The cancer biology of whole-chromosome instability View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

P H G Duijf, R Benezra

ABSTRACT

One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox. We also review the tumor-promoting and tumor-suppressing consequences of W-CIN. Importantly, we do this in the context of cancer as a complex systemic disease, rather than as a simple linearly progressing disorder that arises from a single abnormal cell population. Accordingly, we highlight the often neglected effects of W-CIN on key non-cell-autonomous entities, such as the immune system and the tumor microenvironment. Distinct tissue-specific susceptibilities to W-CIN-induced tumorigenesis and the clinical implications of W-CIN are also discussed. More... »

PAGES

4727

References to SciGraph publications

  • 2012-03. Causes and consequences of aneuploidy in cancer in NATURE REVIEWS GENETICS
  • 2010-01. Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2005-08. Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis in NATURE GENETICS
  • 2004-08. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control in NATURE
  • 2010-03-18. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal in NATURE
  • 2002-01. E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis in ONCOGENE
  • 2010-11-11. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast in NATURE
  • 2010. Centrosomes, Polyploidy and Cancer in POLYPLOIDIZATION AND CANCER
  • 2001-01. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells in NATURE
  • 2010. Polyploidization of liver cells in POLYPLOIDIZATION AND CANCER
  • 2002-11. Cancer immunoediting: from immunosurveillance to tumor escape in NATURE IMMUNOLOGY
  • 2011-06-29. Integrated genomic analyses of ovarian carcinoma in NATURE
  • 2009. Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential in EXPERIMENTAL & MOLECULAR MEDICINE
  • 2008-07. Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice in ONCOGENE
  • 2004-07. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice in NATURE GENETICS
  • 2012-01. Clonal evolution in cancer in NATURE
  • 2010-12. Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas in BMC CANCER
  • 2012-03. Killing cells by targeting mitosis in CELL DEATH & DIFFERENTIATION
  • 2005-04. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis in NATURE
  • 2007-02. Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest in NATURE CELL BIOLOGY
  • 2011-04. A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering in CELL DEATH & DIFFERENTIATION
  • 2008-07. Genomic stability and tumour suppression by the APC/C cofactor Cdh1 in NATURE CELL BIOLOGY
  • 2007-07. Fen1 mutations result in autoimmunity, chronic inflammation and cancers in NATURE MEDICINE
  • 2012-02. Expression of tumour-specific antigens underlies cancer immunoediting in NATURE
  • 2012-01-18. DNA breaks and chromosome pulverization from errors in mitosis in NATURE
  • 2009-07. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-06. Telomere dysfunction and tumour suppression: the senescence connection in NATURE REVIEWS CANCER
  • 2012-01. A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells in NATURE
  • 2011-07. Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-03. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes in NATURE
  • 2006-09. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers in NATURE GENETICS
  • 2010-02-18. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2008-07. Death through a tragedy: mitotic catastrophe in CELL DEATH & DIFFERENTIATION
  • 2010-10. The ploidy conveyor of mature hepatocytes as a source of genetic variation in NATURE
  • 1998-12. Genetic instabilities in human cancers in NATURE
  • 2009-08. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion in NATURE CELL BIOLOGY
  • 2002-11. Natural selection of tumor variants in the generation of “tumor escape” phenotypes in NATURE IMMUNOLOGY
  • 2004-01. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice in NATURE GENETICS
  • 2009-04. Microenvironmental regulation of metastasis in NATURE REVIEWS CANCER
  • 2011-07. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 1995-02. Cancer incidence in men with Klinefelter syndrome in BRITISH JOURNAL OF CANCER
  • 2012-06. Deconvoluting the context-dependent role for autophagy in cancer in NATURE REVIEWS CANCER
  • 2010-02. Mitotic chromosomal instability and cancer: mouse modelling of the human disease in NATURE REVIEWS CANCER
  • 2012-06. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups in NATURE
  • 2011-03. Cancer epigenetics reaches mainstream oncology in NATURE MEDICINE
  • 2012-04. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2012.616

