Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

A Arlt, S Sebens, S Krebs, C Geismann, M Grossmann, M-L Kruse, S Schreiber, H Schäfer

ABSTRACT

Evidence accumulates that the transcription factor nuclear factor E2-related factor 2 (Nrf2) has an essential role in cancer development and chemoresistance, thus pointing to its potential as an anticancer target and undermining its suitability in chemoprevention. Through the induction of cytoprotective and proteasomal genes, Nrf2 confers apoptosis protection in tumor cells, and inhibiting Nrf2 would therefore be an efficient strategy in anticancer therapy. In the present study, pancreatic carcinoma cell lines (Panc1, Colo357 and MiaPaca2) and H6c7 pancreatic duct cells were analyzed for the Nrf2-inhibitory effect of the coffee alkaloid trigonelline (trig), as well as for its impact on Nrf2-dependent proteasome activity and resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and anticancer drug-induced apoptosis. Chemoresistant Panc1 and Colo357 cells exhibit high constitutive Nrf2 activity, whereas chemosensitive MiaPaca2 and H6c7 cells display little basal but strong tert-butylhydroquinone (tBHQ)-inducible Nrf2 activity and drug resistance. Trig efficiently decreased basal and tBHQ-induced Nrf2 activity in all cell lines, an effect relying on a reduced nuclear accumulation of the Nrf2 protein. Along with Nrf2 inhibition, trig blocked the Nrf2-dependent expression of proteasomal genes (for example, s5a/psmd4 and α5/psma5) and reduced proteasome activity in all cell lines tested. These blocking effects were absent after treatment with Nrf2 siRNA, a condition in which proteasomal gene expression and proteasome activity were already decreased, whereas siRNA against the related transcription factor Nrf1 did not affect proteasome activity and the inhibitory effect of trig. Depending on both Nrf2 and proteasomal gene expression, the sensitivity of all cell lines to anticancer drugs and TRAIL-induced apoptosis was enhanced by trig. Moreover, greater antitumor responses toward anticancer drug treatment were observed in tumor-bearing mice when receiving trig. In conclusion, representing an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells, trig might be beneficial in improving anticancer therapy. More... »

PAGES

4825

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2012.493

DOI

http://dx.doi.org/10.1038/onc.2012.493

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032394031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23108405


