Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/EBRAF mutant melanoma depends on JNK and TNF-α signaling View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

J N Kyula, A A Khan, D Mansfield, E M Karapanagiotou, M McLaughlin, V Roulstone, S Zaidi, T Pencavel, Y Touchefeu, R Seth, N G Chen, Y A Yu, Q Zhang, A A Melcher, R G Vile, H S Pandha, M Ajaz, A A Szalay, K J Harrington

ABSTRACT

Melanoma is an aggressive skin cancer that carries an extremely poor prognosis when local invasion, nodal spread or systemic metastasis has occurred. Recent advances in melanoma biology have revealed that RAS-RAF-MEK-ERK signaling has a pivotal role in governing disease progression and treatment resistance. Proof-of-concept clinical studies have shown that direct BRAF inhibition yields impressive responses in advanced disease but these are short-lived as treatment resistance rapidly emerges. Therefore, there is a pressing need to develop new targeted strategies for BRAF mutant melanoma. As such, oncolytic viruses represent a promising cancer-specific approach with significant activity in melanoma. This study investigated interactions between genetically-modified vaccinia virus (GLV-1h68) and radiotherapy in melanoma cell lines with BRAF mutant, Ras mutant or wild-type genotype. Preclinical studies revealed that GLV-1h68 combined with radiotherapy significantly increased cytotoxicity and apoptosis relative to either single agent in (V600D)BRAF/(V600E)BRAF mutant melanoma in vitro and in vivo. The mechanism of enhanced cytotoxicity with GLV-1h68/radiation (RT) was independent of viral replication and due to attenuation of JNK, p38 and ERK MAPK phosphorylation specifically in BRAF mutant cells. Further studies showed that JNK pathway inhibition sensitized BRAF mutant cells to GLV-1h68-mediated cell death, mimicking the effect of RT. GLV-1h68 infection activated MAPK signaling in (V600D)BRAF/(V600E)BRAF mutant cell lines and this was associated with TNF-α secretion which, in turn, provided a prosurvival signal. Combination GLV-1h68/RT (or GLV-1h68/JNK inhibition) caused abrogation of TNF-α secretion. These data provide a strong rationale for combining GLV-1h68 with irradiation in (V600D/E)BRAF mutant tumors. More... »

