MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-18

AUTHORS

S T Guo, C C Jiang, G P Wang, Y P Li, C Y Wang, X Y Guo, R H Yang, Y Feng, F H Wang, H-Y Tseng, R F Thorne, L Jin, X D Zhang

ABSTRACT

Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC) development, progression and resistance to treatment. In this report, we demonstrate that downregulation of microRNA-497 (miR-497) as a result of DNA copy number reduction is involved in upregulation of IGF1-R in CRC cells. MiR-497 and miR-195 of the miR-15/16/195/424/497 family that share the same 3′ untranslated region (3′UTR) binding seed sequence and are predicted to target IGF1-R were concurrently downregulated in the majority of CRC tissues relative to paired adjacent normal mucosa. However, only overexpression of miR-497 led to suppression of the IGF1-R 3′UTR activity and downregulation of the endogenous IGF1-R protein in CRC cells. This was associated with inhibition of cell survival, proliferation and invasion, and increased sensitivity to apoptosis induced by various stimuli including the chemotherapeutic drugs cisplatin and 5-fluorouracil, and the death ligand tumour necrosis factor-related apoptosis-inducing ligand. The biological effect of miR-497 on CRC cells was largely mediated by inhibition of phosphatidylinositol 3-kinase/Akt signalling, as overexpression of an active form of Akt reversed its impact on cell survival and proliferation, recapitulating the effect of overexpression of IGF1-R. Downregulation of miR-497 and miR-195 appeared to associate with copy number loss of a segment of chromosome 17p13.1, where these miRs are located at proximity. Similarly to miR-195, the members of the same miR family, miR-424 that was upregulated, and miR-15a, miR-15b and miR-16 that were unaltered in expression in CRC tissues compared with paired adjacent normal mucosa, did not appear to have a role in regulating the expression of IGF1-R. Taken together, these results identify downregulation of miR-497 as an important mechanism of upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC. More... »

PAGES

1910-1920

References to SciGraph publications

  • 2010-03-19. Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells in CELL DEATH & DIFFERENTIATION
  • 2011-03-21. Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress in ONCOGENE
  • 2004-09-29. A custom microarray platform for analysis of microRNA gene expression in NATURE METHODS
  • 2010-06-15. Molecular circuits of solid tumors: prognostic and predictive tools for bedside use in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2009-01-12. Role of miR-143 targeting KRAS in colorectal tumorigenesis in ONCOGENE
  • 2011-03-10. Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer in MEDICAL ONCOLOGY
  • 2004-07. MicroRNAs: small RNAs with a big role in gene regulation in NATURE REVIEWS GENETICS
  • 2008-12. Insulin and insulin-like growth factor signalling in neoplasia in NATURE REVIEWS CANCER
  • 2008-08-01. Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma in MODERN PATHOLOGY
  • 2007-06-12. Characterization of microRNA expression profiles in normal human tissues in BMC GENOMICS
  • 2011-01-22. miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2 in MEDICAL ONCOLOGY
  • 2006-08-20. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2006-11. MicroRNA signatures in human cancers in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2012.214