    DOI

    http://dx.doi.org/10.1038/onc.2012.616

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028735655

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23318433


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomal Instability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogenes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA", 
                "The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duijf", 
            "givenName": "P H G", 
            "id": "sg:person.014137670424.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014137670424.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benezra", 
            "givenName": "R", 
            "id": "sg:person.0674175575.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674175575.90"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1083/jcb.200906147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000343492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000736346", 
              "https://doi.org/10.1038/nature10166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1917610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001434344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00882-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001627596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2008.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001853364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.34284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001887233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.34284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001887233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.10.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002223417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002516265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0560.2007.00935.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003369644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0b013e3182126f85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003579736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0b013e3182126f85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003579736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0b013e3182126f85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003579736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/igc.0b013e3182126f85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003579736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-1491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004147465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-1944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005412104"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-0663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005861006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2010.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006039070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1742", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006184899", 
              "https://doi.org/10.1038/ncb1742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.26.14295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006320032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/dji240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006999461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.12.5.1315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007285718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.10.4046-4061.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008061452", 
              "https://doi.org/10.1038/nature10802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008470674", 
              "https://doi.org/10.1038/ncb1909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008610787", 
              "https://doi.org/10.1038/ng1605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008610787", 
              "https://doi.org/10.1038/ng1605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008698030", 
              "https://doi.org/10.1038/nature10113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009285166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200507081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009358669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009828897", 
              "https://doi.org/10.1038/nature08803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009828897", 
              "https://doi.org/10.1038/nature08803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010008721", 
              "https://doi.org/10.1038/nature02820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010008721", 
              "https://doi.org/10.1038/nature02820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-3326", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010104374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1203486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010208236", 
              "https://doi.org/10.1038/nature10661"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201012035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010595392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.3858/emm.2009.41.5.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010788331", 
              "https://doi.org/10.3858/emm.2009.41.5.039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.3858/emm.2009.41.5.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010788331", 
              "https://doi.org/10.3858/emm.2009.41.5.039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00392-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011447282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(02)08092-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011542357"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1203619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011556378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.949802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012307300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200904020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012449299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.10.20.2621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012452978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013577696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-991", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013709887", 
              "https://doi.org/10.1038/ni1102-991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m511525200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014019455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200211048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014467139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014607335", 
              "https://doi.org/10.1038/nature10983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014839071", 
              "https://doi.org/10.1038/nature10803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.0563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015613811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-2644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015935730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.01.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016166048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534738", 
              "https://doi.org/10.1038/ng1861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534738", 
              "https://doi.org/10.1038/ng1861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0904343106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016779593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016797479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016903798", 
              "https://doi.org/10.1038/nm.2305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.17558811", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016980552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017159411", 
              "https://doi.org/10.1038/nrc3262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1142210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018543968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.76", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018750757", 
              "https://doi.org/10.1038/onc.2008.76"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1995.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019507465", 
              "https://doi.org/10.1038/bjc.1995.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1995.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019507465", 
              "https://doi.org/10.1038/bjc.1995.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019816173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019816173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcb.2008.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020398107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021173404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021173404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(02)00102-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021177280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1005960107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021658889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021753739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-1825", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021925242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.05.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022033292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200706015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022419699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-010-1026-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023262621", 
              "https://doi.org/10.1007/s10549-010-1026-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023417946", 
              "https://doi.org/10.1038/nrg3123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023540354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-6199-0_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024046272", 
              "https://doi.org/10.1007/978-1-4419-6199-0_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024168378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024297992", 
              "https://doi.org/10.1038/nrm2718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024826508", 
              "https://doi.org/10.1038/sj.onc.1205102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024826508", 
              "https://doi.org/10.1038/sj.onc.1205102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025638147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025645333", 
              "https://doi.org/10.1038/nsmb.2245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2009.07331.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026268137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026742955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(99)05264-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026862461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026896062", 
              "https://doi.org/10.1038/ng1382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026896062", 
              "https://doi.org/10.1038/ng1382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.07.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027560099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029090126", 
              "https://doi.org/10.1038/ncb1529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029090126", 
              "https://doi.org/10.1038/ncb1529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029472856", 
