Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

Katiuchia Uzzun Sales, Stine Friis, Joanne E. Konkel, Sine Godiksen, Marcia Hatakeyama, Karina K. Hansen, Silvia Regina Rogatto, Roman Szabo, Lotte K. Vogel, Wanjun Chen, J. Silvio Gutkind, Thomas H. Bugge

ABSTRACT

The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suffices to induce malignant transformation. Here, we use genetic epistasis analysis to identify proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated oncogenesis. In cell-based assays, matriptase was a potent activator of PAR-2, and PAR-2 activation by matriptase caused robust induction of nuclear factor (NF)κB through Gαi. Importantly, genetic elimination of PAR-2 from mice completely prevented matriptase-induced pre-malignant progression, including inflammatory cytokine production, inflammatory cell recruitment, epidermal hyperplasia and dermal fibrosis. Selective ablation of PAR-2 from bone marrow-derived cells did not prevent matriptase-driven pre-malignant progression, indicating that matriptase activates keratinocyte stem cell PAR-2 to elicit its pro-inflammatory and pro-tumorigenic effects. When combined with previous studies, our data suggest that dual induction of PAR-2-NFκB inflammatory signaling and PI3K-Akt-mTor survival/proliferative signaling underlies the transforming potential of matriptase and may contribute to pro-tumorigenic signaling in human epithelial carcinogenesis. More... »

PAGES

346

References to SciGraph publications

  • 2009-07. Role of Matriptase and Proteinase-Activated Receptor-2 in Nonmelanoma Skin Cancer in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-01. Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer in BRITISH JOURNAL OF CANCER
  • 2003-09. The Proteinase-Activated Receptor-2 Mediates Phagocytosis in a Rho-Dependent Manner in Human Keratinocytes in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-04. Helminth-derived immunomodulators: can understanding the worm produce the pill? in NATURE REVIEWS IMMUNOLOGY
  • 2010-04. The regulatory crosstalk between kinases and proteases in cancer in NATURE REVIEWS CANCER
  • 2006-03. Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters in MODERN PATHOLOGY
  • 2005-01. Agonists of Proteinase-Activated Receptor-2 Stimulate Upregulation of Intercellular Cell Adhesion Molecule-1 in Primary Human Keratinocytes via Activation of NF-kappa B in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2006-12. The ratio of Matriptase/HAI-1mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals in BMC CANCER
  • 2004-05. Proteinase-Activated Receptor-2 Stimulates Prostaglandin Production in Keratinocytes: Analysis of Prostaglandin Receptors on Human Melanocytes and Effects of PGE2 and PGF2α on Melanocyte Dendricity in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2011-04. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase in ONCOGENE
  • 2011-09. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin in NATURE COMMUNICATIONS
  • 2012-01. Protease-activated receptor 2 signaling in inflammation in SEMINARS IN IMMUNOPATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2013.563

