Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07-11

AUTHORS

Christopher L. Neal, Jia Xu, Ping Li, Seiji Mori, Jun Yang, Nina N. Neal, Xiaoyan Zhou, Shannon L. Wyszomierski, Dihua Yu

ABSTRACT

The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3ζ overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we investigated the clinical relevance and molecular mechanism of 14-3-3ζ-overexpression-mediated Akt phosphorylation, and its potential impact on breast cancer progression. We found that 14-3-3ζ overexpression was significantly (P=0.005) associated with increased Akt phosphorylation in human breast tumors. Additionally, 14-3-3ζ overexpression combined with strong Akt phosphorylation was significantly (P=0.01) associated with increased cancer recurrence in patients. In contrast, knockdown of 14-3-3ζ expression by small interfering RNA in cancer cell lines and tumor xenografts reduced Akt phosphorylation. Furthermore, 14-3-3ζ enhanced Akt phosphorylation through activation of phosphoinositide 3-kinase (PI3K). Mechanistically, 14-3-3ζ bound to the p85 regulatory subunit of PI3K and increased PI3K translocation to the cell membrane. A single 14-3-3-binding motif encompassing serine 83 on p85 is largely responsible for 14-3-3ζ-mediated p85 binding and PI3K/Akt activation. Mutation of serine 83 to alanine on p85 inhibited 14-3-3ζ binding to the p85 subunit of PI3K, reduced PI3K membrane localization and activation, impeded anchorage-independent growth and enhanced stress-induced apoptosis. These findings revealed a novel mechanism by which 14-3-3ζ overexpression activates PI3K, a key node in the mitogenic signaling network known to promote malignancies in many cell types. More... »