    DOI

    http://dx.doi.org/10.1038/onc.2012.214

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030059862

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22710713


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "3' Untranslated Regions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cisplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Progression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Down-Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorouracil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Insulin-Like Growth Factor I", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "MicroRNAs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphatidylinositol 3-Kinase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-akt", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor, IGF Type 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "S T", 
            "id": "sg:person.01330754414.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330754414.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.413648.c", 
              "name": [
                "Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia", 
                "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jiang", 
            "givenName": "C C", 
            "id": "sg:person.0617201523.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617201523.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "G P", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Y P", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "C Y", 
            "id": "sg:person.0711326116.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711326116.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "X Y", 
            "id": "sg:person.0764253760.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764253760.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "R H", 
            "id": "sg:person.01155207543.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155207543.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Feng", 
            "givenName": "Y", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "F H", 
            "id": "sg:person.01161050643.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161050643.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.413648.c", 
              "name": [
                "Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia", 
                "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tseng", 
            "givenName": "H-Y", 
            "id": "sg:person.01032164214.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032164214.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Unit, School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.266842.c", 
              "name": [
                "Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia", 
                "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia", 
                "Cancer Research Unit, School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thorne", 
            "givenName": "R F", 
            "id": "sg:person.01210202271.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210202271.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Immunology and Oncology Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.1013.3", 
              "name": [
                "Immunology and Oncology Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jin", 
            "givenName": "L", 
            "id": "sg:person.01246527316.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246527316.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia", 
              "id": "http://www.grid.ac/institutes/grid.413648.c", 
              "name": [
                "Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China", 
                "Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia", 
                "Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "X D", 
            "id": "sg:person.01210116316.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210116316.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrclinonc.2010.84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029236424", 
              "https://doi.org/10.1038/nrclinonc.2010.84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018370469", 
              "https://doi.org/10.1038/onc.2008.474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007628568", 
              "https://doi.org/10.1038/nsmb1138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039031247", 
              "https://doi.org/10.1038/onc.2011.87"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2008.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014814898", 
              "https://doi.org/10.1038/modpathol.2008.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044012298", 
              "https://doi.org/10.1038/nrc1997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2010.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035034614", 
              "https://doi.org/10.1038/cdd.2010.29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033290305", 
              "https://doi.org/10.1038/nmeth704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001799892", 
              "https://doi.org/10.1038/nrg1379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-011-9880-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011246366", 
              "https://doi.org/10.1007/s12032-011-9880-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050986935", 
              "https://doi.org/10.1038/nrc2536"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-010-9797-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030862577", 
              "https://doi.org/10.1007/s12032-010-9797-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-8-166", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015513310", 