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaloids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Etoposide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-E2-Related Factor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteasome Endopeptidase Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TNF-Related Apoptosis-Inducing Ligand", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arlt", 
        "givenName": "A", 
        "id": "sg:person.01151166002.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151166002.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Experimental Medicine, Inflammatory Carcinogenesis Research Group, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sebens", 
        "givenName": "S", 
        "id": "sg:person.01350672604.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350672604.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krebs", 
        "givenName": "S", 
        "id": "sg:person.01163610520.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163610520.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geismann", 
        "givenName": "C", 
        "id": "sg:person.01256203677.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203677.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grossmann", 
        "givenName": "M", 
        "id": "sg:person.01265447232.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265447232.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kruse", 
        "givenName": "M-L", 
        "id": "sg:person.0646153340.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646153340.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany", 
            "Institute of Clinical Molecular Biology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schreiber", 
        "givenName": "S", 
        "id": "sg:person.01223143620.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4fer", 
        "givenName": "H", 
        "id": "sg:person.01064743717.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064743717.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0709483104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000270188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001597760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.r900010200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001746715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004544829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004544829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.23.8786-8794.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006641296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m808084200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007864453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007935211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009994608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2010.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010229710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011803417", 
          "https://doi.org/10.1038/nature10189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-10-37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013400177", 
          "https://doi.org/10.1186/1476-4598-10-37"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2008.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014403116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2008.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016078575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016350180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m503074200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016854009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-011-1266-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017561496", 
          "https://doi.org/10.1007/s11033-011-1266-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-011-1266-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017561496", 
          "https://doi.org/10.1007/s11033-011-1266-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2010.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017850976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-4668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017873726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrrev.2007.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019578631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.08.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019755289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m211898200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019762527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc09-0207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020433485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020529406", 
          "https://doi.org/10.1038/sj.onc.1203462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020529406", 
          "https://doi.org/10.1038/sj.onc.1203462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-1626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024645472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9255-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025115026", 
          "https://doi.org/10.1007/s10555-010-9255-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-010-9255-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025115026", 
          "https://doi.org/10.1007/s10555-010-9255-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2010.3219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027757232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027965781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028482307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.274902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028862730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e3181c31314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029868333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e3181c31314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029868333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e3181c31314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029868333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2010.3301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030045785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.275495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030973740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031161259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031161259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032372131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.031575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035595498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035971307", 
          "https://doi.org/10.1038/sj.onc.1204168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035971307", 
          "https://doi.org/10.1038/sj.onc.1204168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-3007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036678242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.05.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037728637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phrs.2008.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038129710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.9.2883-2892.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039822139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2009.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040400184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10715762.2010.507670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042568523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620521", 
          "https://doi.org/10.1038/nrclinonc.2009.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620521", 
          "https://doi.org/10.1038/nrclinonc.2009.236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2007.08.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045110957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.145862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045215727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jnutbio.2010.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046308603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-7075-8-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046492969", 
          "https://doi.org/10.1186/1743-7075-8-10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2009.180711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046716547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.freeradbiomed.2009.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047932516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrfmmm.2009.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048439321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgn095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049087853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2010.04.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050377083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052759007", 
          "https://doi.org/10.1038/onc.2009.264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052759007", 
          "https://doi.org/10.1038/onc.2009.264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-3352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053248607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0030420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053409424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr8000892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056294305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2010-2642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo_00000846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071518826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or_00000561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071537366"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-10", 
    "datePublishedReg": "2013-10-01", 
    "description": "Evidence accumulates that the transcription factor nuclear factor E2-related factor 2 (Nrf2) has an essential role in cancer development and chemoresistance, thus pointing to its potential as an anticancer target and undermining its suitability in chemoprevention. Through the induction of cytoprotective and proteasomal genes, Nrf2 confers apoptosis protection in tumor cells, and inhibiting Nrf2 would therefore be an efficient strategy in anticancer therapy. In the present study, pancreatic carcinoma cell lines (Panc1, Colo357 and MiaPaca2) and H6c7 pancreatic duct cells were analyzed for the Nrf2-inhibitory effect of the coffee alkaloid trigonelline (trig), as well as for its impact on Nrf2-dependent proteasome activity and resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and anticancer drug-induced apoptosis. Chemoresistant Panc1 and Colo357 cells exhibit high constitutive Nrf2 activity, whereas chemosensitive MiaPaca2 and H6c7 cells display little basal but strong tert-butylhydroquinone (tBHQ)-inducible Nrf2 activity and drug resistance. Trig efficiently decreased basal and tBHQ-induced Nrf2 activity in all cell lines, an effect relying on a reduced nuclear accumulation of the Nrf2 protein. Along with Nrf2 inhibition, trig blocked the Nrf2-dependent expression of proteasomal genes (for example, s5a/psmd4 and \u03b15/psma5) and reduced proteasome activity in all cell lines tested. These blocking effects were absent after treatment with Nrf2 siRNA, a condition in which proteasomal gene expression and proteasome activity were already decreased, whereas siRNA against the related transcription factor Nrf1 did not affect proteasome activity and the inhibitory effect of trig. Depending on both Nrf2 and proteasomal gene expression, the sensitivity of all cell lines to anticancer drugs and TRAIL-induced apoptosis was enhanced by trig. Moreover, greater antitumor responses toward anticancer drug treatment were observed in tumor-bearing mice when receiving trig. In conclusion, representing an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells, trig might be beneficial in improving anticancer therapy. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2012.493", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "40", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity", 
    "pagination": "4825", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9a51dce589e91cf6ab8aed29d4ae571b0c3840b8229a6db3c89b7096852e9c93"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23108405"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2012.493"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032394031"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2012.493", 
      "https://app.dimensions.ai/details/publication/pub.1032394031"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2012493"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.493'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.493'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.493'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.493'


 

This table displays all metadata directly associated to this object as RDF triples.

