Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08-23

AUTHORS

S Radulescu, R A Ridgway, P Appleton, K Kroboth, S Patel, J Woodgett, S Taylor, I S Nathke, O J Sansom

ABSTRACT

Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central tumour-suppressive function, the significance of APC in regulating chromosome instability is less well established. In this study, we test whether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining the response of these cells to Taxol and Vinorelbine. We also show for the first time that APC deficiency compromises the arrest response to Taxol in vivo. This effect is independent of the role that APC has in WNT signalling. At higher levels of Taxol, APC-deficient cells arrest as efficiently as wild-type cells. Importantly, this dose of Taxol strongly suppresses intestinal tumourigenesis in models of benign (APCMin/+ mouse) and invasive (AhCreER+APCfl/+PTENfl/fl) cancer. In contrast to intestinal enterocytes with a general SAC defect because of Bub1 (budding uninhibited by benzimidazole 1) deletion, APC-deficient enterocytes arrest equivalently to wild type when treated with Vinorelbine. This suggests that the failed arrest in response to Taxol is because of a specific defect in microtubule stabilization following Taxol treatment rather than a general role of the APC protein in the mitotic spindle checkpoint. In summary, this study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-deficient cells have a compromised response to Taxol. More... »

PAGES

6418-6427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2010.373

DOI

http://dx.doi.org/10.1038/onc.2010.373

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031298026

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20729907


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenomatous Polyposis Coli", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenomatous Polyposis Coli Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paclitaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spindle Apparatus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vinblastine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vinorelbine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "CR-UK Beatson Institute of Cancer Research, Glasgow, UK", 
          "id": "http://www.grid.ac/institutes/grid.23636.32", 
          "name": [
            "CR-UK Beatson Institute of Cancer Research, Glasgow, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Radulescu", 
        "givenName": "S", 
        "id": "sg:person.01133510555.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133510555.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CR-UK Beatson Institute of Cancer Research, Glasgow, UK", 
          "id": "http://www.grid.ac/institutes/grid.23636.32", 
          "name": [
            "CR-UK Beatson Institute of Cancer Research, Glasgow, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ridgway", 
        "givenName": "R A", 
        "id": "sg:person.01256637575.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256637575.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee, WTB/MSI, Dundee, UK", 
          "id": "http://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "University of Dundee, WTB/MSI, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Appleton", 
        "givenName": "P", 
        "id": "sg:person.01316052355.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316052355.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee, WTB/MSI, Dundee, UK", 
          "id": "http://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "University of Dundee, WTB/MSI, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroboth", 
        "givenName": "K", 
        "id": "sg:person.01272474035.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272474035.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.250674.2", 
          "name": [
            "Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "S", 
        "id": "sg:person.0672254607.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672254607.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.250674.2", 
          "name": [
            "Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woodgett", 
        "givenName": "J", 
        "id": "sg:person.0731233037.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Life Sciences, University of Manchester, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Faculty of Life Sciences, University of Manchester, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "S", 
