Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08

AUTHORS

M Calao, E O Sekyere, H J Cui, B B Cheung, W D Thomas, J Keating, J B Chen, A Raif, K Jankowski, N P Davies, M V Bekkum, B Chen, O Tan, T Ellis, M D Norris, M Haber, E S Kim, J M Shohet, T N Trahair, T Liu, B J Wainwright, H F Ding, G M Marshall

ABSTRACT

Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in embryonal cancer precursor cells causes postnatal rests, and later tumor formation through unknown mechanisms. However, overexpression of Myc in adult tissues normally activates apoptosis and/or senescence signals as an organismal defense mechanism against cancer. Here, we show that perinatal neuroblastoma precursor cells exhibited a transiently diminished p53 response to MycN oncoprotein stress and resistance to trophic factor withdrawal, compared with their adult counterpart cells from the TH-MYCN(+/+) transgenic mouse model of neuroblastoma. The adult stem cell maintenance factor and Polycomb group protein, Bmi1 (B-cell-specific Moloney murine leukemia virus integration site), had a critical role at neuroblastoma initiation in the model, by repressing p53 responses in precursor cells. We further show in neuroblastoma tumor cells that Bmi1 could directly bind p53 in a complex with other Polycomb complex proteins, Ring1A or Ring1B, leading to increased p53 ubiquitination and degradation. Repressed p53 signal responses were also seen in precursor cells for other embryonal cancer types, medulloblastoma and acute lymphoblastic leukemia. Collectively, these date indicate a general mechanism for p53 inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation. More... »