              "https://doi.org/10.1038/nm1599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029480384", 
              "https://doi.org/10.1038/ng1282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029480384", 
              "https://doi.org/10.1038/ng1282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029500774", 
              "https://doi.org/10.1038/cdd.2010.133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029505563", 
              "https://doi.org/10.1038/nature10910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0912143106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029833058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0381639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030009882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0381639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030009882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030135236", 
              "https://doi.org/10.1038/nrc2393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0606343104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030691733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2011.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031169996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1210214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031573445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m407105200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031843670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0811835106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032413558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032794943", 
              "https://doi.org/10.1186/1471-2407-10-182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/536761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033047847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033871070", 
              "https://doi.org/10.1038/25292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033871070", 
              "https://doi.org/10.1038/25292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034906925", 
              "https://doi.org/10.1038/nrclinonc.2009.186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2009.186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034906925", 
              "https://doi.org/10.1038/nrclinonc.2009.186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035074433", 
              "https://doi.org/10.1038/35053094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35053094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035074433", 
              "https://doi.org/10.1038/35053094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.18.2.1055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035244157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036025299", 
              "https://doi.org/10.1038/nature09529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036025299", 
              "https://doi.org/10.1038/nature09529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036098758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0505053102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036997589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m805880200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037129187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2004.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037134328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m203793200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037453492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2010.01.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038205886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2011.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038868786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1917310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039001842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1331931100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039963755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e3182326004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041037264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e3182326004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041037264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2008.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041213023", 
              "https://doi.org/10.1038/cdd.2008.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041793251", 
              "https://doi.org/10.1038/nrc2781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041793251", 
              "https://doi.org/10.1038/nrc2781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0022167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042187391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2007.135004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044025707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2008.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044078984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1700908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044326402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044509580", 
              "https://doi.org/10.1038/nature09414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044509580", 
              "https://doi.org/10.1038/nature09414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.11.3.18994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044650815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200905057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044782196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-130963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044860781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871830", 
              "https://doi.org/10.1038/ni1102-999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1102-999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044871830", 
              "https://doi.org/10.1038/ni1102-999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.11.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045686167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803504105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045745146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2006.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045813898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2012.02.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046120229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-386039-2.00001-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047945644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81988-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048354178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.21.14.4684-4699.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048418118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cancergencyto.2009.12.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048876416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049326401", 
              "https://doi.org/10.1038/nrc2618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049326401", 
              "https://doi.org/10.1038/nrc2618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049809877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-6330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050047251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-1915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050312814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.08.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050438589"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.580710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050486865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-11-1610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050674821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2007.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050904155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2012.04363.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051842253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2265.2012.04363.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051842253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.53.38083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052478000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053038796", 
              "https://doi.org/10.1038/nature10762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4419-6199-0_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053170744", 
              "https://doi.org/10.1007/978-1-4419-6199-0_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2011.197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053322918", 
              "https://doi.org/10.1038/cdd.2011.197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/87.4.280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059819727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1160058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062458400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1206412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062464740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5256.1744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.2005-0137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064327491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/mend.15.11.0729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064332101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.19.6.1295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071511874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.20.9690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074698409", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074801106", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077880336", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083208904", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-10", 
        "datePublishedReg": "2013-10-01", 
        "description": "One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox. We also review the tumor-promoting and tumor-suppressing consequences of W-CIN. Importantly, we do this in the context of cancer as a complex systemic disease, rather than as a simple linearly progressing disorder that arises from a single abnormal cell population. Accordingly, we highlight the often neglected effects of W-CIN on key non-cell-autonomous entities, such as the immune system and the tumor microenvironment. Distinct tissue-specific susceptibilities to W-CIN-induced tumorigenesis and the clinical implications of W-CIN are also discussed. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2012.616", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "40", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "32"
          }
        ], 
        "name": "The cancer biology of whole-chromosome instability", 
        "pagination": "4727", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "88e36914e385a653996a93f0e337d8dd76917a323a2f4537a34dd252510896e1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23318433"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2012.616"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1028735655"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2012.616", 
          "https://app.dimensions.ai/details/publication/pub.1028735655"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000438.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc2012616"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.616'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.616'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.616'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.616'