              "https://doi.org/10.1186/1471-2164-8-166"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-06-18", 
        "datePublishedReg": "2012-06-18", 
        "description": "Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC) development, progression and resistance to treatment. In this report, we demonstrate that downregulation of microRNA-497 (miR-497) as a result of DNA copy number reduction is involved in upregulation of IGF1-R in CRC cells. MiR-497 and miR-195 of the miR-15/16/195/424/497 family that share the same 3\u2032 untranslated region (3\u2032UTR) binding seed sequence and are predicted to target IGF1-R were concurrently downregulated in the majority of CRC tissues relative to paired adjacent normal mucosa. However, only overexpression of miR-497 led to suppression of the IGF1-R 3\u2032UTR activity and downregulation of the endogenous IGF1-R protein in CRC cells. This was associated with inhibition of cell survival, proliferation and invasion, and increased sensitivity to apoptosis induced by various stimuli including the chemotherapeutic drugs cisplatin and 5-fluorouracil, and the death ligand tumour necrosis factor-related apoptosis-inducing ligand. The biological effect of miR-497 on CRC cells was largely mediated by inhibition of phosphatidylinositol 3-kinase/Akt signalling, as overexpression of an active form of Akt reversed its impact on cell survival and proliferation, recapitulating the effect of overexpression of IGF1-R. Downregulation of miR-497 and miR-195 appeared to associate with copy number loss of a segment of chromosome 17p13.1, where these miRs are located at proximity. Similarly to miR-195, the members of the same miR family, miR-424 that was upregulated, and miR-15a, miR-15b and miR-16 that were unaltered in expression in CRC tissues compared with paired adjacent normal mucosa, did not appear to have a role in regulating the expression of IGF1-R. Taken together, these results identify downregulation of miR-497 as an important mechanism of upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/onc.2012.214", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "15", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "32"
          }
        ], 
        "keywords": [
          "insulin-like growth factor-1", 
          "CRC cells", 
          "adjacent normal mucosa", 
          "miR-497", 
          "miR-195", 
          "cell survival", 
          "death ligand tumor necrosis factor-related apoptosis-inducing ligand", 
          "CRC tissues", 
          "normal mucosa", 
          "ligand tumor necrosis factor-related apoptosis-inducing ligand", 
          "inhibition of phosphatidylinositol", 
          "expression of IGF1", 
          "copy number reduction", 
          "insulin-like growth factor 1 receptor", 
          "growth factor 1 receptor", 
          "copy number loss", 
          "colorectal cancer development", 
          "effects of overexpression", 
          "tumor suppressive role", 
          "factor 1 receptor", 
          "human colorectal cancer", 
          "tumor necrosis factor-related apoptosis-inducing ligand", 
          "necrosis factor-related apoptosis-inducing ligand", 
          "factor-related apoptosis-inducing ligand", 
          "growth factor-1", 
          "seed sequence", 
          "apoptosis-inducing ligand", 
          "miR families", 
          "untranslated region", 
          "chemotherapeutic drug cisplatin", 
          "receptor signaling", 
          "chromosome 17p13.1", 
          "colorectal cancer", 
          "microRNA-497", 
          "number loss", 
          "factor 1", 
          "suppressive role", 
          "cancer development", 
          "miR-424", 
          "overexpression", 
          "active form", 
          "miR-15b", 
          "downregulation", 
          "miR-16", 
          "Akt", 
          "important mechanism", 
          "mucosa", 
          "biological effects", 
          "cells", 
          "drug cisplatin", 
          "number reduction", 
          "upregulation", 
          "survival", 
          "expression", 
          "proliferation", 
          "important role", 
          "inhibition", 
          "tissue", 
          "family", 
          "phosphatidylinositol", 
          "signaling", 
          "protein", 
          "role", 
          "malignancy", 
          "apoptosis", 
          "cancer", 
          "cisplatin", 
          "progression", 
          "CRC", 
          "miR", 
          "receptors", 
          "sequence", 
          "invasion", 
          "treatment", 
          "report", 
          "effect", 
          "members", 
          "stimuli", 
          "majority", 
          "suppression", 
          "mechanism", 
          "ligands", 
          "activity", 
          "study", 
          "region", 
          "sensitivity", 
          "resistance", 
          "reduction", 
          "loss", 
          "proximity", 
          "past studies", 
          "results", 
          "segments", 
          "development", 
          "impact", 
          "form"
        ], 
        "name": "MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer", 
        "pagination": "1910-1920", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1030059862"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2012.214"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22710713"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2012.214", 
          "https://app.dimensions.ai/details/publication/pub.1030059862"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:56", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_559.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/onc.2012.214"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.214'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.214'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.214'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2012.214'


