetylation, are altered at these loci. However, the mechanisms of formation of such aberrant gene clusters remain largely unknown. Here, we show that, in cancer cells, the epigenetic remodeling of chromatin into hypoacetylated domains covered with histone H3K27 trimethylation is paralleled by changes in higher-order chromatin structures. Using fluorescence in situ hybridization, we demonstrate that regional epigenetic silencing corresponds to the establishment of compact chromatin domains. We show that gene repression is tightly correlated to the state of chromatin compaction and not to the levels of H3K27me3-its removal through the knockdown of EZH2 does not induce significant gene expression nor chromatin decompaction. Moreover, transcription can occur with intact high-H3K27me3 levels; treatment with histone deacetylase inhibitors can relieve chromatin compaction and gene repression, without altering H3K27me3 levels. Our findings imply that compaction and subsequent repression of large chromatin domains are not direct consequences of PRC2 deregulation in cancer cells. By challenging the role of EZH2 in aberrant gene silencing in cancer, these findings have therapeutical implications, notably for the choice of epigenetic drugs for tumors with multiple regional epigenetic alterations. More... »

PAGES

741

References to SciGraph publications

  • 2006-12. Regional copy number–independent deregulation of transcription in cancer in NATURE GENETICS
  • 2005-05. Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma in BRITISH JOURNAL OF CANCER
  • 2006-05. Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band in NATURE GENETICS
  • 2009-02. Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells in NATURE GENETICS
  • 1998-10. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays in NATURE GENETICS
  • 2008-04. Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis in GENOME BIOLOGY
  • 2010-04. Chromatin structure and the inheritance of epigenetic information in NATURE REVIEWS GENETICS
  • 2002-12. Identification of frequent cytogenetic aberrations in hepatocellular carcinoma using gene-expression microarray data in GENOME BIOLOGY
  • 2008-12. Repression of E-cadherin by the polycomb group protein EZH2 in cancer in ONCOGENE
  • 2013-05. Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-03. Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity in NATURE CELL BIOLOGY
  • 2008-05. An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors in NATURE GENETICS
  • 2005-10. The role of chromatin structure in regulating the expression of clustered genes in NATURE REVIEWS GENETICS
  • 2010-02. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2013.604