     

    This table displays all metadata directly associated to this object as RDF triples.

    612 TRIPLES      21 PREDICATES      191 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2012.616 schema:about N05826689a12b4622852cf082df27e9ad
    2 N33f71154ddfb441ab73af95d15a413b8
    3 N94b0fc56d8114219b0b7fda17f8104d7
    4 N94eeb44fa92d4387be6614a7e9d95abf
    5 N9e77ae864eec42afa89493ae2875bded
    6 Ndaa87db7f5da4667ace0bcd1911a2a2c
    7 Ndacc7c6368a446f39ba1cd446f9b7452
    8 anzsrc-for:06
    9 anzsrc-for:0601
    10 schema:author N1fdf22fbeca749c9be4526ce09d9d3ec
    11 schema:citation sg:pub.10.1007/978-1-4419-6199-0_6
    12 sg:pub.10.1007/978-1-4419-6199-0_8
    13 sg:pub.10.1007/s10549-010-1026-5
    14 sg:pub.10.1038/25292
    15 sg:pub.10.1038/35053094
    16 sg:pub.10.1038/bjc.1995.85
    17 sg:pub.10.1038/cdd.2008.47
    18 sg:pub.10.1038/cdd.2010.133
    19 sg:pub.10.1038/cdd.2011.197
    20 sg:pub.10.1038/nature02820
    21 sg:pub.10.1038/nature03482
    22 sg:pub.10.1038/nature08803
    23 sg:pub.10.1038/nature08822
    24 sg:pub.10.1038/nature09414
    25 sg:pub.10.1038/nature09529
    26 sg:pub.10.1038/nature10113
    27 sg:pub.10.1038/nature10166
    28 sg:pub.10.1038/nature10661
    29 sg:pub.10.1038/nature10762
    30 sg:pub.10.1038/nature10802
    31 sg:pub.10.1038/nature10803
    32 sg:pub.10.1038/nature10910
    33 sg:pub.10.1038/nature10983
    34 sg:pub.10.1038/ncb1529
    35 sg:pub.10.1038/ncb1742
    36 sg:pub.10.1038/ncb1909
    37 sg:pub.10.1038/ng1282
    38 sg:pub.10.1038/ng1382
    39 sg:pub.10.1038/ng1605
    40 sg:pub.10.1038/ng1861
    41 sg:pub.10.1038/ni1102-991
    42 sg:pub.10.1038/ni1102-999
    43 sg:pub.10.1038/nm.2305
    44 sg:pub.10.1038/nm1599
    45 sg:pub.10.1038/nrc2393
    46 sg:pub.10.1038/nrc2618
    47 sg:pub.10.1038/nrc2781
    48 sg:pub.10.1038/nrc3262
    49 sg:pub.10.1038/nrclinonc.2009.186
    50 sg:pub.10.1038/nrg3123
    51 sg:pub.10.1038/nrm2718
    52 sg:pub.10.1038/nsmb.2245
    53 sg:pub.10.1038/onc.2008.76
    54 sg:pub.10.1038/sj.onc.1205102
    55 sg:pub.10.1186/1471-2407-10-182
    56 sg:pub.10.3858/emm.2009.41.5.039
    57 https://app.dimensions.ai/details/publication/pub.1074698409
    58 https://app.dimensions.ai/details/publication/pub.1074801106
    59 https://app.dimensions.ai/details/publication/pub.1077880336
    60 https://app.dimensions.ai/details/publication/pub.1083208904
    61 https://doi.org/10.1002/ajmg.a.34284
    62 https://doi.org/10.1002/ijc.25815
    63 https://doi.org/10.1002/ijc.27924
    64 https://doi.org/10.1016/b978-0-12-386039-2.00001-8
    65 https://doi.org/10.1016/j.cancergencyto.2009.12.006
    66 https://doi.org/10.1016/j.ccr.2005.08.003
    67 https://doi.org/10.1016/j.ccr.2006.10.019
    68 https://doi.org/10.1016/j.ccr.2006.12.003
    69 https://doi.org/10.1016/j.ccr.2008.04.005
    70 https://doi.org/10.1016/j.ccr.2008.07.002
    71 https://doi.org/10.1016/j.ccr.2011.04.017
    72 https://doi.org/10.1016/j.ccr.2011.05.023
    73 https://doi.org/10.1016/j.ccr.2011.08.012
    74 https://doi.org/10.1016/j.ccr.2012.02.022
    75 https://doi.org/10.1016/j.cell.2007.01.029
    76 https://doi.org/10.1016/j.cell.2010.01.025
    77 https://doi.org/10.1016/j.cell.2010.08.038
    78 https://doi.org/10.1016/j.cell.2010.11.055
    79 https://doi.org/10.1016/j.cell.2011.01.017
    80 https://doi.org/10.1016/j.cell.2011.02.013
    81 https://doi.org/10.1016/j.cell.2011.07.042
    82 https://doi.org/10.1016/j.cub.2010.01.034
    83 https://doi.org/10.1016/j.cub.2012.02.030
    84 https://doi.org/10.1016/j.devcel.2004.09.002
    85 https://doi.org/10.1016/j.gde.2007.12.007
    86 https://doi.org/10.1016/j.lungcan.2008.07.016
    87 https://doi.org/10.1016/j.tcb.2008.01.006
    88 https://doi.org/10.1016/j.tcb.2010.12.002
    89 https://doi.org/10.1016/j.tig.2008.07.002
    90 https://doi.org/10.1016/j.tig.2011.12.002
    91 https://doi.org/10.1016/s0092-8674(00)81988-1
    92 https://doi.org/10.1016/s0140-6736(02)08092-3
    93 https://doi.org/10.1016/s0140-6736(99)05264-2
    94 https://doi.org/10.1016/s1535-6108(02)00102-2
    95 https://doi.org/10.1042/bst0381639
    96 https://doi.org/10.1073/pnas.0505053102
    97 https://doi.org/10.1073/pnas.0606343104
    98 https://doi.org/10.1073/pnas.0803504105
    99 https://doi.org/10.1073/pnas.0811835106
    100 https://doi.org/10.1073/pnas.0904343106
    101 https://doi.org/10.1073/pnas.0912143106
    102 https://doi.org/10.1073/pnas.1005960107
    103 https://doi.org/10.1073/pnas.1331931100
    104 https://doi.org/10.1073/pnas.97.26.14295
    105 https://doi.org/10.1074/jbc.274.53.38083
    106 https://doi.org/10.1074/jbc.m203793200
    107 https://doi.org/10.1074/jbc.m407105200
    108 https://doi.org/10.1074/jbc.m511525200
    109 https://doi.org/10.1074/jbc.m805880200
    110 https://doi.org/10.1083/jcb.200211048
    111 https://doi.org/10.1083/jcb.200507081
    112 https://doi.org/10.1083/jcb.200706015
    113 https://doi.org/10.1083/jcb.200904020
    114 https://doi.org/10.1083/jcb.200905057
    115 https://doi.org/10.1083/jcb.200906147
    116 https://doi.org/10.1083/jcb.201012035
    117 https://doi.org/10.1091/mbc.12.5.1315
    118 https://doi.org/10.1093/carcin/bgp127
    119 https://doi.org/10.1093/jnci/87.4.280
    120 https://doi.org/10.1093/jnci/dji240
    121 https://doi.org/10.1096/fj.09-130963
    122 https://doi.org/10.1097/igc.0b013e3182126f85
    123 https://doi.org/10.1097/ppo.0b013e3182326004
    124 https://doi.org/10.1101/gad.10.20.2621
    125 https://doi.org/10.1101/gad.1700908
    126 https://doi.org/10.1101/gad.17558811
    127 https://doi.org/10.1101/gad.1917310
    128 https://doi.org/10.1101/gad.1917610
    129 https://doi.org/10.1101/gad.580710
    130 https://doi.org/10.1101/gad.949802
    131 https://doi.org/10.1111/j.1365-2265.2012.04363.x
    132 https://doi.org/10.1111/j.1600-0560.2007.00935.x
    133 https://doi.org/10.1111/j.1742-4658.2009.07331.x
    134 https://doi.org/10.1126/science.1142210
    135 https://doi.org/10.1126/science.1160058
    136 https://doi.org/10.1126/science.1203486
    137 https://doi.org/10.1126/science.1203619
    138 https://doi.org/10.1126/science.1206412
    139 https://doi.org/10.1126/science.1210214
    140 https://doi.org/10.1126/science.271.5256.1744
    141 https://doi.org/10.1128/mcb.00392-08
    142 https://doi.org/10.1128/mcb.00882-09
    143 https://doi.org/10.1128/mcb.18.2.1055
    144 https://doi.org/10.1128/mcb.21.14.4684-4699.2001
    145 https://doi.org/10.1128/mcb.25.10.4046-4061.2005
    146 https://doi.org/10.1136/gut.2007.135004
    147 https://doi.org/10.1155/2012/536761
    148 https://doi.org/10.1158/0008-5472.can-06-3326
    149 https://doi.org/10.1158/0008-5472.can-07-0663
    150 https://doi.org/10.1158/0008-5472.can-07-1684
    151 https://doi.org/10.1158/0008-5472.can-07-6330
    152 https://doi.org/10.1158/0008-5472.can-08-1915
    153 https://doi.org/10.1158/0008-5472.can-09-1491
