The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic lymphomas View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09

AUTHORS

J Santos, L González-Sánchez, M Villa-Morales, I Ors, P López-Nieva, C Vaquero, E González-Gugel, P Fernández-Navarro, A M Roncero, J-L Guenet, X Montagutelli, J Fernández-Piqueras

ABSTRACT

Using an inter-specific subcongenic strain, Nested Recombinant Haplotype 3 (NRH3), generated between two mouse strains showing extreme differences in γ-radiation-induced thymic lymphoma susceptibility (SEG/Pas and C57BL/6J), we have identified a critical region on chromosome 19 that regulates survival of mice suffering from T-cell lymphoblastic lymphomas. Mapped on this region, the gene encoding the Cd274 ligand is able to trigger an inhibitory effect that modulates T-cell receptor (TCR) signalling and affects thymocyte maturation. Interestingly, this gene shows differential expression between thymic stromal cells from both strains in early response to a single sublethal γ-ray dose, but is inhibited in T-cell lymphoblastic lymphomas. Furthermore, we have identified several polymorphisms in the complementary DNA sequence of this gene that affect the affinity for its Cd279 receptor and are able to induce a differential rate of thymocyte apoptosis. Taken together, our data are consistent with Cd274 acting as a genetic modifier that influences the survival of γ-radiation-induced T-cell lymphoma-bearing mice. The data similarly support the idea of a co-evolution of tumour cells and associated stromal cells to generate a favourable microenvironment for T-cell lymphoma growth. More... »

PAGES

5265

References to SciGraph publications

  • 2001-08. Genetic loci controlling susceptibility to γ-ray-induced thymic lymphoma in ONCOGENE
  • 2002-09. A new locus for resistance to γ-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice in ONCOGENE
  • 2007-05. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2002-11. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas in NATURE GENETICS
  • 2003-02. Mapping of genetic modifiers of thymic lymphoma development in p53-knockout mice in ONCOGENE
  • 1988-08. T-cell receptor gene rearrangement in primary tumors: effect of genetic background and inducing agent in IMMUNOGENETICS
  • 2008-05. Molecular pathogenesis of T-cell leukaemia and lymphoma in NATURE REVIEWS IMMUNOLOGY
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
  • 1994-12. Assignment of a locus for mouse lung tumor susceptibility to proximal Chromosome 19 in MAMMALIAN GENOME
  • 2001-10. Lymphostromal interactions in thymic development and function in NATURE REVIEWS IMMUNOLOGY
  • 1999-10. Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain in NATURE GENETICS
  • 2000-06. The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64 in ONCOGENE
  • 2002-08. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion in NATURE MEDICINE
  • 2007-07. Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells in LEUKEMIA
  • 2006-03. Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to γ-radiation-induced thymic lymphoma in ONCOGENE
  • 2002-09. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion in NATURE MEDICINE
  • 2001-04. Evidence of a possible epigenetic inactivation mechanism operating on a region of mouse chromosome 19 in γ-radiation-induced thymic lymphomas in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2010.280

    DOI

    http://dx.doi.org/10.1038/onc.2010.280

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008042304

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20639904


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