PAGES

3616

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2012.368

DOI

http://dx.doi.org/10.1038/onc.2012.368

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023259044

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22907436


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Medulloblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "N-Myc Proto-Oncogene Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Germ Cell and Embryonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycomb Repressive Complex 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyubiquitin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteasome Endopeptidase Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-mdm2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitination", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calao", 
        "givenName": "M", 
        "id": "sg:person.0663577366.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663577366.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sekyere", 
        "givenName": "E O", 
        "id": "sg:person.01000571227.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000571227.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southwest University", 
          "id": "https://www.grid.ac/institutes/grid.263906.8", 
          "name": [
            "State key laboratory of Silkworm Functional Genome Biology, Institute of Sericulture and System Biology, Southwest University, Chongqing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cui", 
        "givenName": "H J", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "B B", 
        "id": "sg:person.01111156527.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111156527.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "W D", 
        "id": "sg:person.01014270155.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014270155.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keating", 
        "givenName": "J", 
        "id": "sg:person.01031264760.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031264760.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "J B", 
        "id": "sg:person.01305346242.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305346242.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raif", 
        "givenName": "A", 
        "id": "sg:person.01002012262.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002012262.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jankowski", 
        "givenName": "K", 
        "id": "sg:person.01165732215.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165732215.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davies", 
        "givenName": "N P", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bekkum", 
        "givenName": "M V", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tan", 
        "givenName": "O", 
        "id": "sg:person.01225405127.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225405127.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ellis", 
        "givenName": "T", 
        "id": "sg:person.01141021532.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141021532.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Norris", 
        "givenName": "M D", 
        "id": "sg:person.01124105267.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124105267.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haber", 
        "givenName": "M", 
        "id": "sg:person.01155705412.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155705412.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416975.8", 
          "name": [
            "Texas Children\u2019s Hospital, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "E S", 
        "id": "sg:person.0601662637.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601662637.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416975.8", 
          "name": [
            "Texas Children\u2019s Hospital, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shohet", 
        "givenName": "J M", 
        "id": "sg:person.01025071371.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025071371.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sydney Children\u2019s Hospitals Network", 
          "id": "https://www.grid.ac/institutes/grid.430417.5", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia", 
            "Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trahair", 
        "givenName": "T N", 
        "id": "sg:person.0640244611.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640244611.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UNSW Australia", 
          "id": "https://www.grid.ac/institutes/grid.1005.4", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "T", 
        "id": "sg:person.0634661610.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634661610.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Queensland", 
          "id": "https://www.grid.ac/institutes/grid.1003.2", 
          "name": [
            "Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wainwright", 
        "givenName": "B J", 
        "id": "sg:person.01136543370.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136543370.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augusta University", 
          "id": "https://www.grid.ac/institutes/grid.410427.4", 
          "name": [
            "Medical College of Georgia, Augusta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "H F", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sydney Children\u2019s Hospitals Network", 
          "id": "https://www.grid.ac/institutes/grid.430417.5", 
          "name": [
            "Children\u2019s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia", 
            "Sydney Children\u2019s Hospital, Sydney, New South Wales, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marshall", 
        "givenName": "G M", 
        "id": "sg:person.07674015612.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07674015612.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-2598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000408873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90383-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003828208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(04)01424-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004475271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.09466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006579293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2007.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007311127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.8.2992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008538712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008729213", 
          "https://doi.org/10.1038/nature02385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008729213", 
          "https://doi.org/10.1038/nature02385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008818340", 
          "https://doi.org/10.1038/nrc1014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008818340", 
          "https://doi.org/10.1038/nrc1014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508888102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009186749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90382-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011604928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(03)00051-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013217938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0301-0082(03)00051-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013217938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)06020-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013445242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.08778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016030791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.15.3453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018997023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.neo.7900171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019479310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021197931", 
          "https://doi.org/10.1038/nrc1954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021197931", 
          "https://doi.org/10.1038/nrc1954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2007.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021513377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022380826", 
          "https://doi.org/10.1038/nrc1633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022380826", 
          "https://doi.org/10.1038/nrc1633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0008104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023766381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(87)50085-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024341171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011517200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024398653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gene.10208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024966986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0401083101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028159565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-2623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032980764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.060754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035394231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(03)00254-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036301787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(03)00254-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036301787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0325-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037535808", 
          "https://doi.org/10.1007/s10495-009-0325-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-009-0325-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037535808", 
          "https://doi.org/10.1007/s10495-009-0325-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042147496", 
          "https://doi.org/10.1038/onc.2010.22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/abbs/gmp040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042227540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/abbs/gmp040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042227540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043315585", 
          "https://doi.org/10.1038/onc.2009.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044224920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(03)00103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044275143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(03)00103-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044275143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/chc.s4952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047002039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047655857", 
          "https://doi.org/10.1038/cdd.2009.85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2009.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047655857", 
          "https://doi.org/10.1038/cdd.2009.85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.7.757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052047444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.11.2985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052224675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053483613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1080386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062447739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.9.14.12322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072300927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074769876", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-03-00815.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074992002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076254226", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1991.tb07953.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077984408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078996351", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082511035", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08", 
    "datePublishedReg": "2013-08-01", 
    "description": "Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in embryonal cancer precursor cells causes postnatal rests, and later tumor formation through unknown mechanisms. However, overexpression of Myc in adult tissues normally activates apoptosis and/or senescence signals as an organismal defense mechanism against cancer. Here, we show that perinatal neuroblastoma precursor cells exhibited a transiently diminished p53 response to MycN oncoprotein stress and resistance to trophic factor withdrawal, compared with their adult counterpart cells from the TH-MYCN(+/+) transgenic mouse model of neuroblastoma. The adult stem cell maintenance factor and Polycomb group protein, Bmi1 (B-cell-specific Moloney murine leukemia virus integration site), had a critical role at neuroblastoma initiation in the model, by repressing p53 responses in precursor cells. We further show in neuroblastoma tumor cells that Bmi1 could directly bind p53 in a complex with other Polycomb complex proteins, Ring1A or Ring1B, leading to increased p53 ubiquitination and degradation. Repressed p53 signal responses were also seen in precursor cells for other embryonal cancer types, medulloblastoma and acute lymphoblastic leukemia. Collectively, these date indicate a general mechanism for p53 inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2012.368", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "31", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation", 
    "pagination": "3616", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6ecf79a39cad8a5779eb72f4b836f217120d288d7fc88a9ed1e8b7232e05740b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22907436"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2012.368"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023259044"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2012.368", 
      "https://app.dimensions.ai/details/publication/pub.1023259044"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2012368"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.368'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.368'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.368'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.368'


 

This table displays all metadata directly associated to this object as RDF triples.