     

    This table displays all metadata directly associated to this object as RDF triples.

    389 TRIPLES      21 PREDICATES      155 URIs      134 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2012.214 schema:about N0526f83bdc03489782a2228964ca62b0
    2 N0d6ba61491d64738891af5e6d6ccf183
    3 N2218b09a653d4267b1d811d51a8853e9
    4 N37f11b68f8e64f9aaf0690a47db470b7
    5 N413729ca87fb46f18edc293830793c72
    6 N46aed31793ed48caab4fe5c76f4ae0bf
    7 N471a9f9ec4f64baaa743f1c65c219bdf
    8 N4bc8313d22e44305af082db5debeae43
    9 N56acf2eed0624e8eb63c835084ae66cd
    10 N573f4cfc44d74115a166215fa4dd58a4
    11 N6d565ad7d5c345b88870b6035a2c76f6
    12 N70a1431657f44fc4bc2385e62755db4b
    13 N7c6cc51a6023477792099af055da95cf
    14 N862ce21e118a44e69c18d733628d2399
    15 N8bba7d26a9d443afb6c2455b2423c279
    16 N8fb5897e5c564912bf26502af5c2bf57
    17 N975f2e2e46c6498e80b22f557efd93b4
    18 Nc4639adfb5854e6b8417821da9aba365
    19 Nc553fea8ef324bb184f3da89f1ba2478
    20 Nd29278c96be64599b817fb8cf7963fa1
    21 Nec6aa5660a9e47128311d9611d995ce4
    22 anzsrc-for:11
    23 anzsrc-for:1112
    24 schema:author N891ec5f2b0cc4eec805cd4a94f360613
    25 schema:citation sg:pub.10.1007/s12032-010-9797-4
    26 sg:pub.10.1007/s12032-011-9880-5
    27 sg:pub.10.1038/cdd.2010.29
    28 sg:pub.10.1038/modpathol.2008.135
    29 sg:pub.10.1038/nmeth704
    30 sg:pub.10.1038/nrc1997
    31 sg:pub.10.1038/nrc2536
    32 sg:pub.10.1038/nrclinonc.2010.84
    33 sg:pub.10.1038/nrg1379
    34 sg:pub.10.1038/nsmb1138
    35 sg:pub.10.1038/onc.2008.474
    36 sg:pub.10.1038/onc.2011.87
    37 sg:pub.10.1186/1471-2164-8-166
    38 schema:datePublished 2012-06-18
    39 schema:datePublishedReg 2012-06-18
    40 schema:description Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor (IGF1-R) signalling has an important role in colorectal cancer (CRC) development, progression and resistance to treatment. In this report, we demonstrate that downregulation of microRNA-497 (miR-497) as a result of DNA copy number reduction is involved in upregulation of IGF1-R in CRC cells. MiR-497 and miR-195 of the miR-15/16/195/424/497 family that share the same 3′ untranslated region (3′UTR) binding seed sequence and are predicted to target IGF1-R were concurrently downregulated in the majority of CRC tissues relative to paired adjacent normal mucosa. However, only overexpression of miR-497 led to suppression of the IGF1-R 3′UTR activity and downregulation of the endogenous IGF1-R protein in CRC cells. This was associated with inhibition of cell survival, proliferation and invasion, and increased sensitivity to apoptosis induced by various stimuli including the chemotherapeutic drugs cisplatin and 5-fluorouracil, and the death ligand tumour necrosis factor-related apoptosis-inducing ligand. The biological effect of miR-497 on CRC cells was largely mediated by inhibition of phosphatidylinositol 3-kinase/Akt signalling, as overexpression of an active form of Akt reversed its impact on cell survival and proliferation, recapitulating the effect of overexpression of IGF1-R. Downregulation of miR-497 and miR-195 appeared to associate with copy number loss of a segment of chromosome 17p13.1, where these miRs are located at proximity. Similarly to miR-195, the members of the same miR family, miR-424 that was upregulated, and miR-15a, miR-15b and miR-16 that were unaltered in expression in CRC tissues compared with paired adjacent normal mucosa, did not appear to have a role in regulating the expression of IGF1-R. Taken together, these results identify downregulation of miR-497 as an important mechanism of upregulation of IGF1-R in CRC cells that contributes to malignancy of CRC.
    41 schema:genre article
    42 schema:isAccessibleForFree true
    43 schema:isPartOf N069b69753ac64407bf190a119a70f1f3
    44 N581f8599265d40d1a8653873732bec1a
    45 sg:journal.1097543
    46 schema:keywords Akt
    47 CRC
    48 CRC cells
    49 CRC tissues
    50 active form
    51 activity
    52 adjacent normal mucosa
    53 apoptosis
    54 apoptosis-inducing ligand
    55 biological effects
    56 cancer
    57 cancer development
    58 cell survival
    59 cells
    60 chemotherapeutic drug cisplatin
    61 chromosome 17p13.1
    62 cisplatin
    63 colorectal cancer
    64 colorectal cancer development
    65 copy number loss
    66 copy number reduction
    67 death ligand tumor necrosis factor-related apoptosis-inducing ligand
    68 development
    69 downregulation
    70 drug cisplatin
    71 effect
    72 effects of overexpression
    73 expression
    74 expression of IGF1
    75 factor 1
    76 factor 1 receptor
    77 factor-related apoptosis-inducing ligand
    78 family
    79 form
    80 growth factor 1 receptor
    81 growth factor-1
    82 human colorectal cancer
    83 impact
    84 important mechanism
    85 important role
