Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05-24

AUTHORS

J Braun, C Hoang-Vu, H Dralle, S Hüttelmaier

ABSTRACT

Anaplastic thyroid carcinomas (ATCs) arise from epithelial thyroid cells by mesenchymal de-/transdifferentiation and rapidly invade the adjacent tissue. Specific microRNA signatures were suggested to distinguish ATCs from normal thyroid tissue and other thyroid carcinomas of follicular origin. Whether distinct microRNA patterns correlate with de-/transdifferentiation and invasion of ATCs remained elusive. We identified two significantly decreased microRNA families that unambiguously distinguish ATCs from papillary and follicular thyroid carcinomas: miR-200 and miR-30. Expression of these microRNAs in mesenchymal ATC-derived cells reduced their invasive potential and induced mesenchymal–epithelial transition (MET) by regulating the expression of MET marker proteins. Supporting the role of transforming growth factor (TGF)β signaling in modulating MET/epithelial–mesenchymal transition (EMT), expression of SMAD2 and TGFBR1, upregulated in most primary ATCs, was controlled by members of the miR-30 and/or miR-200 families in ATC-derived cells. Inhibition of TGFβ receptor 1 (TGFBR1) in these cells induced MET and reduction of prometastatic miR-21, but caused an increase of the miR-200 family. These findings identify altered microRNA signatures as potent markers for ATCs that promote de-/transdifferentiation (EMT) and invasion of these neoplasias. Hence, TGFBR1 inhibition could have a significant potential for the treatment of ATCs and possibly other invasive tumors. More... »

PAGES

4237-4244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2010.169

DOI

http://dx.doi.org/10.1038/onc.2010.169

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038480751

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20498632


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesoderm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Transforming Growth Factor-beta Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smad2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc Finger E-box Binding Homeobox 2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braun", 
        "givenName": "J", 
        "id": "sg:person.0705662126.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705662126.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoang-Vu", 
        "givenName": "C", 
        "id": "sg:person.0617467150.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617467150.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dralle", 
        "givenName": "H", 
        "id": "sg:person.0761262105.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761262105.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany", 
          "id": "http://www.grid.ac/institutes/grid.9018.0", 
          "name": [
            "Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00fcttelmaier", 
        "givenName": "S", 
        "id": "sg:person.01134707261.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134707261.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1210564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047663958", 
          "https://doi.org/10.1038/sj.onc.1210564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047429448", 
          "https://doi.org/10.1038/ncb1722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013368231", 
          "https://doi.org/10.1038/sj.onc.1210046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2008.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034356455", 
          "https://doi.org/10.1038/cr.2008.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043526861", 
          "https://doi.org/10.1038/nrc1836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032756706", 
          "https://doi.org/10.1038/nature07086"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-05-24", 
    "datePublishedReg": "2010-05-24", 
    "description": "Anaplastic thyroid carcinomas (ATCs) arise from epithelial thyroid cells by mesenchymal de-/transdifferentiation and rapidly invade the adjacent tissue. Specific microRNA signatures were suggested to distinguish ATCs from normal thyroid tissue and other thyroid carcinomas of follicular origin. Whether distinct microRNA patterns correlate with de-/transdifferentiation and invasion of ATCs remained elusive. We identified two significantly decreased microRNA families that unambiguously distinguish ATCs from papillary and follicular thyroid carcinomas: miR-200 and miR-30. Expression of these microRNAs in mesenchymal ATC-derived cells reduced their invasive potential and induced mesenchymal\u2013epithelial transition (MET) by regulating the expression of MET marker proteins. Supporting the role of transforming growth factor (TGF)\u03b2 signaling in modulating MET/epithelial\u2013mesenchymal transition (EMT), expression of SMAD2 and TGFBR1, upregulated in most primary ATCs, was controlled by members of the miR-30 and/or miR-200 families in ATC-derived cells. Inhibition of TGF\u03b2 receptor 1 (TGFBR1) in these cells induced MET and reduction of prometastatic miR-21, but caused an increase of the miR-200 family. These findings identify altered microRNA signatures as potent markers for ATCs that promote de-/transdifferentiation (EMT) and invasion of these neoplasias. Hence, TGFBR1 inhibition could have a significant potential for the treatment of ATCs and possibly other invasive tumors.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/onc.2010.169", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7970328", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "29", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "keywords": [
      "anaplastic thyroid carcinoma", 
      "epithelial-mesenchymal transition", 
      "thyroid carcinoma", 
      "mesenchymal-epithelial transition", 
      "miR-200 family", 
      "primary anaplastic thyroid carcinoma", 
      "treatment of ATC", 
      "TGF\u03b2 receptor 1", 
      "follicular thyroid carcinoma", 
      "expression of Smad2", 
      "invasive potential", 
      "miR-30", 
      "normal thyroid tissue", 
      "invasive tumors", 
      "epithelial thyroid cells", 
      "follicular origin", 
      "downregulation of microRNA", 
      "TGFBR1 inhibition", 
      "receptor 1", 
      "potent marker", 
      "carcinoma", 
      "thyroid tissue", 
      "adjacent tissues", 
      "miR-21", 
      "growth factor", 
      "microRNA patterns", 
      "miR-200", 
      "thyroid cells", 
      "marker proteins", 
      "cells", 
      "invasion", 
      "inhibition", 
      "tissue", 
      "expression", 
      "microRNAs", 
      "neoplasia", 
      "tumors", 
      "TGFBR1", 
      "downregulation", 
      "Smad2", 
      "treatment", 
      "markers", 
      "family", 
      "findings", 
      "factors", 
      "potential", 
      "protein", 
      "role", 
      "increase", 
      "reduction", 
      "significant potential", 
      "patterns", 
      "members", 
      "signatures", 
      "origin", 
      "de", 
      "transition"
    ], 
    "name": "Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas", 
    "pagination": "4237-4244", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038480751"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2010.169"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20498632"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2010.169", 
      "https://app.dimensions.ai/details/publication/pub.1038480751"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_528.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/onc.2010.169"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.169'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.169'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.169'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2010.169'


