Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-05

AUTHORS

M El Hour, A Moncada-Pazos, S Blacher, A Masset, S Cal, S Berndt, J Detilleux, L Host, A J Obaya, C Maillard, J M Foidart, F Ectors, A Noel, C Lopez-Otin

ABSTRACT

ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression. More... »

PAGES

3025

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2010.49

DOI

http://dx.doi.org/10.1038/onc.2010.49

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031667589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20208563


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAM Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ADAMTS Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratinocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laminin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteoglycans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hour", 
        "givenName": "M El", 
        "id": "sg:person.07611441601.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611441601.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moncada-Pazos", 
        "givenName": "A", 
        "id": "sg:person.0705166353.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705166353.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blacher", 
        "givenName": "S", 
        "id": "sg:person.0733275125.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275125.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masset", 
        "givenName": "A", 
        "id": "sg:person.0736525430.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736525430.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cal", 
        "givenName": "S", 
        "id": "sg:person.01357341156.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357341156.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berndt", 
        "givenName": "S", 
        "id": "sg:person.01265614062.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265614062.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Detilleux", 
        "givenName": "J", 
        "id": "sg:person.01141045030.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141045030.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Host", 
        "givenName": "L", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obaya", 
        "givenName": "A J", 
        "id": "sg:person.01167200162.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167200162.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maillard", 
        "givenName": "C", 
        "id": "sg:person.0604025062.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604025062.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foidart", 
        "givenName": "J M", 
        "id": "sg:person.015546730622.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546730622.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "GIGA-Transgenesis, University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ectors", 
        "givenName": "F", 
        "id": "sg:person.01237341036.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237341036.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Li\u00e8ge", 
          "id": "https://www.grid.ac/institutes/grid.4861.b", 
          "name": [
            "Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de G\u00e9noprot\u00e9omique Appliqu\u00e9e-Cancer (GIGA-Cancer), University of Li\u00e8ge, Li\u00e8ge, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noel", 
        "givenName": "A", 
        "id": "sg:person.0677441333.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677441333.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oviedo", 
          "id": "https://www.grid.ac/institutes/grid.10863.3c", 
          "name": [
            "Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez-Otin", 
        "givenName": "C", 
        "id": "sg:person.01326155232.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326155232.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1209287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000691166", 
          "https://doi.org/10.1038/sj.onc.1209287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000691166", 
          "https://doi.org/10.1038/sj.onc.1209287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160946", 
          "https://doi.org/10.1038/ng1249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001160946", 
          "https://doi.org/10.1038/ng1249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.005751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002413565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006076690", 
          "https://doi.org/10.1038/nrm2120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03221.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006452318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2003.tb03221.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006452318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10409230701340019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010880641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-69057-5_17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012217519", 
          "https://doi.org/10.1007/978-0-387-69057-5_17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20040424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015150832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212964200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015244343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.050468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022399939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022949601", 
          "https://doi.org/10.1038/nrc2228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mvr.2007.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023280113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0398-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028118853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.070074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033542309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2007.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033956307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.33.23349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039215449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2006.04.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039370313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042714863", 
          "https://doi.org/10.1038/sj.bjc.6603006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042714863", 
          "https://doi.org/10.1038/sj.bjc.6603006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-008-8633-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044356790", 
          "https://doi.org/10.1007/s00018-008-8633-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046181414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-0113fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049319009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-69057-5_16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049644859", 
          "https://doi.org/10.1007/978-0-387-69057-5_16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-5885fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050424069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1251/bpo30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051116835", 
          "https://doi.org/10.1251/bpo30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2007.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051144883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12541032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053206465", 
          "https://doi.org/10.1111/1523-1747.ep12541032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100534200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053211457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m100534200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053211457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915341"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05", 
    "datePublishedReg": "2010-05-01", 
    "description": "ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2010.49", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "20", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis", 
    "pagination": "3025", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "96dbd43ae094e64c6cf20093af7a491217d26f7e58f9bb6c60bb611d6d5807cd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20208563"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2010.49"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031667589"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2010.49", 
      "https://app.dimensions.ai/details/publication/pub.1031667589"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000442.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc201049"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.49'


 

This table displays all metadata directly associated to this object as RDF triples.