    154 https://doi.org/10.1158/0008-5472.can-10-0603
    155 https://doi.org/10.1158/1078-0432.ccr-07-1825
    156 https://doi.org/10.1158/1078-0432.ccr-08-2644
    157 https://doi.org/10.1158/1078-0432.ccr-11-1610
    158 https://doi.org/10.1158/1078-0432.ccr-11-1944
    159 https://doi.org/10.1200/jco.2008.17.0563
    160 https://doi.org/10.1210/me.2005-0137
    161 https://doi.org/10.1210/mend.15.11.0729
    162 https://doi.org/10.1371/journal.pone.0022167
    163 https://doi.org/10.3892/ijo.19.6.1295
    164 https://doi.org/10.4161/cc.11.3.18994
    165 https://doi.org/10.4161/cc.8.20.9690
    166 schema:datePublished 2013-10
    167 schema:datePublishedReg 2013-10-01
    168 schema:description One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox. We also review the tumor-promoting and tumor-suppressing consequences of W-CIN. Importantly, we do this in the context of cancer as a complex systemic disease, rather than as a simple linearly progressing disorder that arises from a single abnormal cell population. Accordingly, we highlight the often neglected effects of W-CIN on key non-cell-autonomous entities, such as the immune system and the tumor microenvironment. Distinct tissue-specific susceptibilities to W-CIN-induced tumorigenesis and the clinical implications of W-CIN are also discussed.
    169 schema:genre research_article
    170 schema:inLanguage en
    171 schema:isAccessibleForFree true
    172 schema:isPartOf N0f4e042695ee480d95afc7fb900cca3f
    173 Nd05fb4c10fad43559fd6030f16d8541f
    174 sg:journal.1097543
    175 schema:name The cancer biology of whole-chromosome instability
    176 schema:pagination 4727
    177 schema:productId N3d4afb859b954e1e90cc5ca69cca0cb7
    178 N58d77d2332b646109922e5ec9a011e9f
    179 N73f97c0bfbd342e7b095753cfaa035f2
    180 Ncadda6a05aec45048a74ab80ab4071f3
    181 Necfebb0923194a13946b7804bb037d82
    182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028735655
    183 https://doi.org/10.1038/onc.2012.616
    184 schema:sdDatePublished 2019-04-11T00:56
    185 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    186 schema:sdPublisher Na70861b2a4e340f2b29a193f8cbfabf4
    187 schema:url https://www.nature.com/articles/onc2012616
    188 sgo:license sg:explorer/license/
    189 sgo:sdDataset articles
    190 rdf:type schema:ScholarlyArticle
    191 N05826689a12b4622852cf082df27e9ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Mitosis
    193 rdf:type schema:DefinedTerm
    194 N0f4e042695ee480d95afc7fb900cca3f schema:issueNumber 40
    195 rdf:type schema:PublicationIssue
    196 N1fdf22fbeca749c9be4526ce09d9d3ec rdf:first sg:person.014137670424.60
    197 rdf:rest N95d1464b10534233844c016e55327cbd
    198 N33f71154ddfb441ab73af95d15a413b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Humans
    200 rdf:type schema:DefinedTerm
    201 N3d4afb859b954e1e90cc5ca69cca0cb7 schema:name dimensions_id
    202 schema:value pub.1028735655
    203 rdf:type schema:PropertyValue
    204 N58d77d2332b646109922e5ec9a011e9f schema:name pubmed_id
    205 schema:value 23318433
    206 rdf:type schema:PropertyValue
    207 N73f97c0bfbd342e7b095753cfaa035f2 schema:name doi
    208 schema:value 10.1038/onc.2012.616
    209 rdf:type schema:PropertyValue
    210 N94b0fc56d8114219b0b7fda17f8104d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Neoplasms
    212 rdf:type schema:DefinedTerm
    213 N94eeb44fa92d4387be6614a7e9d95abf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Chromosomal Instability
    215 rdf:type schema:DefinedTerm
    216 N95d1464b10534233844c016e55327cbd rdf:first sg:person.0674175575.90
    217 rdf:rest rdf:nil
    218 N9e77ae864eec42afa89493ae2875bded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Oncogenes
    220 rdf:type schema:DefinedTerm
    221 Na70861b2a4e340f2b29a193f8cbfabf4 schema:name Springer Nature - SN SciGraph project
    222 rdf:type schema:Organization
    223 Ncadda6a05aec45048a74ab80ab4071f3 schema:name nlm_unique_id
    224 schema:value 8711562
    225 rdf:type schema:PropertyValue
    226 Nd05fb4c10fad43559fd6030f16d8541f schema:volumeNumber 32
    227 rdf:type schema:PublicationVolume
    228 Ndaa87db7f5da4667ace0bcd1911a2a2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Animals
    230 rdf:type schema:DefinedTerm
    231 Ndacc7c6368a446f39ba1cd446f9b7452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Cell Transformation, Neoplastic
    233 rdf:type schema:DefinedTerm
    234 Necfebb0923194a13946b7804bb037d82 schema:name readcube_id
    235 schema:value 88e36914e385a653996a93f0e337d8dd76917a323a2f4537a34dd252510896e1
    236 rdf:type schema:PropertyValue
    237 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    238 schema:name Biological Sciences
    239 rdf:type schema:DefinedTerm
    240 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    241 schema:name Biochemistry and Cell Biology
    242 rdf:type schema:DefinedTerm
    243 sg:journal.1097543 schema:issn 0950-9232
    244 1476-5594
    245 schema:name Oncogene
    246 rdf:type schema:Periodical
    247 sg:person.014137670424.60 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    248 schema:familyName Duijf
    249 schema:givenName P H G
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014137670424.60
    251 rdf:type schema:Person
    252 sg:person.0674175575.90 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    253 schema:familyName Benezra
    254 schema:givenName R
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674175575.90
    256 rdf:type schema:Person
    257 sg:pub.10.1007/978-1-4419-6199-0_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024046272
    258 https://doi.org/10.1007/978-1-4419-6199-0_6
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/978-1-4419-6199-0_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053170744
    261 https://doi.org/10.1007/978-1-4419-6199-0_8
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s10549-010-1026-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023262621
    264 https://doi.org/10.1007/s10549-010-1026-5
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/25292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033871070
    267 https://doi.org/10.1038/25292
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/35053094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035074433
    270 https://doi.org/10.1038/35053094
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/bjc.1995.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019507465
    273 https://doi.org/10.1038/bjc.1995.85
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/cdd.2008.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041213023
    276 https://doi.org/10.1038/cdd.2008.47
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/cdd.2010.133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029500774
    279 https://doi.org/10.1038/cdd.2010.133
