RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09-20

AUTHORS

K Schouwey, I T Aydin, F Radtke, F Beermann

ABSTRACT

The Notch signaling pathway is an ubiquitous cell–cell interaction mechanism, which is essential in controlling processes like cell proliferation, cell fate decision, differentiation or stem cell maintenance. Recent data have shown that Notch signaling is RBP-Jκ-dependent in melanocytes, being required for survival of these pigment cells that are responsible for coloration of the skin and hairs in mammals. In addition, Notch is believed to function as an oncogene in melanoma, whereas it is a tumor suppressor in mouse epidermis. In this study, we addressed the implication of the Notch signaling in the development of another population of pigment cells forming the retinal pigment epithelium (RPE) in mammalian eyes. The constitutive activity of Notch in Tyrp1::NotchIC/° transgenic mice enhanced RPE cell proliferation, and the resulting RPE-derived pigmented tumor severely affected the overall eye structure. This RPE cell proliferation is dependent on the presence of the transcription factor RBP-Jκ, as it is rescued in mice lacking RBP-Jκ in the RPE. In conclusion, Notch signaling in the RPE uses the canonical pathway, which is dependent on the transcription factor RBP-Jκ. In addition, it is of importance for RPE development, and constitutive Notch activity leads to hyperproliferation and benign tumors of these pigment cells. More... »

PAGES

313-322

References to SciGraph publications

  • 2004-03-09. Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body in BRAIN STRUCTURE AND FUNCTION
  • 1996-08. Adenocarcinoma of the retinal pigment epithelium: A diagnostic and therapeutic challenge in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 1997-07. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 in NATURE GENETICS
  • 1985-10. Interactions between the retinal pigment epithelium and the neural retina in DOCUMENTA OPHTHALMOLOGICA
  • 2006-02. Notch signalling in vertebrate neural development in NATURE REVIEWS NEUROSCIENCE
  • 1997-04-24. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4) in ONCOGENE
  • 2003-09-29. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents in ONCOGENE
  • 2006. Tissue-Specific Transgenic and Knockout Mice in ION CHANNELS
  • 2009-12-18. The transcription factor RBP-J is essential for retinal cell differentiation and lamination in MOLECULAR BRAIN
  • 2000-02. Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1999-01. Generalized lacZ expression with the ROSA26 Cre reporter strain in NATURE GENETICS
  • 2006-09. Notch signalling: a simple pathway becomes complex in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1998-10-19. Tumors of the retinal pigment epithelium metastasize to inguinal lymph nodes and spleen in tyrosinase-related protein 1/SV40 T antigen transgenic mice in ONCOGENE
  • 2003-12. The role of Notch in tumorigenesis: oncogene or tumour suppressor? in NATURE REVIEWS CANCER
  • 2003-02-18. Notch1 functions as a tumor suppressor in mouse skin in NATURE GENETICS
  • 2002-04-22. Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells in NATURE IMMUNOLOGY
  • 2008-09-01. Notch tumor suppressor function in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2010.428

    DOI

    http://dx.doi.org/10.1038/onc.2010.428

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052328179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20856205


