Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05

AUTHORS

M El Hour, A Moncada-Pazos, S Blacher, A Masset, S Cal, S Berndt, J Detilleux, L Host, A J Obaya, C Maillard, J M Foidart, F Ectors, A Noel, C Lopez-Otin

ABSTRACT

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression. More... »

PAGES

3025

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2010.49

DOI

http://dx.doi.org/10.1038/onc.2010.49

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031667589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20208563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAM Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAMTS Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratinocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laminin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteoglycans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hour", 
        "givenName": "M El", 
        "id": "sg:person.07611441601.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611441601.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moncada-Pazos", 
        "givenName": "A", 
        "id": "sg:person.0705166353.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705166353.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blacher", 
        "givenName": "S", 
        "id": "sg:person.0733275125.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275125.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masset", 
        "givenName": "A", 
        "id": "sg:person.0736525430.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736525430.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cal", 
        "givenName": "S", 
        "id": "sg:person.01357341156.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357341156.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berndt", 
        "givenName": "S", 
        "id": "sg:person.01265614062.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265614062.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Detilleux", 
        "givenName": "J", 
        "id": "sg:person.01141045030.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141045030.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Host", 
        "givenName": "L", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obaya", 
        "givenName": "A J", 
        "id": "sg:person.01167200162.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167200162.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maillard", 
        "givenName": "C", 
        "id": "sg:person.0604025062.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604025062.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foidart", 
        "givenName": "J M", 
        "id": "sg:person.015546730622.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546730622.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "GIGA-Transgenesis, University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ectors", 
        "givenName": "F", 
        "id": "sg:person.01237341036.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237341036.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noel", 
        "givenName": "A", 
        "id": "sg:person.0677441333.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677441333.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez-Otin", 
        "givenName": "C", 
        "id": "sg:person.01326155232.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326155232.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1209287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000691166", 
          "https://doi.org/10.1038/sj.onc.1209287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000691166", 
          "https://doi.org/10.1038/sj.onc.1209287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160946", 
          "https://doi.org/10.1038/ng1249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160946", 
          "https://doi.org/10.1038/ng1249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.005751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002413565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006076690", 
          "https://doi.org/10.1038/nrm2120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03221.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006452318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03221.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006452318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10409230701340019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010880641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-69057-5_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012217519", 
          "https://doi.org/10.1007/978-0-387-69057-5_17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212964200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015244343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.050468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022399939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022949601", 
          "https://doi.org/10.1038/nrc2228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mvr.2007.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023280113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0398-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028118853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.070074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033542309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2007.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033956307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.33.23349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039215449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2006.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039370313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042714863", 
          "https://doi.org/10.1038/sj.bjc.6603006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042714863", 
          "https://doi.org/10.1038/sj.bjc.6603006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-008-8633-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044356790", 
