Epigenetic regulation of aging stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

E A Pollina, A Brunet

ABSTRACT

The function of adult tissue-specific stem cells declines with age, which may contribute to the physiological decline in tissue homeostasis and the increased risk of neoplasm during aging. Old stem cells can be 'rejuvenated' by environmental stimuli in some cases, raising the possibility that a subset of age-dependent stem cell changes is regulated by reversible mechanisms. Epigenetic regulators are good candidates for such mechanisms, as they provide a versatile checkpoint to mediate plastic changes in gene expression and have recently been found to control organismal longevity. Here, we review the importance of chromatin regulation in adult stem cell compartments. We particularly focus on the roles of chromatin-modifying complexes and transcription factors that directly impact chromatin in aging stem cells. Understanding the regulation of chromatin states in adult stem cells is likely to have important implications for identifying avenues to maintain the homeostatic balance between sustained function and neoplastic transformation of aging stem cells. More... »

PAGES

3105

References to SciGraph publications

  • 2009-08. Age-related difference of site-specific histone modifications in rat liver in BIOGERONTOLOGY
  • 1997-07. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging in ONCOGENE
  • 2005-04. Wnt signalling in stem cells and cancer in NATURE
  • 2005-08. The adult muscle stem cell comes of age in NATURE MEDICINE
  • 2007-08. HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention in ONCOGENE
  • 2003-02. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement in NATURE IMMUNOLOGY
  • 2006-09. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a in NATURE
  • 2001-08. Purification of a pluripotent neural stem cell from the adult mouse brain in NATURE
  • 2006-02. The Polycomb group protein EZH2 directly controls DNA methylation in NATURE
  • 1998-06. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription in NATURE GENETICS
  • 2007-11. Histone lysine demethylases: emerging roles in development, physiology and disease in NATURE REVIEWS GENETICS
  • 2010-10. Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress in NATURE CELL BIOLOGY
  • 2003-03. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals in NATURE GENETICS
  • 1999-01. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus in NATURE
  • 1998-05. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex in NATURE
  • 2008-10. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain in NATURE NEUROSCIENCE
  • 2000-07. Gene-expression profile of the ageing brain in mice in NATURE GENETICS
  • 2002-05. Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons in NATURE NEUROSCIENCE
  • 2011-01-06. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice in NATURE
  • 2009-07. Telomerase modulates Wnt signalling by association with target gene chromatin in NATURE
  • 2005-08. Conditional telomerase induction causes proliferation of hair follicle stem cells in NATURE
  • 2004-10. Role of histone H2A ubiquitination in Polycomb silencing in NATURE
  • 2009-06. Hematopoietic stem cell ageing is uncoupled from p16INK4A-mediated senescence in ONCOGENE
  • 2005-11. FOXO transcription factors at the interface between longevity and tumor suppression in ONCOGENE
  • 1998-11. Neurogenesis in the adult human hippocampus in NATURE MEDICINE
  • 2005-02. Rejuvenation of aged progenitor cells by exposure to a young systemic environment in NATURE
  • 1996-09. The aging of hematopoietic stem cells in NATURE MEDICINE
  • 2007-09. How stem cells age and why this makes us grow old in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-02. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration in NATURE
  • 2008-04. Sirt1 contributes critically to the redox-dependent fate of neural progenitors in NATURE CELL BIOLOGY
  • 2002-05. Cell fate determination from stem cells in GENE THERAPY
  • 2006-01. Generation of a functional mammary gland from a single stem cell in NATURE
  • 2000-02. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase in NATURE
  • 2010-02. TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia in NATURE
  • 1997-07. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell in NATURE MEDICINE
  • 1999-03. Learning enhances adult neurogenesis in the hippocampal formation in NATURE NEUROSCIENCE
  • 2006-09. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing in NATURE
  • 2005-09. Information networks in the mammary gland in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1999-10. Restoring production of hippocampal neurons in old age in NATURE NEUROSCIENCE
  • 2007-04. The epigenetic regulation of mammalian telomeres in NATURE REVIEWS GENETICS
  • 1977-01. The role of the subependymal plate in glial tumorigenesis in ACTA NEUROPATHOLOGICA
  • 2007-06-07. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age in NATURE
  • 2001-03. Neurogenesis in the adult is involved in the formation of trace memories in NATURE
  • 2010-11. Epigenetic choreographers of neurogenesis in the adult mammalian brain in NATURE NEUROSCIENCE
  • 2009-03-26. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells in NATURE
  • 2006-08. Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9 in NATURE
  • 2010-07. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans in NATURE
  • 2008-07. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells in NATURE
  • 2007-03. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus in NATURE NEUROSCIENCE
  • 2006-10. Hematopoietic stem cell and multilineage defects generated by constitutive β-catenin activation in NATURE IMMUNOLOGY
  • 2003-05. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells in NATURE
  • 2008-03. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin in NATURE
  • 2001-03. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans in NATURE
  • 2007-06-07. DNA repair is limiting for haematopoietic stem cells during ageing in NATURE
  • 2009-05. Bmi1 regulates mitochondrial function and the DNA damage response pathway in NATURE
  • 2004-08. Sirtuin activators mimic caloric restriction and delay ageing in metazoans in NATURE
  • 2008-09. Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency in NATURE NEUROSCIENCE
  • 2006-06. Stem cells, ageing and the quest for immortality in NATURE
  • 2010-01. Chromatin remodelling during development in NATURE
  • 1968-03. Mitotic Activity in the Primate Subependymal Layer and the Genesis of Gliomas in NATURE
  • 2007-09. Aging and the Germ Line: Where Mortality and Immortality Meet in STEM CELL REVIEWS AND REPORTS
  • 2007-10-25. Identification of stem cells in small intestine and colon by marker gene Lgr5 in NATURE
  • 2007-04. Histone acetyltransferase complexes: one size doesn't fit all in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-11. Self-renewal and expansion of single transplanted muscle stem cells in NATURE
  • 2007-11. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron in NATURE
  • 2004-01. Expression and function of orphan nuclear receptor TLX in adult neural stem cells in NATURE
  • 1997-10. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans in NATURE
  • 2003-10. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation in NATURE
  • 2009-06. Histone H4 lysine 16 acetylation regulates cellular lifespan in NATURE
  • 2004-06. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body in NATURE
  • 2010-03. Linking functional decline of telomeres, mitochondria and stem cells during ageing in NATURE
  • 2006-02. Purification and unique properties of mammary epithelial stem cells in NATURE
  • 2007-02. Histone deacetylase inhibitors increase neuronal differentiation in adult forebrain precursor cells in EXPERIMENTAL BRAIN RESEARCH
  • 2008-02. A role for adult TLX-positive neural stem cells in learning and behaviour in NATURE
  • 2003-05. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells in NATURE
  • 2010-01. DNMT1 maintains progenitor function in self-renewing somatic tissue in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2011.45