473 TRIPLES      21 PREDICATES      99 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2012.368 schema:about N091e878dd9d3433b8de692b2cc77e415
2 N0f89211b0ca34e9c95192d6eaffd233c
3 N23882695425f4e918e85209f22049fb0
4 N290c1b9bec884938baafc6525983f310
5 N319bf62d80684fed975a2b67cbee4eb1
6 N32ddff0cc223471c82956f34ee0fb6a6
7 N3ac06aa589eb4266be652aca5ec89198
8 N4a50fa0f0aca4fa78e198a4db720c17d
9 N5c84bcb871f349c286ea33cfc27fe9d4
10 N5c95959bace94e98b3c60983ff21abb5
11 N5e170a96886a41039f296442bb70662e
12 N61a0b0facb874b2e961d3d2685f87a27
13 N68a99e9269b9472395ef607ce59222df
14 N6c2557d5e51949b2865081f58ead3157
15 N7edf0e654add48bfaef137853925cfc1
16 N8d22f84668214c66a11b2dc7696666ef
17 N90851ef8ce1344558d198d37cbe2b2d7
18 N938c8ee9e6164784884a0638a95a9cea
19 Nb5132b846a194268833e87dae9788cc4
20 Nb874f3138b9b4dcfba912dfde7cf3574
21 Nbb6933a43faf4dc8b2db52f4ec7577ba
22 Nbfe3ca64b87a4e20a61df637ff6ad3c5
23 Nccfe490533ca40538fe305a3181b7587
24 Ne8d71d09d0724d8cbb4af8352ccd15f0
25 Nfec33abb7e6b4669aa3b996c1eb30a7a
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author N286d248ff19041b79f7facefad5ec860
29 schema:citation sg:pub.10.1007/s10495-009-0325-y
30 sg:pub.10.1038/cdd.2009.85
31 sg:pub.10.1038/nature02385
32 sg:pub.10.1038/nrc1014
33 sg:pub.10.1038/nrc1633
34 sg:pub.10.1038/nrc1954
35 sg:pub.10.1038/onc.2009.3
36 sg:pub.10.1038/onc.2010.22
37 https://app.dimensions.ai/details/publication/pub.1074769876
38 https://app.dimensions.ai/details/publication/pub.1076254226
39 https://app.dimensions.ai/details/publication/pub.1078996351
40 https://app.dimensions.ai/details/publication/pub.1082511035
41 https://doi.org/10.1002/gene.10208
42 https://doi.org/10.1002/j.1460-2075.1991.tb07953.x
43 https://doi.org/10.1016/0076-6879(87)50085-4
44 https://doi.org/10.1016/0092-8674(91)90382-9
45 https://doi.org/10.1016/0092-8674(91)90383-a
46 https://doi.org/10.1016/j.ccr.2008.07.003
47 https://doi.org/10.1016/j.ejca.2007.03.008
48 https://doi.org/10.1016/j.stem.2007.04.001
49 https://doi.org/10.1016/s0140-6736(96)06020-5
50 https://doi.org/10.1016/s0301-0082(03)00051-0
51 https://doi.org/10.1016/s0304-3835(03)00103-4
52 https://doi.org/10.1016/s1357-2725(03)00254-1
53 https://doi.org/10.1016/s1470-2045(04)01424-x
54 https://doi.org/10.1038/sj.emboj.7601144
55 https://doi.org/10.1038/sj.neo.7900171
56 https://doi.org/10.1073/pnas.0401083101
57 https://doi.org/10.1073/pnas.0508888102
58 https://doi.org/10.1074/jbc.m011517200
59 https://doi.org/10.1093/abbs/gmp040
60 https://doi.org/10.1093/emboj/16.11.2985
61 https://doi.org/10.1093/nar/26.15.3453
62 https://doi.org/10.1101/gad.8.7.757
63 https://doi.org/10.1126/science.1080386
64 https://doi.org/10.1158/0008-5472.can-05-2623
65 https://doi.org/10.1158/0008-5472.can-09-2598
66 https://doi.org/10.1182/blood.v99.8.2992
67 https://doi.org/10.1371/journal.pone.0008104
68 https://doi.org/10.1523/jneurosci.22-03-00815.2002
69 https://doi.org/10.1593/neo.08778
70 https://doi.org/10.1593/neo.09466
71 https://doi.org/10.2147/chc.s4952
72 https://doi.org/10.2353/ajpath.2007.060754
73 https://doi.org/10.4161/cc.9.14.12322
74 schema:datePublished 2013-08
75 schema:datePublishedReg 2013-08-01
76 schema:description Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in embryonal cancer precursor cells causes postnatal rests, and later tumor formation through unknown mechanisms. However, overexpression of Myc in adult tissues normally activates apoptosis and/or senescence signals as an organismal defense mechanism against cancer. Here, we show that perinatal neuroblastoma precursor cells exhibited a transiently diminished p53 response to MycN oncoprotein stress and resistance to trophic factor withdrawal, compared with their adult counterpart cells from the TH-MYCN(+/+) transgenic mouse model of neuroblastoma. The adult stem cell maintenance factor and Polycomb group protein, Bmi1 (B-cell-specific Moloney murine leukemia virus integration site), had a critical role at neuroblastoma initiation in the model, by repressing p53 responses in precursor cells. We further show in neuroblastoma tumor cells that Bmi1 could directly bind p53 in a complex with other Polycomb complex proteins, Ring1A or Ring1B, leading to increased p53 ubiquitination and degradation. Repressed p53 signal responses were also seen in precursor cells for other embryonal cancer types, medulloblastoma and acute lymphoblastic leukemia. Collectively, these date indicate a general mechanism for p53 inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree true