          "https://doi.org/10.1007/s00018-008-8633-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046181414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-0113fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049319009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-69057-5_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049644859", 
          "https://doi.org/10.1007/978-0-387-69057-5_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-5885fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050424069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1251/bpo30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051116835", 
          "https://doi.org/10.1251/bpo30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2007.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051144883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12541032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053206465", 
          "https://doi.org/10.1111/1523-1747.ep12541032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100534200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053211457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100534200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053211457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915341"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05", 
    "datePublishedReg": "2010-05-01", 
    "description": "ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2010.49", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "20", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis", 
    "pagination": "3025", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "96dbd43ae094e64c6cf20093af7a491217d26f7e58f9bb6c60bb611d6d5807cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20208563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2010.49"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031667589"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2010.49", 
      "https://app.dimensions.ai/details/publication/pub.1031667589"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000442.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc201049"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      81 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2010.49 schema:about N0b12062c114d418eb78ad660661de48c
2 N20e8f0677ad74375940256f4a626ffe6
3 N353e343960a04ac384f0ae42dc909c6c
4 N4090b4a78f0c418ba4b74930095f633b
5 N49446c1c97e8488b8120e03e9ddc05c2
6 N4ba307f276e74872ad92e4f5201f7eec
7 N4f4ba9364e4f4f8b858765839823920a
8 N5232c9f0c13941f28c303405bed14c80
9 N8495e12231a14d39968d0519b6ec54fa
10 N86a551c481fe43c0aa30fcbc813ea343
11 N98023d05b9df40c4900e738653c46f1d
12 N99daf0682b7c4618a4921de8b6a189d2
13 N9a66f6a5bb9046bfb79043cf2e984e2a
14 N9a854e96dbfa4598862fdd746e9102f5
15 Na55785ea8b3946dd8c1c3e1e1b209b15
16 Nad25e7270476419587b4adb542491717
17 Nb380894e4fec42c889cea4abcba07b9f
18 Nbe0248522cd44fef9cff9c95ea5969ea
19 Nc49e4bfe963446fa8b2d2b44811b9958
20 Nc677bf6572c6499ca28f2506be67057b
21 Ncc0e7bef80404136858b1363fe830597
22 Nf1d5acd5366d4645912e1d6769332c10
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author Nf2e7df992ef34f31a6dd50fece4d2579
26 schema:citation sg:pub.10.1007/978-0-387-69057-5_16
27 sg:pub.10.1007/978-0-387-69057-5_17
28 sg:pub.10.1007/s00018-008-8633-x
29 sg:pub.10.1038/ng1249
30 sg:pub.10.1038/nrc1477
31 sg:pub.10.1038/nrc2228
32 sg:pub.10.1038/nrc745
33 sg:pub.10.1038/nrm2120
34 sg:pub.10.1038/sj.bjc.6603006
35 sg:pub.10.1038/sj.onc.1209287
36 sg:pub.10.1111/1523-1747.ep12541032
37 sg:pub.10.1251/bpo30
38 https://doi.org/10.1016/j.biochi.2007.08.008
39 https://doi.org/10.1016/j.jaci.2006.04.036
40 https://doi.org/10.1016/j.mvr.2007.09.002
41 https://doi.org/10.1016/j.semcdb.2007.05.011
42 https://doi.org/10.1042/bj20040424
43 https://doi.org/10.1074/jbc.274.33.23349
44 https://doi.org/10.1074/jbc.m100534200
45 https://doi.org/10.1074/jbc.m212964200
46 https://doi.org/10.1080/10409230701340019
47 https://doi.org/10.1096/fj.03-0113fje
48 https://doi.org/10.1096/fj.06-5885fje
49 https://doi.org/10.1111/j.1749-6632.2003.tb03221.x
50 https://doi.org/10.1158/0008-5472.can-05-4315
51 https://doi.org/10.1158/1078-0432.ccr-0398-3
52 https://doi.org/10.1242/jcs.005751
53 https://doi.org/10.1242/jcs.050468
54 https://doi.org/10.2353/ajpath.2007.070074
55 https://doi.org/10.2741/3173
56 schema:datePublished 2010-05
57 schema:datePublishedReg 2010-05-01
58 schema:description ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf N10a0cbff09724d7b9a1317d71922063f
63 N32dc166ec72c48d9989e60d4ab25b871
64 sg:journal.1097543
65 schema:name Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis
66 schema:pagination 3025
67 schema:productId N2da42fa99835446eb8928fc48dd46008
68 N313ed505a5de409f813e4a8c84e648d9
69 N9c2f074563324ff0b6316d42f56b3a54
70 Ncf465d18ec394b6a9ec421f8b61c5555
71 Nf374f22b9dcd4c14b271736ca75e4955
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031667589
73 https://doi.org/10.1038/onc.2010.49
74 schema:sdDatePublished 2019-04-10T13:57
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N1c4df9f249f8419b97b8c0e9661ba1b7
77 schema:url https://www.nature.com/articles/onc201049
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0b12062c114d418eb78ad660661de48c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Humans
83 rdf:type schema:DefinedTerm
84 N0f4e940c5df44557926a40b9bf640767 rdf:first sg:person.0705166353.57
85 rdf:rest N63bf18f319b54a57a30c918b2b4a2b1b
86 N10a0cbff09724d7b9a1317d71922063f schema:issueNumber 20
87 rdf:type schema:PublicationIssue
88 N1c4df9f249f8419b97b8c0e9661ba1b7 schema:name Springer Nature - SN SciGraph project
89 rdf:type schema:Organization
90 N20e8f0677ad74375940256f4a626ffe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Rats, Wistar
92 rdf:type schema:DefinedTerm
93 N2a0cbdcc96294844b6b6abb28329661d rdf:first sg:person.015546730622.36
94 rdf:rest N60a4dcde490c44f5a6aafbde7ac67dcb
95 N2da42fa99835446eb8928fc48dd46008 schema:name pubmed_id
96 schema:value 20208563
97 rdf:type schema:PropertyValue
98 N313ed505a5de409f813e4a8c84e648d9 schema:name dimensions_id
99 schema:value pub.1031667589
100 rdf:type schema:PropertyValue
101 N32dc166ec72c48d9989e60d4ab25b871 schema:volumeNumber 29
102 rdf:type schema:PublicationVolume
103 N353e343960a04ac384f0ae42dc909c6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice, Knockout