    DOI

    http://dx.doi.org/10.1038/onc.2011.45

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040028263

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21441951


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cellular Senescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleoproteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Genetics, Stanford University, Stanford, CA, USA", 
                "Cancer Biology Program, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pollina", 
            "givenName": "E A", 
            "id": "sg:person.01324363651.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324363651.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Genetics, Stanford University, Stanford, CA, USA", 
                "Cancer Biology Program, Stanford University, Stanford, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brunet", 
            "givenName": "A", 
            "id": "sg:person.01057654457.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057654457.41"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1101/gad.1299305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000382265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0907739107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000470475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000523667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000568054", 
              "https://doi.org/10.1038/nature05875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000676670", 
              "https://doi.org/10.1038/ncb1700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2010-03-273011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000812322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001004550", 
              "https://doi.org/10.1038/nature02301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001004550", 
              "https://doi.org/10.1038/nature02301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001431745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2008.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001839137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1186088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001931865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812889106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002066445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812889106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002066445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.08.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002102577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002353562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002683470", 
              "https://doi.org/10.1038/sj.onc.1210599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci22475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002738628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.232568499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003031569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003614107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003614107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-2725(03)00042-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003857222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-2725(03)00042-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003857222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2000037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004000728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1061803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004107821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ydbio.2009.08.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004247307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004325946", 
              "https://doi.org/10.1038/nature05862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1144914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004379651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1000834107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004497675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.11.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004605245"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-0054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005048421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1382606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005144219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00688574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005520513", 
              "https://doi.org/10.1007/bf00688574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005546919", 
              "https://doi.org/10.1038/30764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2006.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005646389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006232285", 
              "https://doi.org/10.1038/nrg2047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4547(20000201)59:3<321::aid-jnr5>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006288011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1148-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006302647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.09.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006532265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006598727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0810407106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007019220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1467506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007038366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4598(199802)21:2<173::aid-mus4>3.0.co;2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007097588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007121562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007203457", 
              "https://doi.org/10.1038/nature05091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007203457", 
              "https://doi.org/10.1038/nature05091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007203457", 
              "https://doi.org/10.1038/nature05091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0050201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008063798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008647780", 
              "https://doi.org/10.1038/nature04958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008647780", 
              "https://doi.org/10.1038/nature04958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008647780", 
              "https://doi.org/10.1038/nature04958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20070140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008696131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20070140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008696131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci1681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008797955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.200810133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008813128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.07.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009037364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.08.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009117044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.1999.7028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009203846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(01)00378-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009256429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0800612105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009394985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009453492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00976-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009600594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.9.1273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009649229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.9.1273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009649229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1588507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009827222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0400593101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010142859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.07.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010190073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010464606", 
              "https://doi.org/10.1038/nrm2145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.02723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010597130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.560310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010714597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.7.2804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010787745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2007.00286.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011036700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011173926", 
              "https://doi.org/10.1038/nature02211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011173926", 
              "https://doi.org/10.1038/nature02211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1098219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011596823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011608783", 
              "https://doi.org/10.1038/nature09603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.08.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011894036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3606-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012214228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2010.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012702371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012807910", 
              "https://doi.org/10.1038/13197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012807910", 
              "https://doi.org/10.1038/13197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jez.1402060314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012862364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jez.1402060314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012862364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013027025", 
              "https://doi.org/10.1038/nature04431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0502738102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013038260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(03)00083-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013451964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(03)00083-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013451964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013496507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013519146", 
              "https://doi.org/10.1038/nature02060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013519146", 
              "https://doi.org/10.1038/nature02060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-12-010272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014270779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014449689", 
              "https://doi.org/10.1038/nrm2241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0805-829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014461573", 
              "https://doi.org/10.1038/nm0805-829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0805-829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014461573", 
              "https://doi.org/10.1038/nm0805-829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/217974a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014574349", 
              "https://doi.org/10.1038/217974a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015082332", 
              "https://doi.org/10.1038/nature03836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015082332", 
              "https://doi.org/10.1038/nature03836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0805498105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015107556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.5.2074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015184172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015302967", 
              "https://doi.org/10.1038/ng1089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015302967", 
              "https://doi.org/10.1038/ng1089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1143578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015340165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0301-472x(00)00169-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015349508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1087573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015440760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015782956", 
              "https://doi.org/10.1038/sj.onc.1209086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015782956", 
              "https://doi.org/10.1038/sj.onc.1209086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015782956", 
              "https://doi.org/10.1038/sj.onc.1209086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2751-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016596945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.19.2570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016621585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0802674106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016837159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017093183", 
              "https://doi.org/10.1038/nature08982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017093183", 
              "https://doi.org/10.1038/nature08982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017457325", 
              "https://doi.org/10.1038/nature08085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017457325", 
              "https://doi.org/10.1038/nature08085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2006-0405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017494319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1144090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017696289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m412357200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017748692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m210256200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017827262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m401138200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017857173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-4695(199808)36:2<249::aid-neu11>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018157900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200401028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018292061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m800517200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018328585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0831-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018430012", 
              "https://doi.org/10.1007/s00221-006-0831-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0831-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018430012", 
              "https://doi.org/10.1007/s00221-006-0831-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2004.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018487280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018684028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80080-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018729685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0303792101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019561902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.10262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019711215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019794166", 
              "https://doi.org/10.1038/nature07034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019839382", 
              "https://doi.org/10.1038/35001622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35001622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019839382", 
              "https://doi.org/10.1038/35001622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020026641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0809594106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020083315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.278.5341.1319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020198490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00465-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020944392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0040010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021146925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2004.08.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021456132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1065768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021498251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.04.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021513377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81181-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021548250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021899418", 
              "https://doi.org/10.1038/sj.gt.3301717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.gt.3301717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021899418", 
              "https://doi.org/10.1038/sj.gt.3301717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1143403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022045585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022308308", 
              "https://doi.org/10.1038/ni876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022308308", 
              "https://doi.org/10.1038/ni876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(02)00013-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022313571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(02)00013-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022313571"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0797-730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022333282", 
              "https://doi.org/10.1038/nm0797-730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)64615-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022458650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.physiol.010908.163145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022484296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.12.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022490462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1115025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022577125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762380", 
              "https://doi.org/10.1038/40194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/40194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022762380", 
              "https://doi.org/10.1038/40194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4608-03.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022891585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022908383", 
              "https://doi.org/10.1038/nn1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1179/174313209x385725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022913951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e07-09-0965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023049012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2009.00493.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023364691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2009.00493.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023364691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.12.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023643706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2010.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023918486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.479308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023938270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024299758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-04-152017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024454351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024497082", 
              "https://doi.org/10.1038/nature01587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024497082", 
              "https://doi.org/10.1038/nature01587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80580-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024660332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)82001-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024840973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2005.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024849201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2005.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024849201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80783-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024856119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00126-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025002057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025477952", 
              "https://doi.org/10.1038/nature08911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025477952", 
              "https://doi.org/10.1038/nature08911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0029(19981001)43:1<34::aid-jemt6>3.0.co;2-g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025800189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025856509", 
              "https://doi.org/10.1038/nn.2185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025905692", 
              "https://doi.org/10.1038/nn.2172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-11-123547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026041201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20091318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026339482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ydbio.2010.07.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026350686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026627772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00302-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027076992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027172656", 
              "https://doi.org/10.1038/561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027172656", 
              "https://doi.org/10.1038/561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1001159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027312439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-0148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027469712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddp459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027606779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1393106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027983110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0047-6374(82)90105-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028204415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0047-6374(82)90105-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028204415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0047-6374(00)00137-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028227229"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1001702107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028693584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.med.54.101601.152334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029491155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.10.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029721839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.10.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029721839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766632", 
