NRAS mutant melanoma: biological behavior and future strategies for therapeutic management View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

I V Fedorenko, G T Gibney, K S M Smalley

ABSTRACT

The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few advances have been made in developing targeted therapeutic strategies for the 50% of patients whose melanomas are BRAF wild-type. The most well-characterized subgroup of BRAF wild-type tumors is the 15-20% of all melanomas that harbor activating NRAS (Neuroblastoma Rat Sarcoma Virus) mutations. Emerging preclinical and clinical evidence suggests that NRAS mutant melanomas have patterns of signal transduction and biological behavior that is distinct from BRAF mutant melanomas. This overview will discuss the unique clinical and prognostic behavior of NRAS mutant melanoma and will summarize the emerging data on how NRAS-driven signaling networks can be translated into novel therapeutic strategies. More... »

PAGES

3009

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2012.453

DOI

http://dx.doi.org/10.1038/onc.2012.453

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003375495

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23069660


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Farnesyl-Diphosphate Farnesyltransferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP Phosphohydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins B-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "Department of Molecular Oncology, Tampa, FL, USA", 
            "The Comprehensive Melanoma Research Center, The Moffitt Cancer Center, Tampa, FL, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fedorenko", 
        "givenName": "I V", 
        "id": "sg:person.01274732656.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274732656.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "The Comprehensive Melanoma Research Center, The Moffitt Cancer Center, Tampa, FL, USA.", 
            "Department of Cutaneous Oncology, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibney", 
        "givenName": "G T", 
        "id": "sg:person.01065153434.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Moffitt Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.468198.a", 
          "name": [
            "Department of Molecular Oncology, Tampa, FL, USA", 
            "The Comprehensive Melanoma Research Center, The Moffitt Cancer Center, Tampa, FL, USA.", 
            "Department of Cutaneous Oncology, Tampa, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smalley", 
        "givenName": "K S M", 
        "id": "sg:person.013751457634.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013751457634.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2011.41.1660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000408054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2011.00943.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000411098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000532983", 
          "https://doi.org/10.1038/nm.1890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.6.2144-2153.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001979773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-5867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002604979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90146-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002820255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374457a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002988644", 
          "https://doi.org/10.1038/374457a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328343a1d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328343a1d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e328343a1d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004846070", 
          "https://doi.org/10.1038/nature11219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2009.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005127033", 
          "https://doi.org/10.1038/jid.2009.287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1105358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006141094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.11064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006472234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916541", 
          "https://doi.org/10.1038/nature08902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006916541", 
          "https://doi.org/10.1038/nature08902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2012.03.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008408030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008929876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009288742", 
          "https://doi.org/10.1038/nature08833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009288742", 
          "https://doi.org/10.1038/nature08833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010952678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011149116", 
          "https://doi.org/10.1038/onc.2010.408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012130507", 
          "https://doi.org/10.1038/nature04304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012130507", 
          "https://doi.org/10.1038/nature04304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012130507", 
          "https://doi.org/10.1038/nature04304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012217489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2010.216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012750944", 
          "https://doi.org/10.1038/jid.2010.216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1002011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012824919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2011.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013269526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m309523200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013336334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2012.63", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013377446", 
          "https://doi.org/10.1038/jid.2012.63"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.1080420419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013392676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013694775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013768299", 
          "https://doi.org/10.1038/sj.jid.5700490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014115295", 
          "https://doi.org/10.1038/sj.onc.1209379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014115295", 
          "https://doi.org/10.1038/sj.onc.1209379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.11.3717-3728.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014638372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-2954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015745271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016085594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016085594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.36.7680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016636989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64609-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016795356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2010.00685.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017083437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017221313", 
          "https://doi.org/10.1038/nature05945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018709041", 
          "https://doi.org/10.1038/onc.2010.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018709041", 
          "https://doi.org/10.1038/onc.2010.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00215-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019563286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.0050120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019757082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019872106", 
          "https://doi.org/10.1038/ng.356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019872106", 
          "https://doi.org/10.1038/ng.356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020420039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/308069a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020514460", 
          "https://doi.org/10.1038/308069a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022938767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-2612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023145197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024888641", 
          "https://doi.org/10.1038/onc.2008.362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2010.00683.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025620338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026239472", 
          "https://doi.org/10.1038/sj.onc.1210239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026373294", 
          "https://doi.org/10.1038/sj.bjc.6604637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci57909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026380858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1211003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026615423", 