353 TRIPLES      21 PREDICATES      81 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2010.49 schema:about N0355936775dd4af499baab036a67ce0f
2 N0a7cb9dd8c6b41d99d96091f6c5cf315
3 N0cc526befc5e45789fff4d58f4780795
4 N1bf34332032748e0ba9521639dc561ba
5 N2431c6a0edf241548f9c62271a43351b
6 N26451d66233c4545a29602c74bfa7e41
7 N379d2201c62348c7afc6e8dcf734c4f7
8 N519bb509ab324637b35f932669d81fc7
9 N621d299352e2450aae88999f4094aabe
10 N68c7b0c4e2894f3caefea1a86ced751b
11 N700fd5b2e5824f1a93154f12d0ba9e6a
12 N74e756a3a27544f291cd3c16b4008f11
13 N8a87b353f2f64ef4b02eab1f14a438cb
14 N997fec739399478c83c0560444b073ba
15 Na7834e9625f24db2b322002fe6184837
16 Nb1a4284b809b468aa444f7b3eb5b6464
17 Nb8944d95ad5442379fa749379ce09fb2
18 Nc3aad436d91d40aaaa3723b6cb2c20bb
19 Nc8abe7d0227c459c9f735f2557d26fb8
20 Ncd125a9ad0e54d1e9c4f3c354a3959fc
21 Necec14c0d9be48869b5b6b503e538de3
22 Nf02ff05ab2a94cbebb8a42a0bea65b55
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author N0f24abef5d61426dbe8b1bc2cbe5896b
26 schema:citation sg:pub.10.1007/978-0-387-69057-5_16
27 sg:pub.10.1007/978-0-387-69057-5_17
28 sg:pub.10.1007/s00018-008-8633-x
29 sg:pub.10.1038/ng1249
30 sg:pub.10.1038/nrc1477
31 sg:pub.10.1038/nrc2228
32 sg:pub.10.1038/nrc745
33 sg:pub.10.1038/nrm2120
34 sg:pub.10.1038/sj.bjc.6603006
35 sg:pub.10.1038/sj.onc.1209287
36 sg:pub.10.1111/1523-1747.ep12541032
37 sg:pub.10.1251/bpo30
38 https://doi.org/10.1016/j.biochi.2007.08.008
39 https://doi.org/10.1016/j.jaci.2006.04.036
40 https://doi.org/10.1016/j.mvr.2007.09.002
41 https://doi.org/10.1016/j.semcdb.2007.05.011
42 https://doi.org/10.1042/bj20040424
43 https://doi.org/10.1074/jbc.274.33.23349
44 https://doi.org/10.1074/jbc.m100534200
45 https://doi.org/10.1074/jbc.m212964200
46 https://doi.org/10.1080/10409230701340019
47 https://doi.org/10.1096/fj.03-0113fje
48 https://doi.org/10.1096/fj.06-5885fje
49 https://doi.org/10.1111/j.1749-6632.2003.tb03221.x
50 https://doi.org/10.1158/0008-5472.can-05-4315
51 https://doi.org/10.1158/1078-0432.ccr-0398-3
52 https://doi.org/10.1242/jcs.005751
53 https://doi.org/10.1242/jcs.050468
54 https://doi.org/10.2353/ajpath.2007.070074
55 https://doi.org/10.2741/3173
56 schema:datePublished 2010-05
57 schema:datePublishedReg 2010-05-01
58 schema:description ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) constitute a family of endopeptidases related to matrix metalloproteinases. These proteases have been largely implicated in tissue remodeling and angiogenesis associated with physiological and pathological processes. To elucidate the in vivo functions of ADAMTS-12, we have generated a knockout mouse strain (Adamts12(-/-)) in which Adamts12 gene was deleted. The mutant mice had normal gestations and no apparent defects in growth, life span and fertility. By applying three different in vivo models of angiogenesis (malignant keratinocyte transplantation, Matrigel plug and aortic ring assays) to Adamts12(-/-) mice, we provide evidence for a protective effect of this host enzyme toward angiogenesis and cancer progression. In the absence of Adamts-12, both the angiogenic response and tumor invasion into host tissue were increased. Complementing results were obtained by using medium conditioned by cells overexpressing human ADAMTS-12, which inhibited vessel outgrowth in the aortic ring assay. This angioinhibitory effect of ADAMTS-12 was independent of its enzymatic activity as a mutated inactive form of the enzyme was similarly efficient in inhibiting endothelial cell sprouting in the aortic ring assay than the wild-type form. Altogether, our results show that ADAMTS-12 displays antiangiogenic properties and protect the host toward tumor progression.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf N1a830046152d43deb99e5361994e3398
63 N89b8ffb05be449cb9e0db9a759d53d63
64 sg:journal.1097543
65 schema:name Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis
66 schema:pagination 3025
67 schema:productId N18ec61c4fd1440d2aebbbc726080241f
68 N21441a66361748eaa694766db291b1a2
69 N56bb0a7f676a46838f77a32c256d73a9
70 Nbd2e15ec85cc4f3b88d2ce62e23e5a2e
71 Ne7ec0d6c7cb545c6944f2dade7651b21
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031667589
73 https://doi.org/10.1038/onc.2010.49
74 schema:sdDatePublished 2019-04-10T13:57
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N4ce8233268194b6eaa0769128d0cba93
77 schema:url https://www.nature.com/articles/onc201049
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N0355936775dd4af499baab036a67ce0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Aorta
83 rdf:type schema:DefinedTerm