              "https://doi.org/10.1038/nature03319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766632", 
              "https://doi.org/10.1038/nature03319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2008.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030233315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030427346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.6003-08.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030430783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.05.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030610297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2007.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030770957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030873412", 
              "https://doi.org/10.1038/nature04980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030873412", 
              "https://doi.org/10.1038/nature04980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.08.032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030907380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2247-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031054883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-03-010413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031136978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10522-008-9176-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031653482", 
              "https://doi.org/10.1007/s10522-008-9176-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10522-008-9176-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031653482", 
              "https://doi.org/10.1007/s10522-008-9176-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-3011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031781627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0503280102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032169193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1673508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032353888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032399604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032499001"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.4.1823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032677018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0704089104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032993565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033156851", 
              "https://doi.org/10.1038/16476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033156851", 
              "https://doi.org/10.1038/16476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033229938", 
              "https://doi.org/10.1038/nature05159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033229938", 
              "https://doi.org/10.1038/nature05159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033229938", 
              "https://doi.org/10.1038/nature05159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.17.4935", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033340693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033386070", 
              "https://doi.org/10.1038/nature06562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1035902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033394366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03247.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033829808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03247.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033829808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3452-04.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034033674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034149663", 
              "https://doi.org/10.1038/nature02789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034149663", 
              "https://doi.org/10.1038/nature02789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2008-05-159848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034276869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1109-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034325533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1088417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034380276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-11-4282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034396342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034782793", 
              "https://doi.org/10.1038/6365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034782793", 
              "https://doi.org/10.1038/6365"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035319327", 
              "https://doi.org/10.1038/nature07726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0407643101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035479407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035614683", 
              "https://doi.org/10.1038/3305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035614683", 
              "https://doi.org/10.1038/3305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1299505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036013538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036229096", 
              "https://doi.org/10.1038/nature09195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036229096", 
              "https://doi.org/10.1038/nature09195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.09.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036343109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2006.06.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036731955"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036869450", 
              "https://doi.org/10.1038/ni1387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036869450", 
              "https://doi.org/10.1038/ni1387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037118397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(03)00687-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037266204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2009.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037466375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037658738", 
              "https://doi.org/10.1038/nature04372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037658738", 
              "https://doi.org/10.1038/nature04372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037658738", 
              "https://doi.org/10.1038/nature04372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2008.07.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037789945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068987", 
              "https://doi.org/10.1038/nn.2672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038068987", 
              "https://doi.org/10.1038/nn.2672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2007-023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038180386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35066584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038263578", 
              "https://doi.org/10.1038/35066584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35066584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038263578", 
              "https://doi.org/10.1038/35066584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2004.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038354843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1173215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1173215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038411243", 
              "https://doi.org/10.1038/onc.2009.94"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.94", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038411243", 
              "https://doi.org/10.1038/onc.2009.94"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1166859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038421782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mcne.1996.0595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038646813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(94)90046-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038964132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.453107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039070086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mus.880060807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039201999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039237755", 
              "https://doi.org/10.1038/nature08040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039237755", 
              "https://doi.org/10.1038/nature08040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039507812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040185730", 
              "https://doi.org/10.1038/nature04496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040185730", 
              "https://doi.org/10.1038/nature04496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040185730", 
              "https://doi.org/10.1038/nature04496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01116-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040310265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040358058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra043666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040422233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra043666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040422233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040694891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12015-007-0009-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040856335", 
              "https://doi.org/10.1007/s12015-007-0009-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/19.8.1839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041153282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1099593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041156786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-7613(94)90037-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041252447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041426400", 
              "https://doi.org/10.1038/nature06270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0404184101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041859976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0060233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042076885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.415507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042100087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042203181", 
              "https://doi.org/10.1038/nature08683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042203181", 
              "https://doi.org/10.1038/nature08683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042385160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043587812", 
              "https://doi.org/10.1038/nrg2218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043703121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1474-9728.2002.00017.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043881456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.183.4.1797", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044033062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044062881", 
              "https://doi.org/10.1038/nature03260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044062881", 
              "https://doi.org/10.1038/nature03260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044089695", 
              "https://doi.org/10.1038/sj.onc.1201178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044089695", 
              "https://doi.org/10.1038/sj.onc.1201178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044122156", 
              "https://doi.org/10.1038/ncb2101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044122156", 
              "https://doi.org/10.1038/ncb2101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m704735200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044434377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07384", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044574283", 
              "https://doi.org/10.1038/nature07384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044670645", 
              "https://doi.org/10.1038/nature06736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00365510802419447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044717719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1787609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044718967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045169905", 
              "https://doi.org/10.1038/35089085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35089085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045169905", 
              "https://doi.org/10.1038/35089085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1094637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045251376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2004-0066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045340739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0996-1011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045465259", 
              "https://doi.org/10.1038/nm0996-1011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.08.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045510569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045711316", 
              "https://doi.org/10.1038/nature01572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045711316", 
              "https://doi.org/10.1038/nature01572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1190485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045945275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.510809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046326493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20052477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046449695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046778728", 
              "https://doi.org/10.1038/nature02549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046778728", 
              "https://doi.org/10.1038/nature02549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.16.6857-6868.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046838325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047226681", 
              "https://doi.org/10.1038/nn844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047226681", 
              "https://doi.org/10.1038/nn844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047968073", 
              "https://doi.org/10.1038/nature08734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047968073", 
              "https://doi.org/10.1038/nature08734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048407942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.05.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048705898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.2002.5653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048819224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.2002.5653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048819224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1109083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049198715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cb.11.110195.000343", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049287270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709002", 
              "https://doi.org/10.1038/nature02985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709002", 
              "https://doi.org/10.1038/nature02985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049743007", 
              "https://doi.org/10.1038/nature08137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049743007", 
              "https://doi.org/10.1038/nature08137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3812-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049884230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049898295", 
              "https://doi.org/10.1038/77046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049898295", 
              "https://doi.org/10.1038/77046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050225537", 
              "https://doi.org/10.1038/nature06196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.511109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050491870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-09-3585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050904912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(07)00377-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050961925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.6.3120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051052670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(72)90188-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051309216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(72)90188-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051309216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(04)00140-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051933422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.7.757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052047444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.06.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052095309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/emmm.200900045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052130474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052266867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2010.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052432184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1131928100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052435481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052667333", 
              "https://doi.org/10.1038/35065638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052667333", 
              "https://doi.org/10.1038/35065638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1849509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053018957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053351550", 
              "https://doi.org/10.1038/nrm1714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053351550", 
              "https://doi.org/10.1038/nrm1714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x10000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x10000049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/rej.2008.0827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059308181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/sageke.2003.14.re4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062439101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1136281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.273.5272.242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062553596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2898810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062571086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.4.3.1518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.6.19.4759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/epi.5.3.11374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072302995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074369681", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074590075", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074643433", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074665002", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080063488", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.04-06-01429.1984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081925057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082479157", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05795.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082818768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.16-06-02027.1996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082877022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083056129", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.17-10-03727.1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083083006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.17-20-07850.1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083154361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-09-03206.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083244682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083245893", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083259855", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-07", 
        "datePublishedReg": "2011-07-01", 
        "description": "The function of adult tissue-specific stem cells declines with age, which may contribute to the physiological decline in tissue homeostasis and the increased risk of neoplasm during aging. Old stem cells can be 'rejuvenated' by environmental stimuli in some cases, raising the possibility that a subset of age-dependent stem cell changes is regulated by reversible mechanisms. Epigenetic regulators are good candidates for such mechanisms, as they provide a versatile checkpoint to mediate plastic changes in gene expression and have recently been found to control organismal longevity. Here, we review the importance of chromatin regulation in adult stem cell compartments. We particularly focus on the roles of chromatin-modifying complexes and transcription factors that directly impact chromatin in aging stem cells. Understanding the regulation of chromatin states in adult stem cells is likely to have important implications for identifying avenues to maintain the homeostatic balance between sustained function and neoplastic transformation of aging stem cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/onc.2011.45", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2434819", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2359779", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "28", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "30"
          }
        ], 
        "name": "Epigenetic regulation of aging stem cells", 
        "pagination": "3105", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "beae1d2edbab1e996539d488c09b0e29143dfcb69dc284d767a14375ef640137"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21441951"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8711562"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2011.45"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1040028263"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2011.45", 
          "https://app.dimensions.ai/details/publication/pub.1040028263"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T14:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000519.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/onc201145"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.45'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.45'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.45'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.45'