    86 inhibition
    87 inhibition of phosphatidylinositol
    88 insulin-like growth factor 1 receptor
    89 insulin-like growth factor-1
    90 invasion
    91 ligand tumor necrosis factor-related apoptosis-inducing ligand
    92 ligands
    93 loss
    94 majority
    95 malignancy
    96 mechanism
    97 members
    98 miR
    99 miR families
    100 miR-15b
    101 miR-16
    102 miR-195
    103 miR-424
    104 miR-497
    105 microRNA-497
    106 mucosa
    107 necrosis factor-related apoptosis-inducing ligand
    108 normal mucosa
    109 number loss
    110 number reduction
    111 overexpression
    112 past studies
    113 phosphatidylinositol
    114 progression
    115 proliferation
    116 protein
    117 proximity
    118 receptor signaling
    119 receptors
    120 reduction
    121 region
    122 report
    123 resistance
    124 results
    125 role
    126 seed sequence
    127 segments
    128 sensitivity
    129 sequence
    130 signaling
    131 stimuli
    132 study
    133 suppression
    134 suppressive role
    135 survival
    136 tissue
    137 treatment
    138 tumor necrosis factor-related apoptosis-inducing ligand
    139 tumor suppressive role
    140 untranslated region
    141 upregulation
    142 schema:name MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
    143 schema:pagination 1910-1920
    144 schema:productId N8dc5b47fa9064cae94210c0b7f6a476a
    145 Nb9953850cdcc42e5818591ca5ea36eaa
    146 Nf43adb31f6cb4583b28d22cd0948b395
    147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030059862
    148 https://doi.org/10.1038/onc.2012.214
    149 schema:sdDatePublished 2022-09-02T15:56
    150 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    151 schema:sdPublisher Ndd87911201b7489b9c21c405708b7245
    152 schema:url https://doi.org/10.1038/onc.2012.214
    153 sgo:license sg:explorer/license/
    154 sgo:sdDataset articles
    155 rdf:type schema:ScholarlyArticle
    156 N0526f83bdc03489782a2228964ca62b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Humans
    158 rdf:type schema:DefinedTerm
    159 N069b69753ac64407bf190a119a70f1f3 schema:volumeNumber 32
    160 rdf:type schema:PublicationVolume
    161 N0d6ba61491d64738891af5e6d6ccf183 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Cell Line, Tumor
    163 rdf:type schema:DefinedTerm
    164 N2218b09a653d4267b1d811d51a8853e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name DNA Copy Number Variations
    166 rdf:type schema:DefinedTerm
    167 N33693456d19344ddb1d8b8fa73297892 schema:affiliation grid-institutes:None
    168 schema:familyName Feng
    169 schema:givenName Y
    170 rdf:type schema:Person
    171 N37f11b68f8e64f9aaf0690a47db470b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Receptor, IGF Type 1
    173 rdf:type schema:DefinedTerm
    174 N413729ca87fb46f18edc293830793c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name MicroRNAs
    176 rdf:type schema:DefinedTerm
    177 N46aed31793ed48caab4fe5c76f4ae0bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Colorectal Neoplasms
    179 rdf:type schema:DefinedTerm
    180 N471a9f9ec4f64baaa743f1c65c219bdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Signal Transduction
    182 rdf:type schema:DefinedTerm
    183 N4bc8313d22e44305af082db5debeae43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Down-Regulation
    185 rdf:type schema:DefinedTerm
    186 N56acf2eed0624e8eb63c835084ae66cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Cisplatin
    188 rdf:type schema:DefinedTerm
    189 N573f4cfc44d74115a166215fa4dd58a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Disease Progression
    191 rdf:type schema:DefinedTerm
    192 N581f8599265d40d1a8653873732bec1a schema:issueNumber 15
    193 rdf:type schema:PublicationIssue
    194 N583807b205aa4831a2cf5440e481dfed rdf:first sg:person.01210116316.18
    195 rdf:rest rdf:nil
    196 N5b82aa4dd5d1469685a998a162f4dbe8 rdf:first sg:person.01161050643.45
    197 rdf:rest Nade6878966974c6da0742f8bc2962f59
    198 N6d565ad7d5c345b88870b6035a2c76f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Insulin-Like Growth Factor I
    200 rdf:type schema:DefinedTerm
    201 N70a1431657f44fc4bc2385e62755db4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Fluorouracil
    203 rdf:type schema:DefinedTerm
    204 N75fbc85a6b7a4cbe9636c74b37666b8a rdf:first N9406343e69494058837b2f9b106575e9
    205 rdf:rest Nf08327a07e9640a6ae0db7c59189be82
    206 N7c6cc51a6023477792099af055da95cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Phosphatidylinositol 3-Kinase
    208 rdf:type schema:DefinedTerm
    209 N8040283912e54901ba5e3bbf27bd79f1 rdf:first sg:person.0764253760.35
    210 rdf:rest Ne1a3e5dacd42423b96684fabcf615628
    211 N862ce21e118a44e69c18d733628d2399 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Apoptosis
    213 rdf:type schema:DefinedTerm