        "id": "sg:person.01206717470.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206717470.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Dundee, WTB/MSI, Dundee, UK", 
          "id": "http://www.grid.ac/institutes/grid.8241.f", 
          "name": [
            "University of Dundee, WTB/MSI, Dundee, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nathke", 
        "givenName": "I S", 
        "id": "sg:person.0715756145.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715756145.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "CR-UK Beatson Institute of Cancer Research, Glasgow, UK", 
          "id": "http://www.grid.ac/institutes/grid.23636.32", 
          "name": [
            "CR-UK Beatson Institute of Cancer Research, Glasgow, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sansom", 
        "givenName": "O J", 
        "id": "sg:person.01155754475.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155754475.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018114117", 
          "https://doi.org/10.1038/ng.256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002848303", 
          "https://doi.org/10.1038/nature05674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027104291", 
          "https://doi.org/10.1038/35070123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35070129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036988128", 
          "https://doi.org/10.1038/35070129"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-08-23", 
    "datePublishedReg": "2010-08-23", 
    "description": "Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central tumour-suppressive function, the significance of APC in regulating chromosome instability is less well established. In this study, we test whether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining the response of these cells to Taxol and Vinorelbine. We also show for the first time that APC deficiency compromises the arrest response to Taxol in vivo. This effect is independent of the role that APC has in WNT signalling. At higher levels of Taxol, APC-deficient cells arrest as efficiently as wild-type cells. Importantly, this dose of Taxol strongly suppresses intestinal tumourigenesis in models of benign (APCMin/+ mouse) and invasive (AhCreER+APCfl/+PTENfl/fl) cancer. In contrast to intestinal enterocytes with a general SAC defect because of Bub1 (budding uninhibited by benzimidazole 1) deletion, APC-deficient enterocytes arrest equivalently to wild type when treated with Vinorelbine. This suggests that the failed arrest in response to Taxol is because of a specific defect in microtubule stabilization following Taxol treatment rather than a general role of the APC protein in the mitotic spindle checkpoint. In summary, this study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-deficient cells have a compromised response to Taxol.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/onc.2010.373", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5145271", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5139401", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "49", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "keywords": [
      "APC-deficient cells", 
      "role of APC", 
      "dose of Taxol", 
      "key initiating event", 
      "tumor suppressive function", 
      "colorectal cancer", 
      "intestinal tumourigenesis", 
      "invasive cancer", 
      "Apc deficiency", 
      "intestinal enterocytes", 
      "taxol treatment", 
      "vinorelbine", 
      "APC", 
      "tumor suppressor", 
      "vivo", 
      "cancer", 
      "control of Wnt", 
      "mitotic spindle checkpoint", 
      "microtubule stabilization", 
      "enterocytes", 
      "arrest response", 
      "taxol", 
      "cells", 
      "initiating event", 
      "Wnt", 
      "response", 
      "specific defects", 
      "high levels", 
      "checkpoint proteins", 
      "dose", 
      "role", 
      "tumourigenesis", 
      "adenomatous polyposis coli (APC) tumor suppressor", 
      "checkpoint", 
      "treatment", 
      "arrest", 
      "protein", 
      "study", 
      "general role", 
      "deficiency", 
      "chromosome instability", 
      "wild-type cells", 
      "APC protein", 
      "mitotic spindle checkpoint proteins", 
      "wild type", 
      "suppressor", 
      "spindle assembly checkpoint", 
      "mutations", 
      "levels", 
      "deletion", 
      "control", 
      "significance", 
      "summary", 
      "events", 
      "contrast", 
      "defects", 
      "effect", 
      "first time", 
      "spindle checkpoint", 
      "function", 
      "types", 
      "time", 