    DOI

    http://dx.doi.org/10.1038/onc.2013.563

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019976302

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24469043


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Squamous Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelial Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "GTP-Binding Protein alpha Subunits, Gi-Go", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Keratinocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precancerous Conditions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, PAR-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reverse Transcriptase Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serine Endopeptidases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Skin Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ras Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Institute of Dental and Craniofacial Research", 
              "id": "https://www.grid.ac/institutes/grid.419633.a", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA", 
                "Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sales", 
            "givenName": "Katiuchia Uzzun", 
            "id": "sg:person.0643507745.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643507745.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA", 
                "Department of Cellular and Molecular Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Friis", 
            "givenName": "Stine", 
            "id": "sg:person.0624572253.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624572253.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Konkel", 
            "givenName": "Joanne E.", 
            "id": "sg:person.01164714173.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164714173.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA", 
                "Department of Cellular and Molecular Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark", 
                "Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Godiksen", 
            "givenName": "Sine", 
            "id": "sg:person.01357767112.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357767112.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "Department of Urology, Faculty of Medicine, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil", 
                "AC Camargo Cancer Center, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hatakeyama", 
            "givenName": "Marcia", 
            "id": "sg:person.013113323300.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013113323300.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hansen", 
            "givenName": "Karina K.", 
            "id": "sg:person.01350176353.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350176353.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "Department of Urology, Faculty of Medicine, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil", 
                "AC Camargo Cancer Center, Sao Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rogatto", 
            "givenName": "Silvia Regina", 
            "id": "sg:person.01372437053.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372437053.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szabo", 
            "givenName": "Roman", 
            "id": "sg:person.01214436364.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214436364.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Department of Cellular and Molecular Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vogel", 
            "givenName": "Lotte K.", 
            "id": "sg:person.01200656015.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200656015.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Wanjun", 
            "id": "sg:person.015033407720.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015033407720.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gutkind", 
            "givenName": "J. Silvio", 
            "id": "sg:person.010576772104.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010576772104.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institutes of Health", 
              "id": "https://www.grid.ac/institutes/grid.94365.3d", 
              "name": [
                "Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bugge", 
            "givenName": "Thomas H.", 
            "id": "sg:person.014711620557.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1084/jem.20101355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003714553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m108555200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005074028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20082242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005159130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2005.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006513746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1218694110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006747512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2009.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008101571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.9.5315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009351266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m100377200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009467511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.0022-202x.2004.22516.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011256957", 
              "https://doi.org/10.1111/j.0022-202x.2004.22516.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci17564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012423184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2006.051071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013131736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.469932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013611593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/14796694.5.1.97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014019296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.11.6504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016876459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64081-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018860490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m513138200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019644058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-011-0289-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019832024", 
              "https://doi.org/10.1007/s00281-011-0289-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.10.5255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020182167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.20.9208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021550187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.11.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022341101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1523-1747.2003.12427.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023699518", 
              "https://doi.org/10.1046/j.1523-1747.2003.12427.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1523-1747.2003.12427.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023699518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023722488", 
              "https://doi.org/10.1038/nrc2823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023722488", 
              "https://doi.org/10.1038/nrc2823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1300705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023731085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms1162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025599745", 
              "https://doi.org/10.1038/ncomms1162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-6-176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028913190", 
              "https://doi.org/10.1186/1471-2407-6-176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.7.4043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029436925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14737159.3.3.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029514960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032069235", 
              "https://doi.org/10.1038/modpathol.3800495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032069235", 
              "https://doi.org/10.1038/modpathol.3800495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20041066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032328919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20041066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032328919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.0022-202x.2004.23539.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032351531", 
              "https://doi.org/10.1111/j.0022-202x.2004.23539.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.20.9151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033411255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033746150", 
              "https://doi.org/10.1038/sj.bjc.6602320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602320", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033746150", 
              "https://doi.org/10.1038/sj.bjc.6602320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m709493200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034533941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r109.021006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034593170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034961064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034961064"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.125.5.1843", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035399921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m801970200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036006607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038672613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2567.1998.00528.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042440198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2567.1998.00528.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042440198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2008.449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042806046", 
              "https://doi.org/10.1038/jid.2008.449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000258862.61067.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044042712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.586", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044766707", 
              "https://doi.org/10.1038/onc.2010.586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/rcmb.2003-0199oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046433892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048326446", 
              "https://doi.org/10.1038/nri2730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048326446", 
              "https://doi.org/10.1038/nri2730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.46.29034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051126532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m002941200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052743483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/106689690601400111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053349913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/106689690601400111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053349913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109064200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053537528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2008-1079254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057569254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075031481", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075246390", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083060972", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-01", 
        "datePublishedReg": "2015-01-01", 
        "description": "The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suffices to induce malignant transformation. Here, we use genetic epistasis analysis to identify proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated oncogenesis. In cell-based assays, matriptase was a potent activator of PAR-2, and PAR-2 activation by matriptase caused robust induction of nuclear factor (NF)\u03baB through G\u03b1i. Importantly, genetic elimination of PAR-2 from mice completely prevented matriptase-induced pre-malignant progression, including inflammatory cytokine production, inflammatory cell recruitment, epidermal hyperplasia and dermal fibrosis. Selective ablation of PAR-2 from bone marrow-derived cells did not prevent matriptase-driven pre-malignant progression, indicating that matriptase activates keratinocyte stem cell PAR-2 to elicit its pro-inflammatory and pro-tumorigenic effects. When combined with previous studies, our data suggest that dual induction of PAR-2-NF\u03baB inflammatory signaling and PI3K-Akt-mTor survival/proliferative signaling underlies the transforming potential of matriptase and may contribute to pro-tumorigenic signaling in human epithelial carcinogenesis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2013.563", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2724655", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2724644", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2724643", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis", 
        "pagination": "346", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5f2df78bcb78744ca39329cce994017f9a402a93baf93a4228366f5219042744"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24469043"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2013.563"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1019976302"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2013.563", 
          "https://app.dimensions.ai/details/publication/pub.1019976302"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2013563"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.563'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.563'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.563'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.563'


     

    This table displays all metadata directly associated to this object as RDF triples.