          "https://doi.org/10.1038/sj.onc.1211003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200104053441401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026812584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-4471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027786788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.12.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028106155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2012.186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030448291", 
          "https://doi.org/10.1038/jid.2012.186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2010.297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031051496", 
          "https://doi.org/10.1038/jid.2010.297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031953930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2009.00585.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032078149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2009.00585.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032078149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.21.2822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033001916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033168397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.62.070193.004223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033190023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.22.3499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035234284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e3282ef4178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035454056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cmr.0b013e3282ef4178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035454056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.23.8225-8235.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035488017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035514155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035733152", 
          "https://doi.org/10.1038/nature09626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035909146", 
          "https://doi.org/10.1038/nature08956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035909146", 
          "https://doi.org/10.1038/nature08956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035969538", 
          "https://doi.org/10.1038/ng1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035969538", 
          "https://doi.org/10.1038/ng1054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035983239", 
          "https://doi.org/10.1038/nrd2221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036046219", 
          "https://doi.org/10.1038/nsmb.2022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060000", 
          "https://doi.org/10.1038/nature11003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-148x.2011.00873.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036293454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00569-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036424072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039048376", 
          "https://doi.org/10.1038/ncb2535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-4254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039184195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-012-1227-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039718387", 
          "https://doi.org/10.1007/s00262-012-1227-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-1875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040107577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041164441", 
          "https://doi.org/10.1038/onc.2009.521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041164441", 
          "https://doi.org/10.1038/onc.2009.521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1103782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041864150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2010.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042625326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042988841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043354551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.0022-202x.2004.22243.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044089294", 
          "https://doi.org/10.1046/j.0022-202x.2004.22243.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044435378", 
          "https://doi.org/10.1038/nrc969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044435378", 
          "https://doi.org/10.1038/nrc969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044819609", 
          "https://doi.org/10.1038/nrc1097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044819609", 
          "https://doi.org/10.1038/nrc1097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0028973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045497074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra062285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047196452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047224534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048145384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e3182372636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048247637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e3182372636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048247637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-10-0512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048426875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2010.05.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049691997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-11-0989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050113307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050986624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0005717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051562220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1203421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051983710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2011.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787397", 
          "https://doi.org/10.1038/jid.2011.218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.4956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052792184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052858036", 
          "https://doi.org/10.1038/sj.onc.1208544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052858036", 
          "https://doi.org/10.1038/sj.onc.1208544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3590001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.2502004re13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062692304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/sgtp.2.5.17814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072310886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074590079", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079010052", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083397228"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few advances have been made in developing targeted therapeutic strategies for the 50% of patients whose melanomas are BRAF wild-type. The most well-characterized subgroup of BRAF wild-type tumors is the 15-20% of all melanomas that harbor activating NRAS (Neuroblastoma Rat Sarcoma Virus) mutations. Emerging preclinical and clinical evidence suggests that NRAS mutant melanomas have patterns of signal transduction and biological behavior that is distinct from BRAF mutant melanomas. This overview will discuss the unique clinical and prognostic behavior of NRAS mutant melanoma and will summarize the emerging data on how NRAS-driven signaling networks can be translated into novel therapeutic strategies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2012.453", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2699085", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2481570", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "25", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "NRAS mutant melanoma: biological behavior and future strategies for therapeutic management", 
    "pagination": "3009", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "10142fbac0a733f839cb393e5b7b6d9729935af31482009d42ab75ca72a08c0b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23069660"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2012.453"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003375495"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2012.453", 
      "https://app.dimensions.ai/details/publication/pub.1003375495"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2012453"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.453'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.453'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.453'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.453'


 

This table displays all metadata directly associated to this object as RDF triples.