     

    This table displays all metadata directly associated to this object as RDF triples.

    1101 TRIPLES      21 PREDICATES      344 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2011.45 schema:about N19f3d97515f24653ae66a24bd6b79a83
    2 N216fc06945254afabea78a42f9263b34
    3 N93c995aad6e94251806e4d12ff719224
    4 Nb0f9b8fd1f214582a66f3316fe66d832
    5 Nbf3601068612416ab8a6bd665c1810fc
    6 Ncced8a9728a5495a9faa33e40e5eaee9
    7 Nced82e8bf15842ed80695455d36e3e67
    8 Nf4efb3a8c89e44dbaf705338bfbb1bfe
    9 anzsrc-for:06
    10 anzsrc-for:0604
    11 schema:author N2aeb4cdb1903439a9d91b40ef6f84279
    12 schema:citation sg:pub.10.1007/bf00688574
    13 sg:pub.10.1007/s00221-006-0831-x
    14 sg:pub.10.1007/s10522-008-9176-0
    15 sg:pub.10.1007/s12015-007-0009-3
    16 sg:pub.10.1038/13197
    17 sg:pub.10.1038/16476
    18 sg:pub.10.1038/217974a0
    19 sg:pub.10.1038/30764
    20 sg:pub.10.1038/3305
    21 sg:pub.10.1038/35001622
    22 sg:pub.10.1038/35065638
    23 sg:pub.10.1038/35066584
    24 sg:pub.10.1038/35089085
    25 sg:pub.10.1038/40194
    26 sg:pub.10.1038/561
    27 sg:pub.10.1038/6365
    28 sg:pub.10.1038/77046
    29 sg:pub.10.1038/nature01572
    30 sg:pub.10.1038/nature01587
    31 sg:pub.10.1038/nature02060
    32 sg:pub.10.1038/nature02211
    33 sg:pub.10.1038/nature02301
    34 sg:pub.10.1038/nature02549
    35 sg:pub.10.1038/nature02789
    36 sg:pub.10.1038/nature02985
    37 sg:pub.10.1038/nature03260
    38 sg:pub.10.1038/nature03319
    39 sg:pub.10.1038/nature03836
    40 sg:pub.10.1038/nature04372
    41 sg:pub.10.1038/nature04431
    42 sg:pub.10.1038/nature04496
    43 sg:pub.10.1038/nature04958
    44 sg:pub.10.1038/nature04980
    45 sg:pub.10.1038/nature05091
    46 sg:pub.10.1038/nature05159
    47 sg:pub.10.1038/nature05862
    48 sg:pub.10.1038/nature05875
    49 sg:pub.10.1038/nature06196
    50 sg:pub.10.1038/nature06270
    51 sg:pub.10.1038/nature06562
    52 sg:pub.10.1038/nature06736
    53 sg:pub.10.1038/nature07034
    54 sg:pub.10.1038/nature07384
    55 sg:pub.10.1038/nature07726
    56 sg:pub.10.1038/nature08040
    57 sg:pub.10.1038/nature08085
    58 sg:pub.10.1038/nature08137
    59 sg:pub.10.1038/nature08683
    60 sg:pub.10.1038/nature08734
    61 sg:pub.10.1038/nature08911
    62 sg:pub.10.1038/nature08982
    63 sg:pub.10.1038/nature09195
    64 sg:pub.10.1038/nature09603
    65 sg:pub.10.1038/ncb1700
    66 sg:pub.10.1038/ncb2101
    67 sg:pub.10.1038/ng1089
    68 sg:pub.10.1038/ni1387
    69 sg:pub.10.1038/ni876
    70 sg:pub.10.1038/nm0797-730
    71 sg:pub.10.1038/nm0805-829
    72 sg:pub.10.1038/nm0996-1011
    73 sg:pub.10.1038/nn.2172
    74 sg:pub.10.1038/nn.2185
    75 sg:pub.10.1038/nn.2672
    76 sg:pub.10.1038/nn1847
    77 sg:pub.10.1038/nn844
    78 sg:pub.10.1038/nrg2047
    79 sg:pub.10.1038/nrg2218
    80 sg:pub.10.1038/nrm1714
    81 sg:pub.10.1038/nrm2145
    82 sg:pub.10.1038/nrm2241
    83 sg:pub.10.1038/onc.2009.94
    84 sg:pub.10.1038/sj.gt.3301717
    85 sg:pub.10.1038/sj.onc.1201178
    86 sg:pub.10.1038/sj.onc.1209086
    87 sg:pub.10.1038/sj.onc.1210599
    88 https://app.dimensions.ai/details/publication/pub.1074369681
    89 https://app.dimensions.ai/details/publication/pub.1074590075
    90 https://app.dimensions.ai/details/publication/pub.1074643433
    91 https://app.dimensions.ai/details/publication/pub.1074665002
    92 https://app.dimensions.ai/details/publication/pub.1080063488
    93 https://app.dimensions.ai/details/publication/pub.1082479157
    94 https://app.dimensions.ai/details/publication/pub.1083056129
    95 https://app.dimensions.ai/details/publication/pub.1083245893
    96 https://app.dimensions.ai/details/publication/pub.1083259855
    97 https://doi.org/10.1002/(sici)1097-0029(19981001)43:1<34::aid-jemt6>3.0.co;2-g
    98 https://doi.org/10.1002/(sici)1097-4547(20000201)59:3<321::aid-jnr5>3.0.co;2-9
    99 https://doi.org/10.1002/(sici)1097-4598(199802)21:2<173::aid-mus4>3.0.co;2-8
    100 https://doi.org/10.1002/(sici)1097-4695(199808)36:2<249::aid-neu11>3.0.co;2-9
    101 https://doi.org/10.1002/ana.10262
    102 https://doi.org/10.1002/emmm.200900045
    103 https://doi.org/10.1002/j.1460-2075.1993.tb05795.x
    104 https://doi.org/10.1002/jez.1402060314
    105 https://doi.org/10.1002/mus.880060807
    106 https://doi.org/10.1002/pmic.200401028
    107 https://doi.org/10.1002/pmic.200800193
    108 https://doi.org/10.1006/excr.2002.5653
    109 https://doi.org/10.1006/exnr.1999.7028
    110 https://doi.org/10.1006/mcne.1996.0595
    111 https://doi.org/10.1016/0024-3205(72)90188-9
    112 https://doi.org/10.1016/0047-6374(82)90105-1
    113 https://doi.org/10.1016/0896-6273(94)90046-9
    114 https://doi.org/10.1016/1074-7613(94)90037-x
    115 https://doi.org/10.1016/j.ccr.2005.07.004
    116 https://doi.org/10.1016/j.ccr.2007.08.032
    117 https://doi.org/10.1016/j.ceb.2007.04.002
    118 https://doi.org/10.1016/j.cell.2004.08.005
    119 https://doi.org/10.1016/j.cell.2005.06.013
    120 https://doi.org/10.1016/j.cell.2005.11.044
    121 https://doi.org/10.1016/j.cell.2006.02.041
    122 https://doi.org/10.1016/j.cell.2006.04.004
    123 https://doi.org/10.1016/j.cell.2006.05.052
    124 https://doi.org/10.1016/j.cell.2006.07.002
    125 https://doi.org/10.1016/j.cell.2006.12.029
    126 https://doi.org/10.1016/j.cell.2007.01.014
    127 https://doi.org/10.1016/j.cell.2008.01.020
    128 https://doi.org/10.1016/j.cell.2008.01.033
    129 https://doi.org/10.1016/j.cell.2008.01.036
    130 https://doi.org/10.1016/j.cell.2008.01.038
    131 https://doi.org/10.1016/j.cell.2008.09.017
    132 https://doi.org/10.1016/j.cell.2008.10.025
    133 https://doi.org/10.1016/j.cell.2008.10.052
    134 https://doi.org/10.1016/j.cell.2009.12.041
    135 https://doi.org/10.1016/j.cmet.2008.08.014
    136 https://doi.org/10.1016/j.cmet.2008.08.017
    137 https://doi.org/10.1016/j.cmet.2010.05.010
    138 https://doi.org/10.1016/j.cmet.2010.06.009
    139 https://doi.org/10.1016/j.coi.2010.06.007
    140 https://doi.org/10.1016/j.exger.2008.06.009
    141 https://doi.org/10.1016/j.immuni.2004.11.004
    142 https://doi.org/10.1016/j.molcel.2004.08.031
    143 https://doi.org/10.1016/j.molcel.2008.03.011
    144 https://doi.org/10.1016/j.neurobiolaging.2005.09.016
    145 https://doi.org/10.1016/j.neurobiolaging.2006.09.015
    146 https://doi.org/10.1016/j.neuron.2006.06.012
    147 https://doi.org/10.1016/j.neuron.2007.06.019
    148 https://doi.org/10.1016/j.neuron.2009.08.021
    149 https://doi.org/10.1016/j.stem.2007.02.001
    150 https://doi.org/10.1016/j.stem.2007.04.001
    151 https://doi.org/10.1016/j.stem.2007.05.015
    152 https://doi.org/10.1016/j.stem.2007.05.019
    153 https://doi.org/10.1016/j.stem.2007.07.002
    154 https://doi.org/10.1016/j.stem.2007.07.017
    155 https://doi.org/10.1016/j.stem.2007.08.002
    156 https://doi.org/10.1016/j.stem.2007.08.014
    157 https://doi.org/10.1016/j.stem.2008.07.024
    158 https://doi.org/10.1016/j.stem.2009.04.003
    159 https://doi.org/10.1016/j.stem.2009.08.016
    160 https://doi.org/10.1016/j.stem.2009.09.013
    161 https://doi.org/10.1016/j.stem.2009.09.014
    162 https://doi.org/10.1016/j.stem.2010.01.005
    163 https://doi.org/10.1016/j.stem.2010.01.011
    164 https://doi.org/10.1016/j.stem.2010.02.002
    165 https://doi.org/10.1016/j.stem.2010.03.017
    166 https://doi.org/10.1016/j.stem.2010.11.017
    167 https://doi.org/10.1016/j.tibs.2004.12.002
    168 https://doi.org/10.1016/j.ydbio.2009.08.014
    169 https://doi.org/10.1016/j.ydbio.2010.07.022
    170 https://doi.org/10.1016/s0002-9440(10)64615-9
    171 https://doi.org/10.1016/s0047-6374(00)00137-8
    172 https://doi.org/10.1016/s0092-8674(00)80080-x
    173 https://doi.org/10.1016/s0092-8674(00)80580-2
    174 https://doi.org/10.1016/s0092-8674(00)80783-7
    175 https://doi.org/10.1016/s0092-8674(00)81181-2
    176 https://doi.org/10.1016/s0092-8674(00)82001-2
    177 https://doi.org/10.1016/s0092-8674(02)00976-5
    178 https://doi.org/10.1016/s0092-8674(03)00687-1
    179 https://doi.org/10.1016/s0092-8674(04)00126-6
    180 https://doi.org/10.1016/s0092-8674(04)00302-2
    181 https://doi.org/10.1016/s0197-4580(03)00083-6
    182 https://doi.org/10.1016/s0301-472x(00)00169-7
    183 https://doi.org/10.1016/s0306-4522(01)00378-5
    184 https://doi.org/10.1016/s0896-6273(04)00140-0
    185 https://doi.org/10.1016/s0959-437x(02)00013-8
    186 https://doi.org/10.1016/s0960-9822(07)00377-6
    187 https://doi.org/10.1016/s1357-2725(03)00042-6
    188 https://doi.org/10.1017/s1740925x10000049
    189 https://doi.org/10.1042/bj20070140
    190 https://doi.org/10.1046/j.1474-9728.2002.00017.x
    191 https://doi.org/10.1056/nejmra043666
    192 https://doi.org/10.1073/pnas.0303792101
    193 https://doi.org/10.1073/pnas.0400593101
    194 https://doi.org/10.1073/pnas.0404184101
    195 https://doi.org/10.1073/pnas.0407643101
    196 https://doi.org/10.1073/pnas.0502738102
    197 https://doi.org/10.1073/pnas.0503280102
    198 https://doi.org/10.1073/pnas.0704089104
    199 https://doi.org/10.1073/pnas.0800612105
    200 https://doi.org/10.1073/pnas.0802674106
    201 https://doi.org/10.1073/pnas.0805498105
    202 https://doi.org/10.1073/pnas.0809594106
    203 https://doi.org/10.1073/pnas.0810407106
    204 https://doi.org/10.1073/pnas.0812889106
    205 https://doi.org/10.1073/pnas.0907739107
    206 https://doi.org/10.1073/pnas.1000834107
    207 https://doi.org/10.1073/pnas.1001702107
    208 https://doi.org/10.1073/pnas.1131928100
    209 https://doi.org/10.1073/pnas.232568499
    210 https://doi.org/10.1073/pnas.89.7.2804
    211 https://doi.org/10.1073/pnas.90.5.2074
    212 https://doi.org/10.1073/pnas.96.6.3120
    213 https://doi.org/10.1073/pnas.97.4.1823
    214 https://doi.org/10.1074/jbc.m210256200
    215 https://doi.org/10.1074/jbc.m401138200
    216 https://doi.org/10.1074/jbc.m412357200
    217 https://doi.org/10.1074/jbc.m704735200
    218 https://doi.org/10.1074/jbc.m800517200
    219 https://doi.org/10.1080/00365510802419447
    220 https://doi.org/10.1083/jcb.200810133
    221 https://doi.org/10.1084/jem.183.4.1797
    222 https://doi.org/10.1084/jem.192.9.1273
    223 https://doi.org/10.1084/jem.20052477
    224 https://doi.org/10.1084/jem.20091318
    225 https://doi.org/10.1089/rej.2008.0827
    226 https://doi.org/10.1091/mbc.e07-09-0965
    227 https://doi.org/10.1093/emboj/19.8.1839
    228 https://doi.org/10.1093/emboj/20.17.4935
    229 https://doi.org/10.1093/hmg/ddp459
    230 https://doi.org/10.1101/gad.1035902
    231 https://doi.org/10.1101/gad.1061803
    232 https://doi.org/10.1101/gad.1143403
    233 https://doi.org/10.1101/gad.1299305
    234 https://doi.org/10.1101/gad.1299505
    235 https://doi.org/10.1101/gad.13.19.2570
    236 https://doi.org/10.1101/gad.1382606
    237 https://doi.org/10.1101/gad.1393106
    238 https://doi.org/10.1101/gad.1467506
    239 https://doi.org/10.1101/gad.1588507
    240 https://doi.org/10.1101/gad.1673508
    241 https://doi.org/10.1101/gad.1787609
    242 https://doi.org/10.1101/gad.1849509
    243 https://doi.org/10.1101/gad.415507
    244 https://doi.org/10.1101/gad.453107
    245 https://doi.org/10.1101/gad.479308
    246 https://doi.org/10.1101/gad.510809
    247 https://doi.org/10.1101/gad.511109
    248 https://doi.org/10.1101/gad.560310
    249 https://doi.org/10.1101/gad.8.7.757