PAGES

1700

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2013.112

DOI

http://dx.doi.org/10.1038/onc.2013.112

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039640449

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23624923


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "JNK Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncolytic Virotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccinia virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyula", 
        "givenName": "J N", 
        "id": "sg:person.0736635032.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736635032.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khan", 
        "givenName": "A A", 
        "id": "sg:person.0640240565.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640240565.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansfield", 
        "givenName": "D", 
        "id": "sg:person.01137030765.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137030765.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karapanagiotou", 
        "givenName": "E M", 
        "id": "sg:person.01364473737.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364473737.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "McLaughlin", 
        "givenName": "M", 
        "id": "sg:person.0775733236.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775733236.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roulstone", 
        "givenName": "V", 
        "id": "sg:person.0577404241.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577404241.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaidi", 
        "givenName": "S", 
        "id": "sg:person.0603015442.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603015442.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pencavel", 
        "givenName": "T", 
        "id": "sg:person.0651130642.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651130642.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Touchefeu", 
        "givenName": "Y", 
        "id": "sg:person.01366341157.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366341157.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seth", 
        "givenName": "R", 
        "id": "sg:person.01173257421.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173257421.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genelux Corp, San Diego Science Center, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "N G", 
        "id": "sg:person.0710627613.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710627613.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genelux Corp, San Diego Science Center, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Y A", 
        "id": "sg:person.01221151236.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221151236.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genelux Corp, San Diego Science Center, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Q", 
        "id": "sg:person.01250432156.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250432156.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Leeds", 
          "id": "https://www.grid.ac/institutes/grid.9909.9", 
          "name": [
            "Leeds Institute of Molecular Medicine, Leeds, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melcher", 
        "givenName": "A A", 
        "id": "sg:person.01266210711.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266210711.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Leeds Institute of Molecular Medicine, Leeds, UK", 
            "Molecular Medicine Program, Mayo Clinic, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vile", 
        "givenName": "R G", 
        "id": "sg:person.01207711633.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207711633.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Postgraduate Medical School, The University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pandha", 
        "givenName": "H S", 
        "id": "sg:person.01215757170.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215757170.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Surrey", 
          "id": "https://www.grid.ac/institutes/grid.5475.3", 
          "name": [
            "Postgraduate Medical School, The University of Surrey, Guildford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ajaz", 
        "givenName": "M", 
        "id": "sg:person.012471767173.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012471767173.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genelux Corp, San Diego Science Center, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szalay", 
        "givenName": "A A", 
        "id": "sg:person.0740225732.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740225732.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cancer Research", 
          "id": "https://www.grid.ac/institutes/grid.18886.3f", 
          "name": [
            "Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harrington", 
        "givenName": "K J", 
        "id": "sg:person.01167312032.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0074-7696(02)14007-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001145476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0509341103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002520676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-06-0166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004420604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2006.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005235724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-8-45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005619715", 
          "https://doi.org/10.1186/1476-4598-8-45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20031375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005655255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20031375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005655255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006410070", 
          "https://doi.org/10.1038/sj.onc.1206701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006410070", 
          "https://doi.org/10.1038/sj.onc.1206701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-11-221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007296371", 
          "https://doi.org/10.1186/1471-2407-11-221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-08-0533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016255699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-2074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017392151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018427704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019050217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cgt.2008.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019544201", 
          "https://doi.org/10.1038/cgt.2008.87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.20.4495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020846176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05661", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021487923", 
          "https://doi.org/10.1038/nature05661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021713506", 
          "https://doi.org/10.1038/sj.gt.3302517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021713506", 
          "https://doi.org/10.1038/sj.gt.3302517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.seminoncol.2007.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022229657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/10552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022564376", 
          "https://doi.org/10.1038/10552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-1432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022577720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022854281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-0796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023771966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2012.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024633685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025202457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.12.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028106155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031485445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1228704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033151116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2008-0316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033408584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036315679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037027954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-0054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040850599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-11-451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041096763", 
          "https://doi.org/10.1186/1471-2407-11-451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.12.071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046903898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100183200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048276058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00245-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051655019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052142992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0711741105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053628579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10430349950016410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059202788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2006.17.1241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2008.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059273160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075706833", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082416870", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-03", 
    "datePublishedReg": "2014-03-01", 
    "description": "Melanoma is an aggressive skin cancer that carries an extremely poor prognosis when local invasion, nodal spread or systemic metastasis has occurred. Recent advances in melanoma biology have revealed that RAS-RAF-MEK-ERK signaling has a pivotal role in governing disease progression and treatment resistance. Proof-of-concept clinical studies have shown that direct BRAF inhibition yields impressive responses in advanced disease but these are short-lived as treatment resistance rapidly emerges. Therefore, there is a pressing need to develop new targeted strategies for BRAF mutant melanoma. As such, oncolytic viruses represent a promising cancer-specific approach with significant activity in melanoma. This study investigated interactions between genetically-modified vaccinia virus (GLV-1h68) and radiotherapy in melanoma cell lines with BRAF mutant, Ras mutant or wild-type genotype. Preclinical studies revealed that GLV-1h68 combined with radiotherapy significantly increased cytotoxicity and apoptosis relative to either single agent in (V600D)BRAF/(V600E)BRAF mutant melanoma in vitro and in vivo. The mechanism of enhanced cytotoxicity with GLV-1h68/radiation (RT) was independent of viral replication and due to attenuation of JNK, p38 and ERK MAPK phosphorylation specifically in BRAF mutant cells. Further studies showed that JNK pathway inhibition sensitized BRAF mutant cells to GLV-1h68-mediated cell death, mimicking the effect of RT. GLV-1h68 infection activated MAPK signaling in (V600D)BRAF/(V600E)BRAF mutant cell lines and this was associated with TNF-\u03b1 secretion which, in turn, provided a prosurvival signal. Combination GLV-1h68/RT (or GLV-1h68/JNK inhibition) caused abrogation of TNF-\u03b1 secretion. These data provide a strong rationale for combining GLV-1h68 with irradiation in (V600D/E)BRAF mutant tumors. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2013.112", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5137414", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "13", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "name": "Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/EBRAF mutant melanoma depends on JNK and TNF-\u03b1 signaling", 
    "pagination": "1700", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bcd421c71fd6e4a05df78f0a6fc49449d32c7fba0f3fcb932161b968aaa601a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23624923"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2013.112"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039640449"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2013.112", 
      "https://app.dimensions.ai/details/publication/pub.1039640449"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117123_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2013112"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.112'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.112'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.112'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2013.112'


 

This table displays all metadata directly associated to this object as RDF triples.