    214 N891ec5f2b0cc4eec805cd4a94f360613 rdf:first sg:person.01330754414.20
    215 rdf:rest Na958d2e7e50d4619bf1b08b6dc2d1296
    216 N8bba7d26a9d443afb6c2455b2423c279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name 3' Untranslated Regions
    218 rdf:type schema:DefinedTerm
    219 N8dc5b47fa9064cae94210c0b7f6a476a schema:name doi
    220 schema:value 10.1038/onc.2012.214
    221 rdf:type schema:PropertyValue
    222 N8fb5897e5c564912bf26502af5c2bf57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Drug Resistance, Neoplasm
    224 rdf:type schema:DefinedTerm
    225 N9406343e69494058837b2f9b106575e9 schema:affiliation grid-institutes:None
    226 schema:familyName Wang
    227 schema:givenName G P
    228 rdf:type schema:Person
    229 N975f2e2e46c6498e80b22f557efd93b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    230 schema:name Gene Expression Regulation, Neoplastic
    231 rdf:type schema:DefinedTerm
    232 N9991c409bcce408bb38e71879731d0da rdf:first sg:person.0711326116.01
    233 rdf:rest N8040283912e54901ba5e3bbf27bd79f1
    234 Na958d2e7e50d4619bf1b08b6dc2d1296 rdf:first sg:person.0617201523.26
    235 rdf:rest N75fbc85a6b7a4cbe9636c74b37666b8a
    236 Nade6878966974c6da0742f8bc2962f59 rdf:first sg:person.01032164214.33
    237 rdf:rest Nf7b5b595302f4e94a94b3338f3782598
    238 Nb9953850cdcc42e5818591ca5ea36eaa schema:name pubmed_id
    239 schema:value 22710713
    240 rdf:type schema:PropertyValue
    241 Nc4639adfb5854e6b8417821da9aba365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Cell Survival
    243 rdf:type schema:DefinedTerm
    244 Nc553fea8ef324bb184f3da89f1ba2478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Cell Proliferation
    246 rdf:type schema:DefinedTerm
    247 Nc990a0cb9f5946a6a7688935dbc071fa schema:affiliation grid-institutes:None
    248 schema:familyName Li
    249 schema:givenName Y P
    250 rdf:type schema:Person
    251 Ncf4e970c210c4fe7967e12047e47e103 rdf:first N33693456d19344ddb1d8b8fa73297892
    252 rdf:rest N5b82aa4dd5d1469685a998a162f4dbe8
    253 Ncf82ed7c402c4e2385a6ce9d1f095e2e rdf:first sg:person.01246527316.15
    254 rdf:rest N583807b205aa4831a2cf5440e481dfed
    255 Nd29278c96be64599b817fb8cf7963fa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    256 schema:name Neoplasm Invasiveness
    257 rdf:type schema:DefinedTerm
    258 Ndd87911201b7489b9c21c405708b7245 schema:name Springer Nature - SN SciGraph project
    259 rdf:type schema:Organization
    260 Ne1a3e5dacd42423b96684fabcf615628 rdf:first sg:person.01155207543.36
    261 rdf:rest Ncf4e970c210c4fe7967e12047e47e103
    262 Nec6aa5660a9e47128311d9611d995ce4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Proto-Oncogene Proteins c-akt
    264 rdf:type schema:DefinedTerm
    265 Nf08327a07e9640a6ae0db7c59189be82 rdf:first Nc990a0cb9f5946a6a7688935dbc071fa
    266 rdf:rest N9991c409bcce408bb38e71879731d0da
    267 Nf43adb31f6cb4583b28d22cd0948b395 schema:name dimensions_id
    268 schema:value pub.1030059862
    269 rdf:type schema:PropertyValue
    270 Nf7b5b595302f4e94a94b3338f3782598 rdf:first sg:person.01210202271.19
    271 rdf:rest Ncf82ed7c402c4e2385a6ce9d1f095e2e
    272 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    273 schema:name Medical and Health Sciences
    274 rdf:type schema:DefinedTerm
    275 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    276 schema:name Oncology and Carcinogenesis
    277 rdf:type schema:DefinedTerm
    278 sg:journal.1097543 schema:issn 0950-9232
    279 1476-5594
    280 schema:name Oncogene
    281 schema:publisher Springer Nature
    282 rdf:type schema:Periodical
    283 sg:person.01032164214.33 schema:affiliation grid-institutes:grid.413648.c
    284 schema:familyName Tseng
    285 schema:givenName H-Y
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032164214.33
    287 rdf:type schema:Person
    288 sg:person.01155207543.36 schema:affiliation grid-institutes:None
    289 schema:familyName Yang
    290 schema:givenName R H
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155207543.36
    292 rdf:type schema:Person
    293 sg:person.01161050643.45 schema:affiliation grid-institutes:None
    294 schema:familyName Wang
    295 schema:givenName F H
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161050643.45
    297 rdf:type schema:Person
    298 sg:person.01210116316.18 schema:affiliation grid-institutes:grid.413648.c
    299 schema:familyName Zhang
    300 schema:givenName X D
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210116316.18
    302 rdf:type schema:Person
    303 sg:person.01210202271.19 schema:affiliation grid-institutes:grid.266842.c
    304 schema:familyName Thorne
    305 schema:givenName R F
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210202271.19
    307 rdf:type schema:Person
    308 sg:person.01246527316.15 schema:affiliation grid-institutes:grid.1013.3