    DOI

    http://dx.doi.org/10.1038/onc.2013.604

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012479290

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24469045


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromatin Immunoprecipitation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enhancer of Zeste Homolog 2 Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Silencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone-Lysine N-Methyltransferase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histones", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb Repressive Complex 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Urinary Bladder Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute Curie", 
              "id": "https://www.grid.ac/institutes/grid.418596.7", 
              "name": [
                "CNRS, UMR 144 - Cell Biology Department, Institut Curie, Paris, France", 
                "Institut Curie, Centre de Recherche, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vallot", 
            "givenName": "C", 
            "id": "sg:person.01255346066.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255346066.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute Curie", 
              "id": "https://www.grid.ac/institutes/grid.418596.7", 
              "name": [
                "CNRS, UMR 144 - Cell Biology Department, Institut Curie, Paris, France", 
                "Institut Curie, Centre de Recherche, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "H\u00e9rault", 
            "givenName": "A", 
            "id": "sg:person.01160450365.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160450365.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Medical Research Council Institute of Genetics and Molecular Medicine", 
              "id": "https://www.grid.ac/institutes/grid.415854.9", 
              "name": [
                "Chromosome and Gene Expression Section, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boyle", 
            "givenName": "S", 
            "id": "sg:person.01002042701.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002042701.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "Chromosome and Gene Expression Section, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Scotland, UK", 
                "Breakthrough Breast Cancer Research Unit, University of Edinburgh, Scotland, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bickmore", 
            "givenName": "W A", 
            "id": "sg:person.01164404501.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164404501.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute Curie", 
              "id": "https://www.grid.ac/institutes/grid.418596.7", 
              "name": [
                "CNRS, UMR 144 - Cell Biology Department, Institut Curie, Paris, France", 
                "Institut Curie, Centre de Recherche, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radvanyi", 
            "givenName": "F", 
            "id": "sg:person.01024575231.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024575231.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001723375", 
              "https://doi.org/10.1038/ng.518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.292104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002405627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003900779", 
              "https://doi.org/10.1038/ng1781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003900779", 
              "https://doi.org/10.1038/ng1781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1933744100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006013665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1272505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007710897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009415129", 
              "https://doi.org/10.1038/ng1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009415129", 
              "https://doi.org/10.1038/ng1923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1171468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009974759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1171468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009974759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200907029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010070073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64665-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010814816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011270239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2002-3-12-research0075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012779695", 
              "https://doi.org/10.1186/gb-2002-3-12-research0075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014497848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014750873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m501379200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015248937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-11-321208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018424481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1163802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018805109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019197578", 
              "https://doi.org/10.1038/ncb2023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019197578", 
              "https://doi.org/10.1038/ncb2023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-1047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019475335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019562121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.08.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019999532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1013224108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020116320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020327469", 
              "https://doi.org/10.1038/nsmb.2532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1100576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020733240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022608960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022937373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2012.11.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026053131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-2498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026405198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026409761", 
              "https://doi.org/10.1038/2524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/2524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026409761", 
              "https://doi.org/10.1038/2524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1227604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027311581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.01293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027611304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1124000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027661592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mrfmmm.2008.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029372216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.08.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033350598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-2761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035163581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038820174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2004.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038965664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041523683", 
              "https://doi.org/10.1038/nrg2752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041523683", 
              "https://doi.org/10.1038/nrg2752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.12.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041907573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.02.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042040888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.080861.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043692654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0034848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044078076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<284::aid-ijc25>3.0.co;2-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044524284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-06-161901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044928187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045156533", 
              "https://doi.org/10.1038/nrg1688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045156533", 
              "https://doi.org/10.1038/nrg1688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045314212", 
              "https://doi.org/10.1038/ng.297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046327348", 
              "https://doi.org/10.1038/onc.2008.333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.01.5180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046338079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047142506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049130438", 
              "https://doi.org/10.1038/ng.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.01813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049260048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2008-9-4-r65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049740347", 
              "https://doi.org/10.1186/gb-2008-9-4-r65"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049949509", 
              "https://doi.org/10.1038/sj.bjc.6602531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049949509", 
              "https://doi.org/10.1038/sj.bjc.6602531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/sqb.2010.75.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050912378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djq470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052549185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053484531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1388286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062478668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075192363", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078392745", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082586564", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-02", 
        "datePublishedReg": "2015-02-01", 
        "description": "The silencing of large chromosomal regions by epigenetic mechanisms has been reported to occur frequently in cancer. Epigenetic marks, such as histone methylation and acetylation, are altered at these loci. However, the mechanisms of formation of such aberrant gene clusters remain largely unknown. Here, we show that, in cancer cells, the epigenetic remodeling of chromatin into hypoacetylated domains covered with histone H3K27 trimethylation is paralleled by changes in higher-order chromatin structures. Using fluorescence in situ hybridization, we demonstrate that regional epigenetic silencing corresponds to the establishment of compact chromatin domains. We show that gene repression is tightly correlated to the state of chromatin compaction and not to the levels of H3K27me3-its removal through the knockdown of EZH2 does not induce significant gene expression nor chromatin decompaction. Moreover, transcription can occur with intact high-H3K27me3 levels; treatment with histone deacetylase inhibitors can relieve chromatin compaction and gene repression, without altering H3K27me3 levels. Our findings imply that compaction and subsequent repression of large chromatin domains are not direct consequences of PRC2 deregulation in cancer cells. By challenging the role of EZH2 in aberrant gene silencing in cancer, these findings have therapeutical implications, notably for the choice of epigenetic drugs for tumors with multiple regional epigenetic alterations. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2013.604", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2753736", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "PRC2-independent chromatin compaction and transcriptional repression in cancer", 
        "pagination": "741", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3b73fc53df3f389e9687ed33e32be55d5be6a347481818b7a7e1d0e44d7ebe64"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24469045"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2013.604"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1012479290"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2013.604", 
          "https://app.dimensions.ai/details/publication/pub.1012479290"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:49", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2013604"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.604'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.604'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.604'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.604'


     

    This table displays all metadata directly associated to this object as RDF triples.

