The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

H Bernard, B Garmy-Susini, N Ainaoui, L Van Den Berghe, A Peurichard, S Javerzat, A Bikfalvi, D P Lane, J C Bourdon, A-C Prats

ABSTRACT

The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development. The p53 gene expresses 12 different proteins (isoforms), including TAp53 (p53 (or p53α), p53β and p53γ) and Δ133p53 isoforms (Δ133p53α, Δ133p53β and Δ133p53γ). The Δ133p53α isoform was shown to modulate p53 transcriptional activity and is overexpressed in various human tumours. However, its role in tumour progression is still unexplored. In the present study, we examined the involvement of Δ133p53 isoforms in tumoural angiogenesis and tumour growth in the highly angiogenic human glioblastoma U87. Our data show that conditioned media from U87 cells depleted for Δ133p53 isoforms block endothelial cell migration and tubulogenesis without affecting endothelial cell proliferation in vitro. The Δ133p53 depletion in U2OS osteosarcoma cells resulted in a similar angiogenesis blockade. Furthermore, using conditioned media from U87 cells ectopically expressing each Δ133p53 isoform, we determined that Δ133p53α and Δ133p53γ but not Δ133p53β, stimulate angiogenesis. Our in vivo data using the chicken chorio-allantoic membrane and mice xenografts establish that angiogenesis and growth of glioblastoma U87 tumours are inhibited upon depletion of Δ133p53 isoforms. By TaqMan low-density array, we show that alteration of expression ratio of Δ133p53 and TAp53 isoforms differentially regulates angiogenic gene expression with Δ133p53 isoforms inducing pro-angiogenic gene expression and repressing anti-angiogenic gene expression. More... »