PAGES

897-906

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2011.284

DOI

http://dx.doi.org/10.1038/onc.2011.284

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027088192

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21743495


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "14-3-3 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Class Ia Phosphatidylinositol 3-Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HEK293 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-akt", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neal", 
        "givenName": "Christopher L.", 
        "id": "sg:person.0703262647.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703262647.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
            "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Jia", 
        "id": "sg:person.0743571573.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743571573.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Ping", 
        "id": "sg:person.012422703077.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012422703077.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Seiji", 
        "id": "sg:person.01337742275.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337742275.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
            "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Jun", 
        "id": "sg:person.010062202604.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010062202604.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neal", 
        "givenName": "Nina N.", 
        "id": "sg:person.0662451375.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662451375.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiaoyan", 
        "id": "sg:person.01010610662.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wyszomierski", 
        "givenName": "Shannon L.", 
        "id": "sg:person.01360553547.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360553547.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.", 
            "Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Dihua", 
        "id": "sg:person.07772164547.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07772164547.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1210011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015340967", 
          "https://doi.org/10.1038/sj.onc.1210011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002140358", 
          "https://doi.org/10.1038/sj.onc.1210027"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-07-11", 
    "datePublishedReg": "2011-07-11", 
    "description": "The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3\u03b6 overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we investigated the clinical relevance and molecular mechanism of 14-3-3\u03b6-overexpression-mediated Akt phosphorylation, and its potential impact on breast cancer progression. We found that 14-3-3\u03b6 overexpression was significantly (P=0.005) associated with increased Akt phosphorylation in human breast tumors. Additionally, 14-3-3\u03b6 overexpression combined with strong Akt phosphorylation was significantly (P=0.01) associated with increased cancer recurrence in patients. In contrast, knockdown of 14-3-3\u03b6 expression by small interfering RNA in cancer cell lines and tumor xenografts reduced Akt phosphorylation. Furthermore, 14-3-3\u03b6 enhanced Akt phosphorylation through activation of phosphoinositide 3-kinase (PI3K). Mechanistically, 14-3-3\u03b6 bound to the p85 regulatory subunit of PI3K and increased PI3K translocation to the cell membrane. A single 14-3-3-binding motif encompassing serine 83 on p85 is largely responsible for 14-3-3\u03b6-mediated p85 binding and PI3K/Akt activation. Mutation of serine 83 to alanine on p85 inhibited 14-3-3\u03b6 binding to the p85 subunit of PI3K, reduced PI3K membrane localization and activation, impeded anchorage-independent growth and enhanced stress-induced apoptosis. These findings revealed a novel mechanism by which 14-3-3\u03b6 overexpression activates PI3K, a key node in the mitogenic signaling network known to promote malignancies in many cell types.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/onc.2011.284", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.100075957", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7136485", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7134297", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2477948", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "keywords": [
      "p85 regulatory subunit", 
      "Akt phosphorylation", 
      "PI3K", 
      "regulatory subunit", 
      "serine 83", 
      "activation of phosphoinositide", 
      "stronger Akt phosphorylation", 
      "stress-induced apoptosis", 
      "human mammary epithelial cells", 
      "PI3K/Akt activation", 
      "mammary epithelial cells", 
      "anchorage-independent growth", 
      "p85 binding", 
      "p85 subunit", 
      "membrane localization", 
      "breast cancer progression", 
      "molecular mechanisms", 
      "Akt activation", 