80 schema:isPartOf N84bc086f3b0846728b90b81e39fe547c
81 Nc36f3cdbe1d34e59ad0f53361ef37681
82 sg:journal.1097543
83 schema:name Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation
84 schema:pagination 3616
85 schema:productId N5dec362c2ee04e4eb23bc1ab9510e7a9
86 N88e35b088ec2475487e779e1cce0976f
87 N9889497f0b5941f28222e04d41647f9d
88 Nb9ec76bbb5a349059abeb1ac3c6b4642
89 Ncd06916764134bf797cf62fa5e857ad4
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023259044
91 https://doi.org/10.1038/onc.2012.368
92 schema:sdDatePublished 2019-04-11T00:56
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N77df9c827a9147b59cc96e8ff8a8186f
95 schema:url https://www.nature.com/articles/onc2012368
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N04c9e5c551e840aca68cb2e5e428f3d7 schema:affiliation https://www.grid.ac/institutes/grid.263906.8
100 schema:familyName Cui
101 schema:givenName H J
102 rdf:type schema:Person
103 N091e878dd9d3433b8de692b2cc77e415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N0c5b35386a174902beef6cbd527423bc rdf:first sg:person.07674015612.04
107 rdf:rest rdf:nil
108 N0f89211b0ca34e9c95192d6eaffd233c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice
110 rdf:type schema:DefinedTerm
111 N194155d0fb8d4dd28f78ef773cb9afd0 rdf:first sg:person.01136543370.53
112 rdf:rest N257f359d15c945d09c3f66a22e4adfc5
113 N1e8c81b825b24c509944b20013f78636 rdf:first sg:person.0634661610.30
114 rdf:rest N194155d0fb8d4dd28f78ef773cb9afd0
115 N2117526c0fce4153ae2c179bade3a4cc rdf:first sg:person.01014270155.83
116 rdf:rest Nbad01e52eb00401f846686d5c1f0d80e
117 N23882695425f4e918e85209f22049fb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Medulloblastoma
119 rdf:type schema:DefinedTerm
120 N23aec4bff9954e4f8a9945f9b55ef1ac rdf:first sg:person.0640244611.27
121 rdf:rest N1e8c81b825b24c509944b20013f78636
122 N24472a42574b4b719519780dad9e6947 rdf:first sg:person.01141021532.75
123 rdf:rest N7ee91b41ce70491ca0628b3c3cb293e8
124 N257f359d15c945d09c3f66a22e4adfc5 rdf:first N88b0b4f2bab249a3b91ccf18d0519261
125 rdf:rest N0c5b35386a174902beef6cbd527423bc
126 N286d248ff19041b79f7facefad5ec860 rdf:first sg:person.0663577366.13
127 rdf:rest Ndb09c95d5ee84c4996f365e47b6ff21b
128 N290c1b9bec884938baafc6525983f310 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Neoplastic Stem Cells
130 rdf:type schema:DefinedTerm
131 N2d2dcb572fee46e1820a67626bf2e9b0 rdf:first Nc22134e08c0247b18fa100ee9d1bb471
132 rdf:rest N45f806db989644d9a485838ff605317a
133 N319bf62d80684fed975a2b67cbee4eb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Proteasome Endopeptidase Complex
135 rdf:type schema:DefinedTerm
136 N32ddff0cc223471c82956f34ee0fb6a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 N3ac06aa589eb4266be652aca5ec89198 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Nuclear Proteins
141 rdf:type schema:DefinedTerm
142 N3e6854e4316d4063bda342cc475d6cf4 rdf:first N04c9e5c551e840aca68cb2e5e428f3d7
143 rdf:rest N844b120f4b7c48899810b64fd866b571
144 N3ecf9be52f384075a8eee874064807cf rdf:first N6a507235a6cb43c7950f93a2f2c62808
145 rdf:rest N2d2dcb572fee46e1820a67626bf2e9b0
146 N45f806db989644d9a485838ff605317a rdf:first sg:person.01225405127.04
147 rdf:rest N24472a42574b4b719519780dad9e6947
148 N4a50fa0f0aca4fa78e198a4db720c17d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Stress, Physiological
150 rdf:type schema:DefinedTerm
151 N4c441009f27f4251bd7ff98e40de829b rdf:first sg:person.01305346242.28
152 rdf:rest N988f48d1281641128e87079229334fdb
153 N52d9b5dcc2f144e9bcccc402cdb92356 rdf:first sg:person.0601662637.51
154 rdf:rest Ndcc1f35eea1145b4983392d93992290c
155 N54b50defa70f44e995358112052105d2 rdf:first sg:person.01155705412.07
156 rdf:rest N52d9b5dcc2f144e9bcccc402cdb92356
157 N5c84bcb871f349c286ea33cfc27fe9d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name N-Myc Proto-Oncogene Protein
159 rdf:type schema:DefinedTerm