    351 TRIPLES      21 PREDICATES      102 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2013.604 schema:about N16776863fb9042559862344d5e483410
    2 N2713998fc89e4be2a5d6dfcabea20f91
    3 N37d0c819077441b4a0b4f529ae61aedc
    4 N550b51e0de2447bb985c6a01c7985694
    5 N693e34ab3fb74ba48094077798311dc8
    6 N7bd9fbae42ac47e081ca6628d43a4e7c
    7 N9714e3e4cd404ac1b327852b0ba073af
    8 N97fc42217144407aae01595e7760f7bf
    9 N9deae08281404d249a1eb7384269b80f
    10 Nc542695705de4f1a85c3302721e4dc54
    11 Ncd3633212b2d4208a2fffd2bd21f3c30
    12 Nceeabdcbd3ec4f53ac515ebc6b53b3a4
    13 Ne31e9f0e57a14add8246bf547dacbc34
    14 Ne96c357d877c4815b2b9741258e96f1a
    15 anzsrc-for:06
    16 anzsrc-for:0604
    17 schema:author N63b64e40214d4d60a33c1f24a64c6427
    18 schema:citation sg:pub.10.1038/2524
    19 sg:pub.10.1038/ncb2023
    20 sg:pub.10.1038/ng.127
    21 sg:pub.10.1038/ng.297
    22 sg:pub.10.1038/ng.518
    23 sg:pub.10.1038/ng1781
    24 sg:pub.10.1038/ng1923
    25 sg:pub.10.1038/nrg1688
    26 sg:pub.10.1038/nrg2752
    27 sg:pub.10.1038/nsmb.2532
    28 sg:pub.10.1038/onc.2008.333
    29 sg:pub.10.1038/sj.bjc.6602531
    30 sg:pub.10.1186/gb-2002-3-12-research0075
    31 sg:pub.10.1186/gb-2008-9-4-r65
    32 https://app.dimensions.ai/details/publication/pub.1075192363
    33 https://app.dimensions.ai/details/publication/pub.1078392745
    34 https://app.dimensions.ai/details/publication/pub.1082586564
    35 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<284::aid-ijc25>3.0.co;2-g
    36 https://doi.org/10.1016/j.cell.2004.08.011
    37 https://doi.org/10.1016/j.cell.2005.01.001
    38 https://doi.org/10.1016/j.cell.2007.02.005
    39 https://doi.org/10.1016/j.cell.2011.12.029
    40 https://doi.org/10.1016/j.celrep.2012.11.026
    41 https://doi.org/10.1016/j.gde.2004.02.001
    42 https://doi.org/10.1016/j.molcel.2008.08.022
    43 https://doi.org/10.1016/j.molcel.2008.10.016
    44 https://doi.org/10.1016/j.molcel.2008.11.004
    45 https://doi.org/10.1016/j.molcel.2010.02.032
    46 https://doi.org/10.1016/j.molcel.2013.01.016
    47 https://doi.org/10.1016/j.molcel.2013.02.013
    48 https://doi.org/10.1016/j.mrfmmm.2008.07.010
    49 https://doi.org/10.1016/j.stem.2007.08.004
    50 https://doi.org/10.1016/s0002-9440(10)64665-2
    51 https://doi.org/10.1073/pnas.1013224108
    52 https://doi.org/10.1073/pnas.1933744100
    53 https://doi.org/10.1074/jbc.m501379200
    54 https://doi.org/10.1083/jcb.200907029
    55 https://doi.org/10.1093/jnci/djq470
    56 https://doi.org/10.1101/gad.1272505
    57 https://doi.org/10.1101/gad.292104
    58 https://doi.org/10.1101/gr.080861.108
    59 https://doi.org/10.1101/sqb.2010.75.053
    60 https://doi.org/10.1126/science.1100576
    61 https://doi.org/10.1126/science.1124000
    62 https://doi.org/10.1126/science.1163802
    63 https://doi.org/10.1126/science.1171468
    64 https://doi.org/10.1126/science.1227604
    65 https://doi.org/10.1126/science.1388286
    66 https://doi.org/10.1158/0008-5472.can-06-2761
    67 https://doi.org/10.1158/0008-5472.can-07-2498
    68 https://doi.org/10.1158/1078-0432.ccr-05-1045
    69 https://doi.org/10.1158/1078-0432.ccr-05-1047
    70 https://doi.org/10.1182/blood-2008-06-161901
    71 https://doi.org/10.1182/blood-2010-11-321208
    72 https://doi.org/10.1200/jco.2005.01.5180
    73 https://doi.org/10.1242/dev.01813
    74 https://doi.org/10.1242/dev.02779
    75 https://doi.org/10.1242/jcs.01293
    76 https://doi.org/10.1371/journal.pone.0034848
    77 schema:datePublished 2015-02
    78 schema:datePublishedReg 2015-02-01
    79 schema:description The silencing of large chromosomal regions by epigenetic mechanisms has been reported to occur frequently in cancer. Epigenetic marks, such as histone methylation and acetylation, are altered at these loci. However, the mechanisms of formation of such aberrant gene clusters remain largely unknown. Here, we show that, in cancer cells, the epigenetic remodeling of chromatin into hypoacetylated domains covered with histone H3K27 trimethylation is paralleled by changes in higher-order chromatin structures. Using fluorescence in situ hybridization, we demonstrate that regional epigenetic silencing corresponds to the establishment of compact chromatin domains. We show that gene repression is tightly correlated to the state of chromatin compaction and not to the levels of H3K27me3-its removal through the knockdown of EZH2 does not induce significant gene expression nor chromatin decompaction. Moreover, transcription can occur with intact high-H3K27me3 levels; treatment with histone deacetylase inhibitors can relieve chromatin compaction and gene repression, without altering H3K27me3 levels. Our findings imply that compaction and subsequent repression of large chromatin domains are not direct consequences of PRC2 deregulation in cancer cells. By challenging the role of EZH2 in aberrant gene silencing in cancer, these findings have therapeutical implications, notably for the choice of epigenetic drugs for tumors with multiple regional epigenetic alterations.
    80 schema:genre research_article
    81 schema:inLanguage en