      "spindle checkpoint proteins", 
      "assembly checkpoint", 
      "functional spindle assembly checkpoint", 
      "stabilization", 
      "instability", 
      "model"
    ], 
    "name": "Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol", 
    "pagination": "6418-6427", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031298026"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2010.373"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20729907"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2010.373", 
      "https://app.dimensions.ai/details/publication/pub.1031298026"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/onc.2010.373"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.373'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.373'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.373'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.373'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      21 PREDICATES      116 URIs      104 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2010.373 schema:about N023b679bd59c4e00b53dc2a8a4935fd2
2 N1613f9a3797044e1bb8bf2bdfef161c4
3 N20d5c58d03474261bd1f8eecd7fa6f7c
4 N22beaf485d2e4107b78e024f09248b44
5 N2a0e5c8097be4da4bbbff3ca4e5b2f00
6 N4e9d20dd3f094dfcb334e13be29ced0f
7 N5ad8223169e446e399bdee7b6b4dc985
8 N63581974c5da4bbd917cdc8227de14c3
9 N65f49dd02b4644478e1c0b69de2725f9
10 N7a623d3165dc4df99de95ddb9fc22a0e
11 N7b77711923684b54aeb4c74bb0dadb66
12 N80c64162e1f14b3597aa74208b3c2ec5
13 N9a799bbf894344c898cd8b834ed05c83
14 Na0448dc17d2a402fadc6c953937ac450
15 Nc0cccdc9133246bb9b104f38756f5c33
16 Nc417466c63d54065932da94be4958edf
17 Nd82a9313da23411c9265a0785a893e5a
18 Ne8ce77ff38604ccab28253d4b598a14b
19 Nf7aa8eb94717442d88d17f8af2d83b4a
20 anzsrc-for:11
21 anzsrc-for:1112
22 schema:author N3da4b1b8ecd54ec985bd68384b7ce3c2
23 schema:citation sg:pub.10.1038/35070123
24 sg:pub.10.1038/35070129
25 sg:pub.10.1038/nature05674
26 sg:pub.10.1038/ng.256
27 schema:datePublished 2010-08-23
28 schema:datePublishedReg 2010-08-23
29 schema:description Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central tumour-suppressive function, the significance of APC in regulating chromosome instability is less well established. In this study, we test whether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining the response of these cells to Taxol and Vinorelbine. We also show for the first time that APC deficiency compromises the arrest response to Taxol in vivo. This effect is independent of the role that APC has in WNT signalling. At higher levels of Taxol, APC-deficient cells arrest as efficiently as wild-type cells. Importantly, this dose of Taxol strongly suppresses intestinal tumourigenesis in models of benign (APCMin/+ mouse) and invasive (AhCreER+APCfl/+PTENfl/fl) cancer. In contrast to intestinal enterocytes with a general SAC defect because of Bub1 (budding uninhibited by benzimidazole 1) deletion, APC-deficient enterocytes arrest equivalently to wild type when treated with Vinorelbine. This suggests that the failed arrest in response to Taxol is because of a specific defect in microtubule stabilization following Taxol treatment rather than a general role of the APC protein in the mitotic spindle checkpoint. In summary, this study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-deficient cells have a compromised response to Taxol.
30 schema:genre article
31 schema:isAccessibleForFree true
32 schema:isPartOf N9b341f7ea99e491795a22a66cbf41af4
33 Nab4b2f46322e477f8321fe6051ae67f2
34 sg:journal.1097543
35 schema:keywords APC
36 APC protein
37 APC-deficient cells
38 Apc deficiency
39 Wnt
40 adenomatous polyposis coli (APC) tumor suppressor
41 arrest
42 arrest response
43 assembly checkpoint
44 cancer
45 cells
46 checkpoint
47 checkpoint proteins
48 chromosome instability
49 colorectal cancer
50 contrast
51 control
52 control of Wnt
53 defects
54 deficiency
55 deletion
56 dose
57 dose of Taxol
58 effect
59 enterocytes
60 events
61 first time
62 function
63 functional spindle assembly checkpoint
64 general role
65 high levels
66 initiating event
67 instability
68 intestinal enterocytes
69 intestinal tumourigenesis
70 invasive cancer
71 key initiating event
72 levels
73 microtubule stabilization
74 mitotic spindle checkpoint
75 mitotic spindle checkpoint proteins
76 model
77 mutations
78 protein
79 response
80 role
81 role of APC
82 significance
83 specific defects
84 spindle assembly checkpoint
85 spindle checkpoint
86 spindle checkpoint proteins
87 stabilization
88 study
89 summary
90 suppressor
91 taxol
92 taxol treatment
93 time
94 treatment