160 N5c95959bace94e98b3c60983ff21abb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Oncogene Proteins
162 rdf:type schema:DefinedTerm
163 N5dec362c2ee04e4eb23bc1ab9510e7a9 schema:name readcube_id
164 schema:value 6ecf79a39cad8a5779eb72f4b836f217120d288d7fc88a9ed1e8b7232e05740b
165 rdf:type schema:PropertyValue
166 N5e170a96886a41039f296442bb70662e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Ubiquitination
168 rdf:type schema:DefinedTerm
169 N61a0b0facb874b2e961d3d2685f87a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Proto-Oncogene Proteins c-mdm2
171 rdf:type schema:DefinedTerm
172 N6294e0b579eb437bb0769a56b59cda2a rdf:first sg:person.01165732215.75
173 rdf:rest N85ea1a206d5a49a2ba7f18274648f47d
174 N68a99e9269b9472395ef607ce59222df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Polyubiquitin
176 rdf:type schema:DefinedTerm
177 N6a507235a6cb43c7950f93a2f2c62808 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
178 schema:familyName Bekkum
179 schema:givenName M V
180 rdf:type schema:Person
181 N6c2557d5e51949b2865081f58ead3157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Proteolysis
183 rdf:type schema:DefinedTerm
184 N77df9c827a9147b59cc96e8ff8a8186f schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 N7edf0e654add48bfaef137853925cfc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Neuroblastoma
188 rdf:type schema:DefinedTerm
189 N7ee91b41ce70491ca0628b3c3cb293e8 rdf:first sg:person.01124105267.13
190 rdf:rest N54b50defa70f44e995358112052105d2
191 N844b120f4b7c48899810b64fd866b571 rdf:first sg:person.01111156527.99
192 rdf:rest N2117526c0fce4153ae2c179bade3a4cc
193 N84bc086f3b0846728b90b81e39fe547c schema:volumeNumber 32
194 rdf:type schema:PublicationVolume
195 N85ea1a206d5a49a2ba7f18274648f47d rdf:first N92339b525a8b4624a262d0d282d6f502
196 rdf:rest N3ecf9be52f384075a8eee874064807cf
197 N88b0b4f2bab249a3b91ccf18d0519261 schema:affiliation https://www.grid.ac/institutes/grid.410427.4
198 schema:familyName Ding
199 schema:givenName H F
200 rdf:type schema:Person
201 N88e35b088ec2475487e779e1cce0976f schema:name dimensions_id
202 schema:value pub.1023259044
203 rdf:type schema:PropertyValue
204 N8d22f84668214c66a11b2dc7696666ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Proto-Oncogene Proteins
206 rdf:type schema:DefinedTerm
207 N90851ef8ce1344558d198d37cbe2b2d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Cyclin-Dependent Kinase Inhibitor p16
209 rdf:type schema:DefinedTerm
210 N92339b525a8b4624a262d0d282d6f502 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
211 schema:familyName Davies
212 schema:givenName N P
213 rdf:type schema:Person
214 N938c8ee9e6164784884a0638a95a9cea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Neoplasms, Germ Cell and Embryonal
216 rdf:type schema:DefinedTerm
217 N9889497f0b5941f28222e04d41647f9d schema:name pubmed_id
218 schema:value 22907436
219 rdf:type schema:PropertyValue
220 N988f48d1281641128e87079229334fdb rdf:first sg:person.01002012262.91
221 rdf:rest N6294e0b579eb437bb0769a56b59cda2a
222 Nb5132b846a194268833e87dae9788cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Cell Line, Tumor
224 rdf:type schema:DefinedTerm
225 Nb874f3138b9b4dcfba912dfde7cf3574 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
226 schema:name Polycomb Repressive Complex 1
227 rdf:type schema:DefinedTerm
228 Nb9ec76bbb5a349059abeb1ac3c6b4642 schema:name doi
229 schema:value 10.1038/onc.2012.368
230 rdf:type schema:PropertyValue
231 Nbad01e52eb00401f846686d5c1f0d80e rdf:first sg:person.01031264760.99
232 rdf:rest N4c441009f27f4251bd7ff98e40de829b
233 Nbb6933a43faf4dc8b2db52f4ec7577ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
234 schema:name Signal Transduction
235 rdf:type schema:DefinedTerm
236 Nbfe3ca64b87a4e20a61df637ff6ad3c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
237 schema:name Tumor Suppressor Protein p53
238 rdf:type schema:DefinedTerm
239 Nc22134e08c0247b18fa100ee9d1bb471 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
240 schema:familyName Chen
241 schema:givenName B
242 rdf:type schema:Person
243 Nc36f3cdbe1d34e59ad0f53361ef37681 schema:issueNumber 31
244 rdf:type schema:PublicationIssue
245 Nccfe490533ca40538fe305a3181b7587 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