105 rdf:type schema:DefinedTerm
106 N4090b4a78f0c418ba4b74930095f633b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Collagen
108 rdf:type schema:DefinedTerm
109 N49446c1c97e8488b8120e03e9ddc05c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aorta
111 rdf:type schema:DefinedTerm
112 N4ba307f276e74872ad92e4f5201f7eec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice, Inbred C57BL
114 rdf:type schema:DefinedTerm
115 N4f4ba9364e4f4f8b858765839823920a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Neoplasms, Experimental
117 rdf:type schema:DefinedTerm
118 N5232c9f0c13941f28c303405bed14c80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name ADAMTS Proteins
120 rdf:type schema:DefinedTerm
121 N55184c0ec76b4ce1ac3a734363557514 rdf:first N7c6d822261414036844dd1b516024304
122 rdf:rest Ndcf16cd202be49fdbb8d17383b2eb407
123 N60a4dcde490c44f5a6aafbde7ac67dcb rdf:first sg:person.01237341036.20
124 rdf:rest Nb0ec6788a7f74b168b6037800e1c992f
125 N63bf18f319b54a57a30c918b2b4a2b1b rdf:first sg:person.0733275125.38
126 rdf:rest Na76fb38194504d40bb1b607ba9d68a01
127 N6ebf26d375944814a44524f9bbb38914 rdf:first sg:person.0604025062.16
128 rdf:rest N2a0cbdcc96294844b6b6abb28329661d
129 N6f797d010f454d769ce6513c9ed39871 rdf:first sg:person.01141045030.87
130 rdf:rest N55184c0ec76b4ce1ac3a734363557514
131 N7c6d822261414036844dd1b516024304 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
132 schema:familyName Host
133 schema:givenName L
134 rdf:type schema:Person
135 N8495e12231a14d39968d0519b6ec54fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name ADAM Proteins
137 rdf:type schema:DefinedTerm
138 N86a551c481fe43c0aa30fcbc813ea343 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Animals
140 rdf:type schema:DefinedTerm
141 N8a605b3f4e1e450bae8669e17896a794 rdf:first sg:person.01265614062.50
142 rdf:rest N6f797d010f454d769ce6513c9ed39871
143 N8cd0e3e00df444a3bea4436d734fb76b rdf:first sg:person.01326155232.01
144 rdf:rest rdf:nil
145 N98023d05b9df40c4900e738653c46f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Male
147 rdf:type schema:DefinedTerm
148 N99daf0682b7c4618a4921de8b6a189d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 N9a66f6a5bb9046bfb79043cf2e984e2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Proteoglycans
153 rdf:type schema:DefinedTerm
154 N9a854e96dbfa4598862fdd746e9102f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Drug Combinations
156 rdf:type schema:DefinedTerm
157 N9c2f074563324ff0b6316d42f56b3a54 schema:name readcube_id
158 schema:value 96dbd43ae094e64c6cf20093af7a491217d26f7e58f9bb6c60bb611d6d5807cd
159 rdf:type schema:PropertyValue
160 Na55785ea8b3946dd8c1c3e1e1b209b15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Keratinocytes
162 rdf:type schema:DefinedTerm
163 Na76fb38194504d40bb1b607ba9d68a01 rdf:first sg:person.0736525430.75
164 rdf:rest Nf5014e69469749629519fa39124362a0
165 Nad25e7270476419587b4adb542491717 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Laminin
167 rdf:type schema:DefinedTerm
168 Nb0ec6788a7f74b168b6037800e1c992f rdf:first sg:person.0677441333.04
169 rdf:rest N8cd0e3e00df444a3bea4436d734fb76b
170 Nb380894e4fec42c889cea4abcba07b9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Fibroblasts
172 rdf:type schema:DefinedTerm
173 Nbe0248522cd44fef9cff9c95ea5969ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice
175 rdf:type schema:DefinedTerm
176 Nc49e4bfe963446fa8b2d2b44811b9958 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Neoplasm Invasiveness
178 rdf:type schema:DefinedTerm
179 Nc677bf6572c6499ca28f2506be67057b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Rats
181 rdf:type schema:DefinedTerm
182 Ncc0e7bef80404136858b1363fe830597 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Collagen Type I
184 rdf:type schema:DefinedTerm
185 Ncf465d18ec394b6a9ec421f8b61c5555 schema:name doi
186 schema:value 10.1038/onc.2010.49
187 rdf:type schema:PropertyValue
188 Ndcf16cd202be49fdbb8d17383b2eb407 rdf:first sg:person.01167200162.60
189 rdf:rest N6ebf26d375944814a44524f9bbb38914
190 Nf1d5acd5366d4645912e1d6769332c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Neovascularization, Pathologic
192 rdf:type schema:DefinedTerm
193 Nf2e7df992ef34f31a6dd50fece4d2579 rdf:first sg:person.07611441601.39
194 rdf:rest N0f4e940c5df44557926a40b9bf640767
195 Nf374f22b9dcd4c14b271736ca75e4955 schema:name nlm_unique_id
196 schema:value 8711562
197 rdf:type schema:PropertyValue
198 Nf5014e69469749629519fa39124362a0 rdf:first sg:person.01357341156.46
199 rdf:rest N8a605b3f4e1e450bae8669e17896a794
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biochemistry and Cell Biology
205 rdf:type schema:DefinedTerm
206 sg:journal.1097543 schema:issn 0950-9232
207 1476-5594
208 schema:name Oncogene
209 rdf:type schema:Periodical
210 sg:person.01141045030.87 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
211 schema:familyName Detilleux
212 schema:givenName J
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141045030.87
214 rdf:type schema:Person
215 sg:person.01167200162.60 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
216 schema:familyName Obaya
217 schema:givenName A J
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167200162.60
219 rdf:type schema:Person
220 sg:person.01237341036.20 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
221 schema:familyName Ectors
222 schema:givenName F
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237341036.20
224 rdf:type schema:Person
225 sg:person.01265614062.50 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
226 schema:familyName Berndt
227 schema:givenName S
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265614062.50
229 rdf:type schema:Person
230 sg:person.01326155232.01 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
231 schema:familyName Lopez-Otin
232 schema:givenName C
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326155232.01
234 rdf:type schema:Person
235 sg:person.01357341156.46 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
236 schema:familyName Cal
237 schema:givenName S
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357341156.46
239 rdf:type schema:Person
240 sg:person.015546730622.36 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
