p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

C Romagosa, S Simonetti, L López-Vicente, A Mazo, M E Lleonart, J Castellvi, S Ramon y Cajal

ABSTRACT

p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16(Ink4a) has also been described in several tumors. This review attempts to elucidate when and why p16(Ink4a) overexpression occurs, and to suggest possible implications of p16(Ink4a) in the diagnosis, prognosis and treatment of cancer. More... »

PAGES

2087

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/onc.2010.614

    DOI

    http://dx.doi.org/10.1038/onc.2010.614

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041845966

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21297668


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