95 tumor suppressive function
96 tumor suppressor
97 tumourigenesis
98 types
99 vinorelbine
100 vivo
101 wild type
102 wild-type cells
103 schema:name Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol
104 schema:pagination 6418-6427
105 schema:productId N177844bdb6b3431480c322850125d689
106 N185d9ea1617b415283657f9364c86245
107 Nefbe4d661caa4b54b50e15df4411ac15
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031298026
109 https://doi.org/10.1038/onc.2010.373
110 schema:sdDatePublished 2022-09-02T15:54
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N856cb16cd91e4c7590957818a240d0db
113 schema:url https://doi.org/10.1038/onc.2010.373
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N01126d9fb04f4d7cb3c44259b3a0d121 rdf:first sg:person.01272474035.40
118 rdf:rest N208702cf8eee45709c2acca0494d74a7
119 N023b679bd59c4e00b53dc2a8a4935fd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Protein Serine-Threonine Kinases
121 rdf:type schema:DefinedTerm
122 N11b24624856e432e8627e1f86acc44ac rdf:first sg:person.0731233037.88
123 rdf:rest N793c4ac4eeb24646ab8b5ba173b61505
124 N1613f9a3797044e1bb8bf2bdfef161c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Sequence Deletion
126 rdf:type schema:DefinedTerm
127 N177844bdb6b3431480c322850125d689 schema:name pubmed_id
128 schema:value 20729907
129 rdf:type schema:PropertyValue
130 N185d9ea1617b415283657f9364c86245 schema:name doi
131 schema:value 10.1038/onc.2010.373
132 rdf:type schema:PropertyValue
133 N208702cf8eee45709c2acca0494d74a7 rdf:first sg:person.0672254607.06
134 rdf:rest N11b24624856e432e8627e1f86acc44ac
135 N20d5c58d03474261bd1f8eecd7fa6f7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Chromosomal Instability
137 rdf:type schema:DefinedTerm
138 N22beaf485d2e4107b78e024f09248b44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Transformation, Neoplastic
140 rdf:type schema:DefinedTerm
141 N27f156a1d5f64f1eb74b7880b9ea7366 rdf:first sg:person.01155754475.41
142 rdf:rest rdf:nil
143 N2a0e5c8097be4da4bbbff3ca4e5b2f00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Paclitaxel
145 rdf:type schema:DefinedTerm
146 N3da4b1b8ecd54ec985bd68384b7ce3c2 rdf:first sg:person.01133510555.61
147 rdf:rest N9676c05016d943ceb5a506c3f930c7a0
148 N4e9d20dd3f094dfcb334e13be29ced0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Spindle Apparatus
150 rdf:type schema:DefinedTerm
151 N51e1047349354717a1b42ab4f2550c68 rdf:first sg:person.0715756145.71
152 rdf:rest N27f156a1d5f64f1eb74b7880b9ea7366
153 N5ad8223169e446e399bdee7b6b4dc985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Animals
155 rdf:type schema:DefinedTerm
156 N63581974c5da4bbd917cdc8227de14c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mice, Inbred C57BL
158 rdf:type schema:DefinedTerm
159 N65f49dd02b4644478e1c0b69de2725f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Vinorelbine
161 rdf:type schema:DefinedTerm
162 N793c4ac4eeb24646ab8b5ba173b61505 rdf:first sg:person.01206717470.32
163 rdf:rest N51e1047349354717a1b42ab4f2550c68
164 N7a623d3165dc4df99de95ddb9fc22a0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Vinblastine
166 rdf:type schema:DefinedTerm
167 N7b77711923684b54aeb4c74bb0dadb66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Enterocytes
169 rdf:type schema:DefinedTerm
170 N80c64162e1f14b3597aa74208b3c2ec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Wnt Proteins
172 rdf:type schema:DefinedTerm
173 N856cb16cd91e4c7590957818a240d0db schema:name Springer Nature - SN SciGraph project
174 rdf:type schema:Organization
175 N9676c05016d943ceb5a506c3f930c7a0 rdf:first sg:person.01256637575.32
176 rdf:rest Nd1cb7760ce7c46b496755fc9a0cd7d7a
177 N9a799bbf894344c898cd8b834ed05c83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Adenomatous Polyposis Coli
179 rdf:type schema:DefinedTerm
180 N9b341f7ea99e491795a22a66cbf41af4 schema:volumeNumber 29
181 rdf:type schema:PublicationVolume
182 Na0448dc17d2a402fadc6c953937ac450 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Antineoplastic Agents, Phytogenic
184 rdf:type schema:DefinedTerm
185 Nab4b2f46322e477f8321fe6051ae67f2 schema:issueNumber 49
186 rdf:type schema:PublicationIssue
187 Nc0cccdc9133246bb9b104f38756f5c33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Adenomatous Polyposis Coli Protein
189 rdf:type schema:DefinedTerm
190 Nc417466c63d54065932da94be4958edf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Male
192 rdf:type schema:DefinedTerm
193 Nd1cb7760ce7c46b496755fc9a0cd7d7a rdf:first sg:person.01316052355.52
194 rdf:rest N01126d9fb04f4d7cb3c44259b3a0d121
195 Nd82a9313da23411c9265a0785a893e5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Cell Cycle