PAGES

2150

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2012.242

DOI

http://dx.doi.org/10.1038/onc.2012.242

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008847976

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22733133


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiogenic Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cattle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chick Embryo", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chorioallantoic Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Umbilical Vein Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Isoforms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Dundee", 
          "id": "https://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France", 
            "Department of Surgery and Molecular Oncology, University of Dundee, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernard", 
        "givenName": "H", 
        "id": "sg:person.01202133516.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202133516.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "D\u00e9l\u00e9gation Midi-Pyr\u00e9n\u00e9es, Limousin", 
          "id": "https://www.grid.ac/institutes/grid.457379.b", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France", 
            "Inserm, U1037, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garmy-Susini", 
        "givenName": "B", 
        "id": "sg:person.0601123317.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601123317.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toulouse", 
          "id": "https://www.grid.ac/institutes/grid.11417.32", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ainaoui", 
        "givenName": "N", 
        "id": "sg:person.01332557702.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332557702.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cardiovascular and Metabolic Diseases", 
          "id": "https://www.grid.ac/institutes/grid.462178.e", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France", 
            "Inserm, U1048, F-31432 Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Den Berghe", 
        "givenName": "L", 
        "id": "sg:person.01006624530.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006624530.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toulouse", 
          "id": "https://www.grid.ac/institutes/grid.11417.32", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peurichard", 
        "givenName": "A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Angiogenesis and Cancer Microenvironment Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.493861.1", 
          "name": [
            "Inserm, U920, Talence, France", 
            "Universit\u00e9 de Bordeaux 1, Angiogenesis and Cancer Microenvironment Laboratory, Talence, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Javerzat", 
        "givenName": "S", 
        "id": "sg:person.0706430103.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706430103.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Angiogenesis and Cancer Microenvironment Laboratory", 
          "id": "https://www.grid.ac/institutes/grid.493861.1", 
          "name": [
            "Inserm, U920, Talence, France", 
            "Universit\u00e9 de Bordeaux 1, Angiogenesis and Cancer Microenvironment Laboratory, Talence, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bikfalvi", 
        "givenName": "A", 
        "id": "sg:person.046113262.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.046113262.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee", 
          "id": "https://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "Department of Surgery and Molecular Oncology, University of Dundee, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lane", 
        "givenName": "D P", 
        "id": "sg:person.01034432262.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034432262.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee", 
          "id": "https://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "Department of Surgery and Molecular Oncology, University of Dundee, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bourdon", 
        "givenName": "J C", 
        "id": "sg:person.01306520207.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306520207.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toulouse", 
          "id": "https://www.grid.ac/institutes/grid.11417.32", 
          "name": [
            "Universit\u00e9 de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies M\u00e9taboliques et Cardiovasculaires, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prats", 
        "givenName": "A-C", 
        "id": "sg:person.0775356502.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775356502.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jocn.2009.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007407929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009327734", 
          "https://doi.org/10.1038/sj.bjc.6603886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009447972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0608017103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011000123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.8.2575-2585.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011572400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012366197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2001.0282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012991962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019118231", 
          "https://doi.org/10.1038/ncb1928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.23313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019535003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2009.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019893607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.01.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020649367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022254339", 