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunoglobulin J Recombination Signal Sequence-Binding Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Notch", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinal Pigment Epithelium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schouwey", 
            "givenName": "K", 
            "id": "sg:person.01105526245.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105526245.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aydin", 
            "givenName": "I T", 
            "id": "sg:person.0674236563.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674236563.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radtke", 
            "givenName": "F", 
            "id": "sg:person.01021176505.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021176505.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, (EPFL), Lausanne, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beermann", 
            "givenName": "F", 
            "id": "sg:person.01253527331.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253527331.59"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrn1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047057402", 
              "https://doi.org/10.1038/nrn1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02343044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042030498", 
              "https://doi.org/10.1007/bf02343044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004707046", 
              "https://doi.org/10.1038/nrc1186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0797-243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050786128", 
              "https://doi.org/10.1038/ng0797-243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/5007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030839891", 
              "https://doi.org/10.1038/5007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-6606-2-38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052354970", 
              "https://doi.org/10.1186/1756-6606-2-38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59745-095-2:185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003770891", 
              "https://doi.org/10.1385/1-59745-095-2:185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00429-004-0382-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041881214", 
              "https://doi.org/10.1007/s00429-004-0382-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019849472", 
              "https://doi.org/10.1038/nrm2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018549599", 
              "https://doi.org/10.1038/sj.onc.1206758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041697410", 
              "https://doi.org/10.1038/ng1099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00000685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040273899", 
              "https://doi.org/10.1007/pl00000685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010498766", 
              "https://doi.org/10.1038/sj.onc.1201035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045423530", 
              "https://doi.org/10.1038/ni793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007930979", 
              "https://doi.org/10.1038/sj.onc.1202196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016759404", 
              "https://doi.org/10.1038/onc.2008.225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00158922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015404958", 
              "https://doi.org/10.1007/bf00158922"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-09-20", 
        "datePublishedReg": "2010-09-20", 
        "description": "The Notch signaling pathway is an ubiquitous cell\u2013cell interaction mechanism, which is essential in controlling processes like cell proliferation, cell fate decision, differentiation or stem cell maintenance. Recent data have shown that Notch signaling is RBP-J\u03ba-dependent in melanocytes, being required for survival of these pigment cells that are responsible for coloration of the skin and hairs in mammals. In addition, Notch is believed to function as an oncogene in melanoma, whereas it is a tumor suppressor in mouse epidermis. In this study, we addressed the implication of the Notch signaling in the development of another population of pigment cells forming the retinal pigment epithelium (RPE) in mammalian eyes. The constitutive activity of Notch in Tyrp1::NotchIC/\u00b0 transgenic mice enhanced RPE cell proliferation, and the resulting RPE-derived pigmented tumor severely affected the overall eye structure. This RPE cell proliferation is dependent on the presence of the transcription factor RBP-J\u03ba, as it is rescued in mice lacking RBP-J\u03ba in the RPE. In conclusion, Notch signaling in the RPE uses the canonical pathway, which is dependent on the transcription factor RBP-J\u03ba. In addition, it is of importance for RPE development, and constitutive Notch activity leads to hyperproliferation and benign tumors of these pigment cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/onc.2010.428", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5226611", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1097543", 
            "issn": [
              "0950-9232", 
              "1476-5594"
            ], 
            "name": "Oncogene", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "30"
          }
        ], 
        "keywords": [
          "RBP-J\u03ba", 
          "pigment cells", 
          "Notch signaling", 
          "cell proliferation", 
          "RPE cell proliferation", 
          "cell-cell interaction mechanism", 
          "cell fate decisions", 
          "stem cell maintenance", 
          "constitutive Notch activity", 
          "retinal pigment epithelium", 
          "dependent Notch signaling", 
          "fate decisions", 
          "cell maintenance", 
          "Notch activity", 
          "transgenic mice", 
          "canonical pathways", 
          "tumor suppressor", 
          "RPE development", 
          "constitutive activity", 
          "epithelial cell proliferation", 
          "retinal pigment epithelial cell proliferation", 
          "mammalian eye", 
          "signaling", 
          "proliferation", 
          "pathway", 
          "Notch", 
          "cells", 
          "benign tumors", 
          "pigmented tumors", 
          "pigment epithelium", 
          "mouse epidermis", 
          "mammals", 
          "eye structures", 
          "recent data", 
          "mice", 
          "suppressor", 
          "oncogene", 
          "tumors", 
          "coloration", 
          "differentiation", 
          "melanocytes", 
          "activity", 
          "hyperproliferation", 
          "epidermis", 
          "maintenance", 
          "melanoma", 
          "epithelium", 
          "hair", 
          "mechanism", 
          "development", 
          "survival", 
          "interaction mechanism", 
          "population", 
          "skin", 
          "eyes", 
          "addition", 
          "conclusion", 
          "presence", 
          "importance", 
          "structure", 
          "study", 
          "process", 
          "implications", 
          "data", 
          "decisions"
        ], 
        "name": "RBP-J\u03ba-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice", 
        "pagination": "313-322", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1052328179"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/onc.2010.428"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20856205"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/onc.2010.428", 
          "https://app.dimensions.ai/details/publication/pub.1052328179"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_523.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/onc.2010.428"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.428'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.428'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.428'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.428'


     

    This table displays all metadata directly associated to this object as RDF triples.