197 rdf:type schema:DefinedTerm
198 Ne8ce77ff38604ccab28253d4b598a14b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Drug Resistance, Neoplasm
200 rdf:type schema:DefinedTerm
201 Nefbe4d661caa4b54b50e15df4411ac15 schema:name dimensions_id
202 schema:value pub.1031298026
203 rdf:type schema:PropertyValue
204 Nf7aa8eb94717442d88d17f8af2d83b4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice
206 rdf:type schema:DefinedTerm
207 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
208 schema:name Medical and Health Sciences
209 rdf:type schema:DefinedTerm
210 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
211 schema:name Oncology and Carcinogenesis
212 rdf:type schema:DefinedTerm
213 sg:grant.5139401 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2010.373
214 rdf:type schema:MonetaryGrant
215 sg:grant.5145271 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2010.373
216 rdf:type schema:MonetaryGrant
217 sg:journal.1097543 schema:issn 0950-9232
218 1476-5594
219 schema:name Oncogene
220 schema:publisher Springer Nature
221 rdf:type schema:Periodical
222 sg:person.01133510555.61 schema:affiliation grid-institutes:grid.23636.32
223 schema:familyName Radulescu
224 schema:givenName S
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133510555.61
226 rdf:type schema:Person
227 sg:person.01155754475.41 schema:affiliation grid-institutes:grid.23636.32
228 schema:familyName Sansom
229 schema:givenName O J
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155754475.41
231 rdf:type schema:Person
232 sg:person.01206717470.32 schema:affiliation grid-institutes:grid.5379.8
233 schema:familyName Taylor
234 schema:givenName S
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206717470.32
236 rdf:type schema:Person
237 sg:person.01256637575.32 schema:affiliation grid-institutes:grid.23636.32
238 schema:familyName Ridgway
239 schema:givenName R A
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256637575.32
241 rdf:type schema:Person
242 sg:person.01272474035.40 schema:affiliation grid-institutes:grid.8241.f
243 schema:familyName Kroboth
244 schema:givenName K
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272474035.40
246 rdf:type schema:Person
247 sg:person.01316052355.52 schema:affiliation grid-institutes:grid.8241.f
248 schema:familyName Appleton
249 schema:givenName P
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316052355.52
251 rdf:type schema:Person
252 sg:person.0672254607.06 schema:affiliation grid-institutes:grid.250674.2
253 schema:familyName Patel
254 schema:givenName S
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672254607.06
256 rdf:type schema:Person
257 sg:person.0715756145.71 schema:affiliation grid-institutes:grid.8241.f
258 schema:familyName Nathke
259 schema:givenName I S
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715756145.71
261 rdf:type schema:Person
262 sg:person.0731233037.88 schema:affiliation grid-institutes:grid.250674.2
263 schema:familyName Woodgett
264 schema:givenName J
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88
266 rdf:type schema:Person
267 sg:pub.10.1038/35070123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027104291
268 https://doi.org/10.1038/35070123
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/35070129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036988128
271 https://doi.org/10.1038/35070129
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nature05674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002848303
274 https://doi.org/10.1038/nature05674
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ng.256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018114117
277 https://doi.org/10.1038/ng.256
278 rdf:type schema:CreativeWork
279 grid-institutes:grid.23636.32 schema:alternateName CR-UK Beatson Institute of Cancer Research, Glasgow, UK
280 schema:name CR-UK Beatson Institute of Cancer Research, Glasgow, UK
281 rdf:type schema:Organization
282 grid-institutes:grid.250674.2 schema:alternateName Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
283 schema:name Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
284 rdf:type schema:Organization
285 grid-institutes:grid.5379.8 schema:alternateName Faculty of Life Sciences, University of Manchester, Manchester, UK
286 schema:name Faculty of Life Sciences, University of Manchester, Manchester, UK
287 rdf:type schema:Organization
288 grid-institutes:grid.8241.f schema:alternateName University of Dundee, WTB/MSI, Dundee, UK
289 schema:name University of Dundee, WTB/MSI, Dundee, UK
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...