SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

D Herranz, A Maraver, M Cañamero, G Gómez-López, L Inglada-Pérez, M Robledo, E Castelblanco, X Matias-Guiu, M Serrano

ABSTRACT

Current genetic evidence in mice indicates that SIRT1 has potent tumor suppressor activity in a variety of cancer models, with no evidence yet for SIRT1 oncogenic activity in vivo. We report here that transgenic Sirt1 expression is oncogenic in murine thyroid and prostate carcinogenesis initiated by Pten-deficiency. Based on mRNA expression analyses of pre-tumoral murine thyroids, we find that SIRT1 increases c-MYC transcriptional programs. Moreover, we show higher c-MYC protein levels in murine thyroid cancers from Sirt1 transgenic mice. Similarly, SIRT1 is overexpressed in human thyroid cancers and it is positively correlated with c-MYC protein levels. Finally, we show in cultured thyroid cancer cells that SIRT1 stabilizes c-MYC protein. These results implicate SIRT1 as a new candidate target for the treatment of thyroid carcinomas. More... »

PAGES

4052

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2012.407

DOI

http://dx.doi.org/10.1038/onc.2012.407

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017094536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22986535


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