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/cdd.2011.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053322918
    282 https://doi.org/10.1038/cdd.2011.197
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nature02820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010008721
    285 https://doi.org/10.1038/nature02820
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
    288 https://doi.org/10.1038/nature03482
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nature08803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009828897
    291 https://doi.org/10.1038/nature08803
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    294 https://doi.org/10.1038/nature08822
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nature09414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044509580
    297 https://doi.org/10.1038/nature09414
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nature09529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036025299
    300 https://doi.org/10.1038/nature09529
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nature10113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008698030
    303 https://doi.org/10.1038/nature10113
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
    306 https://doi.org/10.1038/nature10166
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nature10661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208236
    309 https://doi.org/10.1038/nature10661
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nature10762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053038796
    312 https://doi.org/10.1038/nature10762
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nature10802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008061452
    315 https://doi.org/10.1038/nature10802
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/nature10803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014839071
    318 https://doi.org/10.1038/nature10803
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature10910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029505563
    321 https://doi.org/10.1038/nature10910
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
    324 https://doi.org/10.1038/nature10983
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/ncb1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029090126
    327 https://doi.org/10.1038/ncb1529
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/ncb1742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006184899
    330 https://doi.org/10.1038/ncb1742
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/ncb1909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008470674
    333 https://doi.org/10.1038/ncb1909
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/ng1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029480384
    336 https://doi.org/10.1038/ng1282
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/ng1382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026896062
    339 https://doi.org/10.1038/ng1382
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/ng1605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008610787
    342 https://doi.org/10.1038/ng1605
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/ng1861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534738
    345 https://doi.org/10.1038/ng1861
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/ni1102-991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013709887
    348 https://doi.org/10.1038/ni1102-991
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/ni1102-999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044871830
    351 https://doi.org/10.1038/ni1102-999
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nm.2305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016903798
    354 https://doi.org/10.1038/nm.2305
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nm1599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029472856
    357 https://doi.org/10.1038/nm1599
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nrc2393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030135236
    360 https://doi.org/10.1038/nrc2393
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrc2618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326401
    363 https://doi.org/10.1038/nrc2618
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/nrc2781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041793251
    366 https://doi.org/10.1038/nrc2781
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/nrc3262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017159411
    369 https://doi.org/10.1038/nrc3262
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/nrclinonc.2009.186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034906925
    372 https://doi.org/10.1038/nrclinonc.2009.186
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/nrg3123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023417946
    375 https://doi.org/10.1038/nrg3123
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/nrm2718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024297992
    378 https://doi.org/10.1038/nrm2718
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/nsmb.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025645333
    381 https://doi.org/10.1038/nsmb.2245
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/onc.2008.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018750757
    384 https://doi.org/10.1038/onc.2008.76
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/sj.onc.1205102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024826508
    387 https://doi.org/10.1038/sj.onc.1205102
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1186/1471-2407-10-182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032794943
    390 https://doi.org/10.1186/1471-2407-10-182
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.3858/emm.2009.41.5.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010788331
    393 https://doi.org/10.3858/emm.2009.41.5.039
    394 rdf:type schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1074698409 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1074801106 schema:CreativeWork
    397 https://app.dimensions.ai/details/publication/pub.1077880336 schema:CreativeWork
    398 https://app.dimensions.ai/details/publication/pub.1083208904 schema:CreativeWork
    399 https://doi.org/10.1002/ajmg.a.34284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001887233
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1002/ijc.25815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049809877
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1002/ijc.27924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016797479
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/b978-0-12-386039-2.00001-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047945644