    82 schema:isAccessibleForFree false
    83 schema:isPartOf N60ae0f2d4f4d428aaec698122c3717e7
    84 Nc5d5b1c686b2405082189dfd3d489197
    85 sg:journal.1097543
    86 schema:name PRC2-independent chromatin compaction and transcriptional repression in cancer
    87 schema:pagination 741
    88 schema:productId N93c67f1f6f34498c93c54f069af5897f
    89 N99603de30083419ab0331f1e83396d8b
    90 Nd6ab9b7f8dda40ac9081b2273e530630
    91 Nd8bb2a94bbaa48fdacad7c1fe8db02e1
    92 Nfb7b0144256348c3be611f139df9cd6a
    93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012479290
    94 https://doi.org/10.1038/onc.2013.604
    95 schema:sdDatePublished 2019-04-10T14:49
    96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    97 schema:sdPublisher N38edaf01fe744bce956a4ecba581572c
    98 schema:url https://www.nature.com/articles/onc2013604
    99 sgo:license sg:explorer/license/
    100 sgo:sdDataset articles
    101 rdf:type schema:ScholarlyArticle
    102 N16776863fb9042559862344d5e483410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Gene Expression Regulation, Neoplastic
    104 rdf:type schema:DefinedTerm
    105 N2713998fc89e4be2a5d6dfcabea20f91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Polycomb Repressive Complex 2
    107 rdf:type schema:DefinedTerm
    108 N37d0c819077441b4a0b4f529ae61aedc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name In Situ Hybridization, Fluorescence
    110 rdf:type schema:DefinedTerm
    111 N38edaf01fe744bce956a4ecba581572c schema:name Springer Nature - SN SciGraph project
    112 rdf:type schema:Organization
    113 N3ef61ea072ec44ccb912aaa0531955b9 rdf:first sg:person.01164404501.34
    114 rdf:rest N6a8a9a7f25d8472c9daeac23617d0873
    115 N550b51e0de2447bb985c6a01c7985694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Chromatin Immunoprecipitation
    117 rdf:type schema:DefinedTerm
    118 N60ae0f2d4f4d428aaec698122c3717e7 schema:volumeNumber 34
    119 rdf:type schema:PublicationVolume
    120 N63b64e40214d4d60a33c1f24a64c6427 rdf:first sg:person.01255346066.62
    121 rdf:rest Nf0efe23d85684e0b93d92a6254dd9daa
    122 N693e34ab3fb74ba48094077798311dc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Cell Line, Tumor
    124 rdf:type schema:DefinedTerm
    125 N6a8a9a7f25d8472c9daeac23617d0873 rdf:first sg:person.01024575231.12
    126 rdf:rest rdf:nil
    127 N7bd9fbae42ac47e081ca6628d43a4e7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Enhancer of Zeste Homolog 2 Protein
    129 rdf:type schema:DefinedTerm
    130 N93c67f1f6f34498c93c54f069af5897f schema:name readcube_id
    131 schema:value 3b73fc53df3f389e9687ed33e32be55d5be6a347481818b7a7e1d0e44d7ebe64
    132 rdf:type schema:PropertyValue
    133 N9714e3e4cd404ac1b327852b0ba073af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Gene Silencing
    135 rdf:type schema:DefinedTerm
    136 N97fc42217144407aae01595e7760f7bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Epigenesis, Genetic
    138 rdf:type schema:DefinedTerm
    139 N99603de30083419ab0331f1e83396d8b schema:name dimensions_id
    140 schema:value pub.1012479290
    141 rdf:type schema:PropertyValue
    142 N9deae08281404d249a1eb7384269b80f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Histones
    144 rdf:type schema:DefinedTerm
    145 Nc542695705de4f1a85c3302721e4dc54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Humans
    147 rdf:type schema:DefinedTerm
    148 Nc5d5b1c686b2405082189dfd3d489197 schema:issueNumber 6
    149 rdf:type schema:PublicationIssue
    150 Ncd3633212b2d4208a2fffd2bd21f3c30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Urinary Bladder Neoplasms
    152 rdf:type schema:DefinedTerm
    153 Nceeabdcbd3ec4f53ac515ebc6b53b3a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Chromatin
    155 rdf:type schema:DefinedTerm
    156 Nd6ab9b7f8dda40ac9081b2273e530630 schema:name pubmed_id
    157 schema:value 24469045
    158 rdf:type schema:PropertyValue
    159 Nd8bb2a94bbaa48fdacad7c1fe8db02e1 schema:name doi
    160 schema:value 10.1038/onc.2013.604
    161 rdf:type schema:PropertyValue
    162 Ne31e9f0e57a14add8246bf547dacbc34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name DNA Methylation
    164 rdf:type schema:DefinedTerm
    165 Ne96c357d877c4815b2b9741258e96f1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Histone-Lysine N-Methyltransferase
    167 rdf:type schema:DefinedTerm
    168 Nf0efe23d85684e0b93d92a6254dd9daa rdf:first sg:person.01160450365.49
    169 rdf:rest Nf464cb408e844c7494f2e303848a0056
    170 Nf464cb408e844c7494f2e303848a0056 rdf:first sg:person.01002042701.09
    171 rdf:rest N3ef61ea072ec44ccb912aaa0531955b9
    172 Nfb7b0144256348c3be611f139df9cd6a schema:name nlm_unique_id
    173 schema:value 8711562
    174 rdf:type schema:PropertyValue
    175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Biological Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Genetics
    180 rdf:type schema:DefinedTerm
    181 sg:grant.2753736 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2013.604
    182 rdf:type schema:MonetaryGrant
    183 sg:journal.1097543 schema:issn 0950-9232
    184 1476-5594
    185 schema:name Oncogene