    421 TRIPLES      21 PREDICATES      104 URIs      43 LITERALS      31 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2013.563 schema:about N0b4b0431519848e68e05d98035e8eac6
    2 N1f8f353b722f4423a7972a7c61660891
    3 N2968c04807b2448dbac1695571e9c737
    4 N2b11373368354915a3e561de40c8dd0f
    5 N2ea42e3f01db46afbe51fc99573a078f
    6 N3ae9be0e9a214cc289a55a5d2a7578f9
    7 N62a45fd3a0134e89860c9139f29fb9d3
    8 N7f7a8c7a10ad411189662c5e56ad1f81
    9 N8a37984951be482e82b50a8ace6e7e42
    10 N8b32e016d31e43ea88bb388da8969563
    11 N8b4ef8f38c95448eb6e653db99c62e18
    12 N920988a1c3374f4aade58ed098f909ad
    13 N9f9ae099ef7a4402af8b154e5bd7a64a
    14 Na41b8b3e1fbd4592a4152dc8373c92d3
    15 Na84e67b5f2c34c09b310951c551b6894
    16 Nb04eca845e5d4b16804ef9bfe2f1e288
    17 Nbffe3960ce0d40dd95c6f6f2c0afde5c
    18 Ncbab8ff757ca411d96a44733385d8b88
    19 Ndb338797aaa84748874418f1c0dab978
    20 Nea641c8acc5d439db45b1e5f0e2618f0
    21 Nf3c59f6c28ba49d8821064be02736357
    22 Nf72b6eae14b548de85937e93689854d4
    23 anzsrc-for:06
    24 anzsrc-for:0604
    25 schema:author N0104d62a287f478abcced622683a4fdd
    26 schema:citation sg:pub.10.1007/s00281-011-0289-1
    27 sg:pub.10.1038/jid.2008.449
    28 sg:pub.10.1038/modpathol.3800495
    29 sg:pub.10.1038/ncomms1162
    30 sg:pub.10.1038/nrc2823
    31 sg:pub.10.1038/nri2730
    32 sg:pub.10.1038/onc.2010.586
    33 sg:pub.10.1038/sj.bjc.6602320
    34 sg:pub.10.1046/j.1523-1747.2003.12427.x
    35 sg:pub.10.1111/j.0022-202x.2004.22516.x
    36 sg:pub.10.1111/j.0022-202x.2004.23539.x
    37 sg:pub.10.1186/1471-2407-6-176
    38 https://app.dimensions.ai/details/publication/pub.1075031481
    39 https://app.dimensions.ai/details/publication/pub.1075246390
    40 https://app.dimensions.ai/details/publication/pub.1083060972
    41 https://doi.org/10.1016/j.cell.2005.11.043
    42 https://doi.org/10.1016/j.devcel.2009.11.014
    43 https://doi.org/10.1016/j.humpath.2005.03.003
    44 https://doi.org/10.1016/s0002-9440(10)64081-3
    45 https://doi.org/10.1042/bj20041066
    46 https://doi.org/10.1046/j.1365-2567.1998.00528.x
    47 https://doi.org/10.1046/j.1523-1747.2003.12427.x
    48 https://doi.org/10.1055/s-2008-1079254
    49 https://doi.org/10.1073/pnas.1218694110
    50 https://doi.org/10.1073/pnas.91.20.9208
    51 https://doi.org/10.1073/pnas.92.20.9151
    52 https://doi.org/10.1073/pnas.97.10.5255
    53 https://doi.org/10.1074/jbc.271.46.29034
    54 https://doi.org/10.1074/jbc.272.7.4043
    55 https://doi.org/10.1074/jbc.m002941200
    56 https://doi.org/10.1074/jbc.m100377200
    57 https://doi.org/10.1074/jbc.m108555200
    58 https://doi.org/10.1074/jbc.m109064200
    59 https://doi.org/10.1074/jbc.m113.469932
    60 https://doi.org/10.1074/jbc.m513138200
    61 https://doi.org/10.1074/jbc.m709493200
    62 https://doi.org/10.1074/jbc.m801970200
    63 https://doi.org/10.1074/jbc.r109.021006
    64 https://doi.org/10.1084/jem.20082242
    65 https://doi.org/10.1084/jem.20101355
    66 https://doi.org/10.1093/carcin/bgp153
    67 https://doi.org/10.1101/gad.1300705
    68 https://doi.org/10.1161/01.atv.0000258862.61067.14
    69 https://doi.org/10.1165/rcmb.2003-0199oc
    70 https://doi.org/10.1172/jci17564
    71 https://doi.org/10.1177/106689690601400111
    72 https://doi.org/10.1371/journal.pgen.1002937
    73 https://doi.org/10.1378/chest.125.5.1843
    74 https://doi.org/10.1586/14737159.3.3.331
    75 https://doi.org/10.2217/14796694.5.1.97
    76 https://doi.org/10.2353/ajpath.2006.051071
    77 https://doi.org/10.4049/jimmunol.165.11.6504
    78 https://doi.org/10.4049/jimmunol.169.9.5315
    79 schema:datePublished 2015-01
    80 schema:datePublishedReg 2015-01-01
    81 schema:description The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suffices to induce malignant transformation. Here, we use genetic epistasis analysis to identify proteinase-activated receptor (PAR)-2-dependent inflammatory signaling as an essential component of matriptase-mediated oncogenesis. In cell-based assays, matriptase was a potent activator of PAR-2, and PAR-2 activation by matriptase caused robust induction of nuclear factor (NF)κB through Gαi. Importantly, genetic elimination of PAR-2 from mice completely prevented matriptase-induced pre-malignant progression, including inflammatory cytokine production, inflammatory cell recruitment, epidermal hyperplasia and dermal fibrosis. Selective ablation of PAR-2 from bone marrow-derived cells did not prevent matriptase-driven pre-malignant progression, indicating that matriptase activates keratinocyte stem cell PAR-2 to elicit its pro-inflammatory and pro-tumorigenic effects. When combined with previous studies, our data suggest that dual induction of PAR-2-NFκB inflammatory signaling and PI3K-Akt-mTor survival/proliferative signaling underlies the transforming potential of matriptase and may contribute to pro-tumorigenic signaling in human epithelial carcinogenesis.