497 TRIPLES      21 PREDICATES      149 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2012.453 schema:about N055e278bd34f41b9ad26abb9c7d1f9d7
2 N1f6a073aee7e4adcb25478c57d1c76dd
3 N26b6c54c5a3948b8b7865d3e21907ae7
4 N2ed6ca40fdd3494590c92b22ae9497ed
5 N37a003f489c44fc8a84635dde19c3db3
6 N3c5b88cc0641439cbdc3f51ad98f12c4
7 N56623eb1f2774f7fa4d0dd50427b7d23
8 N598492e3176d46d29a29859c3b39a80a
9 N64febbbb18344c80aabb85dd3c1192e9
10 N7cb41db232c044acaee7af6c15f29695
11 Nb0beecd9dbe44002b945a523883729d6
12 Nf28aba69ff0c47c48edfa93d986ef6ee
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N28c6e0065d53405d9864d3a2b2f99e39
16 schema:citation sg:pub.10.1007/s00262-012-1227-3
17 sg:pub.10.1038/308069a0
18 sg:pub.10.1038/374457a0
19 sg:pub.10.1038/jid.2009.287
20 sg:pub.10.1038/jid.2010.216
21 sg:pub.10.1038/jid.2010.297
22 sg:pub.10.1038/jid.2011.218
23 sg:pub.10.1038/jid.2012.186
24 sg:pub.10.1038/jid.2012.63
25 sg:pub.10.1038/nature00766
26 sg:pub.10.1038/nature03890
27 sg:pub.10.1038/nature04304
28 sg:pub.10.1038/nature05945
29 sg:pub.10.1038/nature08833
30 sg:pub.10.1038/nature08902
31 sg:pub.10.1038/nature08956
32 sg:pub.10.1038/nature09626
33 sg:pub.10.1038/nature11003
34 sg:pub.10.1038/nature11219
35 sg:pub.10.1038/ncb2535
36 sg:pub.10.1038/ng.356
37 sg:pub.10.1038/ng1054
38 sg:pub.10.1038/nm.1890
39 sg:pub.10.1038/nrc1097
40 sg:pub.10.1038/nrc969
41 sg:pub.10.1038/nrd2221
42 sg:pub.10.1038/nsmb.2022
43 sg:pub.10.1038/onc.2008.362
44 sg:pub.10.1038/onc.2009.521
45 sg:pub.10.1038/onc.2010.224
46 sg:pub.10.1038/onc.2010.408
47 sg:pub.10.1038/sj.bjc.6604637
48 sg:pub.10.1038/sj.jid.5700490
49 sg:pub.10.1038/sj.onc.1208544
50 sg:pub.10.1038/sj.onc.1209379
51 sg:pub.10.1038/sj.onc.1210239
52 sg:pub.10.1038/sj.onc.1211003
53 sg:pub.10.1046/j.0022-202x.2004.22243.x
54 https://app.dimensions.ai/details/publication/pub.1074590079
55 https://app.dimensions.ai/details/publication/pub.1079010052
56 https://doi.org/10.1002/cncr.26724
57 https://doi.org/10.1002/ijc.10978
58 https://doi.org/10.1002/ijc.11064
59 https://doi.org/10.1002/ijc.23876
60 https://doi.org/10.1002/mrd.1080420419
61 https://doi.org/10.1016/0092-8674(93)90146-h
62 https://doi.org/10.1016/j.bcp.2010.04.006
63 https://doi.org/10.1016/j.bcp.2011.05.015
64 https://doi.org/10.1016/j.ccr.2005.09.006
65 https://doi.org/10.1016/j.ccr.2010.05.023
66 https://doi.org/10.1016/j.cell.2009.12.040
67 https://doi.org/10.1016/j.cell.2012.02.053
68 https://doi.org/10.1016/j.cub.2012.03.067
69 https://doi.org/10.1016/s0002-9440(10)64609-3
70 https://doi.org/10.1016/s0092-8674(04)00215-6
71 https://doi.org/10.1042/0264-6021:3590001
72 https://doi.org/10.1056/nejm200104053441401
73 https://doi.org/10.1056/nejmoa050092
74 https://doi.org/10.1056/nejmoa1002011
75 https://doi.org/10.1056/nejmoa1003466
76 https://doi.org/10.1056/nejmoa1103782
77 https://doi.org/10.1056/nejmoa1105358
78 https://doi.org/10.1056/nejmoa1203421
79 https://doi.org/10.1056/nejmra062285
80 https://doi.org/10.1074/jbc.m309523200
81 https://doi.org/10.1097/cji.0b013e3182372636
82 https://doi.org/10.1097/cmr.0b013e3282ef4178
83 https://doi.org/10.1097/cmr.0b013e328343a1d6
84 https://doi.org/10.1101/gad.11.21.2822
85 https://doi.org/10.1101/gad.12.22.3499
86 https://doi.org/10.1111/j.1755-148x.2009.00585.x
87 https://doi.org/10.1111/j.1755-148x.2010.00683.x
88 https://doi.org/10.1111/j.1755-148x.2010.00685.x
89 https://doi.org/10.1111/j.1755-148x.2011.00873.x
90 https://doi.org/10.1111/j.1755-148x.2011.00943.x
91 https://doi.org/10.1126/stke.2502004re13
92 https://doi.org/10.1128/mcb.00569-09
93 https://doi.org/10.1128/mcb.21.23.8225-8235.2001
94 https://doi.org/10.1128/mcb.21.6.2144-2153.2001
95 https://doi.org/10.1128/mcb.22.11.3717-3728.2002
96 https://doi.org/10.1146/annurev.bi.62.070193.004223
97 https://doi.org/10.1158/0008-5472.can-05-4227
98 https://doi.org/10.1158/0008-5472.can-07-2300
99 https://doi.org/10.1158/0008-5472.can-07-2615
100 https://doi.org/10.1158/0008-5472.can-07-5867
101 https://doi.org/10.1158/0008-5472.can-09-4254
102 https://doi.org/10.1158/0008-5472.can-09-4471
103 https://doi.org/10.1158/0008-5472.can-10-0902
104 https://doi.org/10.1158/0008-5472.can-10-2954
105 https://doi.org/10.1158/0008-5472.can-11-1875
106 https://doi.org/10.1158/1078-0432.ccr-07-1440
107 https://doi.org/10.1158/1078-0432.ccr-09-1985
108 https://doi.org/10.1158/1078-0432.ccr-10-2200
109 https://doi.org/10.1158/1078-0432.ccr-10-2276
110 https://doi.org/10.1158/1078-0432.ccr-11-1122
111 https://doi.org/10.1158/1078-0432.ccr-11-2612
112 https://doi.org/10.1158/1535-7163.mct-11-0989
113 https://doi.org/10.1158/1541-7786.mcr-10-0512
114 https://doi.org/10.1158/2159-8290.cd-12-0018
115 https://doi.org/10.1172/jci57909
116 https://doi.org/10.1200/jco.2007.14.4956
117 https://doi.org/10.1200/jco.2011.36.7680
118 https://doi.org/10.1200/jco.2011.41.1660
119 https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509
120 https://doi.org/10.1371/journal.pmed.0050120
121 https://doi.org/10.1371/journal.pone.0005717
122 https://doi.org/10.1371/journal.pone.0028973
123 https://doi.org/10.4161/sgtp.2.5.17814
124 schema:datePublished 2013-06
125 schema:datePublishedReg 2013-06-01