246 schema:name Leukemia
247 rdf:type schema:DefinedTerm
248 Ncd06916764134bf797cf62fa5e857ad4 schema:name nlm_unique_id
249 schema:value 8711562
250 rdf:type schema:PropertyValue
251 Ndb09c95d5ee84c4996f365e47b6ff21b rdf:first sg:person.01000571227.21
252 rdf:rest N3e6854e4316d4063bda342cc475d6cf4
253 Ndcc1f35eea1145b4983392d93992290c rdf:first sg:person.01025071371.87
254 rdf:rest N23aec4bff9954e4f8a9945f9b55ef1ac
255 Ne8d71d09d0724d8cbb4af8352ccd15f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
256 schema:name Apoptosis
257 rdf:type schema:DefinedTerm
258 Nfec33abb7e6b4669aa3b996c1eb30a7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Protein Stability
260 rdf:type schema:DefinedTerm
261 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
262 schema:name Medical and Health Sciences
263 rdf:type schema:DefinedTerm
264 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
265 schema:name Oncology and Carcinogenesis
266 rdf:type schema:DefinedTerm
267 sg:journal.1097543 schema:issn 0950-9232
268 1476-5594
269 schema:name Oncogene
270 rdf:type schema:Periodical
271 sg:person.01000571227.21 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
272 schema:familyName Sekyere
273 schema:givenName E O
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000571227.21
275 rdf:type schema:Person
276 sg:person.01002012262.91 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
277 schema:familyName Raif
278 schema:givenName A
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002012262.91
280 rdf:type schema:Person
281 sg:person.01014270155.83 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
282 schema:familyName Thomas
283 schema:givenName W D
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014270155.83
285 rdf:type schema:Person
286 sg:person.01025071371.87 schema:affiliation https://www.grid.ac/institutes/grid.416975.8
287 schema:familyName Shohet
288 schema:givenName J M
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025071371.87
290 rdf:type schema:Person
291 sg:person.01031264760.99 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
292 schema:familyName Keating
293 schema:givenName J
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031264760.99
295 rdf:type schema:Person
296 sg:person.01111156527.99 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
297 schema:familyName Cheung
298 schema:givenName B B
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111156527.99
300 rdf:type schema:Person
301 sg:person.01124105267.13 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
302 schema:familyName Norris
303 schema:givenName M D
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124105267.13
305 rdf:type schema:Person
306 sg:person.01136543370.53 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
307 schema:familyName Wainwright
308 schema:givenName B J
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136543370.53
310 rdf:type schema:Person
311 sg:person.01141021532.75 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
312 schema:familyName Ellis
313 schema:givenName T
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141021532.75
315 rdf:type schema:Person
316 sg:person.01155705412.07 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
317 schema:familyName Haber
318 schema:givenName M
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155705412.07
320 rdf:type schema:Person
321 sg:person.01165732215.75 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
322 schema:familyName Jankowski
323 schema:givenName K
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165732215.75
325 rdf:type schema:Person
326 sg:person.01225405127.04 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
327 schema:familyName Tan
328 schema:givenName O
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225405127.04
330 rdf:type schema:Person
331 sg:person.01305346242.28 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
332 schema:familyName Chen
333 schema:givenName J B
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305346242.28
335 rdf:type schema:Person
336 sg:person.0601662637.51 schema:affiliation https://www.grid.ac/institutes/grid.416975.8
337 schema:familyName Kim
338 schema:givenName E S
