Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Punita Dhawan, Rizwan Ahmad, Rupesh Chaturvedi, J. Joshua Smith, Rajiv Midha, Mukul Mittal, Moorthy Krishnan, Xi Chen, Steven Eschrich, Timothy J. Yeatman, Raymond C. Harris, M. Kay Washington, Keith T. Wilson, R. Daniel Beauchamp, Amar B. Singh

ABSTRACT

Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial leakiness in vitro. However, recent evidence suggests potential functions of claudin-2 that are relevant to neoplastic transformation and growth. In accordance, here we report, on the basis of analysis of mRNA and protein expression using a total of 309 patient samples that claudin-2 expression is significantly increased in colorectal cancer and correlates with cancer progression. We also report similar increases in claudin-2 expression in inflammatory bowel disease-associated colorectal cancer. Most importantly, we demonstrate that the increased claudin-2 expression in colorectal cancer is causally associated with tumor growth as forced claudin-2 expression in colon cancer cells that do not express claudin-2 resulted in significant increases in cell proliferation, anchorage-independent growth and tumor growth in vivo. We further show that the colonic microenvironment regulates claudin-2 expression in a manner dependent on signaling through the EGF receptor (EGFR), a key regulator of colon tumorigenesis. In addition, claudin-2 expression is specifically decreased in the colon of waved-2 mice, naturally deficient in EGFR activation. Furthermore, genetic silencing of claudin-2 expression in Caco-2, a colon cancer cell line, prevents the EGF-induced increase in cell proliferation. Taken together, these results uncover a novel role for claudin-2 in promoting colon cancer, potentially via EGFR transactivation. More... »

PAGES

3234

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2011.43

DOI

http://dx.doi.org/10.1038/onc.2011.43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052551075

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21383692


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