84 N0a7cb9dd8c6b41d99d96091f6c5cf315 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Drug Combinations
86 rdf:type schema:DefinedTerm
87 N0cc526befc5e45789fff4d58f4780795 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Rats, Wistar
89 rdf:type schema:DefinedTerm
90 N0ed7467d3b12439e9101690f30a1622c rdf:first sg:person.015546730622.36
91 rdf:rest N3824374b3887438fa260e697e58c8323
92 N0f24abef5d61426dbe8b1bc2cbe5896b rdf:first sg:person.07611441601.39
93 rdf:rest N92b9341f7bbc47ba857a7bb39804a845
94 N18ec61c4fd1440d2aebbbc726080241f schema:name nlm_unique_id
95 schema:value 8711562
96 rdf:type schema:PropertyValue
97 N1a830046152d43deb99e5361994e3398 schema:volumeNumber 29
98 rdf:type schema:PublicationVolume
99 N1bf34332032748e0ba9521639dc561ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Proteoglycans
101 rdf:type schema:DefinedTerm
102 N21441a66361748eaa694766db291b1a2 schema:name pubmed_id
103 schema:value 20208563
104 rdf:type schema:PropertyValue
105 N2431c6a0edf241548f9c62271a43351b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Fibroblasts
107 rdf:type schema:DefinedTerm
108 N26451d66233c4545a29602c74bfa7e41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Collagen
110 rdf:type schema:DefinedTerm
111 N379d2201c62348c7afc6e8dcf734c4f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name ADAM Proteins
113 rdf:type schema:DefinedTerm
114 N3824374b3887438fa260e697e58c8323 rdf:first sg:person.01237341036.20
115 rdf:rest N5ac17b5623374392b536f91df2d7f2ce
116 N4ce8233268194b6eaa0769128d0cba93 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N519bb509ab324637b35f932669d81fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Keratinocytes
120 rdf:type schema:DefinedTerm
121 N56bb0a7f676a46838f77a32c256d73a9 schema:name doi
122 schema:value 10.1038/onc.2010.49
123 rdf:type schema:PropertyValue
124 N5ac17b5623374392b536f91df2d7f2ce rdf:first sg:person.0677441333.04
125 rdf:rest N799c3e41963041e29e465cd95373a791
126 N5d21be36b5cc4b68bec564f769ac5f2a rdf:first sg:person.0604025062.16
127 rdf:rest N0ed7467d3b12439e9101690f30a1622c
128 N621d299352e2450aae88999f4094aabe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Animals
130 rdf:type schema:DefinedTerm
131 N64f0969a053740c297f0200bf05f9779 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
132 schema:familyName Host
133 schema:givenName L
134 rdf:type schema:Person
135 N68c7b0c4e2894f3caefea1a86ced751b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Collagen Type I
137 rdf:type schema:DefinedTerm
138 N700fd5b2e5824f1a93154f12d0ba9e6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Mice
140 rdf:type schema:DefinedTerm
141 N74e756a3a27544f291cd3c16b4008f11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neoplasm Invasiveness
143 rdf:type schema:DefinedTerm
144 N799c3e41963041e29e465cd95373a791 rdf:first sg:person.01326155232.01
145 rdf:rest rdf:nil
146 N7a5a666bad0a4b2bb79445ec505266c6 rdf:first sg:person.0733275125.38
147 rdf:rest Ned2e4439b17649ddab3f6ca63d71b5a8
148 N89b8ffb05be449cb9e0db9a759d53d63 schema:issueNumber 20
149 rdf:type schema:PublicationIssue
150 N8a87b353f2f64ef4b02eab1f14a438cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 N92b9341f7bbc47ba857a7bb39804a845 rdf:first sg:person.0705166353.57
154 rdf:rest N7a5a666bad0a4b2bb79445ec505266c6
155 N988ba6cbd00c49598e569f34b8cd5760 rdf:first N64f0969a053740c297f0200bf05f9779
156 rdf:rest Ne6383d5ef4af492598bc856c896e9b8e
157 N997fec739399478c83c0560444b073ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Neovascularization, Pathologic
159 rdf:type schema:DefinedTerm
160 Na7834e9625f24db2b322002fe6184837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Male
162 rdf:type schema:DefinedTerm
163 Nb1a4284b809b468aa444f7b3eb5b6464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasms, Experimental
165 rdf:type schema:DefinedTerm
166 Nb8944d95ad5442379fa749379ce09fb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Mice, Inbred C57BL
168 rdf:type schema:DefinedTerm
169 Nbd2e15ec85cc4f3b88d2ce62e23e5a2e schema:name dimensions_id
170 schema:value pub.1031667589
171 rdf:type schema:PropertyValue
172 Nc3aad436d91d40aaaa3723b6cb2c20bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Laminin
174 rdf:type schema:DefinedTerm
175 Nc8abe7d0227c459c9f735f2557d26fb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Humans
177 rdf:type schema:DefinedTerm
178 Ncd125a9ad0e54d1e9c4f3c354a3959fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name ADAMTS Proteins
180 rdf:type schema:DefinedTerm
181 Ndc18eeeb5b6e43b8b347f06028830a5f rdf:first sg:person.01357341156.46