      "phosphorylation", 
      "cell types", 
      "cancer progression", 
      "cancer cell lines", 
      "novel mechanism", 
      "cell membrane", 
      "overexpression", 
      "subunits", 
      "cancer cells", 
      "cell lines", 
      "epithelial cells", 
      "p85", 
      "human breast tumors", 
      "activation", 
      "key nodes", 
      "cells", 
      "phosphoinositide", 
      "tumor xenografts", 
      "knockdown", 
      "RNA", 
      "protein", 
      "translocation", 
      "motif", 
      "mutations", 
      "apoptosis", 
      "pathway", 
      "mechanism", 
      "Mechanistically", 
      "binding", 
      "potential impact", 
      "expression", 
      "membrane", 
      "localization", 
      "breast tumors", 
      "growth", 
      "cancer recurrence", 
      "lines", 
      "progression", 
      "clinical relevance", 
      "xenografts", 
      "contrast", 
      "types", 
      "relevance", 
      "patients", 
      "recurrence", 
      "malignancy", 
      "tumors", 
      "findings", 
      "transformation", 
      "impact", 
      "network", 
      "nodes", 
      "PI3K translocation", 
      "K translocation", 
      "PI3K membrane localization", 
      "K membrane localization", 
      "enhanced stress-induced apoptosis"
    ], 
    "name": "Overexpression of 14-3-3\u03b6 in cancer cells activates PI3K via binding the p85 regulatory subunit", 
    "pagination": "897-906", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027088192"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2011.284"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21743495"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2011.284", 
      "https://app.dimensions.ai/details/publication/pub.1027088192"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_547.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/onc.2011.284"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.284'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.284'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.284'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.284'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      22 PREDICATES      124 URIs      114 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2011.284 schema:about N0238f50925f34258bc10c450ba8a5923
2 N095a8b5af0f6498c869400d2635783c3
3 N0ebae9f29545445bbf70b5dbf98d80e4
4 N1325ab64665e438db6010ae0905000e2
5 N3a23cdb01acf4a9683a850afc2804d69
6 N4c8d7b723dcc4f59a185c1ef94e81282
7 N4e574f3fabc14687906f4d2a52cbd466
8 N506f7869e5aa48aa9358cddffc554866
9 N551ed675cdc34b7abcae0aa1f93909cd
10 N7019337068a24049a23abd76523f9815
11 N82153e614ff74e68b50efcef07cf0bb1
12 N84edcf6180dc47139e4827fb52d89168
13 Na6713c86f0bc4c3598492cb46cf585fe
14 Nbd4cf8c974d14e64ae7a81accff5f6bf
15 Nc005472afc7f40ecad2c9253e1b58de8
16 Ncccfdbe982ca44588361a070a6d3f6cd
17 Nd5648090da69468fa4b391ca8acc890c
18 Nd574596d77af49c4a49720ba19b4c33e
19 Ne2e9b9dc2d1e4e1f8aed238265d63ac7
20 Ne64aa1d1863d411f9926aadaeef023e8
21 Nf48dbf75764049c8a16971edb7a94b68
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author N352da39012454f04b0dfde857b4d2f5b
25 schema:citation sg:pub.10.1038/sj.onc.1210011
26 sg:pub.10.1038/sj.onc.1210027
27 schema:datePublished 2011-07-11
28 schema:datePublishedReg 2011-07-11
29 schema:description The ubiquitously expressed 14-3-3 proteins regulate many pathways involved in transformation. Previously, we found that 14-3-3ζ overexpression increased Akt phosphorylation in human mammary epithelial cells. Here, we investigated the clinical relevance and molecular mechanism of 14-3-3ζ-overexpression-mediated Akt phosphorylation, and its potential impact on breast cancer progression. We found that 14-3-3ζ overexpression was significantly (P=0.005) associated with increased Akt phosphorylation in human breast tumors. Additionally, 14-3-3ζ overexpression combined with strong Akt phosphorylation was significantly (P=0.01) associated with increased cancer recurrence in patients. In contrast, knockdown of 14-3-3ζ expression by small interfering RNA in cancer cell lines and tumor xenografts reduced Akt phosphorylation. Furthermore, 14-3-3ζ enhanced Akt phosphorylation through activation of phosphoinositide 3-kinase (PI3K). Mechanistically, 14-3-3ζ bound to the p85 regulatory subunit of PI3K and increased PI3K translocation to the cell membrane. A single 14-3-3-binding motif encompassing serine 83 on p85 is largely responsible for 14-3-3ζ-mediated p85 binding and PI3K/Akt activation. Mutation of serine 83 to alanine on p85 inhibited 14-3-3ζ binding to the p85 subunit of PI3K, reduced PI3K membrane localization and activation, impeded anchorage-independent growth and enhanced stress-induced apoptosis. These findings revealed a novel mechanism by which 14-3-3ζ overexpression activates PI3K, a key node in the mitogenic signaling network known to promote malignancies in many cell types.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf Nbb4850b7e18d47c4863df5e2a57ffdaf
34 Nfe7838c2596e41fbb7710345696a511d
35 sg:journal.1097543
36 schema:keywords Akt activation
37 Akt phosphorylation