    186 rdf:type schema:Periodical
    187 sg:person.01002042701.09 schema:affiliation https://www.grid.ac/institutes/grid.415854.9
    188 schema:familyName Boyle
    189 schema:givenName S
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002042701.09
    191 rdf:type schema:Person
    192 sg:person.01024575231.12 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
    193 schema:familyName Radvanyi
    194 schema:givenName F
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024575231.12
    196 rdf:type schema:Person
    197 sg:person.01160450365.49 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
    198 schema:familyName Hérault
    199 schema:givenName A
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160450365.49
    201 rdf:type schema:Person
    202 sg:person.01164404501.34 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    203 schema:familyName Bickmore
    204 schema:givenName W A
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164404501.34
    206 rdf:type schema:Person
    207 sg:person.01255346066.62 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
    208 schema:familyName Vallot
    209 schema:givenName C
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255346066.62
    211 rdf:type schema:Person
    212 sg:pub.10.1038/2524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026409761
    213 https://doi.org/10.1038/2524
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/ncb2023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019197578
    216 https://doi.org/10.1038/ncb2023
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/ng.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049130438
    219 https://doi.org/10.1038/ng.127
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/ng.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045314212
    222 https://doi.org/10.1038/ng.297
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/ng.518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001723375
    225 https://doi.org/10.1038/ng.518
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/ng1781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003900779
    228 https://doi.org/10.1038/ng1781
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/ng1923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009415129
    231 https://doi.org/10.1038/ng1923
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nrg1688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045156533
    234 https://doi.org/10.1038/nrg1688
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nrg2752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041523683
    237 https://doi.org/10.1038/nrg2752
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nsmb.2532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020327469
    240 https://doi.org/10.1038/nsmb.2532
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/onc.2008.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046327348
    243 https://doi.org/10.1038/onc.2008.333
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/sj.bjc.6602531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049949509
    246 https://doi.org/10.1038/sj.bjc.6602531
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/gb-2002-3-12-research0075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012779695
    249 https://doi.org/10.1186/gb-2002-3-12-research0075
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/gb-2008-9-4-r65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049740347
    252 https://doi.org/10.1186/gb-2008-9-4-r65
    253 rdf:type schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1075192363 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1078392745 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1082586564 schema:CreativeWork
    257 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<284::aid-ijc25>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1044524284
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.cell.2004.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019999532
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.cell.2005.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019562121
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.cell.2007.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022937373
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.cell.2011.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041907573
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.celrep.2012.11.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026053131
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.gde.2004.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038965664
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.molcel.2008.08.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033350598
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.molcel.2008.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014750873
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.molcel.2008.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053484531