    250 https://doi.org/10.1111/j.1474-9726.2007.00286.x
    251 https://doi.org/10.1111/j.1474-9726.2009.00493.x
    252 https://doi.org/10.1111/j.1749-6632.2003.tb03247.x
    253 https://doi.org/10.1126/sageke.2003.14.re4
    254 https://doi.org/10.1126/science.1065768
    255 https://doi.org/10.1126/science.1087573
    256 https://doi.org/10.1126/science.1088417
    257 https://doi.org/10.1126/science.1094637
    258 https://doi.org/10.1126/science.1098219
    259 https://doi.org/10.1126/science.1099593
    260 https://doi.org/10.1126/science.1109083
    261 https://doi.org/10.1126/science.1115025
    262 https://doi.org/10.1126/science.1136281
    263 https://doi.org/10.1126/science.1143578
    264 https://doi.org/10.1126/science.1144090
    265 https://doi.org/10.1126/science.1144914
    266 https://doi.org/10.1126/science.1166859
    267 https://doi.org/10.1126/science.1173215
    268 https://doi.org/10.1126/science.1186088
    269 https://doi.org/10.1126/science.1190485
    270 https://doi.org/10.1126/science.273.5272.242
    271 https://doi.org/10.1126/science.278.5341.1319
    272 https://doi.org/10.1126/science.2898810
    273 https://doi.org/10.1126/scisignal.2000037
    274 https://doi.org/10.1128/mcb.00465-10
    275 https://doi.org/10.1128/mcb.01116-09
    276 https://doi.org/10.1128/mcb.25.16.6857-6868.2005
    277 https://doi.org/10.1146/annurev.cb.11.110195.000343
    278 https://doi.org/10.1146/annurev.med.54.101601.152334
    279 https://doi.org/10.1146/annurev.physiol.010908.163145
    280 https://doi.org/10.1158/0008-5472.can-04-3011
    281 https://doi.org/10.1158/0008-5472.can-06-0054
    282 https://doi.org/10.1158/0008-5472.can-10-0148
    283 https://doi.org/10.1172/jci1681
    284 https://doi.org/10.1172/jci22475
    285 https://doi.org/10.1179/174313209x385725
    286 https://doi.org/10.1182/blood-2004-11-4282
    287 https://doi.org/10.1182/blood-2005-09-3585
    288 https://doi.org/10.1182/blood-2005-12-010272
    289 https://doi.org/10.1182/blood-2006-03-010413
    290 https://doi.org/10.1182/blood-2007-11-123547
    291 https://doi.org/10.1182/blood-2008-04-152017
    292 https://doi.org/10.1182/blood-2008-05-159848
    293 https://doi.org/10.1182/blood-2010-03-273011
    294 https://doi.org/10.1215/15228517-2007-023
    295 https://doi.org/10.1242/dev.02723
    296 https://doi.org/10.1371/journal.pbio.0050201
    297 https://doi.org/10.1371/journal.pbio.0060233
    298 https://doi.org/10.1371/journal.pgen.0040010
    299 https://doi.org/10.1371/journal.pgen.1001159
    300 https://doi.org/10.1523/jneurosci.04-06-01429.1984
    301 https://doi.org/10.1523/jneurosci.1109-04.2004
    302 https://doi.org/10.1523/jneurosci.1148-04.2004
    303 https://doi.org/10.1523/jneurosci.16-06-02027.1996
    304 https://doi.org/10.1523/jneurosci.17-10-03727.1997
    305 https://doi.org/10.1523/jneurosci.17-20-07850.1997
    306 https://doi.org/10.1523/jneurosci.18-09-03206.1998
    307 https://doi.org/10.1523/jneurosci.2247-06.2006
    308 https://doi.org/10.1523/jneurosci.2751-04.2004
    309 https://doi.org/10.1523/jneurosci.3452-04.2005
    310 https://doi.org/10.1523/jneurosci.3606-09.2009
    311 https://doi.org/10.1523/jneurosci.3812-07.2007
    312 https://doi.org/10.1523/jneurosci.4608-03.2004
    313 https://doi.org/10.1523/jneurosci.6003-08.2009
    314 https://doi.org/10.1634/stemcells.2004-0066
    315 https://doi.org/10.1634/stemcells.2006-0405
    316 https://doi.org/10.4161/cc.4.3.1518
    317 https://doi.org/10.4161/cc.6.19.4759
    318 https://doi.org/10.4161/epi.5.3.11374
    319 schema:datePublished 2011-07
    320 schema:datePublishedReg 2011-07-01
    321 schema:description The function of adult tissue-specific stem cells declines with age, which may contribute to the physiological decline in tissue homeostasis and the increased risk of neoplasm during aging. Old stem cells can be 'rejuvenated' by environmental stimuli in some cases, raising the possibility that a subset of age-dependent stem cell changes is regulated by reversible mechanisms. Epigenetic regulators are good candidates for such mechanisms, as they provide a versatile checkpoint to mediate plastic changes in gene expression and have recently been found to control organismal longevity. Here, we review the importance of chromatin regulation in adult stem cell compartments. We particularly focus on the roles of chromatin-modifying complexes and transcription factors that directly impact chromatin in aging stem cells. Understanding the regulation of chromatin states in adult stem cells is likely to have important implications for identifying avenues to maintain the homeostatic balance between sustained function and neoplastic transformation of aging stem cells.
    322 schema:genre research_article
    323 schema:inLanguage en
    324 schema:isAccessibleForFree true
    325 schema:isPartOf N2940aa1a3cc6438b9e11177fa0f97678
    326 N52dae009eadc46a38a4f2e5b9e0703b2
    327 sg:journal.1097543
    328 schema:name Epigenetic regulation of aging stem cells
    329 schema:pagination 3105
    330 schema:productId N4bcb17adc365476c87f0c21fdae454fe
    331 N4cff4142791647d7badfcc75f3f384cc
    332 Nb198ca48e8b84cd29037c17db99e8bfd
    333 Nc31b8356c6ef40c4a02a26cfb54ccb01
    334 Nf2a5b775405a4c85b4194482b59c01a0
    335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040028263
    336 https://doi.org/10.1038/onc.2011.45
    337 schema:sdDatePublished 2019-04-10T14:11
    338 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    339 schema:sdPublisher N97868354919d44eb9d02e6f7cae4d7a4
    340 schema:url https://www.nature.com/articles/onc201145
    341 sgo:license sg:explorer/license/
    342 sgo:sdDataset articles
    343 rdf:type schema:ScholarlyArticle
    344 N19f3d97515f24653ae66a24bd6b79a83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    345 schema:name Epigenesis, Genetic
    346 rdf:type schema:DefinedTerm
    347 N216fc06945254afabea78a42f9263b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    348 schema:name Transcription Factors
    349 rdf:type schema:DefinedTerm
    350 N2940aa1a3cc6438b9e11177fa0f97678 schema:issueNumber 28
    351 rdf:type schema:PublicationIssue
    352 N2aeb4cdb1903439a9d91b40ef6f84279 rdf:first sg:person.01324363651.89
    353 rdf:rest N3e88b19b09284ee49ecbebf3419ff987
    354 N3e88b19b09284ee49ecbebf3419ff987 rdf:first sg:person.01057654457.41
    355 rdf:rest rdf:nil
    356 N4bcb17adc365476c87f0c21fdae454fe schema:name readcube_id
    357 schema:value beae1d2edbab1e996539d488c09b0e29143dfcb69dc284d767a14375ef640137
    358 rdf:type schema:PropertyValue
    359 N4cff4142791647d7badfcc75f3f384cc schema:name pubmed_id
    360 schema:value 21441951
    361 rdf:type schema:PropertyValue
    362 N52dae009eadc46a38a4f2e5b9e0703b2 schema:volumeNumber 30
    363 rdf:type schema:PublicationVolume
    364 N93c995aad6e94251806e4d12ff719224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    365 schema:name Stem Cells
    366 rdf:type schema:DefinedTerm
    367 N97868354919d44eb9d02e6f7cae4d7a4 schema:name Springer Nature - SN SciGraph project
    368 rdf:type schema:Organization
    369 Nb0f9b8fd1f214582a66f3316fe66d832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    370 schema:name Cellular Senescence
    371 rdf:type schema:DefinedTerm
    372 Nb198ca48e8b84cd29037c17db99e8bfd schema:name dimensions_id
    373 schema:value pub.1040028263
    374 rdf:type schema:PropertyValue
    375 Nbf3601068612416ab8a6bd665c1810fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    376 schema:name Neoplasms
    377 rdf:type schema:DefinedTerm
    378 Nc31b8356c6ef40c4a02a26cfb54ccb01 schema:name nlm_unique_id
    379 schema:value 8711562
    380 rdf:type schema:PropertyValue
    381 Ncced8a9728a5495a9faa33e40e5eaee9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    382 schema:name Nucleoproteins
    383 rdf:type schema:DefinedTerm
    384 Nced82e8bf15842ed80695455d36e3e67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    385 schema:name Humans
    386 rdf:type schema:DefinedTerm
    387 Nf2a5b775405a4c85b4194482b59c01a0 schema:name doi
    388 schema:value 10.1038/onc.2011.45
    389 rdf:type schema:PropertyValue
    390 Nf4efb3a8c89e44dbaf705338bfbb1bfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    391 schema:name Animals
    392 rdf:type schema:DefinedTerm
    393 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    394 schema:name Biological Sciences
    395 rdf:type schema:DefinedTerm
    396 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    397 schema:name Genetics
    398 rdf:type schema:DefinedTerm
    399 sg:grant.2359779 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.45
    400 rdf:type schema:MonetaryGrant
    401 sg:grant.2434819 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.45
    402 rdf:type schema:MonetaryGrant
    403 sg:journal.1097543 schema:issn 0950-9232
    404 1476-5594
    405 schema:name Oncogene
    406 rdf:type schema:Periodical
    407 sg:person.01057654457.41 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    408 schema:familyName Brunet
    409 schema:givenName A
    410 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057654457.41
    411 rdf:type schema:Person
    412 sg:person.01324363651.89 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    413 schema:familyName Pollina
    414 schema:givenName E A
    415 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324363651.89
    416 rdf:type schema:Person
    417 sg:pub.10.1007/bf00688574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005520513
    418 https://doi.org/10.1007/bf00688574
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1007/s00221-006-0831-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018430012
    421 https://doi.org/10.1007/s00221-006-0831-x
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1007/s10522-008-9176-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031653482
    424 https://doi.org/10.1007/s10522-008-9176-0
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1007/s12015-007-0009-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040856335
    427 https://doi.org/10.1007/s12015-007-0009-3
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/13197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012807910
    430 https://doi.org/10.1038/13197
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1038/16476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033156851
    433 https://doi.org/10.1038/16476
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1038/217974a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014574349
    436 https://doi.org/10.1038/217974a0
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1038/30764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005546919
    439 https://doi.org/10.1038/30764
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/3305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035614683
    442 https://doi.org/10.1038/3305
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/35001622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019839382
    445 https://doi.org/10.1038/35001622
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/35065638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052667333
    448 https://doi.org/10.1038/35065638
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/35066584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038263578