415 TRIPLES      21 PREDICATES      88 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2013.112 schema:about N0cc46745ab59462892fd5e544970c6e6
2 N3e241f07f05543ce82b759d04c5b07fd
3 N450e4d5956f54099827d1cb071d44140
4 N455ef2256f074275ba5ed9adddfce2f0
5 N4d89f147f9ca49e6989830f6e8f69618
6 N6661eb489e0040bab483ef2f637a760e
7 N6aa1e1fc57d04fd484209bc527d14149
8 N6bbe5a999343496ebbe166424960d168
9 N75a24054fb474ba596e4f7f9bb49fc27
10 N89e91158e12e43dca0ae99599549f419
11 Na265b8a4a3a04f88a36294a8306de66d
12 Na47ff79339f14c4683efa917d3cd142b
13 Na60ecee56ac743538b4c0a097b09136a
14 Nb2cd685e24f144baa02d2bebdf5f97a8
15 Ncced14f139604cec8acc800094ec1aed
16 Ne0f62fd549794091afab4ea42a488c19
17 Ne8a1ccdd4f52436c985c475a9637d756
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N4672c85c73c14358a771ed320142a125
21 schema:citation sg:pub.10.1038/10552
22 sg:pub.10.1038/cgt.2008.87
23 sg:pub.10.1038/nature05661
24 sg:pub.10.1038/sj.gt.3302517
25 sg:pub.10.1038/sj.onc.1206701
26 sg:pub.10.1186/1471-2407-11-221
27 sg:pub.10.1186/1471-2407-11-451
28 sg:pub.10.1186/1476-4598-8-45
29 https://app.dimensions.ai/details/publication/pub.1075706833
30 https://app.dimensions.ai/details/publication/pub.1082416870
31 https://doi.org/10.1002/cncr.10776
32 https://doi.org/10.1016/j.bcp.2006.07.003
33 https://doi.org/10.1016/j.cell.2009.12.040
34 https://doi.org/10.1016/j.ijrobp.2010.12.071
35 https://doi.org/10.1016/j.oraloncology.2012.07.019
36 https://doi.org/10.1016/s0074-7696(02)14007-1
37 https://doi.org/10.1042/bj20031375
38 https://doi.org/10.1053/j.seminoncol.2007.09.008
39 https://doi.org/10.1056/nejmoa1103782
40 https://doi.org/10.1073/pnas.0509341103
41 https://doi.org/10.1073/pnas.0711741105
42 https://doi.org/10.1074/jbc.m100183200
43 https://doi.org/10.1089/10430349950016410
44 https://doi.org/10.1089/hum.2006.17.1241
45 https://doi.org/10.1089/hum.2008.036
46 https://doi.org/10.1101/gad.1228704
47 https://doi.org/10.1128/jvi.00245-09
48 https://doi.org/10.1158/0008-5472.can-05-0154
49 https://doi.org/10.1158/0008-5472.can-06-1880
50 https://doi.org/10.1158/0008-5472.can-06-2554
51 https://doi.org/10.1158/0008-5472.can-07-0146
52 https://doi.org/10.1158/1078-0432.ccr-04-1432
53 https://doi.org/10.1158/1078-0432.ccr-07-1400
54 https://doi.org/10.1158/1078-0432.ccr-09-0796
55 https://doi.org/10.1158/1078-0432.ccr-09-2074
56 https://doi.org/10.1158/1078-0432.ccr-10-0054
57 https://doi.org/10.1158/1078-0432.ccr-10-1233
58 https://doi.org/10.1158/1535-7163.mct-06-0166
59 https://doi.org/10.1158/1535-7163.mct-08-0533
60 https://doi.org/10.1172/jci24808
61 https://doi.org/10.1200/jco.2008.20.4495
62 https://doi.org/10.1210/jc.2008-0316
63 schema:datePublished 2014-03
64 schema:datePublishedReg 2014-03-01
65 schema:description Melanoma is an aggressive skin cancer that carries an extremely poor prognosis when local invasion, nodal spread or systemic metastasis has occurred. Recent advances in melanoma biology have revealed that RAS-RAF-MEK-ERK signaling has a pivotal role in governing disease progression and treatment resistance. Proof-of-concept clinical studies have shown that direct BRAF inhibition yields impressive responses in advanced disease but these are short-lived as treatment resistance rapidly emerges. Therefore, there is a pressing need to develop new targeted strategies for BRAF mutant melanoma. As such, oncolytic viruses represent a promising cancer-specific approach with significant activity in melanoma. This study investigated interactions between genetically-modified vaccinia virus (GLV-1h68) and radiotherapy in melanoma cell lines with BRAF mutant, Ras mutant or wild-type genotype. Preclinical studies revealed that GLV-1h68 combined with radiotherapy significantly increased cytotoxicity and apoptosis relative to either single agent in (V600D)BRAF/(V600E)BRAF mutant melanoma in vitro and in vivo. The mechanism of enhanced cytotoxicity with GLV-1h68/radiation (RT) was independent of viral replication and due to attenuation of JNK, p38 and ERK MAPK phosphorylation specifically in BRAF mutant cells. Further studies showed that JNK pathway inhibition sensitized BRAF mutant cells to GLV-1h68-mediated cell death, mimicking the effect of RT. GLV-1h68 infection activated MAPK signaling in (V600D)BRAF/(V600E)BRAF mutant cell lines and this was associated with TNF-α secretion which, in turn, provided a prosurvival signal. Combination GLV-1h68/RT (or GLV-1h68/JNK inhibition) caused abrogation of TNF-α secretion. These data provide a strong rationale for combining GLV-1h68 with irradiation in (V600D/E)BRAF mutant tumors.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N3ad797e75dd3471fb29bf03a8098a62e
