Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01-31

AUTHORS

J Jung, H Y Kim, M Kim, K Sohn, M Kim, K Lee

ABSTRACT

Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the α subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase α subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase )–AKT, Ras–Raf–MEK–ERK1/2, Rac–PAK1/2, MKK3/6–p38 and phospholipase C (PLC)-γ pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression. More... »

PAGES

2264-2274

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2010.604

DOI

http://dx.doi.org/10.1038/onc.2010.604

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022962741

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21278788


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NADPH Oxidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "src-Family Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "J", 
        "id": "sg:person.0611141226.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611141226.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "H Y", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sohn", 
        "givenName": "K", 
        "id": "sg:person.01053034200.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053034200.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea", 
          "id": "http://www.grid.ac/institutes/grid.255649.9", 
          "name": [
            "College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "K", 
        "id": "sg:person.01263750706.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263750706.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1203912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036305391", 
          "https://doi.org/10.1038/sj.onc.1203912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00436-007-0671-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021493489", 
          "https://doi.org/10.1007/s00436-007-0671-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014900254", 
          "https://doi.org/10.1186/bcr55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-005-9053-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031912377", 
          "https://doi.org/10.1007/s10549-005-9053-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010603530", 
          "https://doi.org/10.1038/nrc1366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042527210", 
          "https://doi.org/10.1038/sj.onc.1203347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-005-9011-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053303057", 
          "https://doi.org/10.1007/s10549-005-9011-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039645144", 
          "https://doi.org/10.1038/nrc1892"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-01-31", 
    "datePublishedReg": "2011-01-31", 
    "description": "Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the \u03b1 subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase \u03b1 subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase )\u2013AKT, Ras\u2013Raf\u2013MEK\u2013ERK1/2, Rac\u2013PAK1/2, MKK3/6\u2013p38 and phospholipase C (PLC)-\u03b3 pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/onc.2010.604", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "keywords": [
      "tumor protein", 
      "breast epithelial cell transformation", 
      "third cytoplasmic domain", 
      "activation of Src", 
      "Src-dependent EGFR transactivation", 
      "epithelial cell transformation", 
      "ATPase \u03b1 subunit", 
      "subunit of Na", 
      "NADPH oxidase-dependent reactive oxygen species generation", 
      "human breast epithelial cells", 
      "cytoplasmic domain", 
      "cytoskeletal remodeling", 
      "Ras-Raf", 
      "EGFR transactivation", 
      "growth factor receptor", 
      "Src activation", 
      "breast epithelial cells", 
      "cell motility", 
      "\u03b1 subunit", 
      "reactive oxygen species generation", 
      "signaling pathways", 
      "cell transformation", 
      "PI3K", 
      "phospholipase C", 
      "oxygen species generation", 
      "cell growth", 
      "MEK-ERK1/2", 
      "factor receptor", 
      "TCTP", 
      "ROS generation", 
      "epithelial cells", 
      "subunits", 
      "species generation", 
      "tumor progression", 
      "protein", 
      "tumorigenesis", 
      "pathway", 
      "adenoviral infection", 
      "malignant transformation", 
      "matrix metalloproteinase-3", 
      "metalloproteinase-3", 
      "MMP expression", 
      "activation", 
      "transactivation", 
      "phosphatidylinositol", 
      "Src", 
      "ATPase", 
      "anti-epidermal growth factor receptor", 
      "motility", 
      "expression", 
      "remodeling", 
      "cells", 
      "receptors", 
      "domain", 
      "growth", 
      "role", 
      "progression", 
      "interaction", 
      "generation", 
      "release", 
      "transformation", 
      "Na", 
      "infection", 
      "findings", 
      "study", 
      "network", 
      "TCTP-induced tumor progression", 
      "Src release", 
      "tyrosine residues 845", 
      "residues 845", 
      "Rac\u2013PAK1/2", 
      "oxidase-dependent reactive oxygen species (ROS) generation", 
      "TCTP induces tumorigenesis", 
      "induces tumorigenesis", 
      "distinct multicellular signaling pathways", 
      "multicellular signaling pathways", 
      "human breast epithelial cell transformation"
    ], 
    "name": "Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src", 