          "https://doi.org/10.1186/bcr2811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1339905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022277460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023231275", 
          "https://doi.org/10.1038/nature04871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.19.9009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025806612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2010.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031058360", 
          "https://doi.org/10.1038/onc.2010.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2010.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031927795", 
          "https://doi.org/10.1038/cdd.2010.91"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-10-102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032010095", 
          "https://doi.org/10.1186/1471-213x-10-102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1761609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033279928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1761609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033279928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.070011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037059154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2342-8-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041063545", 
          "https://doi.org/10.1186/1471-2342-8-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042029677", 
          "https://doi.org/10.1038/sj.onc.1204271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042029677", 
          "https://doi.org/10.1038/sj.onc.1204271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0221-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042163119", 
          "https://doi.org/10.1007/s00109-007-0221-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-007-0221-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042163119", 
          "https://doi.org/10.1007/s00109-007-0221-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0408622102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048544695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911408893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050181761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601911408893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050181761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7521539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062647420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.3542006pe35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062693457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.16.3018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074578268", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074881987", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04", 
    "datePublishedReg": "2013-04-01", 
    "description": "The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development. The p53 gene expresses 12 different proteins (isoforms), including TAp53 (p53 (or p53\u03b1), p53\u03b2 and p53\u03b3) and \u0394133p53 isoforms (\u0394133p53\u03b1, \u0394133p53\u03b2 and \u0394133p53\u03b3). The \u0394133p53\u03b1 isoform was shown to modulate p53 transcriptional activity and is overexpressed in various human tumours. However, its role in tumour progression is still unexplored. In the present study, we examined the involvement of \u0394133p53 isoforms in tumoural angiogenesis and tumour growth in the highly angiogenic human glioblastoma U87. Our data show that conditioned media from U87 cells depleted for \u0394133p53 isoforms block endothelial cell migration and tubulogenesis without affecting endothelial cell proliferation in vitro. The \u0394133p53 depletion in U2OS osteosarcoma cells resulted in a similar angiogenesis blockade. Furthermore, using conditioned media from U87 cells ectopically expressing each \u0394133p53 isoform, we determined that \u0394133p53\u03b1 and \u0394133p53\u03b3 but not \u0394133p53\u03b2, stimulate angiogenesis. Our in vivo data using the chicken chorio-allantoic membrane and mice xenografts establish that angiogenesis and growth of glioblastoma U87 tumours are inhibited upon depletion of \u0394133p53 isoforms. By TaqMan low-density array, we show that alteration of expression ratio of \u0394133p53 and TAp53 isoforms differentially regulates angiogenic gene expression with \u0394133p53 isoforms inducing pro-angiogenic gene expression and repressing anti-angiogenic gene expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2012.242", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5142213", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "17", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "32"
      }
    ], 
    "name": "The p53 isoform, \u0394133p53\u03b1, stimulates angiogenesis and tumour progression", 
    "pagination": "2150", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2a27a771c57bae3ca94b5ebedc62a8554d705a1754f830680538831deb300d03"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22733133"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2012.242"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008847976"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2012.242", 
      "https://app.dimensions.ai/details/publication/pub.1008847976"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2012242"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.242'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.242'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.242'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.242'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      80 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2012.242 schema:about N0dd6c6c4e0af41e5b1a2fda031a5d003