70 Nc49cc8022cc64d8f9eb2dc15a125600b
71 sg:journal.1097543
72 schema:name Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in V600D/EBRAF mutant melanoma depends on JNK and TNF-α signaling
73 schema:pagination 1700
74 schema:productId N612f9bc7186744728ad9aceea8a05247
75 N967a7a9884784a5fa1a9ba8704462630
76 Nb2c53bab5fce43b781f334d9884c1f92
77 Nc87400f75fdd4c61bb817591651265cb
78 Nc87798a45d8747ebb73e74c6c2d183a9
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039640449
80 https://doi.org/10.1038/onc.2013.112
81 schema:sdDatePublished 2019-04-11T14:20
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N907019e15f404e8f870c9a2e9c57fa37
84 schema:url https://www.nature.com/articles/onc2013112
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N021d9d66fe08415192dd1a7547785a32 schema:name Genelux Corp, San Diego Science Center, San Diego, CA, USA
89 rdf:type schema:Organization
90 N0696c52fd59742fda4f804067b676114 rdf:first sg:person.01215757170.08
91 rdf:rest Na3c7d09c296d45e0ba13aed451aebb68
92 N0cc46745ab59462892fd5e544970c6e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Tumor Necrosis Factor-alpha
94 rdf:type schema:DefinedTerm
95 N14c6316b74774fa7b2ea1ccd10adf383 rdf:first sg:person.01221151236.44
96 rdf:rest Ne7531ea7cb214e0ca6e7538af4a95136
97 N1763790ba7a042ad96c46eaf7c4dbe29 schema:name Genelux Corp, San Diego Science Center, San Diego, CA, USA
98 rdf:type schema:Organization
99 N18088877caec451b8608a50f62b9bdb9 rdf:first sg:person.01173257421.23
100 rdf:rest N9e3c2c2bdacd45478207cf54fa06d54d
101 N2d393a9894104acda5f3624b30d9a204 rdf:first sg:person.0603015442.05
102 rdf:rest Na20f1b037a8d43ec82a5b57a9cb06d25
103 N34bd278baa4d4ec6a3d274b4c7a357a3 rdf:first sg:person.01364473737.08
104 rdf:rest N3f93db48d67348948faf05534ebf09c1
105 N3ad797e75dd3471fb29bf03a8098a62e schema:issueNumber 13
106 rdf:type schema:PublicationIssue
107 N3e241f07f05543ce82b759d04c5b07fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Animals
109 rdf:type schema:DefinedTerm
110 N3f93db48d67348948faf05534ebf09c1 rdf:first sg:person.0775733236.62
111 rdf:rest N41063b3bc33c43fbacb86688e3345676
112 N41063b3bc33c43fbacb86688e3345676 rdf:first sg:person.0577404241.37
113 rdf:rest N2d393a9894104acda5f3624b30d9a204
114 N450e4d5956f54099827d1cb071d44140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Mice, Inbred BALB C
116 rdf:type schema:DefinedTerm
117 N455ef2256f074275ba5ed9adddfce2f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cell Line, Tumor
119 rdf:type schema:DefinedTerm
120 N4672c85c73c14358a771ed320142a125 rdf:first sg:person.0736635032.72
121 rdf:rest Nc56095d1e78a4cd09fba73c9cf26026d
122 N4d89f147f9ca49e6989830f6e8f69618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Proto-Oncogene Proteins B-raf
124 rdf:type schema:DefinedTerm
125 N5ca3dac31cc84845a76b04b5b386e384 rdf:first sg:person.01167312032.35
126 rdf:rest rdf:nil
127 N612f9bc7186744728ad9aceea8a05247 schema:name dimensions_id
128 schema:value pub.1039640449
129 rdf:type schema:PropertyValue
130 N6661eb489e0040bab483ef2f637a760e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Mice, Nude
132 rdf:type schema:DefinedTerm
133 N6aa1e1fc57d04fd484209bc527d14149 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Vaccinia virus
135 rdf:type schema:DefinedTerm
136 N6bbe5a999343496ebbe166424960d168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice
138 rdf:type schema:DefinedTerm
139 N75a24054fb474ba596e4f7f9bb49fc27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Death
141 rdf:type schema:DefinedTerm
142 N89e91158e12e43dca0ae99599549f419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Xenograft Model Antitumor Assays
144 rdf:type schema:DefinedTerm
145 N907019e15f404e8f870c9a2e9c57fa37 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N9465031c430c4aaeb47385c2f607b4cb rdf:first sg:person.0740225732.59
148 rdf:rest N5ca3dac31cc84845a76b04b5b386e384
149 N967a7a9884784a5fa1a9ba8704462630 schema:name nlm_unique_id
150 schema:value 8711562
151 rdf:type schema:PropertyValue
152 N9e3c2c2bdacd45478207cf54fa06d54d rdf:first sg:person.0710627613.05
153 rdf:rest N14c6316b74774fa7b2ea1ccd10adf383
154 Na20f1b037a8d43ec82a5b57a9cb06d25 rdf:first sg:person.0651130642.53
155 rdf:rest Nb8b3d45de0de4fe5a5f77ed60eb43cab
156 Na265b8a4a3a04f88a36294a8306de66d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Random Allocation
158 rdf:type schema:DefinedTerm