182 rdf:rest Nf855b6907ccd4e078312152400f0be06
183 Ne6383d5ef4af492598bc856c896e9b8e rdf:first sg:person.01167200162.60
184 rdf:rest N5d21be36b5cc4b68bec564f769ac5f2a
185 Ne7ec0d6c7cb545c6944f2dade7651b21 schema:name readcube_id
186 schema:value 96dbd43ae094e64c6cf20093af7a491217d26f7e58f9bb6c60bb611d6d5807cd
187 rdf:type schema:PropertyValue
188 Necec14c0d9be48869b5b6b503e538de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Rats
190 rdf:type schema:DefinedTerm
191 Ned2e4439b17649ddab3f6ca63d71b5a8 rdf:first sg:person.0736525430.75
192 rdf:rest Ndc18eeeb5b6e43b8b347f06028830a5f
193 Nf02ff05ab2a94cbebb8a42a0bea65b55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Mice, Knockout
195 rdf:type schema:DefinedTerm
196 Nf4c1b792441a4c45b8f55e82b8a3921c rdf:first sg:person.01141045030.87
197 rdf:rest N988ba6cbd00c49598e569f34b8cd5760
198 Nf855b6907ccd4e078312152400f0be06 rdf:first sg:person.01265614062.50
199 rdf:rest Nf4c1b792441a4c45b8f55e82b8a3921c
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biochemistry and Cell Biology
205 rdf:type schema:DefinedTerm
206 sg:journal.1097543 schema:issn 0950-9232
207 1476-5594
208 schema:name Oncogene
209 rdf:type schema:Periodical
210 sg:person.01141045030.87 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
211 schema:familyName Detilleux
212 schema:givenName J
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141045030.87
214 rdf:type schema:Person
215 sg:person.01167200162.60 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
216 schema:familyName Obaya
217 schema:givenName A J
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167200162.60
219 rdf:type schema:Person
220 sg:person.01237341036.20 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
221 schema:familyName Ectors
222 schema:givenName F
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237341036.20
224 rdf:type schema:Person
225 sg:person.01265614062.50 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
226 schema:familyName Berndt
227 schema:givenName S
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265614062.50
229 rdf:type schema:Person
230 sg:person.01326155232.01 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
231 schema:familyName Lopez-Otin
232 schema:givenName C
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326155232.01
234 rdf:type schema:Person
235 sg:person.01357341156.46 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
236 schema:familyName Cal
237 schema:givenName S
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357341156.46
239 rdf:type schema:Person
240 sg:person.015546730622.36 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
241 schema:familyName Foidart
242 schema:givenName J M
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015546730622.36
244 rdf:type schema:Person
245 sg:person.0604025062.16 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
246 schema:familyName Maillard
247 schema:givenName C
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604025062.16
249 rdf:type schema:Person
250 sg:person.0677441333.04 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
251 schema:familyName Noel
252 schema:givenName A
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677441333.04
254 rdf:type schema:Person
255 sg:person.0705166353.57 schema:affiliation https://www.grid.ac/institutes/grid.10863.3c
256 schema:familyName Moncada-Pazos
257 schema:givenName A
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705166353.57
259 rdf:type schema:Person
260 sg:person.0733275125.38 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
261 schema:familyName Blacher
262 schema:givenName S
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733275125.38
264 rdf:type schema:Person
265 sg:person.0736525430.75 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
266 schema:familyName Masset
267 schema:givenName A
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736525430.75
269 rdf:type schema:Person
270 sg:person.07611441601.39 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
271 schema:familyName Hour
272 schema:givenName M El
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07611441601.39
274 rdf:type schema:Person
275 sg:pub.10.1007/978-0-387-69057-5_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049644859
276 https://doi.org/10.1007/978-0-387-69057-5_16
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/978-0-387-69057-5_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012217519
279 https://doi.org/10.1007/978-0-387-69057-5_17
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00018-008-8633-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044356790