38 K membrane localization
39 K translocation
40 Mechanistically
41 PI3K
42 PI3K membrane localization
43 PI3K translocation
44 PI3K/Akt activation
45 RNA
46 activation
47 activation of phosphoinositide
48 anchorage-independent growth
49 apoptosis
50 binding
51 breast cancer progression
52 breast tumors
53 cancer cell lines
54 cancer cells
55 cancer progression
56 cancer recurrence
57 cell lines
58 cell membrane
59 cell types
60 cells
61 clinical relevance
62 contrast
63 enhanced stress-induced apoptosis
64 epithelial cells
65 expression
66 findings
67 growth
68 human breast tumors
69 human mammary epithelial cells
70 impact
71 key nodes
72 knockdown
73 lines
74 localization
75 malignancy
76 mammary epithelial cells
77 mechanism
78 membrane
79 membrane localization
80 molecular mechanisms
81 motif
82 mutations
83 network
84 nodes
85 novel mechanism
86 overexpression
87 p85
88 p85 binding
89 p85 regulatory subunit
90 p85 subunit
91 pathway
92 patients
93 phosphoinositide
94 phosphorylation
95 potential impact
96 progression
97 protein
98 recurrence
99 regulatory subunit
100 relevance
101 serine 83
102 stress-induced apoptosis
103 stronger Akt phosphorylation
104 subunits
105 transformation
106 translocation
107 tumor xenografts
108 tumors
109 types
110 xenografts
111 schema:name Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit
112 schema:pagination 897-906
113 schema:productId N1475ceab9a7d4f12a1b2553e3235032d
114 N74b6f1bc0f0144f2813e76eb3ae69f3e
115 Nfabca75b6d3848f7a6ed7b043fb5e466
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027088192
117 https://doi.org/10.1038/onc.2011.284
118 schema:sdDatePublished 2022-01-01T18:25
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher N5d679bdfc13445eebbdee615fa7164b3
121 schema:url https://doi.org/10.1038/onc.2011.284
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N0238f50925f34258bc10c450ba8a5923 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Gene Expression Regulation, Neoplastic
127 rdf:type schema:DefinedTerm
128 N05cef587e9f84f95a5763d2a938fe329 rdf:first sg:person.012422703077.00
129 rdf:rest Nc9fbc5e9a1244a7ea862cb77cc8ead57
130 N095a8b5af0f6498c869400d2635783c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Proto-Oncogene Proteins c-akt
132 rdf:type schema:DefinedTerm
133 N0ebae9f29545445bbf70b5dbf98d80e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cells, Cultured
135 rdf:type schema:DefinedTerm
136 N121ce923363f44569019a7b927ce6751 rdf:first sg:person.07772164547.83
137 rdf:rest rdf:nil
138 N1325ab64665e438db6010ae0905000e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Enzyme Activation
140 rdf:type schema:DefinedTerm
141 N1475ceab9a7d4f12a1b2553e3235032d schema:name doi
142 schema:value 10.1038/onc.2011.284
143 rdf:type schema:PropertyValue
144 N2a4afd4119804b418b56bbf38e183780 rdf:first sg:person.0743571573.32
145 rdf:rest N05cef587e9f84f95a5763d2a938fe329
146 N352da39012454f04b0dfde857b4d2f5b rdf:first sg:person.0703262647.62
147 rdf:rest N2a4afd4119804b418b56bbf38e183780
148 N3a23cdb01acf4a9683a850afc2804d69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Animals
150 rdf:type schema:DefinedTerm
151 N4c8d7b723dcc4f59a185c1ef94e81282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mutation
153 rdf:type schema:DefinedTerm
154 N4e574f3fabc14687906f4d2a52cbd466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Protein Binding
156 rdf:type schema:DefinedTerm
157 N506f7869e5aa48aa9358cddffc554866 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name RNA Interference
159 rdf:type schema:DefinedTerm
160 N551ed675cdc34b7abcae0aa1f93909cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Immunoblotting
162 rdf:type schema:DefinedTerm
163 N5d679bdfc13445eebbdee615fa7164b3 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N7019337068a24049a23abd76523f9815 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name HEK293 Cells
167 rdf:type schema:DefinedTerm
168 N74b6f1bc0f0144f2813e76eb3ae69f3e schema:name pubmed_id
169 schema:value 21743495
170 rdf:type schema:PropertyValue
171 N7bf7faeeae93414db8c8e0596222f529 rdf:first sg:person.0662451375.43
172 rdf:rest Nb643ac8a640c456c9c229600fac47adb
173 N82153e614ff74e68b50efcef07cf0bb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Amino Acid Substitution
175 rdf:type schema:DefinedTerm
176 N84edcf6180dc47139e4827fb52d89168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cell Line
178 rdf:type schema:DefinedTerm
179 Na6713c86f0bc4c3598492cb46cf585fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Class Ia Phosphatidylinositol 3-Kinase
181 rdf:type schema:DefinedTerm
182 Nb33c329c53e348b6b61c7246f65368ea rdf:first sg:person.010062202604.45
183 rdf:rest N7bf7faeeae93414db8c8e0596222f529
184 Nb643ac8a640c456c9c229600fac47adb rdf:first sg:person.01010610662.09
185 rdf:rest Nf4708339f9fe4b0abc4baf6edd492d60
186 Nbb4850b7e18d47c4863df5e2a57ffdaf schema:volumeNumber 31
187 rdf:type schema:PublicationVolume
188 Nbd4cf8c974d14e64ae7a81accff5f6bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name 14-3-3 Proteins
190 rdf:type schema:DefinedTerm
191 Nc005472afc7f40ecad2c9253e1b58de8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Immunohistochemistry