    257 TRIPLES      21 PREDICATES      117 URIs      91 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/onc.2010.428 schema:about N1b32135c11d841f5a2d5868f42945022
    2 N3a40dc1db4a34ba1a857466f579e9e3e
    3 N509962a6e5f846888b59fa894ce1b33a
    4 N5b7b376aa1524e97ad4f3e9ac8c31771
    5 N5e6ffe5a09dc4bb1b7f9f5a47d8c3e47
    6 N82e3d3513586475aa7836c9430007a38
    7 N8aa6fa94e1ab42f88f81f3f3e2fd2808
    8 N9eeac893820b4fb8a6d9198726ee6b56
    9 Nda476e004a3348898cfcc0d540aa22d0
    10 anzsrc-for:11
    11 anzsrc-for:1103
    12 anzsrc-for:1112
    13 schema:author Na0ea0889ff344b588a247f767032427c
    14 schema:citation sg:pub.10.1007/bf00158922
    15 sg:pub.10.1007/bf02343044
    16 sg:pub.10.1007/pl00000685
    17 sg:pub.10.1007/s00429-004-0382-5
    18 sg:pub.10.1038/5007
    19 sg:pub.10.1038/ng0797-243
    20 sg:pub.10.1038/ng1099
    21 sg:pub.10.1038/ni793
    22 sg:pub.10.1038/nrc1186
    23 sg:pub.10.1038/nrm2009
    24 sg:pub.10.1038/nrn1847
    25 sg:pub.10.1038/onc.2008.225
    26 sg:pub.10.1038/sj.onc.1201035
    27 sg:pub.10.1038/sj.onc.1202196
    28 sg:pub.10.1038/sj.onc.1206758
    29 sg:pub.10.1186/1756-6606-2-38
    30 sg:pub.10.1385/1-59745-095-2:185
    31 schema:datePublished 2010-09-20
    32 schema:datePublishedReg 2010-09-20
    33 schema:description The Notch signaling pathway is an ubiquitous cell–cell interaction mechanism, which is essential in controlling processes like cell proliferation, cell fate decision, differentiation or stem cell maintenance. Recent data have shown that Notch signaling is RBP-Jκ-dependent in melanocytes, being required for survival of these pigment cells that are responsible for coloration of the skin and hairs in mammals. In addition, Notch is believed to function as an oncogene in melanoma, whereas it is a tumor suppressor in mouse epidermis. In this study, we addressed the implication of the Notch signaling in the development of another population of pigment cells forming the retinal pigment epithelium (RPE) in mammalian eyes. The constitutive activity of Notch in Tyrp1::NotchIC/° transgenic mice enhanced RPE cell proliferation, and the resulting RPE-derived pigmented tumor severely affected the overall eye structure. This RPE cell proliferation is dependent on the presence of the transcription factor RBP-Jκ, as it is rescued in mice lacking RBP-Jκ in the RPE. In conclusion, Notch signaling in the RPE uses the canonical pathway, which is dependent on the transcription factor RBP-Jκ. In addition, it is of importance for RPE development, and constitutive Notch activity leads to hyperproliferation and benign tumors of these pigment cells.
    34 schema:genre article
    35 schema:isAccessibleForFree false
    36 schema:isPartOf N0e0f6fd73ede44e8815e4fb961cfd630
    37 N1592802f6a0f470f91f788b7b5431f9d
    38 sg:journal.1097543
    39 schema:keywords Notch
    40 Notch activity
    41 Notch signaling
    42 RBP-Jκ
    43 RPE cell proliferation
    44 RPE development
    45 activity
    46 addition
    47 benign tumors
    48 canonical pathways
    49 cell fate decisions
    50 cell maintenance
    51 cell proliferation
    52 cell-cell interaction mechanism
    53 cells
    54 coloration
    55 conclusion
    56 constitutive Notch activity
    57 constitutive activity
    58 data
    59 decisions
    60 dependent Notch signaling
    61 development
    62 differentiation
    63 epidermis
    64 epithelial cell proliferation
    65 epithelium
    66 eye structures
    67 eyes
    68 fate decisions
    69 hair
    70 hyperproliferation
    71 implications
    72 importance
    73 interaction mechanism
    74 maintenance
    75 mammalian eye
    76 mammals
    77 mechanism
    78 melanocytes
    79 melanoma
    80 mice
    81 mouse epidermis
    82 oncogene
    83 pathway
    84 pigment cells
    85 pigment epithelium
    86 pigmented tumors
    87 population
    88 presence
    89 process
    90 proliferation
    91 recent data
    92 retinal pigment epithelial cell proliferation
    93 retinal pigment epithelium
    94 signaling
    95 skin
    96 stem cell maintenance