    309 schema:familyName Jin
    310 schema:givenName L
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246527316.15
    312 rdf:type schema:Person
    313 sg:person.01330754414.20 schema:affiliation grid-institutes:None
    314 schema:familyName Guo
    315 schema:givenName S T
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330754414.20
    317 rdf:type schema:Person
    318 sg:person.0617201523.26 schema:affiliation grid-institutes:grid.413648.c
    319 schema:familyName Jiang
    320 schema:givenName C C
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617201523.26
    322 rdf:type schema:Person
    323 sg:person.0711326116.01 schema:affiliation grid-institutes:None
    324 schema:familyName Wang
    325 schema:givenName C Y
    326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711326116.01
    327 rdf:type schema:Person
    328 sg:person.0764253760.35 schema:affiliation grid-institutes:None
    329 schema:familyName Guo
    330 schema:givenName X Y
    331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764253760.35
    332 rdf:type schema:Person
    333 sg:pub.10.1007/s12032-010-9797-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030862577
    334 https://doi.org/10.1007/s12032-010-9797-4
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s12032-011-9880-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011246366
    337 https://doi.org/10.1007/s12032-011-9880-5
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/cdd.2010.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035034614
    340 https://doi.org/10.1038/cdd.2010.29
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/modpathol.2008.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014814898
    343 https://doi.org/10.1038/modpathol.2008.135
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nmeth704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033290305
    346 https://doi.org/10.1038/nmeth704
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nrc1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044012298
    349 https://doi.org/10.1038/nrc1997
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nrc2536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986935
    352 https://doi.org/10.1038/nrc2536
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nrclinonc.2010.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029236424
    355 https://doi.org/10.1038/nrclinonc.2010.84
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nrg1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001799892
    358 https://doi.org/10.1038/nrg1379
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nsmb1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007628568
    361 https://doi.org/10.1038/nsmb1138
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/onc.2008.474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018370469
    364 https://doi.org/10.1038/onc.2008.474
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/onc.2011.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039031247
    367 https://doi.org/10.1038/onc.2011.87
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1186/1471-2164-8-166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015513310
    370 https://doi.org/10.1186/1471-2164-8-166
    371 rdf:type schema:CreativeWork
    372 grid-institutes:None schema:alternateName Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Taiyuan, China
    373 Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China
    374 schema:name Department of Colorectal Surgery, Shanxi Cancer Hospital and Institute, Taiyuan, China
    375 Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China
    376 rdf:type schema:Organization
    377 grid-institutes:grid.1013.3 schema:alternateName Immunology and Oncology Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
    378 schema:name Immunology and Oncology Laboratory, Kolling Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
    379 rdf:type schema:Organization
    380 grid-institutes:grid.266842.c schema:alternateName Cancer Research Unit, School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia
    381 schema:name Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    382 Cancer Research Unit, School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia
    383 Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia
    384 rdf:type schema:Organization
    385 grid-institutes:grid.413648.c schema:alternateName Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    386 schema:name Cancer Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    387 Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, China
    388 Priority Research Centre for Cancer Research, University of Newcastle, Newcastle, New South Wales, Australia
    389 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...