    451 https://doi.org/10.1038/35066584
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1038/35089085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045169905
    454 https://doi.org/10.1038/35089085
    455 rdf:type schema:CreativeWork
    456 sg:pub.10.1038/40194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022762380
    457 https://doi.org/10.1038/40194
    458 rdf:type schema:CreativeWork
    459 sg:pub.10.1038/561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027172656
    460 https://doi.org/10.1038/561
    461 rdf:type schema:CreativeWork
    462 sg:pub.10.1038/6365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034782793
    463 https://doi.org/10.1038/6365
    464 rdf:type schema:CreativeWork
    465 sg:pub.10.1038/77046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049898295
    466 https://doi.org/10.1038/77046
    467 rdf:type schema:CreativeWork
    468 sg:pub.10.1038/nature01572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045711316
    469 https://doi.org/10.1038/nature01572
    470 rdf:type schema:CreativeWork
    471 sg:pub.10.1038/nature01587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024497082
    472 https://doi.org/10.1038/nature01587
    473 rdf:type schema:CreativeWork
    474 sg:pub.10.1038/nature02060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013519146
    475 https://doi.org/10.1038/nature02060
    476 rdf:type schema:CreativeWork
    477 sg:pub.10.1038/nature02211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011173926
    478 https://doi.org/10.1038/nature02211
    479 rdf:type schema:CreativeWork
    480 sg:pub.10.1038/nature02301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001004550
    481 https://doi.org/10.1038/nature02301
    482 rdf:type schema:CreativeWork
    483 sg:pub.10.1038/nature02549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046778728
    484 https://doi.org/10.1038/nature02549
    485 rdf:type schema:CreativeWork
    486 sg:pub.10.1038/nature02789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034149663
    487 https://doi.org/10.1038/nature02789
    488 rdf:type schema:CreativeWork
    489 sg:pub.10.1038/nature02985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709002
    490 https://doi.org/10.1038/nature02985
    491 rdf:type schema:CreativeWork
    492 sg:pub.10.1038/nature03260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044062881
    493 https://doi.org/10.1038/nature03260
    494 rdf:type schema:CreativeWork
    495 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
    496 https://doi.org/10.1038/nature03319
    497 rdf:type schema:CreativeWork
    498 sg:pub.10.1038/nature03836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015082332
    499 https://doi.org/10.1038/nature03836
    500 rdf:type schema:CreativeWork
    501 sg:pub.10.1038/nature04372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037658738
    502 https://doi.org/10.1038/nature04372
    503 rdf:type schema:CreativeWork
    504 sg:pub.10.1038/nature04431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013027025
    505 https://doi.org/10.1038/nature04431
    506 rdf:type schema:CreativeWork
    507 sg:pub.10.1038/nature04496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040185730
    508 https://doi.org/10.1038/nature04496
    509 rdf:type schema:CreativeWork
    510 sg:pub.10.1038/nature04958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008647780
    511 https://doi.org/10.1038/nature04958
    512 rdf:type schema:CreativeWork
    513 sg:pub.10.1038/nature04980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030873412
    514 https://doi.org/10.1038/nature04980
    515 rdf:type schema:CreativeWork
    516 sg:pub.10.1038/nature05091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007203457
    517 https://doi.org/10.1038/nature05091
    518 rdf:type schema:CreativeWork
    519 sg:pub.10.1038/nature05159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033229938
    520 https://doi.org/10.1038/nature05159
    521 rdf:type schema:CreativeWork
    522 sg:pub.10.1038/nature05862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004325946
    523 https://doi.org/10.1038/nature05862
    524 rdf:type schema:CreativeWork
    525 sg:pub.10.1038/nature05875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000568054
    526 https://doi.org/10.1038/nature05875
    527 rdf:type schema:CreativeWork
    528 sg:pub.10.1038/nature06196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225537
    529 https://doi.org/10.1038/nature06196
    530 rdf:type schema:CreativeWork
    531 sg:pub.10.1038/nature06270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041426400
    532 https://doi.org/10.1038/nature06270
    533 rdf:type schema:CreativeWork
    534 sg:pub.10.1038/nature06562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033386070
    535 https://doi.org/10.1038/nature06562
    536 rdf:type schema:CreativeWork
    537 sg:pub.10.1038/nature06736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044670645
    538 https://doi.org/10.1038/nature06736
    539 rdf:type schema:CreativeWork
    540 sg:pub.10.1038/nature07034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019794166
    541 https://doi.org/10.1038/nature07034
    542 rdf:type schema:CreativeWork
    543 sg:pub.10.1038/nature07384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044574283
    544 https://doi.org/10.1038/nature07384
    545 rdf:type schema:CreativeWork
    546 sg:pub.10.1038/nature07726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319327
    547 https://doi.org/10.1038/nature07726
    548 rdf:type schema:CreativeWork
    549 sg:pub.10.1038/nature08040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039237755
    550 https://doi.org/10.1038/nature08040
    551 rdf:type schema:CreativeWork
    552 sg:pub.10.1038/nature08085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017457325
    553 https://doi.org/10.1038/nature08085
    554 rdf:type schema:CreativeWork
    555 sg:pub.10.1038/nature08137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049743007
    556 https://doi.org/10.1038/nature08137
    557 rdf:type schema:CreativeWork
    558 sg:pub.10.1038/nature08683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042203181
    559 https://doi.org/10.1038/nature08683
    560 rdf:type schema:CreativeWork
    561 sg:pub.10.1038/nature08734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047968073
    562 https://doi.org/10.1038/nature08734
    563 rdf:type schema:CreativeWork
    564 sg:pub.10.1038/nature08911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025477952
    565 https://doi.org/10.1038/nature08911
    566 rdf:type schema:CreativeWork
    567 sg:pub.10.1038/nature08982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017093183
    568 https://doi.org/10.1038/nature08982
    569 rdf:type schema:CreativeWork
    570 sg:pub.10.1038/nature09195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036229096
    571 https://doi.org/10.1038/nature09195
    572 rdf:type schema:CreativeWork
    573 sg:pub.10.1038/nature09603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011608783
    574 https://doi.org/10.1038/nature09603
    575 rdf:type schema:CreativeWork
    576 sg:pub.10.1038/ncb1700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000676670
    577 https://doi.org/10.1038/ncb1700
    578 rdf:type schema:CreativeWork
    579 sg:pub.10.1038/ncb2101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044122156
    580 https://doi.org/10.1038/ncb2101
    581 rdf:type schema:CreativeWork
    582 sg:pub.10.1038/ng1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015302967
    583 https://doi.org/10.1038/ng1089
    584 rdf:type schema:CreativeWork
    585 sg:pub.10.1038/ni1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036869450
    586 https://doi.org/10.1038/ni1387
    587 rdf:type schema:CreativeWork
    588 sg:pub.10.1038/ni876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022308308
    589 https://doi.org/10.1038/ni876
    590 rdf:type schema:CreativeWork
    591 sg:pub.10.1038/nm0797-730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022333282
    592 https://doi.org/10.1038/nm0797-730
    593 rdf:type schema:CreativeWork
    594 sg:pub.10.1038/nm0805-829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014461573
    595 https://doi.org/10.1038/nm0805-829
    596 rdf:type schema:CreativeWork
    597 sg:pub.10.1038/nm0996-1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045465259
    598 https://doi.org/10.1038/nm0996-1011
    599 rdf:type schema:CreativeWork
    600 sg:pub.10.1038/nn.2172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025905692
    601 https://doi.org/10.1038/nn.2172
    602 rdf:type schema:CreativeWork
    603 sg:pub.10.1038/nn.2185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025856509
    604 https://doi.org/10.1038/nn.2185
    605 rdf:type schema:CreativeWork
    606 sg:pub.10.1038/nn.2672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038068987
    607 https://doi.org/10.1038/nn.2672
    608 rdf:type schema:CreativeWork
    609 sg:pub.10.1038/nn1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022908383
    610 https://doi.org/10.1038/nn1847
    611 rdf:type schema:CreativeWork
    612 sg:pub.10.1038/nn844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047226681
    613 https://doi.org/10.1038/nn844
    614 rdf:type schema:CreativeWork
    615 sg:pub.10.1038/nrg2047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006232285
    616 https://doi.org/10.1038/nrg2047
    617 rdf:type schema:CreativeWork
    618 sg:pub.10.1038/nrg2218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043587812
    619 https://doi.org/10.1038/nrg2218
    620 rdf:type schema:CreativeWork
    621 sg:pub.10.1038/nrm1714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053351550
    622 https://doi.org/10.1038/nrm1714
    623 rdf:type schema:CreativeWork
    624 sg:pub.10.1038/nrm2145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010464606
    625 https://doi.org/10.1038/nrm2145
    626 rdf:type schema:CreativeWork
    627 sg:pub.10.1038/nrm2241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014449689
    628 https://doi.org/10.1038/nrm2241
    629 rdf:type schema:CreativeWork
    630 sg:pub.10.1038/onc.2009.94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038411243
    631 https://doi.org/10.1038/onc.2009.94
    632 rdf:type schema:CreativeWork
    633 sg:pub.10.1038/sj.gt.3301717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021899418
    634 https://doi.org/10.1038/sj.gt.3301717
    635 rdf:type schema:CreativeWork
    636 sg:pub.10.1038/sj.onc.1201178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044089695
    637 https://doi.org/10.1038/sj.onc.1201178
    638 rdf:type schema:CreativeWork
    639 sg:pub.10.1038/sj.onc.1209086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015782956
    640 https://doi.org/10.1038/sj.onc.1209086
    641 rdf:type schema:CreativeWork
    642 sg:pub.10.1038/sj.onc.1210599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002683470
    643 https://doi.org/10.1038/sj.onc.1210599
    644 rdf:type schema:CreativeWork
    645 https://app.dimensions.ai/details/publication/pub.1074369681 schema:CreativeWork
    646 https://app.dimensions.ai/details/publication/pub.1074590075 schema:CreativeWork