    "pagination": "2264-2274", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022962741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2010.604"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21278788"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2010.604", 
      "https://app.dimensions.ai/details/publication/pub.1022962741"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_539.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/onc.2010.604"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.604'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.604'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.604'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.604'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      22 PREDICATES      123 URIs      106 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2010.604 schema:about N01892950b9e8489996ce1839764b4cb6
2 N147cfe67deff4a6489d4e08b3cd0e911
3 N421ab515a2cf43cca18610977098c7b4
4 N4648d494fffa47f5b670eee2cab92e95
5 N4859f53171044c839153055a110698b6
6 N66a4268f1d8c42abb6578a23eccbff5e
7 N9a91585727c74e50bfd8f172a6e46f5c
8 Na177f5fe8c894044a02e3f58293caf76
9 Nd4cad88ad10d45b6ac880eb21da188df
10 Ne61c2e6cf0c147ea9a3fe2ac9b994db9
11 Nea5c04dba4b34c0cb7213aca40bf6840
12 anzsrc-for:11
13 anzsrc-for:1103
14 anzsrc-for:1112
15 schema:author N966d2e8a46e74872b857e74b6b85c720
16 schema:citation sg:pub.10.1007/s00436-007-0671-z
17 sg:pub.10.1007/s10549-005-9011-0
18 sg:pub.10.1007/s10549-005-9053-3
19 sg:pub.10.1038/nrc1366
20 sg:pub.10.1038/nrc1892
21 sg:pub.10.1038/sj.onc.1203347
22 sg:pub.10.1038/sj.onc.1203912
23 sg:pub.10.1186/bcr55
24 schema:datePublished 2011-01-31
25 schema:datePublishedReg 2011-01-31
26 schema:description Translationally controlled tumor protein (TCTP) is implicated in cell growth and malignant transformation. TCTP has been found to interact directly with the third cytoplasmic domain of the α subunit of Na,K-ATPase, but whether this interaction has a role in tumorigenesis is unclear. In this study, we examined TCTP-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. We found that TCTP (a) induces Src release from Na,K-ATPase α subunit and Src activation; (b) phosphorylates tyrosine residues 845, 992, 1086, 1148 and 1173 on anti-epidermal growth factor receptor (EGFR); (c) activates PI3K (phosphatidylinositol 3-kinase )–AKT, Ras–Raf–MEK–ERK1/2, Rac–PAK1/2, MKK3/6–p38 and phospholipase C (PLC)-γ pathways; (d) enhances NADPH oxidase-dependent reactive oxygen species (ROS) generation; (e) stimulates cytoskeletal remodeling and cell motility and (f) upregulates matrix metalloproteinase (MMP) 3 and 13. These findings suggest that TCTP induces tumorigenesis through distinct multicellular signaling pathways involving Src-dependent EGFR transactivation, ROS generation and MMP expression.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N141ae1929820462eb25764201c44509f
31 Na3e44e340e234a89b7b63b96db69c1b8
32 sg:journal.1097543
33 schema:keywords ATPase
34 ATPase α subunit
35 EGFR transactivation
36 MEK-ERK1/2
37 MMP expression
38 NADPH oxidase-dependent reactive oxygen species generation
39 Na
40 PI3K
41 ROS generation
42 Rac–PAK1/2
43 Ras-Raf
44 Src
45 Src activation
46 Src release
47 Src-dependent EGFR transactivation
48 TCTP
49 TCTP induces tumorigenesis
50 TCTP-induced tumor progression
51 activation
52 activation of Src
53 adenoviral infection
54 anti-epidermal growth factor receptor
55 breast epithelial cell transformation
56 breast epithelial cells
57 cell growth
58 cell motility
59 cell transformation
60 cells
61 cytoplasmic domain
62 cytoskeletal remodeling
63 distinct multicellular signaling pathways
64 domain
65 epithelial cell transformation
66 epithelial cells
67 expression
68 factor receptor
69 findings
70 generation
71 growth
72 growth factor receptor
73 human breast epithelial cell transformation
74 human breast epithelial cells
75 induces tumorigenesis
76 infection
77 interaction
78 malignant transformation
79 matrix metalloproteinase-3
80 metalloproteinase-3
81 motility
82 multicellular signaling pathways
83 network
84 oxidase-dependent reactive oxygen species (ROS) generation
85 oxygen species generation
86 pathway
87 phosphatidylinositol
88 phospholipase C
89 progression
90 protein
91 reactive oxygen species generation
92 receptors
93 release
94 remodeling
95 residues 845
96 role
97 signaling pathways
98 species generation
99 study
100 subunit of Na
101 subunits
102 third cytoplasmic domain
103 transactivation
104 transformation
105 tumor progression
106 tumor protein
107 tumorigenesis
108 tyrosine residues 845
109 α subunit
110 schema:name Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src
111 schema:pagination 2264-2274
112 schema:productId N0076a26d2a34448d86df283b1d36c118
113 N8fb566c1ee77417e9d81077f06757e0a
114 N9f0a4135947d464698655a22d6aff672
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022962741
116 https://doi.org/10.1038/onc.2010.604
117 schema:sdDatePublished 2022-01-01T18:25
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher N46340157ef5240ed87fd694c3166c185
120 schema:url https://doi.org/10.1038/onc.2010.604
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N0076a26d2a34448d86df283b1d36c118 schema:name doi
125 schema:value 10.1038/onc.2010.604
126 rdf:type schema:PropertyValue
127 N01892950b9e8489996ce1839764b4cb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name ErbB Receptors
129 rdf:type schema:DefinedTerm
130 N141ae1929820462eb25764201c44509f schema:volumeNumber 30
131 rdf:type schema:PublicationVolume
132 N147cfe67deff4a6489d4e08b3cd0e911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Breast Neoplasms