126 schema:description The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few advances have been made in developing targeted therapeutic strategies for the 50% of patients whose melanomas are BRAF wild-type. The most well-characterized subgroup of BRAF wild-type tumors is the 15-20% of all melanomas that harbor activating NRAS (Neuroblastoma Rat Sarcoma Virus) mutations. Emerging preclinical and clinical evidence suggests that NRAS mutant melanomas have patterns of signal transduction and biological behavior that is distinct from BRAF mutant melanomas. This overview will discuss the unique clinical and prognostic behavior of NRAS mutant melanoma and will summarize the emerging data on how NRAS-driven signaling networks can be translated into novel therapeutic strategies.
127 schema:genre research_article
128 schema:inLanguage en
129 schema:isAccessibleForFree true
130 schema:isPartOf N699a98ac1ab54653ba19b1789475efc4
131 N87868629f0db4eefad1bae00d6080ab1
132 sg:journal.1097543
133 schema:name NRAS mutant melanoma: biological behavior and future strategies for therapeutic management
134 schema:pagination 3009
135 schema:productId N0978642125b94b51a469ecff8bcae3c8
136 N29450284efbe4219a5444ddb5d42df99
137 N333200100afc4f188ac961f1401e9e2d
138 N6b72f0c4d72449cba6fa051b8b3af8da
139 Nfca28d0d4f6746d7b48761084f5889c6
140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003375495
141 https://doi.org/10.1038/onc.2012.453
142 schema:sdDatePublished 2019-04-11T00:56
143 schema:sdLicense https://scigraph.springernature.com/explorer/license/
144 schema:sdPublisher N160afbb6d8894e2ba5a6f672792e3524
145 schema:url https://www.nature.com/articles/onc2012453
146 sgo:license sg:explorer/license/
147 sgo:sdDataset articles
148 rdf:type schema:ScholarlyArticle
149 N055e278bd34f41b9ad26abb9c7d1f9d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name GTP Phosphohydrolases
151 rdf:type schema:DefinedTerm
152 N0978642125b94b51a469ecff8bcae3c8 schema:name doi
153 schema:value 10.1038/onc.2012.453
154 rdf:type schema:PropertyValue
155 N160afbb6d8894e2ba5a6f672792e3524 schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N1f6a073aee7e4adcb25478c57d1c76dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Prognosis
159 rdf:type schema:DefinedTerm
160 N26b6c54c5a3948b8b7865d3e21907ae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Skin Neoplasms
162 rdf:type schema:DefinedTerm
163 N28c6e0065d53405d9864d3a2b2f99e39 rdf:first sg:person.01274732656.46
164 rdf:rest Ndad8e58027214e8f975e4851d0fc50f1
165 N29450284efbe4219a5444ddb5d42df99 schema:name pubmed_id
166 schema:value 23069660
167 rdf:type schema:PropertyValue
168 N2ed6ca40fdd3494590c92b22ae9497ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Phosphatidylinositol 3-Kinases
170 rdf:type schema:DefinedTerm
171 N333200100afc4f188ac961f1401e9e2d schema:name readcube_id
172 schema:value 10142fbac0a733f839cb393e5b7b6d9729935af31482009d42ab75ca72a08c0b
173 rdf:type schema:PropertyValue
174 N37a003f489c44fc8a84635dde19c3db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Proto-Oncogene Proteins B-raf
176 rdf:type schema:DefinedTerm
177 N3c5b88cc0641439cbdc3f51ad98f12c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Humans
179 rdf:type schema:DefinedTerm
180 N500a34acaee5424c8a9073bfeb80f476 rdf:first sg:person.013751457634.24
181 rdf:rest rdf:nil
182 N56623eb1f2774f7fa4d0dd50427b7d23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Melanoma
184 rdf:type schema:DefinedTerm
185 N598492e3176d46d29a29859c3b39a80a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Signal Transduction
187 rdf:type schema:DefinedTerm
188 N64febbbb18344c80aabb85dd3c1192e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Mutation
190 rdf:type schema:DefinedTerm
191 N699a98ac1ab54653ba19b1789475efc4 schema:volumeNumber 32
192 rdf:type schema:PublicationVolume
193 N6b72f0c4d72449cba6fa051b8b3af8da schema:name nlm_unique_id
194 schema:value 8711562
195 rdf:type schema:PropertyValue
196 N7cb41db232c044acaee7af6c15f29695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Farnesyl-Diphosphate Farnesyltransferase
198 rdf:type schema:DefinedTerm
199 N87868629f0db4eefad1bae00d6080ab1 schema:issueNumber 25
200 rdf:type schema:PublicationIssue
201 Nb0beecd9dbe44002b945a523883729d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Membrane Proteins
203 rdf:type schema:DefinedTerm
204 Ndad8e58027214e8f975e4851d0fc50f1 rdf:first sg:person.01065153434.51
205 rdf:rest N500a34acaee5424c8a9073bfeb80f476
206 Nf28aba69ff0c47c48edfa93d986ef6ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Mitogen-Activated Protein Kinase Kinases
208 rdf:type schema:DefinedTerm
209 Nfca28d0d4f6746d7b48761084f5889c6 schema:name dimensions_id
210 schema:value pub.1003375495
211 rdf:type schema:PropertyValue
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
216 schema:name Oncology and Carcinogenesis
217 rdf:type schema:DefinedTerm
218 sg:grant.2481570 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2012.453
219 rdf:type schema:MonetaryGrant
220 sg:grant.2699085 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2012.453
221 rdf:type schema:MonetaryGrant
222 sg:journal.1097543 schema:issn 0950-9232
223 1476-5594
224 schema:name Oncogene
225 rdf:type schema:Periodical
226 sg:person.01065153434.51 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
227 schema:familyName Gibney
228 schema:givenName G T
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065153434.51
230 rdf:type schema:Person
231 sg:person.01274732656.46 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
232 schema:familyName Fedorenko
233 schema:givenName I V
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274732656.46
235 rdf:type schema:Person