    647 https://app.dimensions.ai/details/publication/pub.1074643433 schema:CreativeWork
    648 https://app.dimensions.ai/details/publication/pub.1074665002 schema:CreativeWork
    649 https://app.dimensions.ai/details/publication/pub.1080063488 schema:CreativeWork
    650 https://app.dimensions.ai/details/publication/pub.1082479157 schema:CreativeWork
    651 https://app.dimensions.ai/details/publication/pub.1083056129 schema:CreativeWork
    652 https://app.dimensions.ai/details/publication/pub.1083245893 schema:CreativeWork
    653 https://app.dimensions.ai/details/publication/pub.1083259855 schema:CreativeWork
    654 https://doi.org/10.1002/(sici)1097-0029(19981001)43:1<34::aid-jemt6>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1025800189
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1002/(sici)1097-4547(20000201)59:3<321::aid-jnr5>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006288011
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1002/(sici)1097-4598(199802)21:2<173::aid-mus4>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007097588
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1002/(sici)1097-4695(199808)36:2<249::aid-neu11>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018157900
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1002/ana.10262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019711215
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1002/emmm.200900045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052130474
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1002/j.1460-2075.1993.tb05795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082818768
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1002/jez.1402060314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012862364
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1002/mus.880060807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039201999
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1002/pmic.200401028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018292061
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1002/pmic.200800193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013496507
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1006/excr.2002.5653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048819224
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1006/exnr.1999.7028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009203846
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1006/mcne.1996.0595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038646813
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1016/0024-3205(72)90188-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051309216
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1016/0047-6374(82)90105-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028204415
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.1016/0896-6273(94)90046-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038964132
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1016/1074-7613(94)90037-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041252447
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1016/j.ccr.2005.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009037364
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.1016/j.ccr.2007.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030907380
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.1016/j.ceb.2007.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030770957
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.1016/j.cell.2004.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011894036
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.1016/j.cell.2005.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048407942
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.1016/j.cell.2005.11.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004605245
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.1016/j.cell.2006.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427346
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.1016/j.cell.2006.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006598727
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.1016/j.cell.2006.05.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048705898
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.1016/j.cell.2006.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040358058
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.1016/j.cell.2006.12.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022490462
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.1016/j.cell.2007.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002353562
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.1016/j.cell.2008.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009453492
    715 rdf:type schema:CreativeWork
    716 https://doi.org/10.1016/j.cell.2008.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052266867
    717 rdf:type schema:CreativeWork
    718 https://doi.org/10.1016/j.cell.2008.01.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000523667
    719 rdf:type schema:CreativeWork
    720 https://doi.org/10.1016/j.cell.2008.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020026641
    721 rdf:type schema:CreativeWork
    722 https://doi.org/10.1016/j.cell.2008.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006532265
    723 rdf:type schema:CreativeWork
    724 https://doi.org/10.1016/j.cell.2008.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039507812
    725 rdf:type schema:CreativeWork
    726 https://doi.org/10.1016/j.cell.2008.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029721839
    727 rdf:type schema:CreativeWork
    728 https://doi.org/10.1016/j.cell.2009.12.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023643706
    729 rdf:type schema:CreativeWork
    730 https://doi.org/10.1016/j.cmet.2008.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009117044
    731 rdf:type schema:CreativeWork
    732 https://doi.org/10.1016/j.cmet.2008.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030233315
    733 rdf:type schema:CreativeWork
    734 https://doi.org/10.1016/j.cmet.2010.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012702371
    735 rdf:type schema:CreativeWork
    736 https://doi.org/10.1016/j.cmet.2010.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052432184
    737 rdf:type schema:CreativeWork
    738 https://doi.org/10.1016/j.coi.2010.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023918486
    739 rdf:type schema:CreativeWork
    740 https://doi.org/10.1016/j.exger.2008.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001839137
    741 rdf:type schema:CreativeWork
    742 https://doi.org/10.1016/j.immuni.2004.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018487280
    743 rdf:type schema:CreativeWork
    744 https://doi.org/10.1016/j.molcel.2004.08.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021456132
    745 rdf:type schema:CreativeWork
    746 https://doi.org/10.1016/j.molcel.2008.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001431745
    747 rdf:type schema:CreativeWork
    748 https://doi.org/10.1016/j.neurobiolaging.2005.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024849201
    749 rdf:type schema:CreativeWork
    750 https://doi.org/10.1016/j.neurobiolaging.2006.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005646389
    751 rdf:type schema:CreativeWork
    752 https://doi.org/10.1016/j.neuron.2006.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036731955
    753 rdf:type schema:CreativeWork
    754 https://doi.org/10.1016/j.neuron.2007.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052095309
    755 rdf:type schema:CreativeWork
    756 https://doi.org/10.1016/j.neuron.2009.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102577
    757 rdf:type schema:CreativeWork
    758 https://doi.org/10.1016/j.stem.2007.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018684028
    759 rdf:type schema:CreativeWork
    760 https://doi.org/10.1016/j.stem.2007.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021513377
    761 rdf:type schema:CreativeWork
    762 https://doi.org/10.1016/j.stem.2007.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030610297
    763 rdf:type schema:CreativeWork
    764 https://doi.org/10.1016/j.stem.2007.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032399604
    765 rdf:type schema:CreativeWork
    766 https://doi.org/10.1016/j.stem.2007.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043703121
    767 rdf:type schema:CreativeWork
    768 https://doi.org/10.1016/j.stem.2007.07.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010190073
    769 rdf:type schema:CreativeWork
    770 https://doi.org/10.1016/j.stem.2007.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032499001
    771 rdf:type schema:CreativeWork
    772 https://doi.org/10.1016/j.stem.2007.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045510569
    773 rdf:type schema:CreativeWork
    774 https://doi.org/10.1016/j.stem.2008.07.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037789945
    775 rdf:type schema:CreativeWork
    776 https://doi.org/10.1016/j.stem.2009.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037466375
    777 rdf:type schema:CreativeWork
    778 https://doi.org/10.1016/j.stem.2009.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024299758
    779 rdf:type schema:CreativeWork
    780 https://doi.org/10.1016/j.stem.2009.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036343109
    781 rdf:type schema:CreativeWork
    782 https://doi.org/10.1016/j.stem.2009.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003614107
    783 rdf:type schema:CreativeWork
    784 https://doi.org/10.1016/j.stem.2010.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040694891
    785 rdf:type schema:CreativeWork
    786 https://doi.org/10.1016/j.stem.2010.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042385160
    787 rdf:type schema:CreativeWork
    788 https://doi.org/10.1016/j.stem.2010.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026627772
    789 rdf:type schema:CreativeWork
    790 https://doi.org/10.1016/j.stem.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118397
    791 rdf:type schema:CreativeWork
    792 https://doi.org/10.1016/j.stem.2010.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007121562
    793 rdf:type schema:CreativeWork
    794 https://doi.org/10.1016/j.tibs.2004.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038354843
    795 rdf:type schema:CreativeWork
    796 https://doi.org/10.1016/j.ydbio.2009.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004247307
    797 rdf:type schema:CreativeWork
    798 https://doi.org/10.1016/j.ydbio.2010.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026350686
    799 rdf:type schema:CreativeWork
    800 https://doi.org/10.1016/s0002-9440(10)64615-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022458650
    801 rdf:type schema:CreativeWork
    802 https://doi.org/10.1016/s0047-6374(00)00137-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028227229
    803 rdf:type schema:CreativeWork
    804 https://doi.org/10.1016/s0092-8674(00)80080-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018729685