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601662637.51
340 rdf:type schema:Person
341 sg:person.0634661610.30 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
342 schema:familyName Liu
343 schema:givenName T
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634661610.30
345 rdf:type schema:Person
346 sg:person.0640244611.27 schema:affiliation https://www.grid.ac/institutes/grid.430417.5
347 schema:familyName Trahair
348 schema:givenName T N
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640244611.27
350 rdf:type schema:Person
351 sg:person.0663577366.13 schema:affiliation https://www.grid.ac/institutes/grid.1005.4
352 schema:familyName Calao
353 schema:givenName M
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663577366.13
355 rdf:type schema:Person
356 sg:person.07674015612.04 schema:affiliation https://www.grid.ac/institutes/grid.430417.5
357 schema:familyName Marshall
358 schema:givenName G M
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07674015612.04
360 rdf:type schema:Person
361 sg:pub.10.1007/s10495-009-0325-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037535808
362 https://doi.org/10.1007/s10495-009-0325-y
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/cdd.2009.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047655857
365 https://doi.org/10.1038/cdd.2009.85
366 rdf:type schema:CreativeWork
367 sg:pub.10.1038/nature02385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008729213
368 https://doi.org/10.1038/nature02385
369 rdf:type schema:CreativeWork
370 sg:pub.10.1038/nrc1014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008818340
371 https://doi.org/10.1038/nrc1014
372 rdf:type schema:CreativeWork
373 sg:pub.10.1038/nrc1633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022380826
374 https://doi.org/10.1038/nrc1633
375 rdf:type schema:CreativeWork
376 sg:pub.10.1038/nrc1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021197931
377 https://doi.org/10.1038/nrc1954
378 rdf:type schema:CreativeWork
379 sg:pub.10.1038/onc.2009.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043315585
380 https://doi.org/10.1038/onc.2009.3
381 rdf:type schema:CreativeWork
382 sg:pub.10.1038/onc.2010.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042147496
383 https://doi.org/10.1038/onc.2010.22
384 rdf:type schema:CreativeWork
385 https://app.dimensions.ai/details/publication/pub.1074769876 schema:CreativeWork
386 https://app.dimensions.ai/details/publication/pub.1076254226 schema:CreativeWork
387 https://app.dimensions.ai/details/publication/pub.1078996351 schema:CreativeWork
388 https://app.dimensions.ai/details/publication/pub.1082511035 schema:CreativeWork
389 https://doi.org/10.1002/gene.10208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024966986
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1002/j.1460-2075.1991.tb07953.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077984408
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1016/0076-6879(87)50085-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024341171
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1016/0092-8674(91)90382-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011604928
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1016/0092-8674(91)90383-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1003828208
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/j.ccr.2008.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053483613
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1016/j.ejca.2007.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007311127
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/j.stem.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021513377
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/s0140-6736(96)06020-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013445242
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/s0301-0082(03)00051-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013217938
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/s0304-3835(03)00103-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044275143
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1016/s1357-2725(03)00254-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036301787