    97 structure
    98 study
    99 suppressor
    100 survival
    101 transgenic mice
    102 tumor suppressor
    103 tumors
    104 schema:name RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice
    105 schema:pagination 313-322
    106 schema:productId N383c2cfb7ccc4af59c0a2169ba311539
    107 N9935613729db4ae4b4737755e386593a
    108 Nb9301c8d16f2459dbb80a0058890951f
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052328179
    110 https://doi.org/10.1038/onc.2010.428
    111 schema:sdDatePublished 2022-12-01T06:28
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher N0b03e760888a4b91ac027ad30d9859cc
    114 schema:url https://doi.org/10.1038/onc.2010.428
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0b03e760888a4b91ac027ad30d9859cc schema:name Springer Nature - SN SciGraph project
    119 rdf:type schema:Organization
    120 N0e0f6fd73ede44e8815e4fb961cfd630 schema:volumeNumber 30
    121 rdf:type schema:PublicationVolume
    122 N1592802f6a0f470f91f788b7b5431f9d schema:issueNumber 3
    123 rdf:type schema:PublicationIssue
    124 N1b32135c11d841f5a2d5868f42945022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Mice, Transgenic
    126 rdf:type schema:DefinedTerm
    127 N383c2cfb7ccc4af59c0a2169ba311539 schema:name pubmed_id
    128 schema:value 20856205
    129 rdf:type schema:PropertyValue
    130 N3a218303a25340a79e6ac127f6f7f367 rdf:first sg:person.01253527331.59
    131 rdf:rest rdf:nil
    132 N3a40dc1db4a34ba1a857466f579e9e3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Receptors, Notch
    134 rdf:type schema:DefinedTerm
    135 N509962a6e5f846888b59fa894ce1b33a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Cell Proliferation
    137 rdf:type schema:DefinedTerm
    138 N5b7b376aa1524e97ad4f3e9ac8c31771 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Retinal Pigment Epithelium
    140 rdf:type schema:DefinedTerm
    141 N5e6ffe5a09dc4bb1b7f9f5a47d8c3e47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Mice, Inbred C57BL
    143 rdf:type schema:DefinedTerm
    144 N82e3d3513586475aa7836c9430007a38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Mice
    146 rdf:type schema:DefinedTerm
    147 N8aa6fa94e1ab42f88f81f3f3e2fd2808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Animals
    149 rdf:type schema:DefinedTerm
    150 N8c5b22f28e014d4ba1500055bbbaead6 rdf:first sg:person.01021176505.96
    151 rdf:rest N3a218303a25340a79e6ac127f6f7f367
    152 N9935613729db4ae4b4737755e386593a schema:name dimensions_id
    153 schema:value pub.1052328179
    154 rdf:type schema:PropertyValue
    155 N9eeac893820b4fb8a6d9198726ee6b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Immunoglobulin J Recombination Signal Sequence-Binding Protein
    157 rdf:type schema:DefinedTerm
    158 Na0ea0889ff344b588a247f767032427c rdf:first sg:person.01105526245.09
    159 rdf:rest Na7c3f72f822c4744a96ac803f7dd7300
    160 Na7c3f72f822c4744a96ac803f7dd7300 rdf:first sg:person.0674236563.97
    161 rdf:rest N8c5b22f28e014d4ba1500055bbbaead6
    162 Nb9301c8d16f2459dbb80a0058890951f schema:name doi
    163 schema:value 10.1038/onc.2010.428
    164 rdf:type schema:PropertyValue
    165 Nda476e004a3348898cfcc0d540aa22d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Signal Transduction
    167 rdf:type schema:DefinedTerm
    168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    169 schema:name Medical and Health Sciences
    170 rdf:type schema:DefinedTerm
    171 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    172 schema:name Clinical Sciences
    173 rdf:type schema:DefinedTerm
    174 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    175 schema:name Oncology and Carcinogenesis
    176 rdf:type schema:DefinedTerm
    177 sg:grant.5226611 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2010.428
    178 rdf:type schema:MonetaryGrant
    179 sg:journal.1097543 schema:issn 0950-9232
    180 1476-5594
    181 schema:name Oncogene
    182 schema:publisher Springer Nature
    183 rdf:type schema:Periodical
    184 sg:person.01021176505.96 schema:affiliation grid-institutes:grid.5333.6
