Ontology type: schema:ScholarlyArticle Open Access: True
2012-01
AUTHORSF Xing, Y Persaud, C A Pratilas, B S Taylor, M Janakiraman, Q-B She, H Gallardo, C Liu, T Merghoub, B Hefter, I Dolgalev, A Viale, A Heguy, E De Stanchina, D Cobrinik, G Bollag, J Wolchok, A Houghton, D B Solit
ABSTRACTIdentifying the spectrum of genetic alterations that cooperate with critical oncogenes to promote transformation provides a foundation for understanding the diversity of clinical phenotypes observed in human cancers. Here, we performed integrated analyses to identify genomic alterations that co-occur with oncogenic BRAF in melanoma and abrogate cellular dependence upon this oncogene. We identified concurrent mutational inactivation of the PTEN and RB1 tumor suppressors as a mechanism for loss of BRAF/MEK dependence in melanomas harboring (V600E)BRAF mutations. RB1 alterations were mutually exclusive with loss of p16(INK4A), suggesting that whereas p16(INK4A) and RB1 may have overlapping roles in preventing tumor formation, tumors with loss of RB1 exhibit diminished dependence upon BRAF signaling for cell proliferation. These findings provide a genetic basis for the heterogeneity of clinical outcomes in patients treated with targeted inhibitors of the mitogen-activated protein kinase pathway. Our results also suggest a need for comprehensive screening for RB1 and PTEN inactivation in patients treated with RAF and MEK-selective inhibitors to determine whether these alterations are associated with diminished clinical benefit in patients whose cancers harbor mutant BRAF. More... »
PAGES446
http://scigraph.springernature.com/pub.10.1038/onc.2011.250
DOIhttp://dx.doi.org/10.1038/onc.2011.250
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1047080070
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21725359
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclin-Dependent Kinase 4",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Melanoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mitogen-Activated Protein Kinase Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "PTEN Phosphohydrolase",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphatidylinositol 3-Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins B-raf",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-akt",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retinoblastoma Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Suppressor Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "raf Kinases",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Xing",
"givenName": "F",
"id": "sg:person.01201342305.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201342305.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Persaud",
"givenName": "Y",
"id": "sg:person.01274464746.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274464746.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA",
"The Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Pratilas",
"givenName": "C A",
"id": "sg:person.01232552412.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232552412.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Taylor",
"givenName": "B S",
"id": "sg:person.01333376013.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333376013.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Janakiraman",
"givenName": "M",
"id": "sg:person.01342600146.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342600146.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "She",
"givenName": "Q-B",
"id": "sg:person.0652474177.06",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652474177.06"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Gallardo",
"givenName": "H",
"id": "sg:person.01105360775.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105360775.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Liu",
"givenName": "C",
"id": "sg:person.0726076314.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726076314.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA",
"The Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Merghoub",
"givenName": "T",
"id": "sg:person.01046024744.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024744.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Hefter",
"givenName": "B",
"id": "sg:person.015763241643.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015763241643.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Dolgalev",
"givenName": "I",
"id": "sg:person.0663124601.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663124601.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Viale",
"givenName": "A",
"id": "sg:person.0712021032.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Heguy",
"givenName": "A",
"id": "sg:person.015614157607.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015614157607.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "De Stanchina",
"givenName": "E",
"id": "sg:person.01255530067.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255530067.36"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Cobrinik",
"givenName": "D",
"id": "sg:person.0776365066.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776365066.92"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Plexxikon Inc, Berkeley, CA, USA"
],
"type": "Organization"
},
"familyName": "Bollag",
"givenName": "G",
"id": "sg:person.0711247771.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711247771.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA",
"The Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Wolchok",
"givenName": "J",
"id": "sg:person.0645565266.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645565266.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Houghton",
"givenName": "A",
"id": "sg:person.0740431650.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740431650.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA",
"The Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA"
],
"type": "Organization"
},
"familyName": "Solit",
"givenName": "D B",
"id": "sg:person.0656335277.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656335277.50"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003324113",
"https://doi.org/10.1038/nature03890"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04874",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005734911",
"https://doi.org/10.1038/nature04874"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04874",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005734911",
"https://doi.org/10.1038/nature04874"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04874",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005734911",
"https://doi.org/10.1038/nature04874"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.89.10.4549",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005956938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-08-2223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006397342"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08902",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006916541",
"https://doi.org/10.1038/nature08902"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08902",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006916541",
"https://doi.org/10.1038/nature08902"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-3433",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007018612"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-3433",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007018612"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08833",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009288742",
"https://doi.org/10.1038/nature08833"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08833",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009288742",
"https://doi.org/10.1038/nature08833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1516407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011130565"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012130507",
"https://doi.org/10.1038/nature04304"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012130507",
