Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

D Wang, W Ning, D Xie, L Guo, R N DuBois

ABSTRACT

Peroxisome proliferator-activated receptor γ (PPARγ) may serve as a useful target for drug development in non-diabetic diseases. However, some colorectal cancer cells are resistant to PPARγ agonists by mechanisms that are poorly understood. Here, we provide the first evidence that elevated PPARδ expression and/or activation of PPARδ antagonize the ability of PPARγ to induce colorectal carcinoma cell death. More importantly, the opposing effects of PPARδ and PPARγ in regulating programmed cell death are mediated by survivin and caspase-3. We found that activation of PPARγ results in decreased survivin expression and increased caspase-3 activity, whereas activation of PPARδ counteracts these effects. Our findings suggest that PPARδ and PPARγ coordinately regulate cancer cell fate by controlling the balance between the cell death and survival and demonstrate that inhibition of PPARδ can reprogram PPARγ ligand-resistant cells to respond to PPARγ agonists. More... »

PAGES

onc2011299

References to SciGraph publications

  • 1998-09. Activators of the nuclear receptor PPARγ enhance colon polyp formation in NATURE MEDICINE
  • 1998-09. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice in NATURE MEDICINE
  • 2006-05. PPARγ insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor-κB signaling pathway in ONCOGENE
  • 1998-09. Differentiation and reversal of malignant changes in colon cancer through PPARγ in NATURE MEDICINE
  • 2004-03. Activation of nuclear hormone receptor peroxisome proliferator–activated receptor-δ accelerates intestinal adenoma growth in NATURE MEDICINE
  • 2006-10. Antineoplastic effects of rosiglitazone and PPARγ transactivation in neuroblastoma cells in BRITISH JOURNAL OF CANCER
  • 2003-01. Validating survivin as a cancer therapeutic target in NATURE REVIEWS CANCER
  • 2001-05. Immunohistochemical Detection of the Anti-Apoptosis Protein, Survivin, Predicts Survival After Curative Resection of Stage II Colorectal Carcinomas in ANNALS OF SURGICAL ONCOLOGY
  • 2006-10. Expression of PPARδ in multistage carcinogenesis of the colorectum: implications of malignant cancer morphology in BRITISH JOURNAL OF CANCER
  • 2002-06. Apoptosis: IAP proteins: blocking the road to death's door in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-06. Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study in BREAST CANCER RESEARCH AND TREATMENT
  • 2004-05. Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2011.299

    DOI

    http://dx.doi.org/10.1038/onc.2011.299

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043576307

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21765467


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