2 N1589b106ed834d2397f5d706d2864adc
3 N4a36270a0c96476a83c60b1f39ed993c
4 N4e0401767700498a95e8d88b0265ba69
5 N5a09beca8d4649fab48bbc5550b5999b
6 N6c45316301864be8b5f149e0ad3789b8
7 N6dbe76bc0e58441b96b286d20418d551
8 N72fc88c9867e41cab715b292d3ccaa85
9 N905f46b8e49f46b6a76ed2ea4364bea0
10 N9cd83a770ec34cac98328f8d55da9dd2
11 N9e1ace7238744851a3dcd931ef9e72f3
12 Na9837b1d032f4e9e93e0ef96d265cd65
13 Nb17296ae7bf44f18a26769df8d5c4d0d
14 Nba21b98b060c47bf8f30b6f95764f5fc
15 Nc5cf828baad44ca9ba2eb4f5727ed8da
16 Nd9e0d11ff1e54466b69917039ffb8646
17 Ndf0608ab5726489590ca9636272c907f
18 Ne3ab2fb09594412a9a8eb6844310d37e
19 Ne60a8a87a50a4d099f12267c787707cd
20 Ne836e0114b7445dd9caae6bf6e4b9a48
21 Ne83ff83ddee4488c85520e60b195d631
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author N1f3b90e8eb8147c483aa4d9ff455c9e4
25 schema:citation sg:pub.10.1007/s00109-007-0221-2
26 sg:pub.10.1038/cdd.2010.91
27 sg:pub.10.1038/nature04871
28 sg:pub.10.1038/ncb1928
29 sg:pub.10.1038/onc.2010.26
30 sg:pub.10.1038/sj.bjc.6603886
31 sg:pub.10.1038/sj.onc.1204271
32 sg:pub.10.1186/1471-213x-10-102
33 sg:pub.10.1186/1471-2342-8-16
34 sg:pub.10.1186/bcr2811
35 https://app.dimensions.ai/details/publication/pub.1074578268
36 https://app.dimensions.ai/details/publication/pub.1074881987
37 https://doi.org/10.1002/ijc.23313
38 https://doi.org/10.1006/mthe.2001.0282
39 https://doi.org/10.1016/j.ccr.2009.01.021
40 https://doi.org/10.1016/j.ccr.2009.01.027
41 https://doi.org/10.1016/j.devcel.2009.01.003
42 https://doi.org/10.1016/j.jocn.2009.02.009
43 https://doi.org/10.1073/pnas.0408622102
44 https://doi.org/10.1073/pnas.0608017103
45 https://doi.org/10.1073/pnas.91.19.9009
46 https://doi.org/10.1101/gad.1339905
47 https://doi.org/10.1101/gad.1761609
48 https://doi.org/10.1126/science.7521539
49 https://doi.org/10.1126/stke.3542006pe35
50 https://doi.org/10.1128/mcb.22.8.2575-2585.2002
51 https://doi.org/10.1158/0008-5472.can-04-0287
52 https://doi.org/10.1177/1947601911408893
53 https://doi.org/10.2353/ajpath.2007.070011
54 https://doi.org/10.4161/cc.5.16.3018
55 schema:datePublished 2013-04
56 schema:datePublishedReg 2013-04-01
57 schema:description The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development. The p53 gene expresses 12 different proteins (isoforms), including TAp53 (p53 (or p53α), p53β and p53γ) and Δ133p53 isoforms (Δ133p53α, Δ133p53β and Δ133p53γ). The Δ133p53α isoform was shown to modulate p53 transcriptional activity and is overexpressed in various human tumours. However, its role in tumour progression is still unexplored. In the present study, we examined the involvement of Δ133p53 isoforms in tumoural angiogenesis and tumour growth in the highly angiogenic human glioblastoma U87. Our data show that conditioned media from U87 cells depleted for Δ133p53 isoforms block endothelial cell migration and tubulogenesis without affecting endothelial cell proliferation in vitro. The Δ133p53 depletion in U2OS osteosarcoma cells resulted in a similar angiogenesis blockade. Furthermore, using conditioned media from U87 cells ectopically expressing each Δ133p53 isoform, we determined that Δ133p53α and Δ133p53γ but not Δ133p53β, stimulate angiogenesis. Our in vivo data using the chicken chorio-allantoic membrane and mice xenografts establish that angiogenesis and growth of glioblastoma U87 tumours are inhibited upon depletion of Δ133p53 isoforms. By TaqMan low-density array, we show that alteration of expression ratio of Δ133p53 and TAp53 isoforms differentially regulates angiogenic gene expression with Δ133p53 isoforms inducing pro-angiogenic gene expression and repressing anti-angiogenic gene expression.
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree true
61 schema:isPartOf N25948c894060403f97588aa9932085c5
62 Nda6746c3828d4faf9f541f4a9c1a3636
63 sg:journal.1097543
64 schema:name The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression
65 schema:pagination 2150
66 schema:productId N09732adee78e4cdfb51ba36cfc1652b3
67 N4917670f81e64c6abe2892176437cb86
68 N831b9639902640f48d6fbe86dc69fa4c
69 N95aa97e782c24abdb89e66fc1c5f7043
70 Ncb11ed21abf342a7a85db60e819c2ef0
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008847976
72 https://doi.org/10.1038/onc.2012.242
73 schema:sdDatePublished 2019-04-10T21:25
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N69fafeae6cd34475812f49067959aecb
76 schema:url https://www.nature.com/articles/onc2012242
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N09732adee78e4cdfb51ba36cfc1652b3 schema:name doi
81 schema:value 10.1038/onc.2012.242
82 rdf:type schema:PropertyValue
83 N0dd6c6c4e0af41e5b1a2fda031a5d003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Glioblastoma
85 rdf:type schema:DefinedTerm
86 N1589b106ed834d2397f5d706d2864adc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cell Line, Tumor
88 rdf:type schema:DefinedTerm
89 N1f3b90e8eb8147c483aa4d9ff455c9e4 rdf:first sg:person.01202133516.87
90 rdf:rest Nb25a88e42ea34a73a77297f5184e5fb3
91 N25948c894060403f97588aa9932085c5 schema:volumeNumber 32
92 rdf:type schema:PublicationVolume
93 N4917670f81e64c6abe2892176437cb86 schema:name nlm_unique_id
94 schema:value 8711562
95 rdf:type schema:PropertyValue
96 N4a36270a0c96476a83c60b1f39ed993c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Human Umbilical Vein Endothelial Cells
98 rdf:type schema:DefinedTerm
99 N4e0401767700498a95e8d88b0265ba69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Cattle
101 rdf:type schema:DefinedTerm
102 N5a09beca8d4649fab48bbc5550b5999b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Protein Isoforms
104 rdf:type schema:DefinedTerm
105 N63ea4c1dc2834e7c921d9d1d0f5cbf13 rdf:first N6c56598ae5ac413bab9100bb22ebd5e5