    82 schema:genre research_article
    83 schema:inLanguage en
    84 schema:isAccessibleForFree true
    85 schema:isPartOf N91432f24e7bc478e8853ad697759432d
    86 Na5390aec9eb04736b5613ed5a408d5d8
    87 sg:journal.1097543
    88 schema:name Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis
    89 schema:pagination 346
    90 schema:productId N18dae418e53f4a46997dc0f9120e4295
    91 N89268c0582ec429aaa1f1c60afee3ce2
    92 N8e09a21399c945cab115b8d9da32d0ca
    93 N9cfdf8ec859642ea8662b97947602714
    94 Nc469c2dcafe24ebea41bf5ed5471ff44
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019976302
    96 https://doi.org/10.1038/onc.2013.563
    97 schema:sdDatePublished 2019-04-10T19:46
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N8cb69e5421cb47e5970f4254694eb816
    100 schema:url https://www.nature.com/articles/onc2013563
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N0104d62a287f478abcced622683a4fdd rdf:first sg:person.0643507745.49
    105 rdf:rest N729a3ae4dc6044b7a658ddb54500f7b5
    106 N0b4b0431519848e68e05d98035e8eac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Mice, Knockout
    108 rdf:type schema:DefinedTerm
    109 N18dae418e53f4a46997dc0f9120e4295 schema:name dimensions_id
    110 schema:value pub.1019976302
    111 rdf:type schema:PropertyValue
    112 N1f8f353b722f4423a7972a7c61660891 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Cells, Cultured
    114 rdf:type schema:DefinedTerm
    115 N2968c04807b2448dbac1695571e9c737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name ras Proteins
    117 rdf:type schema:DefinedTerm
    118 N2b11373368354915a3e561de40c8dd0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Mice, Inbred C57BL
    120 rdf:type schema:DefinedTerm
    121 N2ea42e3f01db46afbe51fc99573a078f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Disease Progression
    123 rdf:type schema:DefinedTerm
    124 N392107b470cc4c0c953eefb5dd5bdf93 rdf:first sg:person.013113323300.30
    125 rdf:rest N939327226c5944268aee8db4676faa8e
    126 N3ae9be0e9a214cc289a55a5d2a7578f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Cytokines
    128 rdf:type schema:DefinedTerm
    129 N3d347e8fb58f4df8829d15b16b2b32c2 rdf:first sg:person.010576772104.21
    130 rdf:rest Na90db49543214ba7921d4155f3be495f
    131 N4d68c19b8657470da9154583c61659d0 rdf:first sg:person.01214436364.64
    132 rdf:rest Na315f20abb0646a1be9a0abccb0dd171
    133 N62a45fd3a0134e89860c9139f29fb9d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Keratinocytes
    135 rdf:type schema:DefinedTerm
    136 N729a3ae4dc6044b7a658ddb54500f7b5 rdf:first sg:person.0624572253.19
    137 rdf:rest Nb2444d193d4a45aa9658315a56067894
    138 N772f248d22b7469091a24090da0e4917 rdf:first sg:person.01357767112.98
    139 rdf:rest N392107b470cc4c0c953eefb5dd5bdf93
    140 N7f7a8c7a10ad411189662c5e56ad1f81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Carcinoma, Squamous Cell
    142 rdf:type schema:DefinedTerm
    143 N89268c0582ec429aaa1f1c60afee3ce2 schema:name nlm_unique_id
    144 schema:value 8711562
    145 rdf:type schema:PropertyValue
    146 N8a37984951be482e82b50a8ace6e7e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Humans
    148 rdf:type schema:DefinedTerm
    149 N8b32e016d31e43ea88bb388da8969563 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Skin Neoplasms
    151 rdf:type schema:DefinedTerm
    152 N8b4ef8f38c95448eb6e653db99c62e18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Serine Endopeptidases
    154 rdf:type schema:DefinedTerm
    155 N8cb69e5421cb47e5970f4254694eb816 schema:name Springer Nature - SN SciGraph project
    156 rdf:type schema:Organization
    157 N8e09a21399c945cab115b8d9da32d0ca schema:name doi
    158 schema:value 10.1038/onc.2013.563
    159 rdf:type schema:PropertyValue
    160 N91432f24e7bc478e8853ad697759432d schema:volumeNumber 34
    161 rdf:type schema:PublicationVolume
    162 N920988a1c3374f4aade58ed098f909ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Animals
    164 rdf:type schema:DefinedTerm
    165 N939327226c5944268aee8db4676faa8e rdf:first sg:person.01350176353.57
    166 rdf:rest Ne9bf14f9db654a96be94803067d41a17
    167 N9cfdf8ec859642ea8662b97947602714 schema:name pubmed_id
    168 schema:value 24469043
    169 rdf:type schema:PropertyValue
    170 N9f9ae099ef7a4402af8b154e5bd7a64a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name NF-kappa B
    172 rdf:type schema:DefinedTerm
    173 Na315f20abb0646a1be9a0abccb0dd171 rdf:first sg:person.01200656015.10
    174 rdf:rest Ne2c50f4fc2b1493e94563f640e987ac9
    175 Na41b8b3e1fbd4592a4152dc8373c92d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Epithelial Cells