359 TRIPLES      21 PREDICATES      101 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2012.493 schema:about N00f7ebec2ef940828e49f1ae5f868d36
2 N0a86b82fb38049a78dc9cfcda8e91298
3 N0bf4e885db444f529935e5a016d39349
4 N0e86d53ce7644059ace045e7ce9feb35
5 N1eb9ac842f3b491e9c5ff94e346569ef
6 N256bcc9dd4804a97a408ff5dd777646a
7 N416da5677ef44ec58c0a5c6c8f9226c2
8 N89cd780ad29e4df8868a57c9e7a4c63f
9 N97c9997ce8a24a06a1a9c3ecd8f4b298
10 Nd7c87edd2fa44ed2bbe0119d71bd7827
11 Ne4199e90462e47588eac13ddb60c8a5d
12 Nf5216521e89647d6b8846d0dd9d88a01
13 Nf5704c1d3a38448fadbed2ebc7f95ce7
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N0a1056d94b7145e49283528092c237c3
17 schema:citation sg:pub.10.1007/s10555-010-9255-y
18 sg:pub.10.1007/s11033-011-1266-4
19 sg:pub.10.1038/nature10189
20 sg:pub.10.1038/nrclinonc.2009.236
21 sg:pub.10.1038/onc.2009.264
22 sg:pub.10.1038/sj.onc.1203462
23 sg:pub.10.1038/sj.onc.1204168
24 sg:pub.10.1186/1476-4598-10-37
25 sg:pub.10.1186/1743-7075-8-10
26 https://doi.org/10.1002/path.2653
27 https://doi.org/10.1016/j.bbrc.2006.05.043
28 https://doi.org/10.1016/j.bbrc.2007.08.051
29 https://doi.org/10.1016/j.bbrc.2008.06.004
30 https://doi.org/10.1016/j.bbrc.2010.04.108
31 https://doi.org/10.1016/j.ccr.2011.08.007
32 https://doi.org/10.1016/j.ccr.2011.09.006
33 https://doi.org/10.1016/j.ccr.2011.10.005
34 https://doi.org/10.1016/j.ejca.2009.05.017
35 https://doi.org/10.1016/j.freeradbiomed.2008.05.011
36 https://doi.org/10.1016/j.freeradbiomed.2009.09.006
37 https://doi.org/10.1016/j.freeradbiomed.2010.09.006
38 https://doi.org/10.1016/j.jnutbio.2010.03.011
39 https://doi.org/10.1016/j.mce.2007.08.011
40 https://doi.org/10.1016/j.molcel.2010.02.029
41 https://doi.org/10.1016/j.molcel.2010.09.012
42 https://doi.org/10.1016/j.mrfmmm.2009.09.007
43 https://doi.org/10.1016/j.mrrev.2007.11.006
44 https://doi.org/10.1016/j.phrs.2008.09.003
45 https://doi.org/10.1016/j.tibs.2008.12.008
46 https://doi.org/10.1021/pr8000892
47 https://doi.org/10.1073/pnas.0709483104
48 https://doi.org/10.1074/jbc.m109.031575
49 https://doi.org/10.1074/jbc.m110.145862
50 https://doi.org/10.1074/jbc.m111.274902
51 https://doi.org/10.1074/jbc.m111.275495
52 https://doi.org/10.1074/jbc.m211898200
53 https://doi.org/10.1074/jbc.m503074200
54 https://doi.org/10.1074/jbc.m808084200
55 https://doi.org/10.1074/jbc.r900010200
56 https://doi.org/10.1089/ars.2010.3219
57 https://doi.org/10.1089/ars.2010.3301
58 https://doi.org/10.1093/carcin/bgn095
59 https://doi.org/10.1097/mpa.0b013e3181c31314
60 https://doi.org/10.1128/mcb.22.9.2883-2892.2002
61 https://doi.org/10.1128/mcb.23.23.8786-8794.2003
62 https://doi.org/10.1136/gut.2009.180711
63 https://doi.org/10.1158/0008-5472.can-04-1626
64 https://doi.org/10.1158/0008-5472.can-05-0201
65 https://doi.org/10.1158/0008-5472.can-06-1181
66 https://doi.org/10.1158/0008-5472.can-10-0713
67 https://doi.org/10.1158/0008-5472.can-10-3007
68 https://doi.org/10.1158/0008-5472.can-10-4668
69 https://doi.org/10.1158/1078-0432.ccr-09-3352
70 https://doi.org/10.1210/jc.2010-2642
71 https://doi.org/10.1371/journal.pmed.0030420
72 https://doi.org/10.2337/dc09-0207
73 https://doi.org/10.3109/10715762.2010.507670
74 https://doi.org/10.3892/ijo_00000846
75 https://doi.org/10.3892/or_00000561
76 schema:datePublished 2013-10
77 schema:datePublishedReg 2013-10-01
78 schema:description Evidence accumulates that the transcription factor nuclear factor E2-related factor 2 (Nrf2) has an essential role in cancer development and chemoresistance, thus pointing to its potential as an anticancer target and undermining its suitability in chemoprevention. Through the induction of cytoprotective and proteasomal genes, Nrf2 confers apoptosis protection in tumor cells, and inhibiting Nrf2 would therefore be an efficient strategy in anticancer therapy. In the present study, pancreatic carcinoma cell lines (Panc1, Colo357 and MiaPaca2) and H6c7 pancreatic duct cells were analyzed for the Nrf2-inhibitory effect of the coffee alkaloid trigonelline (trig), as well as for its impact on Nrf2-dependent proteasome activity and resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and anticancer drug-induced apoptosis. Chemoresistant Panc1 and Colo357 cells exhibit high constitutive Nrf2 activity, whereas chemosensitive MiaPaca2 and H6c7 cells display little basal but strong tert-butylhydroquinone (tBHQ)-inducible Nrf2 activity and drug resistance. Trig efficiently decreased basal and tBHQ-induced Nrf2 activity in all cell lines, an effect relying on a reduced nuclear accumulation of the Nrf2 protein. Along with Nrf2 inhibition, trig blocked the Nrf2-dependent expression of proteasomal genes (for example, s5a/psmd4 and α5/psma5) and reduced proteasome activity in all cell lines tested. These blocking effects were absent after treatment with Nrf2 siRNA, a condition in which proteasomal gene expression and proteasome activity were already decreased, whereas siRNA against the related transcription factor Nrf1 did not affect proteasome activity and the inhibitory effect of trig. Depending on both Nrf2 and proteasomal gene expression, the sensitivity of all cell lines to anticancer drugs and TRAIL-induced apoptosis was enhanced by trig. Moreover, greater antitumor responses toward anticancer drug treatment were observed in tumor-bearing mice when receiving trig. In conclusion, representing an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells, trig might be beneficial in improving anticancer therapy.