159 Na3c7d09c296d45e0ba13aed451aebb68 rdf:first sg:person.012471767173.18
160 rdf:rest N9465031c430c4aaeb47385c2f607b4cb
161 Na47ff79339f14c4683efa917d3cd142b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name MAP Kinase Signaling System
163 rdf:type schema:DefinedTerm
164 Na60ecee56ac743538b4c0a097b09136a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Female
166 rdf:type schema:DefinedTerm
167 Nace507bfc1fd421db4d60aa22cdaa83b rdf:first sg:person.01207711633.71
168 rdf:rest N0696c52fd59742fda4f804067b676114
169 Nb2c53bab5fce43b781f334d9884c1f92 schema:name readcube_id
170 schema:value bcd421c71fd6e4a05df78f0a6fc49449d32c7fba0f3fcb932161b968aaa601a0
171 rdf:type schema:PropertyValue
172 Nb2cd685e24f144baa02d2bebdf5f97a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Oncolytic Virotherapy
174 rdf:type schema:DefinedTerm
175 Nb83c39f59cff4a30862fdb249f38b964 rdf:first sg:person.01137030765.45
176 rdf:rest N34bd278baa4d4ec6a3d274b4c7a357a3
177 Nb8b3d45de0de4fe5a5f77ed60eb43cab rdf:first sg:person.01366341157.75
178 rdf:rest N18088877caec451b8608a50f62b9bdb9
179 Nc49cc8022cc64d8f9eb2dc15a125600b schema:volumeNumber 33
180 rdf:type schema:PublicationVolume
181 Nc56095d1e78a4cd09fba73c9cf26026d rdf:first sg:person.0640240565.72
182 rdf:rest Nb83c39f59cff4a30862fdb249f38b964
183 Nc87400f75fdd4c61bb817591651265cb schema:name pubmed_id
184 schema:value 23624923
185 rdf:type schema:PropertyValue
186 Nc87798a45d8747ebb73e74c6c2d183a9 schema:name doi
187 schema:value 10.1038/onc.2013.112
188 rdf:type schema:PropertyValue
189 Ncced14f139604cec8acc800094ec1aed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Nd68d06b5728c4e92bc68bf4a15195291 schema:name Genelux Corp, San Diego Science Center, San Diego, CA, USA
193 rdf:type schema:Organization
194 Ndc038c818f4a48e19ca0d26efc4f025c rdf:first sg:person.01266210711.38
195 rdf:rest Nace507bfc1fd421db4d60aa22cdaa83b
196 Ndf551af4fdad4a2e9bb3eb0f61853270 schema:name Genelux Corp, San Diego Science Center, San Diego, CA, USA
197 rdf:type schema:Organization
198 Ne0f62fd549794091afab4ea42a488c19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Melanoma
200 rdf:type schema:DefinedTerm
201 Ne7531ea7cb214e0ca6e7538af4a95136 rdf:first sg:person.01250432156.27
202 rdf:rest Ndc038c818f4a48e19ca0d26efc4f025c
203 Ne8a1ccdd4f52436c985c475a9637d756 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name JNK Mitogen-Activated Protein Kinases
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:grant.5137414 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2013.112
213 rdf:type schema:MonetaryGrant
214 sg:journal.1097543 schema:issn 0950-9232
215 1476-5594
216 schema:name Oncogene
217 rdf:type schema:Periodical
218 sg:person.01137030765.45 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
219 schema:familyName Mansfield
220 schema:givenName D
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137030765.45
222 rdf:type schema:Person
223 sg:person.01167312032.35 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
224 schema:familyName Harrington
225 schema:givenName K J
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167312032.35
227 rdf:type schema:Person
228 sg:person.01173257421.23 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
229 schema:familyName Seth
230 schema:givenName R
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173257421.23
232 rdf:type schema:Person
233 sg:person.01207711633.71 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
234 schema:familyName Vile
235 schema:givenName R G
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207711633.71
237 rdf:type schema:Person
238 sg:person.01215757170.08 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
239 schema:familyName Pandha
240 schema:givenName H S
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215757170.08
242 rdf:type schema:Person
243 sg:person.01221151236.44 schema:affiliation Ndf551af4fdad4a2e9bb3eb0f61853270
244 schema:familyName Yu
245 schema:givenName Y A
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221151236.44
247 rdf:type schema:Person
248 sg:person.012471767173.18 schema:affiliation https://www.grid.ac/institutes/grid.5475.3
249 schema:familyName Ajaz
250 schema:givenName M
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012471767173.18
252 rdf:type schema:Person
253 sg:person.01250432156.27 schema:affiliation Nd68d06b5728c4e92bc68bf4a15195291
254 schema:familyName Zhang
255 schema:givenName Q
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250432156.27
257 rdf:type schema:Person