    177 rdf:type schema:DefinedTerm
    178 Na5390aec9eb04736b5613ed5a408d5d8 schema:issueNumber 3
    179 rdf:type schema:PublicationIssue
    180 Na84e67b5f2c34c09b310951c551b6894 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Receptor, PAR-2
    182 rdf:type schema:DefinedTerm
    183 Na90db49543214ba7921d4155f3be495f rdf:first sg:person.014711620557.63
    184 rdf:rest rdf:nil
    185 Nb04eca845e5d4b16804ef9bfe2f1e288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Reverse Transcriptase Polymerase Chain Reaction
    187 rdf:type schema:DefinedTerm
    188 Nb2444d193d4a45aa9658315a56067894 rdf:first sg:person.01164714173.25
    189 rdf:rest N772f248d22b7469091a24090da0e4917
    190 Nbffe3960ce0d40dd95c6f6f2c0afde5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Immunohistochemistry
    192 rdf:type schema:DefinedTerm
    193 Nc469c2dcafe24ebea41bf5ed5471ff44 schema:name readcube_id
    194 schema:value 5f2df78bcb78744ca39329cce994017f9a402a93baf93a4228366f5219042744
    195 rdf:type schema:PropertyValue
    196 Ncbab8ff757ca411d96a44733385d8b88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cell Line
    198 rdf:type schema:DefinedTerm
    199 Ndb338797aaa84748874418f1c0dab978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Precancerous Conditions
    201 rdf:type schema:DefinedTerm
    202 Ne2c50f4fc2b1493e94563f640e987ac9 rdf:first sg:person.015033407720.62
    203 rdf:rest N3d347e8fb58f4df8829d15b16b2b32c2
    204 Ne9bf14f9db654a96be94803067d41a17 rdf:first sg:person.01372437053.03
    205 rdf:rest N4d68c19b8657470da9154583c61659d0
    206 Nea641c8acc5d439db45b1e5f0e2618f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Cell Transformation, Neoplastic
    208 rdf:type schema:DefinedTerm
    209 Nf3c59f6c28ba49d8821064be02736357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name GTP-Binding Protein alpha Subunits, Gi-Go
    211 rdf:type schema:DefinedTerm
    212 Nf72b6eae14b548de85937e93689854d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name HEK293 Cells
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Biological Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Genetics
    220 rdf:type schema:DefinedTerm
    221 sg:grant.2724643 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2013.563
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.2724644 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2013.563
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2724655 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2013.563
    226 rdf:type schema:MonetaryGrant
    227 sg:journal.1097543 schema:issn 0950-9232
    228 1476-5594
    229 schema:name Oncogene
    230 rdf:type schema:Periodical
    231 sg:person.010576772104.21 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    232 schema:familyName Gutkind
    233 schema:givenName J. Silvio
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010576772104.21
    235 rdf:type schema:Person
    236 sg:person.01164714173.25 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    237 schema:familyName Konkel
    238 schema:givenName Joanne E.
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164714173.25
    240 rdf:type schema:Person
    241 sg:person.01200656015.10 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    242 schema:familyName Vogel
    243 schema:givenName Lotte K.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200656015.10
    245 rdf:type schema:Person
    246 sg:person.01214436364.64 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    247 schema:familyName Szabo
    248 schema:givenName Roman
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01214436364.64
    250 rdf:type schema:Person
    251 sg:person.013113323300.30 schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    252 schema:familyName Hatakeyama
    253 schema:givenName Marcia
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013113323300.30
    255 rdf:type schema:Person
    256 sg:person.01350176353.57 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    257 schema:familyName Hansen
    258 schema:givenName Karina K.
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350176353.57
    260 rdf:type schema:Person
    261 sg:person.01357767112.98 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    262 schema:familyName Godiksen
    263 schema:givenName Sine
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357767112.98
    265 rdf:type schema:Person
    266 sg:person.01372437053.03 schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    267 schema:familyName Rogatto
    268 schema:givenName Silvia Regina
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372437053.03
    270 rdf:type schema:Person
    271 sg:person.014711620557.63 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    272 schema:familyName Bugge