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/j.cancergencyto.2009.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048876416
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1016/j.ccr.2005.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021173404
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1016/j.ccr.2006.10.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002223417
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/j.ccr.2006.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045813898
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.ccr.2008.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013577696
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.ccr.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026742955
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.ccr.2011.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038868786
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.ccr.2011.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022033292
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.ccr.2011.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024168378
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.ccr.2012.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002516265
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.cell.2007.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009285166
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.cell.2010.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016166048
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.cell.2010.08.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050438589
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.cell.2010.11.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045686167
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.cell.2011.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021753739
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.cell.2011.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023540354
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.cell.2011.07.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027560099
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.cub.2010.01.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038205886
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.cub.2012.02.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046120229
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.devcel.2004.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037134328
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.gde.2007.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050904155
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.lungcan.2008.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044078984
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.tcb.2008.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020398107
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.tcb.2010.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006039070
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.tig.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001853364
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.tig.2011.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031169996
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/s0092-8674(00)81988-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048354178
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/s0140-6736(02)08092-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011542357
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/s0140-6736(99)05264-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026862461
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/s1535-6108(02)00102-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021177280
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1042/bst0381639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030009882
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1073/pnas.0505053102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036997589
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1073/pnas.0606343104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030691733
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1073/pnas.0803504105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045745146
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1073/pnas.0811835106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032413558
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1073/pnas.0904343106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016779593
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1073/pnas.0912143106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029833058
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1073/pnas.1005960107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021658889
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1073/pnas.1331931100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039963755
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1073/pnas.97.26.14295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006320032
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1074/jbc.274.53.38083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052478000
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1074/jbc.m203793200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037453492
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1074/jbc.m407105200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031843670
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1074/jbc.m511525200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014019455
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1074/jbc.m805880200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037129187
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1083/jcb.200211048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014467139
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1083/jcb.200507081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009358669
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1083/jcb.200706015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022419699
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1083/jcb.200904020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012449299
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1083/jcb.200905057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044782196
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1083/jcb.200906147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000343492
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1083/jcb.201012035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010595392