258 sg:person.01266210711.38 schema:affiliation https://www.grid.ac/institutes/grid.9909.9
259 schema:familyName Melcher
260 schema:givenName A A
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266210711.38
262 rdf:type schema:Person
263 sg:person.01364473737.08 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
264 schema:familyName Karapanagiotou
265 schema:givenName E M
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364473737.08
267 rdf:type schema:Person
268 sg:person.01366341157.75 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
269 schema:familyName Touchefeu
270 schema:givenName Y
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366341157.75
272 rdf:type schema:Person
273 sg:person.0577404241.37 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
274 schema:familyName Roulstone
275 schema:givenName V
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577404241.37
277 rdf:type schema:Person
278 sg:person.0603015442.05 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
279 schema:familyName Zaidi
280 schema:givenName S
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603015442.05
282 rdf:type schema:Person
283 sg:person.0640240565.72 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
284 schema:familyName Khan
285 schema:givenName A A
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640240565.72
287 rdf:type schema:Person
288 sg:person.0651130642.53 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
289 schema:familyName Pencavel
290 schema:givenName T
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651130642.53
292 rdf:type schema:Person
293 sg:person.0710627613.05 schema:affiliation N1763790ba7a042ad96c46eaf7c4dbe29
294 schema:familyName Chen
295 schema:givenName N G
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710627613.05
297 rdf:type schema:Person
298 sg:person.0736635032.72 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
299 schema:familyName Kyula
300 schema:givenName J N
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736635032.72
302 rdf:type schema:Person
303 sg:person.0740225732.59 schema:affiliation N021d9d66fe08415192dd1a7547785a32
304 schema:familyName Szalay
305 schema:givenName A A
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740225732.59
307 rdf:type schema:Person
308 sg:person.0775733236.62 schema:affiliation https://www.grid.ac/institutes/grid.18886.3f
309 schema:familyName McLaughlin
310 schema:givenName M
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775733236.62
312 rdf:type schema:Person
313 sg:pub.10.1038/10552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022564376
314 https://doi.org/10.1038/10552
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/cgt.2008.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019544201
317 https://doi.org/10.1038/cgt.2008.87
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nature05661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021487923
320 https://doi.org/10.1038/nature05661
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/sj.gt.3302517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021713506
323 https://doi.org/10.1038/sj.gt.3302517
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/sj.onc.1206701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006410070
326 https://doi.org/10.1038/sj.onc.1206701
327 rdf:type schema:CreativeWork
328 sg:pub.10.1186/1471-2407-11-221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007296371
329 https://doi.org/10.1186/1471-2407-11-221
330 rdf:type schema:CreativeWork
331 sg:pub.10.1186/1471-2407-11-451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041096763
332 https://doi.org/10.1186/1471-2407-11-451
333 rdf:type schema:CreativeWork
334 sg:pub.10.1186/1476-4598-8-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005619715
335 https://doi.org/10.1186/1476-4598-8-45
336 rdf:type schema:CreativeWork
337 https://app.dimensions.ai/details/publication/pub.1075706833 schema:CreativeWork
338 https://app.dimensions.ai/details/publication/pub.1082416870 schema:CreativeWork
339 https://doi.org/10.1002/cncr.10776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036315679
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.bcp.2006.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005235724
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.cell.2009.12.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028106155
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.ijrobp.2010.12.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046903898