    273 schema:givenName Thomas H.
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63
    275 rdf:type schema:Person
    276 sg:person.015033407720.62 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
    277 schema:familyName Chen
    278 schema:givenName Wanjun
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015033407720.62
    280 rdf:type schema:Person
    281 sg:person.0624572253.19 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    282 schema:familyName Friis
    283 schema:givenName Stine
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624572253.19
    285 rdf:type schema:Person
    286 sg:person.0643507745.49 schema:affiliation https://www.grid.ac/institutes/grid.419633.a
    287 schema:familyName Sales
    288 schema:givenName Katiuchia Uzzun
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643507745.49
    290 rdf:type schema:Person
    291 sg:pub.10.1007/s00281-011-0289-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019832024
    292 https://doi.org/10.1007/s00281-011-0289-1
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/jid.2008.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042806046
    295 https://doi.org/10.1038/jid.2008.449
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/modpathol.3800495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032069235
    298 https://doi.org/10.1038/modpathol.3800495
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/ncomms1162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025599745
    301 https://doi.org/10.1038/ncomms1162
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/nrc2823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023722488
    304 https://doi.org/10.1038/nrc2823
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/nri2730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048326446
    307 https://doi.org/10.1038/nri2730
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/onc.2010.586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044766707
    310 https://doi.org/10.1038/onc.2010.586
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/sj.bjc.6602320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033746150
    313 https://doi.org/10.1038/sj.bjc.6602320
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1046/j.1523-1747.2003.12427.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023699518
    316 https://doi.org/10.1046/j.1523-1747.2003.12427.x
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1111/j.0022-202x.2004.22516.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011256957
    319 https://doi.org/10.1111/j.0022-202x.2004.22516.x
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1111/j.0022-202x.2004.23539.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032351531
    322 https://doi.org/10.1111/j.0022-202x.2004.23539.x
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1186/1471-2407-6-176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028913190
    325 https://doi.org/10.1186/1471-2407-6-176
    326 rdf:type schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1075031481 schema:CreativeWork
    328 https://app.dimensions.ai/details/publication/pub.1075246390 schema:CreativeWork
    329 https://app.dimensions.ai/details/publication/pub.1083060972 schema:CreativeWork
    330 https://doi.org/10.1016/j.cell.2005.11.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022341101
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1016/j.devcel.2009.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008101571
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1016/j.humpath.2005.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006513746
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1016/s0002-9440(10)64081-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860490
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1042/bj20041066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032328919
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1046/j.1365-2567.1998.00528.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042440198
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1046/j.1523-1747.2003.12427.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023699518
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1055/s-2008-1079254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057569254
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1073/pnas.1218694110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006747512
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1073/pnas.91.20.9208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021550187
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1073/pnas.92.20.9151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033411255