79 schema:genre research_article
80 schema:inLanguage en
81 schema:isAccessibleForFree true
82 schema:isPartOf N381b33591e3b45e68e5072d7b303fc02
83 Nb7b0d585f87d4e85b4b78f91918be786
84 sg:journal.1097543
85 schema:name Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
86 schema:pagination 4825
87 schema:productId N02057f222fca4cd1990a117537f716b3
88 N2529347a29a64de8a8cae87d00abfcc8
89 N6ad404aafb434557a7c908804933880c
90 N923546042c4a4b9faa10ad718dc573b6
91 Naef968df5f5d45798b2c1d66f52bdda2
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032394031
93 https://doi.org/10.1038/onc.2012.493
94 schema:sdDatePublished 2019-04-10T13:57
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N609abf6e3bb84b0190f600155c7306ca
97 schema:url https://www.nature.com/articles/onc2012493
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N00f7ebec2ef940828e49f1ae5f868d36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Alkaloids
103 rdf:type schema:DefinedTerm
104 N02057f222fca4cd1990a117537f716b3 schema:name pubmed_id
105 schema:value 23108405
106 rdf:type schema:PropertyValue
107 N0a1056d94b7145e49283528092c237c3 rdf:first sg:person.01151166002.67
108 rdf:rest N3c75ba222f0344a5bff9695fa3d4e2d2
109 N0a86b82fb38049a78dc9cfcda8e91298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Animals
111 rdf:type schema:DefinedTerm
112 N0bf4e885db444f529935e5a016d39349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Apoptosis
114 rdf:type schema:DefinedTerm
115 N0e86d53ce7644059ace045e7ce9feb35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Etoposide
117 rdf:type schema:DefinedTerm
118 N1eb9ac842f3b491e9c5ff94e346569ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name TNF-Related Apoptosis-Inducing Ligand
120 rdf:type schema:DefinedTerm
121 N2529347a29a64de8a8cae87d00abfcc8 schema:name readcube_id
122 schema:value 9a51dce589e91cf6ab8aed29d4ae571b0c3840b8229a6db3c89b7096852e9c93
123 rdf:type schema:PropertyValue
124 N256bcc9dd4804a97a408ff5dd777646a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mice, SCID
126 rdf:type schema:DefinedTerm
127 N2f5f50b66a9447eebae79f90cf5dda03 rdf:first sg:person.0646153340.23
128 rdf:rest Na7f51998f7be427ebe683d465a20bf4f
129 N381b33591e3b45e68e5072d7b303fc02 schema:issueNumber 40
130 rdf:type schema:PublicationIssue
131 N3c75ba222f0344a5bff9695fa3d4e2d2 rdf:first sg:person.01350672604.12
132 rdf:rest Nf7129b6338814f09b418fa1bb1c62a16
133 N416da5677ef44ec58c0a5c6c8f9226c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N609abf6e3bb84b0190f600155c7306ca schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N63a2bab566584a7aa95c730f54059fc9 rdf:first sg:person.01256203677.70
139 rdf:rest N9913485b7cd447cc8d4707643f02b55c
140 N6ad404aafb434557a7c908804933880c schema:name dimensions_id
141 schema:value pub.1032394031
142 rdf:type schema:PropertyValue
143 N7e9acc0f3c9345429a8352a6326cb9c3 schema:name Institute of Experimental Medicine, Inflammatory Carcinogenesis Research Group, Kiel, Germany
144 rdf:type schema:Organization
145 N89cd780ad29e4df8868a57c9e7a4c63f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Line, Tumor
147 rdf:type schema:DefinedTerm
148 N915fe4979cf240dc837b69d28f5deabc rdf:first sg:person.01064743717.91
149 rdf:rest rdf:nil
150 N923546042c4a4b9faa10ad718dc573b6 schema:name nlm_unique_id
151 schema:value 8711562
152 rdf:type schema:PropertyValue
153 N97c9997ce8a24a06a1a9c3ecd8f4b298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name NF-E2-Related Factor 2
155 rdf:type schema:DefinedTerm
156 N9913485b7cd447cc8d4707643f02b55c rdf:first sg:person.01265447232.00
157 rdf:rest N2f5f50b66a9447eebae79f90cf5dda03
158 Na7f51998f7be427ebe683d465a20bf4f rdf:first sg:person.01223143620.01
159 rdf:rest N915fe4979cf240dc837b69d28f5deabc
160 Naef968df5f5d45798b2c1d66f52bdda2 schema:name doi
161 schema:value 10.1038/onc.2012.493
162 rdf:type schema:PropertyValue
163 Nb7b0d585f87d4e85b4b78f91918be786 schema:volumeNumber 32
164 rdf:type schema:PublicationVolume
165 Nd7c87edd2fa44ed2bbe0119d71bd7827 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Proteasome Endopeptidase Complex
167 rdf:type schema:DefinedTerm
168 Ne4199e90462e47588eac13ddb60c8a5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mice
170 rdf:type schema:DefinedTerm
171 Nf5216521e89647d6b8846d0dd9d88a01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Pancreatic Neoplasms
173 rdf:type schema:DefinedTerm
174 Nf5704c1d3a38448fadbed2ebc7f95ce7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Xenograft Model Antitumor Assays
176 rdf:type schema:DefinedTerm
177 Nf7129b6338814f09b418fa1bb1c62a16 rdf:first sg:person.01163610520.20
178 rdf:rest N63a2bab566584a7aa95c730f54059fc9
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
183 schema:name Oncology and Carcinogenesis
184 rdf:type schema:DefinedTerm
185 sg:journal.1097543 schema:issn 0950-9232
186 1476-5594