241 schema:familyName Foidart
242 schema:givenName J M
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546730622.36
244 rdf:type schema:Person
245 sg:person.0604025062.16 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
246 schema:familyName Maillard
247 schema:givenName C
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604025062.16
249 rdf:type schema:Person
250 sg:person.0677441333.04 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
251 schema:familyName Noel
252 schema:givenName A
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677441333.04
254 rdf:type schema:Person
255 sg:person.0705166353.57 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
256 schema:familyName Moncada-Pazos
257 schema:givenName A
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705166353.57
259 rdf:type schema:Person
260 sg:person.0733275125.38 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
261 schema:familyName Blacher
262 schema:givenName S
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275125.38
264 rdf:type schema:Person
265 sg:person.0736525430.75 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
266 schema:familyName Masset
267 schema:givenName A
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736525430.75
269 rdf:type schema:Person
270 sg:person.07611441601.39 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
271 schema:familyName Hour
272 schema:givenName M El
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611441601.39
274 rdf:type schema:Person
275 sg:pub.10.1007/978-0-387-69057-5_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049644859
276 https://doi.org/10.1007/978-0-387-69057-5_16
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/978-0-387-69057-5_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012217519
279 https://doi.org/10.1007/978-0-387-69057-5_17
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00018-008-8633-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044356790
282 https://doi.org/10.1007/s00018-008-8633-x
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/ng1249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001160946
285 https://doi.org/10.1038/ng1249
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nrc1477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043686693
288 https://doi.org/10.1038/nrc1477
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nrc2228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022949601
291 https://doi.org/10.1038/nrc2228
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nrc745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039076536
294 https://doi.org/10.1038/nrc745
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nrm2120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006076690
297 https://doi.org/10.1038/nrm2120
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/sj.bjc.6603006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042714863
300 https://doi.org/10.1038/sj.bjc.6603006
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/sj.onc.1209287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000691166
303 https://doi.org/10.1038/sj.onc.1209287
304 rdf:type schema:CreativeWork
305 sg:pub.10.1111/1523-1747.ep12541032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053206465
306 https://doi.org/10.1111/1523-1747.ep12541032
307 rdf:type schema:CreativeWork
308 sg:pub.10.1251/bpo30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051116835
309 https://doi.org/10.1251/bpo30
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.biochi.2007.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051144883
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.jaci.2006.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039370313
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.mvr.2007.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023280113
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.semcdb.2007.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033956307
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1042/bj20040424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015150832
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1074/jbc.274.33.23349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039215449
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1074/jbc.m100534200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053211457
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m212964200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015244343
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1080/10409230701340019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010880641
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1096/fj.03-0113fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1049319009
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1096/fj.06-5885fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1050424069
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1749-6632.2003.tb03221.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006452318
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/0008-5472.can-05-4315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046181414
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1078-0432.ccr-0398-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028118853
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1242/jcs.005751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002413565
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1242/jcs.050468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022399939
342 rdf:type schema:CreativeWork
343 https://doi.org/10.2353/ajpath.2007.070074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033542309
344 rdf:type schema:CreativeWork
345 https://doi.org/10.2741/3173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915341
346 rdf:type schema:CreativeWork
347 https://www.grid.ac/institutes/grid.10863.3c schema:alternateName University of Oviedo
348 schema:name Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain
349 rdf:type schema:Organization
350 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
351 schema:name GIGA-Transgenesis, University of Liège, Liège, Belgium
352 Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...