    805 rdf:type schema:CreativeWork
    806 https://doi.org/10.1016/s0092-8674(00)80580-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024660332
    807 rdf:type schema:CreativeWork
    808 https://doi.org/10.1016/s0092-8674(00)80783-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024856119
    809 rdf:type schema:CreativeWork
    810 https://doi.org/10.1016/s0092-8674(00)81181-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021548250
    811 rdf:type schema:CreativeWork
    812 https://doi.org/10.1016/s0092-8674(00)82001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024840973
    813 rdf:type schema:CreativeWork
    814 https://doi.org/10.1016/s0092-8674(02)00976-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009600594
    815 rdf:type schema:CreativeWork
    816 https://doi.org/10.1016/s0092-8674(03)00687-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037266204
    817 rdf:type schema:CreativeWork
    818 https://doi.org/10.1016/s0092-8674(04)00126-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025002057
    819 rdf:type schema:CreativeWork
    820 https://doi.org/10.1016/s0092-8674(04)00302-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027076992
    821 rdf:type schema:CreativeWork
    822 https://doi.org/10.1016/s0197-4580(03)00083-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013451964
    823 rdf:type schema:CreativeWork
    824 https://doi.org/10.1016/s0301-472x(00)00169-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015349508
    825 rdf:type schema:CreativeWork
    826 https://doi.org/10.1016/s0306-4522(01)00378-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009256429
    827 rdf:type schema:CreativeWork
    828 https://doi.org/10.1016/s0896-6273(04)00140-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051933422
    829 rdf:type schema:CreativeWork
    830 https://doi.org/10.1016/s0959-437x(02)00013-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022313571
    831 rdf:type schema:CreativeWork
    832 https://doi.org/10.1016/s0960-9822(07)00377-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050961925
    833 rdf:type schema:CreativeWork
    834 https://doi.org/10.1016/s1357-2725(03)00042-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003857222
    835 rdf:type schema:CreativeWork
    836 https://doi.org/10.1017/s1740925x10000049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054941802
    837 rdf:type schema:CreativeWork
    838 https://doi.org/10.1042/bj20070140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008696131
    839 rdf:type schema:CreativeWork
    840 https://doi.org/10.1046/j.1474-9728.2002.00017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043881456
    841 rdf:type schema:CreativeWork
    842 https://doi.org/10.1056/nejmra043666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040422233
    843 rdf:type schema:CreativeWork
    844 https://doi.org/10.1073/pnas.0303792101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019561902
    845 rdf:type schema:CreativeWork
    846 https://doi.org/10.1073/pnas.0400593101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010142859
    847 rdf:type schema:CreativeWork
    848 https://doi.org/10.1073/pnas.0404184101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041859976
    849 rdf:type schema:CreativeWork
    850 https://doi.org/10.1073/pnas.0407643101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035479407
    851 rdf:type schema:CreativeWork
    852 https://doi.org/10.1073/pnas.0502738102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013038260
    853 rdf:type schema:CreativeWork
    854 https://doi.org/10.1073/pnas.0503280102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032169193
    855 rdf:type schema:CreativeWork
    856 https://doi.org/10.1073/pnas.0704089104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032993565
    857 rdf:type schema:CreativeWork
    858 https://doi.org/10.1073/pnas.0800612105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009394985
    859 rdf:type schema:CreativeWork
    860 https://doi.org/10.1073/pnas.0802674106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016837159
    861 rdf:type schema:CreativeWork
    862 https://doi.org/10.1073/pnas.0805498105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015107556
    863 rdf:type schema:CreativeWork
    864 https://doi.org/10.1073/pnas.0809594106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020083315
    865 rdf:type schema:CreativeWork
    866 https://doi.org/10.1073/pnas.0810407106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007019220
    867 rdf:type schema:CreativeWork
    868 https://doi.org/10.1073/pnas.0812889106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002066445
    869 rdf:type schema:CreativeWork
    870 https://doi.org/10.1073/pnas.0907739107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000470475
    871 rdf:type schema:CreativeWork
    872 https://doi.org/10.1073/pnas.1000834107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004497675
    873 rdf:type schema:CreativeWork
    874 https://doi.org/10.1073/pnas.1001702107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028693584
    875 rdf:type schema:CreativeWork
    876 https://doi.org/10.1073/pnas.1131928100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052435481
    877 rdf:type schema:CreativeWork
    878 https://doi.org/10.1073/pnas.232568499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003031569
    879 rdf:type schema:CreativeWork
    880 https://doi.org/10.1073/pnas.89.7.2804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010787745
    881 rdf:type schema:CreativeWork
    882 https://doi.org/10.1073/pnas.90.5.2074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015184172
    883 rdf:type schema:CreativeWork
    884 https://doi.org/10.1073/pnas.96.6.3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051052670
    885 rdf:type schema:CreativeWork
    886 https://doi.org/10.1073/pnas.97.4.1823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032677018
    887 rdf:type schema:CreativeWork
    888 https://doi.org/10.1074/jbc.m210256200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017827262
    889 rdf:type schema:CreativeWork
    890 https://doi.org/10.1074/jbc.m401138200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017857173
    891 rdf:type schema:CreativeWork
    892 https://doi.org/10.1074/jbc.m412357200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017748692
    893 rdf:type schema:CreativeWork
    894 https://doi.org/10.1074/jbc.m704735200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044434377
    895 rdf:type schema:CreativeWork
    896 https://doi.org/10.1074/jbc.m800517200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018328585
    897 rdf:type schema:CreativeWork
    898 https://doi.org/10.1080/00365510802419447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044717719
    899 rdf:type schema:CreativeWork
    900 https://doi.org/10.1083/jcb.200810133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008813128
    901 rdf:type schema:CreativeWork
    902 https://doi.org/10.1084/jem.183.4.1797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044033062
    903 rdf:type schema:CreativeWork
    904 https://doi.org/10.1084/jem.192.9.1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009649229
    905 rdf:type schema:CreativeWork
    906 https://doi.org/10.1084/jem.20052477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046449695
    907 rdf:type schema:CreativeWork
    908 https://doi.org/10.1084/jem.20091318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026339482
    909 rdf:type schema:CreativeWork
    910 https://doi.org/10.1089/rej.2008.0827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059308181
    911 rdf:type schema:CreativeWork
    912 https://doi.org/10.1091/mbc.e07-09-0965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023049012
    913 rdf:type schema:CreativeWork
    914 https://doi.org/10.1093/emboj/19.8.1839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041153282
    915 rdf:type schema:CreativeWork
    916 https://doi.org/10.1093/emboj/20.17.4935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033340693
    917 rdf:type schema:CreativeWork
    918 https://doi.org/10.1093/hmg/ddp459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027606779
    919 rdf:type schema:CreativeWork
    920 https://doi.org/10.1101/gad.1035902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394366
    921 rdf:type schema:CreativeWork
    922 https://doi.org/10.1101/gad.1061803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004107821
    923 rdf:type schema:CreativeWork
    924 https://doi.org/10.1101/gad.1143403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022045585
    925 rdf:type schema:CreativeWork
    926 https://doi.org/10.1101/gad.1299305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000382265
    927 rdf:type schema:CreativeWork
    928 https://doi.org/10.1101/gad.1299505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036013538
    929 rdf:type schema:CreativeWork
    930 https://doi.org/10.1101/gad.13.19.2570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016621585
    931 rdf:type schema:CreativeWork
    932 https://doi.org/10.1101/gad.1382606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005144219
    933 rdf:type schema:CreativeWork
    934 https://doi.org/10.1101/gad.1393106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027983110
    935 rdf:type schema:CreativeWork
    936 https://doi.org/10.1101/gad.1467506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007038366
    937 rdf:type schema:CreativeWork
    938 https://doi.org/10.1101/gad.1588507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009827222
    939 rdf:type schema:CreativeWork
    940 https://doi.org/10.1101/gad.1673508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032353888
    941 rdf:type schema:CreativeWork
    942 https://doi.org/10.1101/gad.1787609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044718967
    943 rdf:type schema:CreativeWork
    944 https://doi.org/10.1101/gad.1849509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053018957
    945 rdf:type schema:CreativeWork
    946 https://doi.org/10.1101/gad.415507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042100087
    947 rdf:type schema:CreativeWork
    948 https://doi.org/10.1101/gad.453107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039070086
    949 rdf:type schema:CreativeWork
    950 https://doi.org/10.1101/gad.479308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023938270
    951 rdf:type schema:CreativeWork
    952 https://doi.org/10.1101/gad.510809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046326493
    953 rdf:type schema:CreativeWork
    954 https://doi.org/10.1101/gad.511109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050491870
    955 rdf:type schema:CreativeWork
    956 https://doi.org/10.1101/gad.560310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010714597
    957 rdf:type schema:CreativeWork
    958 https://doi.org/10.1101/gad.8.7.757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052047444
    959 rdf:type schema:CreativeWork
    960 https://doi.org/10.1111/j.1474-9726.2007.00286.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011036700
    961 rdf:type schema:CreativeWork