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/j.oraloncology.2012.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024633685
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/s0074-7696(02)14007-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001145476
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1042/bj20031375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005655255
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1053/j.seminoncol.2007.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022229657
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1073/pnas.0509341103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002520676
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1073/pnas.0711741105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053628579
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1074/jbc.m100183200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048276058
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1089/10430349950016410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202788
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1089/hum.2006.17.1241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272743
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1089/hum.2008.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059273160
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1101/gad.1228704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033151116
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1128/jvi.00245-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051655019
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1158/0008-5472.can-05-0154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052142992
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1158/0008-5472.can-06-1880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019050217
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1158/0008-5472.can-06-2554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022854281
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1158/0008-5472.can-07-0146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037027954
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1158/1078-0432.ccr-04-1432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022577720
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1158/1078-0432.ccr-07-1400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018427704
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1158/1078-0432.ccr-09-0796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023771966
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1158/1078-0432.ccr-09-2074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017392151
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1158/1078-0432.ccr-10-0054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040850599
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1158/1078-0432.ccr-10-1233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031485445
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1158/1535-7163.mct-06-0166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004420604
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1158/1535-7163.mct-08-0533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016255699
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1172/jci24808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025202457
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1200/jco.2008.20.4495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020846176
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1210/jc.2008-0316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033408584
402 rdf:type schema:CreativeWork
403 https://www.grid.ac/institutes/grid.18886.3f schema:alternateName Institute of Cancer Research
404 schema:name Targeted Therapy Team, Divisions of Cancer Biology, The Institute of Cancer Research, London, UK
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.5475.3 schema:alternateName University of Surrey
407 schema:name Postgraduate Medical School, The University of Surrey, Guildford, UK
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
410 schema:name Leeds Institute of Molecular Medicine, Leeds, UK
411 Molecular Medicine Program, Mayo Clinic, Rochester, MN, USA
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.9909.9 schema:alternateName University of Leeds
414 schema:name Leeds Institute of Molecular Medicine, Leeds, UK
415 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...