282 https://doi.org/10.1007/s00018-008-8633-x
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/ng1249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001160946
285 https://doi.org/10.1038/ng1249
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/nrc1477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043686693
288 https://doi.org/10.1038/nrc1477
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nrc2228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022949601
291 https://doi.org/10.1038/nrc2228
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/nrc745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039076536
294 https://doi.org/10.1038/nrc745
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nrm2120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006076690
297 https://doi.org/10.1038/nrm2120
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/sj.bjc.6603006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042714863
300 https://doi.org/10.1038/sj.bjc.6603006
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/sj.onc.1209287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000691166
303 https://doi.org/10.1038/sj.onc.1209287
304 rdf:type schema:CreativeWork
305 sg:pub.10.1111/1523-1747.ep12541032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053206465
306 https://doi.org/10.1111/1523-1747.ep12541032
307 rdf:type schema:CreativeWork
308 sg:pub.10.1251/bpo30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051116835
309 https://doi.org/10.1251/bpo30
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.biochi.2007.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051144883
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.jaci.2006.04.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039370313
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.mvr.2007.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023280113
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.semcdb.2007.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033956307
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1042/bj20040424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015150832
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1074/jbc.274.33.23349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039215449
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1074/jbc.m100534200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053211457
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m212964200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015244343
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1080/10409230701340019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010880641
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1096/fj.03-0113fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1049319009
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1096/fj.06-5885fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1050424069
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.1749-6632.2003.tb03221.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006452318
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/0008-5472.can-05-4315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046181414
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1078-0432.ccr-0398-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028118853
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1242/jcs.005751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002413565
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1242/jcs.050468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022399939
342 rdf:type schema:CreativeWork
343 https://doi.org/10.2353/ajpath.2007.070074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033542309
344 rdf:type schema:CreativeWork
345 https://doi.org/10.2741/3173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915341
346 rdf:type schema:CreativeWork
347 https://www.grid.ac/institutes/grid.10863.3c schema:alternateName University of Oviedo
348 schema:name Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, Instituto Universitario de Oncologia, Asturias, Spain
349 rdf:type schema:Organization
350 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
351 schema:name GIGA-Transgenesis, University of Liège, Liège, Belgium
352 Laboratory of Tumor and Developmental Biology, Groupe Interdisciplinaire de Génoprotéomique Appliquée-Cancer (GIGA-Cancer), University of Liège, Liège, Belgium
353 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...