236 sg:person.013751457634.24 schema:affiliation https://www.grid.ac/institutes/grid.468198.a
237 schema:familyName Smalley
238 schema:givenName K S M
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013751457634.24
240 rdf:type schema:Person
241 sg:pub.10.1007/s00262-012-1227-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039718387
242 https://doi.org/10.1007/s00262-012-1227-3
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/308069a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020514460
245 https://doi.org/10.1038/308069a0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/374457a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002988644
248 https://doi.org/10.1038/374457a0
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/jid.2009.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005127033
251 https://doi.org/10.1038/jid.2009.287
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/jid.2010.216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012750944
254 https://doi.org/10.1038/jid.2010.216
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/jid.2010.297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031051496
257 https://doi.org/10.1038/jid.2010.297
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/jid.2011.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052787397
260 https://doi.org/10.1038/jid.2011.218
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/jid.2012.186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030448291
263 https://doi.org/10.1038/jid.2012.186
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/jid.2012.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013377446
266 https://doi.org/10.1038/jid.2012.63
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
269 https://doi.org/10.1038/nature00766
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nature03890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003324113
272 https://doi.org/10.1038/nature03890
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nature04304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012130507
275 https://doi.org/10.1038/nature04304
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nature05945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017221313
278 https://doi.org/10.1038/nature05945
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nature08833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009288742
281 https://doi.org/10.1038/nature08833
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nature08902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006916541
284 https://doi.org/10.1038/nature08902
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nature08956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035909146
287 https://doi.org/10.1038/nature08956
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nature09626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035733152
290 https://doi.org/10.1038/nature09626
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nature11003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060000
293 https://doi.org/10.1038/nature11003
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nature11219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004846070
296 https://doi.org/10.1038/nature11219
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/ncb2535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039048376
299 https://doi.org/10.1038/ncb2535
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/ng.356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019872106
302 https://doi.org/10.1038/ng.356
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/ng1054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035969538
305 https://doi.org/10.1038/ng1054
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nm.1890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000532983
308 https://doi.org/10.1038/nm.1890
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nrc1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044819609
311 https://doi.org/10.1038/nrc1097
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nrc969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044435378
314 https://doi.org/10.1038/nrc969
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nrd2221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035983239
317 https://doi.org/10.1038/nrd2221
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nsmb.2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036046219
320 https://doi.org/10.1038/nsmb.2022
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/onc.2008.362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024888641
323 https://doi.org/10.1038/onc.2008.362
324 rdf:type schema:CreativeWork
325 sg:pub.10.1038/onc.2009.521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041164441
326 https://doi.org/10.1038/onc.2009.521
327 rdf:type schema:CreativeWork
328 sg:pub.10.1038/onc.2010.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018709041
329 https://doi.org/10.1038/onc.2010.224
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/onc.2010.408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011149116
332 https://doi.org/10.1038/onc.2010.408
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/sj.bjc.6604637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026373294
335 https://doi.org/10.1038/sj.bjc.6604637