134 rdf:type schema:DefinedTerm
135 N421ab515a2cf43cca18610977098c7b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Epithelial Cells
137 rdf:type schema:DefinedTerm
138 N46340157ef5240ed87fd694c3166c185 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N4648d494fffa47f5b670eee2cab92e95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Phosphorylation
142 rdf:type schema:DefinedTerm
143 N4859f53171044c839153055a110698b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 N5146615845b44dc9b09ad9d75ae433ed rdf:first Nb0f889f809a8499d86585814c0e41fd6
147 rdf:rest N81c72e5bebca4999a9d0e3614f6f7a18
148 N66a4268f1d8c42abb6578a23eccbff5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Reactive Oxygen Species
150 rdf:type schema:DefinedTerm
151 N81c72e5bebca4999a9d0e3614f6f7a18 rdf:first sg:person.01053034200.91
152 rdf:rest Na1d06d627305429bab8c14d3e4e57560
153 N8fb566c1ee77417e9d81077f06757e0a schema:name dimensions_id
154 schema:value pub.1022962741
155 rdf:type schema:PropertyValue
156 N966d2e8a46e74872b857e74b6b85c720 rdf:first sg:person.0611141226.34
157 rdf:rest Nd2b017ec8e6e4189aea7eae5e7cdb311
158 N9a91585727c74e50bfd8f172a6e46f5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Enzyme Activation
160 rdf:type schema:DefinedTerm
161 N9dc95dbee6ec42d890b55e7f3f0cf253 rdf:first sg:person.01263750706.38
162 rdf:rest rdf:nil
163 N9f0a4135947d464698655a22d6aff672 schema:name pubmed_id
164 schema:value 21278788
165 rdf:type schema:PropertyValue
166 Na177f5fe8c894044a02e3f58293caf76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name NADPH Oxidases
168 rdf:type schema:DefinedTerm
169 Na1d06d627305429bab8c14d3e4e57560 rdf:first Na83cf14959974c049627d07f751f7199
170 rdf:rest N9dc95dbee6ec42d890b55e7f3f0cf253
171 Na3e44e340e234a89b7b63b96db69c1b8 schema:issueNumber 19
172 rdf:type schema:PublicationIssue
173 Na83cf14959974c049627d07f751f7199 schema:affiliation grid-institutes:grid.255649.9
174 schema:familyName Kim
175 schema:givenName M
176 rdf:type schema:Person
177 Nb0f889f809a8499d86585814c0e41fd6 schema:affiliation grid-institutes:grid.255649.9
178 schema:familyName Kim
179 schema:givenName M
180 rdf:type schema:Person
181 Nd2b017ec8e6e4189aea7eae5e7cdb311 rdf:first Ne2dd7b5494fa41069986e843d0ccdefb
182 rdf:rest N5146615845b44dc9b09ad9d75ae433ed
183 Nd4cad88ad10d45b6ac880eb21da188df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Humans
185 rdf:type schema:DefinedTerm
186 Ne2dd7b5494fa41069986e843d0ccdefb schema:affiliation grid-institutes:grid.255649.9
187 schema:familyName Kim
188 schema:givenName H Y
189 rdf:type schema:Person
190 Ne61c2e6cf0c147ea9a3fe2ac9b994db9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name src-Family Kinases
192 rdf:type schema:DefinedTerm
193 Nea5c04dba4b34c0cb7213aca40bf6840 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Transcription, Genetic
195 rdf:type schema:DefinedTerm
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
200 schema:name Clinical Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
203 schema:name Oncology and Carcinogenesis
204 rdf:type schema:DefinedTerm
205 sg:journal.1097543 schema:issn 0950-9232
206 1476-5594
207 schema:name Oncogene
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01053034200.91 schema:affiliation grid-institutes:grid.255649.9
211 schema:familyName Sohn
212 schema:givenName K
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053034200.91
214 rdf:type schema:Person
215 sg:person.01263750706.38 schema:affiliation grid-institutes:grid.255649.9
216 schema:familyName Lee
217 schema:givenName K
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263750706.38
219 rdf:type schema:Person
220 sg:person.0611141226.34 schema:affiliation grid-institutes:grid.255649.9
221 schema:familyName Jung
222 schema:givenName J
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611141226.34
224 rdf:type schema:Person
225 sg:pub.10.1007/s00436-007-0671-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1021493489
226 https://doi.org/10.1007/s00436-007-0671-z
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s10549-005-9011-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053303057
229 https://doi.org/10.1007/s10549-005-9011-0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s10549-005-9053-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031912377
232 https://doi.org/10.1007/s10549-005-9053-3
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrc1366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010603530
235 https://doi.org/10.1038/nrc1366
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nrc1892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039645144
238 https://doi.org/10.1038/nrc1892
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/sj.onc.1203347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042527210
241 https://doi.org/10.1038/sj.onc.1203347
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/sj.onc.1203912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036305391
244 https://doi.org/10.1038/sj.onc.1203912
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/bcr55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014900254
247 https://doi.org/10.1186/bcr55
248 rdf:type schema:CreativeWork
249 grid-institutes:grid.255649.9 schema:alternateName College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea
250 schema:name College of Pharmacy, Center for Cell Signalling & Drug Discovery Research, Ewha Womans University, Seoul, Korea
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...