"https://doi.org/10.1038/nature04304"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012130507",
"https://doi.org/10.1038/nature04304"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1986.110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012780442",
"https://doi.org/10.1038/bjc.1986.110"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1986.110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012780442",
"https://doi.org/10.1038/bjc.1986.110"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1002011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012824919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990110707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015461572"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cyto.990110707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015461572"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-2264(199811)23:3<273::aid-gcc11>3.0.co;2-n",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015909323"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc2401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015933644",
"https://doi.org/10.1038/nrc2401"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017445972",
"https://doi.org/10.1038/nsmb859"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nsmb859",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017445972",
"https://doi.org/10.1038/nsmb859"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019872106",
"https://doi.org/10.1038/ng.356"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019872106",
"https://doi.org/10.1038/ng.356"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1954",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021197931",
"https://doi.org/10.1038/nrc1954"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1954",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021197931",
"https://doi.org/10.1038/nrc1954"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1975",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021860958",
"https://doi.org/10.1038/ng1975"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature00766",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023536940",
"https://doi.org/10.1038/nature00766"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.12.040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028106155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0003179",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029898087"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btl646",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031224678"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032620847",
"https://doi.org/10.1038/nature09454"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09454",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032620847",
"https://doi.org/10.1038/nature09454"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1503",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033502588",
"https://doi.org/10.1038/nrc1503"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1503",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033502588",
"https://doi.org/10.1038/nrc1503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-0192",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036424950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1008990107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039016844"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature07385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039570773",
"https://doi.org/10.1038/nature07385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-0902",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042988841"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cub.2005.01.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046159905"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1479-5876-8-39",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050587923",
"https://doi.org/10.1186/1479-5876-8-39"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2010.01.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051517999"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-03-3739",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051999053"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.4956",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052792184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0711741105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053628579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/85.14.1121",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059818040"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.2537532",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062542761"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076569024",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1989.tb08594.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079024711"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2008.26.15_suppl.9033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079374487"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082566659",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082957628",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083182833",
"type": "CreativeWork"
}
],
"datePublished": "2012-01",
"datePublishedReg": "2012-01-01",
"description": "Identifying the spectrum of genetic alterations that cooperate with critical oncogenes to promote transformation provides a foundation for understanding the diversity of clinical phenotypes observed in human cancers. Here, we performed integrated analyses to identify genomic alterations that co-occur with oncogenic BRAF in melanoma and abrogate cellular dependence upon this oncogene. We identified concurrent mutational inactivation of the PTEN and RB1 tumor suppressors as a mechanism for loss of BRAF/MEK dependence in melanomas harboring (V600E)BRAF mutations. RB1 alterations were mutually exclusive with loss of p16(INK4A), suggesting that whereas p16(INK4A) and RB1 may have overlapping roles in preventing tumor formation, tumors with loss of RB1 exhibit diminished dependence upon BRAF signaling for cell proliferation. These findings provide a genetic basis for the heterogeneity of clinical outcomes in patients treated with targeted inhibitors of the mitogen-activated protein kinase pathway. Our results also suggest a need for comprehensive screening for RB1 and PTEN inactivation in patients treated with RAF and MEK-selective inhibitors to determine whether these alterations are associated with diminished clinical benefit in patients whose cancers harbor mutant BRAF.",
"genre": "research_article",
"id": "sg:pub.10.1038/onc.2011.250",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2438793",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2479261",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2411178",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1097543",
"issn": [
"0950-9232",
"1476-5594"
],
"name": "Oncogene",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"name": "Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF",
"pagination": "446",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e0466d8d487040f4555109f803d64959d6916de7d853d70ef94997ff92b06243"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21725359"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8711562"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/onc.2011.250"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1047080070"
]
}
],
"sameAs": [
"https://doi.org/10.1038/onc.2011.250",
"https://app.dimensions.ai/details/publication/pub.1047080070"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000426.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/onc2011250"
}
]
Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.250'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.250'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.250'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2011.250'
This table displays all metadata directly associated to this object as RDF triples.
403 TRIPLES
21 PREDICATES
85 URIs
35 LITERALS
23 BLANK NODES