106 rdf:rest Ne3975823528349a9bc0460821e3f7251
107 N69fafeae6cd34475812f49067959aecb schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N6c45316301864be8b5f149e0ad3789b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Gene Expression Regulation, Neoplastic
111 rdf:type schema:DefinedTerm
112 N6c56598ae5ac413bab9100bb22ebd5e5 schema:affiliation https://www.grid.ac/institutes/grid.11417.32
113 schema:familyName Peurichard
114 schema:givenName A
115 rdf:type schema:Person
116 N6dbe76bc0e58441b96b286d20418d551 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Chick Embryo
118 rdf:type schema:DefinedTerm
119 N72fc88c9867e41cab715b292d3ccaa85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Tumor Burden
121 rdf:type schema:DefinedTerm
122 N80ddaabcf1aa4f6885e05de6799ecd8c rdf:first sg:person.0775356502.86
123 rdf:rest rdf:nil
124 N831b9639902640f48d6fbe86dc69fa4c schema:name readcube_id
125 schema:value 2a27a771c57bae3ca94b5ebedc62a8554d705a1754f830680538831deb300d03
126 rdf:type schema:PropertyValue
127 N8785a29597884107bd06701f995d1afe rdf:first sg:person.01306520207.63
128 rdf:rest N80ddaabcf1aa4f6885e05de6799ecd8c
129 N889e36a13e7e4023a5f6be71e99c52c0 rdf:first sg:person.01332557702.13
130 rdf:rest Neadbd1efaf134be190b2594d5ba792a1
131 N905f46b8e49f46b6a76ed2ea4364bea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Angiogenic Proteins
133 rdf:type schema:DefinedTerm
134 N95aa97e782c24abdb89e66fc1c5f7043 schema:name dimensions_id
135 schema:value pub.1008847976
136 rdf:type schema:PropertyValue
137 N9cd83a770ec34cac98328f8d55da9dd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Tumor Suppressor Protein p53
139 rdf:type schema:DefinedTerm
140 N9e1ace7238744851a3dcd931ef9e72f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Gene Expression
142 rdf:type schema:DefinedTerm
143 Na9837b1d032f4e9e93e0ef96d265cd65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mice, Nude
145 rdf:type schema:DefinedTerm
146 Nb17296ae7bf44f18a26769df8d5c4d0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 Nb25a88e42ea34a73a77297f5184e5fb3 rdf:first sg:person.0601123317.74
150 rdf:rest N889e36a13e7e4023a5f6be71e99c52c0
151 Nba21b98b060c47bf8f30b6f95764f5fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Brain Neoplasms
153 rdf:type schema:DefinedTerm
154 Nbc3dc91303cf49d0899b6bf66faa6cba rdf:first sg:person.046113262.70
155 rdf:rest Neebe39738f2a4f7cbaa9323e935ad9d4
156 Nc5cf828baad44ca9ba2eb4f5727ed8da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Humans
158 rdf:type schema:DefinedTerm
159 Ncb11ed21abf342a7a85db60e819c2ef0 schema:name pubmed_id
160 schema:value 22733133
161 rdf:type schema:PropertyValue
162 Nd9e0d11ff1e54466b69917039ffb8646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Chorioallantoic Membrane
164 rdf:type schema:DefinedTerm
165 Nda6746c3828d4faf9f541f4a9c1a3636 schema:issueNumber 17
166 rdf:type schema:PublicationIssue
167 Ndf0608ab5726489590ca9636272c907f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neoplasm Transplantation
169 rdf:type schema:DefinedTerm
170 Ne3975823528349a9bc0460821e3f7251 rdf:first sg:person.0706430103.52
171 rdf:rest Nbc3dc91303cf49d0899b6bf66faa6cba
172 Ne3ab2fb09594412a9a8eb6844310d37e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Mice
174 rdf:type schema:DefinedTerm
175 Ne60a8a87a50a4d099f12267c787707cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cell Proliferation
177 rdf:type schema:DefinedTerm
178 Ne836e0114b7445dd9caae6bf6e4b9a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Neovascularization, Pathologic
180 rdf:type schema:DefinedTerm
181 Ne83ff83ddee4488c85520e60b195d631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cell Movement
183 rdf:type schema:DefinedTerm
184 Neadbd1efaf134be190b2594d5ba792a1 rdf:first sg:person.01006624530.84
185 rdf:rest N63ea4c1dc2834e7c921d9d1d0f5cbf13
186 Neebe39738f2a4f7cbaa9323e935ad9d4 rdf:first sg:person.01034432262.26
187 rdf:rest N8785a29597884107bd06701f995d1afe
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
192 schema:name Oncology and Carcinogenesis
193 rdf:type schema:DefinedTerm
194 sg:grant.5142213 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2012.242
195 rdf:type schema:MonetaryGrant
196 sg:journal.1097543 schema:issn 0950-9232
197 1476-5594
198 schema:name Oncogene
199 rdf:type schema:Periodical
200 sg:person.01006624530.84 schema:affiliation https://www.grid.ac/institutes/grid.462178.e
201 schema:familyName Van Den Berghe
202 schema:givenName L
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006624530.84
204 rdf:type schema:Person
205 sg:person.01034432262.26 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
206 schema:familyName Lane
207 schema:givenName D P
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034432262.26
209 rdf:type schema:Person
210 sg:person.01202133516.87 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
211 schema:familyName Bernard
212 schema:givenName H
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202133516.87
214 rdf:type schema:Person
215 sg:person.01306520207.63 schema:affiliation https://www.grid.ac/institutes/grid.8241.f
216 schema:familyName Bourdon
217 schema:givenName J C
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306520207.63
219 rdf:type schema:Person
220 sg:person.01332557702.13 schema:affiliation https://www.grid.ac/institutes/grid.11417.32
221 schema:familyName Ainaoui
222 schema:givenName N
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332557702.13
224 rdf:type schema:Person
225 sg:person.046113262.70 schema:affiliation https://www.grid.ac/institutes/grid.493861.1
226 schema:familyName Bikfalvi
227 schema:givenName A
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.046113262.70
229 rdf:type schema:Person
230 sg:person.0601123317.74 schema:affiliation https://www.grid.ac/institutes/grid.457379.b
231 schema:familyName Garmy-Susini
232 schema:givenName B