187 schema:name Oncogene
188 rdf:type schema:Periodical
189 sg:person.01064743717.91 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
190 schema:familyName Schäfer
191 schema:givenName H
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064743717.91
193 rdf:type schema:Person
194 sg:person.01151166002.67 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
195 schema:familyName Arlt
196 schema:givenName A
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151166002.67
198 rdf:type schema:Person
199 sg:person.01163610520.20 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
200 schema:familyName Krebs
201 schema:givenName S
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163610520.20
203 rdf:type schema:Person
204 sg:person.01223143620.01 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
205 schema:familyName Schreiber
206 schema:givenName S
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01
208 rdf:type schema:Person
209 sg:person.01256203677.70 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
210 schema:familyName Geismann
211 schema:givenName C
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256203677.70
213 rdf:type schema:Person
214 sg:person.01265447232.00 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
215 schema:familyName Grossmann
216 schema:givenName M
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265447232.00
218 rdf:type schema:Person
219 sg:person.01350672604.12 schema:affiliation N7e9acc0f3c9345429a8352a6326cb9c3
220 schema:familyName Sebens
221 schema:givenName S
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350672604.12
223 rdf:type schema:Person
224 sg:person.0646153340.23 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
225 schema:familyName Kruse
226 schema:givenName M-L
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646153340.23
228 rdf:type schema:Person
229 sg:pub.10.1007/s10555-010-9255-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1025115026
230 https://doi.org/10.1007/s10555-010-9255-y
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s11033-011-1266-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017561496
233 https://doi.org/10.1007/s11033-011-1266-4
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/nature10189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011803417
236 https://doi.org/10.1038/nature10189
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nrclinonc.2009.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620521
239 https://doi.org/10.1038/nrclinonc.2009.236
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/onc.2009.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052759007
242 https://doi.org/10.1038/onc.2009.264
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/sj.onc.1203462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020529406
245 https://doi.org/10.1038/sj.onc.1203462
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/sj.onc.1204168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035971307
248 https://doi.org/10.1038/sj.onc.1204168
249 rdf:type schema:CreativeWork
250 sg:pub.10.1186/1476-4598-10-37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013400177
251 https://doi.org/10.1186/1476-4598-10-37
252 rdf:type schema:CreativeWork
253 sg:pub.10.1186/1743-7075-8-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046492969
254 https://doi.org/10.1186/1743-7075-8-10
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/path.2653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031161259
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.bbrc.2006.05.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037728637
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.bbrc.2007.08.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019755289
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.bbrc.2008.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016350180
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.bbrc.2010.04.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050377083
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.ccr.2011.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004544829
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.ccr.2011.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007935211
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.ccr.2011.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009994608
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.ejca.2009.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040400184
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.freeradbiomed.2008.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016078575
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.freeradbiomed.2009.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047932516
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.freeradbiomed.2010.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850976
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.jnutbio.2010.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046308603
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.mce.2007.08.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045110957