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1073/pnas.97.10.5255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020182167
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1074/jbc.271.46.29034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051126532
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1074/jbc.272.7.4043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029436925
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1074/jbc.m002941200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052743483
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1074/jbc.m100377200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009467511
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1074/jbc.m108555200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005074028
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1074/jbc.m109064200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053537528
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1074/jbc.m113.469932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013611593
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1074/jbc.m513138200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019644058
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1074/jbc.m709493200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034533941
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1074/jbc.m801970200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036006607
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1074/jbc.r109.021006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034593170
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1084/jem.20082242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005159130
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1084/jem.20101355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003714553
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1093/carcin/bgp153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034961064
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1101/gad.1300705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023731085
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1161/01.atv.0000258862.61067.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044042712
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1165/rcmb.2003-0199oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1046433892
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1172/jci17564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012423184
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1177/106689690601400111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053349913
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1371/journal.pgen.1002937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038672613
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1378/chest.125.5.1843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035399921
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1586/14737159.3.3.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029514960
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.2217/14796694.5.1.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019296
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.2353/ajpath.2006.051071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013131736
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.4049/jimmunol.165.11.6504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016876459
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.4049/jimmunol.169.9.5315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009351266
    405 rdf:type schema:CreativeWork
    406 https://www.grid.ac/institutes/grid.413320.7 schema:alternateName AC Camargo Hospital
    407 schema:name AC Camargo Cancer Center, Sao Paulo, Brazil
    408 Department of Urology, Faculty of Medicine, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil
    409 rdf:type schema:Organization
    410 https://www.grid.ac/institutes/grid.419633.a schema:alternateName National Institute of Dental and Craniofacial Research
    411 schema:name Clinical Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    412 Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA
    413 rdf:type schema:Organization
    414 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
    415 schema:name Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    416 Department of Cellular and Molecular Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark
    417 Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA
    418 rdf:type schema:Organization
    419 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
    420 schema:name Oral and Pharyngeal Cancer Branch, National Institutes of Health, Bethesda, MD, USA
    421 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...