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/sj.jid.5700490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013768299
338 https://doi.org/10.1038/sj.jid.5700490
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/sj.onc.1208544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052858036
341 https://doi.org/10.1038/sj.onc.1208544
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/sj.onc.1209379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014115295
344 https://doi.org/10.1038/sj.onc.1209379
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/sj.onc.1210239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026239472
347 https://doi.org/10.1038/sj.onc.1210239
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/sj.onc.1211003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026615423
350 https://doi.org/10.1038/sj.onc.1211003
351 rdf:type schema:CreativeWork
352 sg:pub.10.1046/j.0022-202x.2004.22243.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044089294
353 https://doi.org/10.1046/j.0022-202x.2004.22243.x
354 rdf:type schema:CreativeWork
355 https://app.dimensions.ai/details/publication/pub.1074590079 schema:CreativeWork
356 https://app.dimensions.ai/details/publication/pub.1079010052 schema:CreativeWork
357 https://doi.org/10.1002/cncr.26724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031953930
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1002/ijc.10978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020420039
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1002/ijc.11064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006472234
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1002/ijc.23876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022938767
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1002/mrd.1080420419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013392676
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/0092-8674(93)90146-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1002820255
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1016/j.bcp.2010.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042625326
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1016/j.bcp.2011.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013269526
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1016/j.ccr.2005.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016085594
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1016/j.ccr.2010.05.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049691997
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1016/j.cell.2009.12.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028106155
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1016/j.cell.2012.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986624
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1016/j.cub.2012.03.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008408030
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1016/s0002-9440(10)64609-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016795356
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1016/s0092-8674(04)00215-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019563286
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1042/0264-6021:3590001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715749
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1056/nejm200104053441401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026812584
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1056/nejmoa050092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050226
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1056/nejmoa1002011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012824919
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1056/nejmoa1103782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041864150
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1056/nejmoa1105358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006141094
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1056/nejmoa1203421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051983710
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1056/nejmra062285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047196452
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1074/jbc.m309523200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013336334
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1097/cji.0b013e3182372636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048247637
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1097/cmr.0b013e3282ef4178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035454056
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1097/cmr.0b013e328343a1d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003730920
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1101/gad.11.21.2822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033001916
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1101/gad.12.22.3499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035234284
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1111/j.1755-148x.2009.00585.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032078149
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1111/j.1755-148x.2010.00683.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025620338