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.molcel.2010.02.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042040888
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.molcel.2013.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038820174
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.molcel.2013.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047142506
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.mrfmmm.2008.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029372216
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.stem.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022608960
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/s0002-9440(10)64665-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010814816
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1073/pnas.1013224108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020116320
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1073/pnas.1933744100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013665
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1074/jbc.m501379200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015248937
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1083/jcb.200907029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010070073
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/jnci/djq470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052549185
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1101/gad.1272505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007710897
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1101/gad.292104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405627
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1101/gr.080861.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043692654
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1101/sqb.2010.75.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050912378
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1126/science.1100576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020733240
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1126/science.1124000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027661592
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1126/science.1163802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018805109
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1126/science.1171468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009974759
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1126/science.1227604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027311581
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1126/science.1388286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062478668
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1158/0008-5472.can-06-2761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035163581
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1158/0008-5472.can-07-2498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026405198
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1158/1078-0432.ccr-05-1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014497848
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1158/1078-0432.ccr-05-1047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019475335
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1182/blood-2008-06-161901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044928187
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1182/blood-2010-11-321208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424481
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1200/jco.2005.01.5180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046338079
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1242/dev.01813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049260048
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1242/dev.02779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011270239
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1242/jcs.01293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027611304
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1371/journal.pone.0034848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044078076
    340 rdf:type schema:CreativeWork
    341 https://www.grid.ac/institutes/grid.415854.9 schema:alternateName Medical Research Council Institute of Genetics and Molecular Medicine
    342 schema:name Chromosome and Gene Expression Section, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Scotland, UK
    343 rdf:type schema:Organization
    344 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
    345 schema:name CNRS, UMR 144 - Cell Biology Department, Institut Curie, Paris, France
    346 Institut Curie, Centre de Recherche, Paris, France
    347 rdf:type schema:Organization
    348 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
    349 schema:name Breakthrough Breast Cancer Research Unit, University of Edinburgh, Scotland, UK
    350 Chromosome and Gene Expression Section, MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Scotland, UK
    351 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...