    185 schema:familyName Radtke
    186 schema:givenName F
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021176505.96
    188 rdf:type schema:Person
    189 sg:person.01105526245.09 schema:affiliation grid-institutes:grid.5333.6
    190 schema:familyName Schouwey
    191 schema:givenName K
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105526245.09
    193 rdf:type schema:Person
    194 sg:person.01253527331.59 schema:affiliation grid-institutes:grid.5333.6
    195 schema:familyName Beermann
    196 schema:givenName F
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253527331.59
    198 rdf:type schema:Person
    199 sg:person.0674236563.97 schema:affiliation grid-institutes:grid.5333.6
    200 schema:familyName Aydin
    201 schema:givenName I T
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674236563.97
    203 rdf:type schema:Person
    204 sg:pub.10.1007/bf00158922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015404958
    205 https://doi.org/10.1007/bf00158922
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/bf02343044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042030498
    208 https://doi.org/10.1007/bf02343044
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1007/pl00000685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040273899
    211 https://doi.org/10.1007/pl00000685
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1007/s00429-004-0382-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881214
    214 https://doi.org/10.1007/s00429-004-0382-5
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/5007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030839891
    217 https://doi.org/10.1038/5007
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/ng0797-243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050786128
    220 https://doi.org/10.1038/ng0797-243
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/ng1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041697410
    223 https://doi.org/10.1038/ng1099
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/ni793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045423530
    226 https://doi.org/10.1038/ni793
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/nrc1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004707046
    229 https://doi.org/10.1038/nrc1186
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/nrm2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019849472
    232 https://doi.org/10.1038/nrm2009
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/nrn1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047057402
    235 https://doi.org/10.1038/nrn1847
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/onc.2008.225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016759404
    238 https://doi.org/10.1038/onc.2008.225
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/sj.onc.1201035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010498766
    241 https://doi.org/10.1038/sj.onc.1201035
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/sj.onc.1202196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007930979
    244 https://doi.org/10.1038/sj.onc.1202196
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/sj.onc.1206758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018549599
    247 https://doi.org/10.1038/sj.onc.1206758
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1186/1756-6606-2-38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052354970
    250 https://doi.org/10.1186/1756-6606-2-38
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1385/1-59745-095-2:185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003770891
    253 https://doi.org/10.1385/1-59745-095-2:185
    254 rdf:type schema:CreativeWork
    255 grid-institutes:grid.5333.6 schema:alternateName Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, (EPFL), Lausanne, Switzerland
    256 schema:name Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, (EPFL), Lausanne, Switzerland
    257 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...