193 rdf:type schema:DefinedTerm
194 Nc9fbc5e9a1244a7ea862cb77cc8ead57 rdf:first sg:person.01337742275.35
195 rdf:rest Nb33c329c53e348b6b61c7246f65368ea
196 Ncccfdbe982ca44588361a070a6d3f6cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Cell Line, Tumor
198 rdf:type schema:DefinedTerm
199 Nd5648090da69468fa4b391ca8acc890c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Mice
201 rdf:type schema:DefinedTerm
202 Nd574596d77af49c4a49720ba19b4c33e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Humans
204 rdf:type schema:DefinedTerm
205 Ne2e9b9dc2d1e4e1f8aed238265d63ac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Mice, Knockout
207 rdf:type schema:DefinedTerm
208 Ne64aa1d1863d411f9926aadaeef023e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Breast Neoplasms
210 rdf:type schema:DefinedTerm
211 Nf4708339f9fe4b0abc4baf6edd492d60 rdf:first sg:person.01360553547.35
212 rdf:rest N121ce923363f44569019a7b927ce6751
213 Nf48dbf75764049c8a16971edb7a94b68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Phosphorylation
215 rdf:type schema:DefinedTerm
216 Nfabca75b6d3848f7a6ed7b043fb5e466 schema:name dimensions_id
217 schema:value pub.1027088192
218 rdf:type schema:PropertyValue
219 Nfe7838c2596e41fbb7710345696a511d schema:issueNumber 7
220 rdf:type schema:PublicationIssue
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
225 schema:name Oncology and Carcinogenesis
226 rdf:type schema:DefinedTerm
227 sg:grant.100075957 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
228 rdf:type schema:MonetaryGrant
229 sg:grant.2435793 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
230 rdf:type schema:MonetaryGrant
231 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
232 rdf:type schema:MonetaryGrant
233 sg:grant.2477948 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
234 rdf:type schema:MonetaryGrant
235 sg:grant.7134297 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
236 rdf:type schema:MonetaryGrant
237 sg:grant.7136485 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2011.284
238 rdf:type schema:MonetaryGrant
239 sg:journal.1097543 schema:issn 0950-9232
240 1476-5594
241 schema:name Oncogene
242 schema:publisher Springer Nature
243 rdf:type schema:Periodical
244 sg:person.010062202604.45 schema:affiliation grid-institutes:None
245 schema:familyName Yang
246 schema:givenName Jun
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010062202604.45
248 rdf:type schema:Person
249 sg:person.01010610662.09 schema:affiliation grid-institutes:grid.240145.6
250 schema:familyName Zhou
251 schema:givenName Xiaoyan
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010610662.09
253 rdf:type schema:Person
254 sg:person.012422703077.00 schema:affiliation grid-institutes:grid.240145.6
255 schema:familyName Li
256 schema:givenName Ping
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012422703077.00
258 rdf:type schema:Person
259 sg:person.01337742275.35 schema:affiliation grid-institutes:grid.240145.6
260 schema:familyName Mori
261 schema:givenName Seiji
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337742275.35
263 rdf:type schema:Person
264 sg:person.01360553547.35 schema:affiliation grid-institutes:grid.240145.6
265 schema:familyName Wyszomierski
266 schema:givenName Shannon L.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360553547.35
268 rdf:type schema:Person
269 sg:person.0662451375.43 schema:affiliation grid-institutes:grid.240145.6
270 schema:familyName Neal
271 schema:givenName Nina N.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662451375.43
273 rdf:type schema:Person
274 sg:person.0703262647.62 schema:affiliation grid-institutes:grid.240145.6
275 schema:familyName Neal
276 schema:givenName Christopher L.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703262647.62
278 rdf:type schema:Person
279 sg:person.0743571573.32 schema:affiliation grid-institutes:None
280 schema:familyName Xu
281 schema:givenName Jia
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743571573.32
283 rdf:type schema:Person
284 sg:person.07772164547.83 schema:affiliation grid-institutes:None
285 schema:familyName Yu
286 schema:givenName Dihua
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07772164547.83
288 rdf:type schema:Person
289 sg:pub.10.1038/sj.onc.1210011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015340967
290 https://doi.org/10.1038/sj.onc.1210011
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/sj.onc.1210027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002140358
293 https://doi.org/10.1038/sj.onc.1210027
294 rdf:type schema:CreativeWork
295 grid-institutes:None schema:alternateName Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.
296 schema:name Cancer Biology Program, the University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, 77030, USA.
297 Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
298 rdf:type schema:Organization
299 grid-institutes:grid.240145.6 schema:alternateName Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
300 schema:name Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...