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601123317.74
234 rdf:type schema:Person
235 sg:person.0706430103.52 schema:affiliation https://www.grid.ac/institutes/grid.493861.1
236 schema:familyName Javerzat
237 schema:givenName S
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706430103.52
239 rdf:type schema:Person
240 sg:person.0775356502.86 schema:affiliation https://www.grid.ac/institutes/grid.11417.32
241 schema:familyName Prats
242 schema:givenName A-C
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775356502.86
244 rdf:type schema:Person
245 sg:pub.10.1007/s00109-007-0221-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163119
246 https://doi.org/10.1007/s00109-007-0221-2
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/cdd.2010.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031927795
249 https://doi.org/10.1038/cdd.2010.91
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature04871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023231275
252 https://doi.org/10.1038/nature04871
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/ncb1928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019118231
255 https://doi.org/10.1038/ncb1928
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/onc.2010.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031058360
258 https://doi.org/10.1038/onc.2010.26
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/sj.bjc.6603886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009327734
261 https://doi.org/10.1038/sj.bjc.6603886
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/sj.onc.1204271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042029677
264 https://doi.org/10.1038/sj.onc.1204271
265 rdf:type schema:CreativeWork
266 sg:pub.10.1186/1471-213x-10-102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032010095
267 https://doi.org/10.1186/1471-213x-10-102
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/1471-2342-8-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041063545
270 https://doi.org/10.1186/1471-2342-8-16
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/bcr2811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022254339
273 https://doi.org/10.1186/bcr2811
274 rdf:type schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1074578268 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1074881987 schema:CreativeWork
277 https://doi.org/10.1002/ijc.23313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019535003
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1006/mthe.2001.0282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012991962
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.ccr.2009.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012366197
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.ccr.2009.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020649367
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.devcel.2009.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019893607
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.jocn.2009.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007407929
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.0408622102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048544695
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.0608017103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011000123
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.91.19.9009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025806612
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1101/gad.1339905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022277460
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1101/gad.1761609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033279928
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.7521539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647420
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/stke.3542006pe35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062693457
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/mcb.22.8.2575-2585.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011572400
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1158/0008-5472.can-04-0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009447972
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1177/1947601911408893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050181761
308 rdf:type schema:CreativeWork
309 https://doi.org/10.2353/ajpath.2007.070011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037059154
310 rdf:type schema:CreativeWork
311 https://doi.org/10.4161/cc.5.16.3018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298564
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.11417.32 schema:alternateName University of Toulouse
314 schema:name Université de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.457379.b schema:alternateName Délégation Midi-Pyrénées, Limousin
317 schema:name Inserm, U1037, Toulouse, France
318 Université de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.462178.e schema:alternateName Institute of Cardiovascular and Metabolic Diseases
321 schema:name Inserm, U1048, F-31432 Toulouse, France
322 Université de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.493861.1 schema:alternateName Angiogenesis and Cancer Microenvironment Laboratory
325 schema:name Inserm, U920, Talence, France
326 Université de Bordeaux 1, Angiogenesis and Cancer Microenvironment Laboratory, Talence, France
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.8241.f schema:alternateName University of Dundee
329 schema:name Department of Surgery and Molecular Oncology, University of Dundee, Dundee, UK
330 Université de Toulouse, UPS, TRADGENE, Laboratory of Translational Control and Gene Therapy of Vascular Diseases, EA4554, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...