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1016/s1470-2045(04)01424-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004475271
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1038/sj.emboj.7601144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044224920
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1038/sj.neo.7900171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019479310
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1073/pnas.0401083101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028159565
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1073/pnas.0508888102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009186749
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1074/jbc.m011517200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024398653
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1093/abbs/gmp040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042227540
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1093/emboj/16.11.2985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052224675
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1093/nar/26.15.3453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018997023
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1101/gad.8.7.757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052047444
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1126/science.1080386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447739
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1158/0008-5472.can-05-2623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032980764
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1158/0008-5472.can-09-2598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000408873
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1182/blood.v99.8.2992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008538712
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1371/journal.pone.0008104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023766381
442 rdf:type schema:CreativeWork
443 https://doi.org/10.1523/jneurosci.22-03-00815.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074992002
444 rdf:type schema:CreativeWork
445 https://doi.org/10.1593/neo.08778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016030791
446 rdf:type schema:CreativeWork
447 https://doi.org/10.1593/neo.09466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006579293
448 rdf:type schema:CreativeWork
449 https://doi.org/10.2147/chc.s4952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047002039
450 rdf:type schema:CreativeWork
451 https://doi.org/10.2353/ajpath.2007.060754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035394231
452 rdf:type schema:CreativeWork
453 https://doi.org/10.4161/cc.9.14.12322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300927
454 rdf:type schema:CreativeWork
455 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
456 schema:name Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia
457 rdf:type schema:Organization
458 https://www.grid.ac/institutes/grid.1005.4 schema:alternateName UNSW Australia
459 schema:name Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia
460 rdf:type schema:Organization
461 https://www.grid.ac/institutes/grid.263906.8 schema:alternateName Southwest University
462 schema:name State key laboratory of Silkworm Functional Genome Biology, Institute of Sericulture and System Biology, Southwest University, Chongqing, China
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.410427.4 schema:alternateName Augusta University
465 schema:name Medical College of Georgia, Augusta, GA, USA
466 rdf:type schema:Organization
467 https://www.grid.ac/institutes/grid.416975.8 schema:alternateName Texas Children's Hospital
468 schema:name Texas Children’s Hospital, Houston, TX, USA
469 rdf:type schema:Organization
470 https://www.grid.ac/institutes/grid.430417.5 schema:alternateName Sydney Children’s Hospitals Network
471 schema:name Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia
472 Sydney Children’s Hospital, Sydney, New South Wales, Australia
473 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...