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1091/mbc.12.5.1315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007285718
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1093/carcin/bgp127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019816173
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1093/jnci/87.4.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819727
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1093/jnci/dji240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006999461
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1096/fj.09-130963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044860781
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1097/igc.0b013e3182126f85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003579736
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1097/ppo.0b013e3182326004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041037264
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1101/gad.10.20.2621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012452978
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1101/gad.1700908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044326402
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1101/gad.17558811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016980552
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1101/gad.1917310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039001842
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1101/gad.1917610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001434344
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1101/gad.580710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050486865
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1101/gad.949802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012307300
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1111/j.1365-2265.2012.04363.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051842253
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1111/j.1600-0560.2007.00935.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003369644
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1111/j.1742-4658.2009.07331.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026268137
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1126/science.1142210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018543968
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1126/science.1160058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458400
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1126/science.1203486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010153811
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1126/science.1203619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011556378
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1126/science.1206412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062464740
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1126/science.1210214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031573445
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1126/science.271.5256.1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552531
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1128/mcb.00392-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011447282
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1128/mcb.00882-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001627596
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1128/mcb.18.2.1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035244157
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1128/mcb.21.14.4684-4699.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048418118
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1128/mcb.25.10.4046-4061.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007293874
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1136/gut.2007.135004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044025707
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1155/2012/536761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033047847
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1158/0008-5472.can-06-3326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010104374
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1158/0008-5472.can-07-0663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005861006
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1158/0008-5472.can-07-1684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025638147
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1158/0008-5472.can-07-6330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050047251
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1158/0008-5472.can-08-1915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050312814
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1158/0008-5472.can-09-1491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004147465
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1158/0008-5472.can-10-0603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036098758
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1158/1078-0432.ccr-07-1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021925242
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1158/1078-0432.ccr-08-2644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015935730
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1158/1078-0432.ccr-11-1610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050674821
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1158/1078-0432.ccr-11-1944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005412104
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1200/jco.2008.17.0563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015613811
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1210/me.2005-0137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327491
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1210/mend.15.11.0729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064332101
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1371/journal.pone.0022167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042187391
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.3892/ijo.19.6.1295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511874
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.4161/cc.11.3.18994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044650815
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.4161/cc.8.20.9690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300359
    608 rdf:type schema:CreativeWork
    609 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
    610 schema:name Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    611 The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    612 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...