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1111/j.1755-148x.2010.00685.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017083437
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1111/j.1755-148x.2011.00873.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036293454
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1111/j.1755-148x.2011.00943.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000411098
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1126/stke.2502004re13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062692304
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1128/mcb.00569-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036424072
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1128/mcb.21.23.8225-8235.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035488017
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1128/mcb.21.6.2144-2153.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001979773
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1128/mcb.22.11.3717-3728.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014638372
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1146/annurev.bi.62.070193.004223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033190023
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1158/0008-5472.can-05-4227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013694775
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1158/0008-5472.can-07-2300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047224534
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1158/0008-5472.can-07-2615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012217489
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1158/0008-5472.can-07-5867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002604979
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1158/0008-5472.can-09-4254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039184195
448 rdf:type schema:CreativeWork
449 https://doi.org/10.1158/0008-5472.can-09-4471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027786788
450 rdf:type schema:CreativeWork
451 https://doi.org/10.1158/0008-5472.can-10-0902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042988841
452 rdf:type schema:CreativeWork
453 https://doi.org/10.1158/0008-5472.can-10-2954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015745271
454 rdf:type schema:CreativeWork
455 https://doi.org/10.1158/0008-5472.can-11-1875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040107577
456 rdf:type schema:CreativeWork
457 https://doi.org/10.1158/1078-0432.ccr-07-1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048145384
458 rdf:type schema:CreativeWork
459 https://doi.org/10.1158/1078-0432.ccr-09-1985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033168397
460 rdf:type schema:CreativeWork
461 https://doi.org/10.1158/1078-0432.ccr-10-2200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010952678
462 rdf:type schema:CreativeWork
463 https://doi.org/10.1158/1078-0432.ccr-10-2276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008929876
464 rdf:type schema:CreativeWork
465 https://doi.org/10.1158/1078-0432.ccr-11-1122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043354551
466 rdf:type schema:CreativeWork
467 https://doi.org/10.1158/1078-0432.ccr-11-2612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023145197
468 rdf:type schema:CreativeWork
469 https://doi.org/10.1158/1535-7163.mct-11-0989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050113307
470 rdf:type schema:CreativeWork
471 https://doi.org/10.1158/1541-7786.mcr-10-0512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048426875
472 rdf:type schema:CreativeWork
473 https://doi.org/10.1158/2159-8290.cd-12-0018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035514155
474 rdf:type schema:CreativeWork
475 https://doi.org/10.1172/jci57909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026380858
476 rdf:type schema:CreativeWork
477 https://doi.org/10.1200/jco.2007.14.4956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052792184
478 rdf:type schema:CreativeWork
479 https://doi.org/10.1200/jco.2011.36.7680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016636989
480 rdf:type schema:CreativeWork
481 https://doi.org/10.1200/jco.2011.41.1660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000408054
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1200/jco.2012.30.18_suppl.lba8509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083397228
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1371/journal.pmed.0050120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019757082
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1371/journal.pone.0005717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051562220
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1371/journal.pone.0028973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045497074
490 rdf:type schema:CreativeWork
491 https://doi.org/10.4161/sgtp.2.5.17814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310886
492 rdf:type schema:CreativeWork
493 https://www.grid.ac/institutes/grid.468198.a schema:alternateName Moffitt Cancer Center
494 schema:name Department of Cutaneous Oncology, Tampa, FL, USA
495 Department of Molecular Oncology, Tampa, FL, USA
496 The Comprehensive Melanoma Research Center, The Moffitt Cancer Center, Tampa, FL, USA.
497 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...