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.molcel.2010.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010229710
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.molcel.2010.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001597760
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.mrfmmm.2009.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048439321
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.mrrev.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019578631
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.phrs.2008.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038129710
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.tibs.2008.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014403116
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1021/pr8000892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056294305
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.0709483104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000270188
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m109.031575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035595498
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m110.145862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045215727
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m111.274902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028862730
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1074/jbc.m111.275495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030973740
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1074/jbc.m211898200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019762527
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1074/jbc.m503074200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016854009
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1074/jbc.m808084200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007864453
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1074/jbc.r900010200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001746715
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1089/ars.2010.3219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027757232
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1089/ars.2010.3301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030045785
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/carcin/bgn095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049087853
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1097/mpa.0b013e3181c31314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029868333
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1128/mcb.22.9.2883-2892.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039822139
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1128/mcb.23.23.8786-8794.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006641296
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1136/gut.2009.180711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046716547
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1158/0008-5472.can-04-1626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024645472
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1158/0008-5472.can-05-0201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027965781
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1158/0008-5472.can-06-1181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032372131
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1158/0008-5472.can-10-0713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028482307
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1158/0008-5472.can-10-3007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036678242
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1158/0008-5472.can-10-4668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017873726
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1158/1078-0432.ccr-09-3352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053248607
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1210/jc.2010-2642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292559
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1371/journal.pmed.0030420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053409424
347 rdf:type schema:CreativeWork
348 https://doi.org/10.2337/dc09-0207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020433485
349 rdf:type schema:CreativeWork
350 https://doi.org/10.3109/10715762.2010.507670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042568523
351 rdf:type schema:CreativeWork
352 https://doi.org/10.3892/ijo_00000846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071518826
353 rdf:type schema:CreativeWork
354 https://doi.org/10.3892/or_00000561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071537366
355 rdf:type schema:CreativeWork
356 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
357 schema:name Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & Hepatology, UKSH, Kiel, Germany
358 Institute of Clinical Molecular Biology, UKSH, Kiel, Germany
359 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...