 

This table displays all metadata directly associated to this object as RDF triples.

235 TRIPLES      21 PREDICATES      105 URIs      90 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2010.169 schema:about N160f99e8de454955875a934f706d16f5
2 N36ff990b4db6475faeb18da5df81e171
3 N381d018c4a794673910693a38ebca41c
4 N44899ce6db134033b044977397dfebb1
5 N4724dcee082a42328862373f2b38a39b
6 N6d4ffe9cde6e4bda8e2dc0fb8cc9a835
7 N754ff16f3617454fb23f03e0e41f86b3
8 N77d129eb6a134d5b9515b94b5733e903
9 Na1e324b1bab847cda28a92c02a12f162
10 Na977deccc5764ad5ba78cfbb8400055c
11 Nb0e6e86f2cd34ca1bdcdcf1f94e50821
12 Nb41b62ac331042d18816dacfbfae9309
13 Nc565a90838df44ed8e2f465d0fab183d
14 Nd081a17cf0fa414d96d7c66fe221ed9e
15 Nde1aed97062c4f9e8ab7763d8ad8cf1c
16 Nee16c04e205449e7a4e1ecbd8ed5448b
17 anzsrc-for:11
18 anzsrc-for:1103
19 anzsrc-for:1112
20 schema:author N2d3153d2fc514d96bafe6cb1d07ee62c
21 schema:citation sg:pub.10.1038/cr.2008.24
22 sg:pub.10.1038/nature07086
23 sg:pub.10.1038/ncb1722
24 sg:pub.10.1038/nrc1836
25 sg:pub.10.1038/sj.onc.1210046
26 sg:pub.10.1038/sj.onc.1210564
27 schema:datePublished 2010-05-24
28 schema:datePublishedReg 2010-05-24
29 schema:description Anaplastic thyroid carcinomas (ATCs) arise from epithelial thyroid cells by mesenchymal de-/transdifferentiation and rapidly invade the adjacent tissue. Specific microRNA signatures were suggested to distinguish ATCs from normal thyroid tissue and other thyroid carcinomas of follicular origin. Whether distinct microRNA patterns correlate with de-/transdifferentiation and invasion of ATCs remained elusive. We identified two significantly decreased microRNA families that unambiguously distinguish ATCs from papillary and follicular thyroid carcinomas: miR-200 and miR-30. Expression of these microRNAs in mesenchymal ATC-derived cells reduced their invasive potential and induced mesenchymal–epithelial transition (MET) by regulating the expression of MET marker proteins. Supporting the role of transforming growth factor (TGF)β signaling in modulating MET/epithelial–mesenchymal transition (EMT), expression of SMAD2 and TGFBR1, upregulated in most primary ATCs, was controlled by members of the miR-30 and/or miR-200 families in ATC-derived cells. Inhibition of TGFβ receptor 1 (TGFBR1) in these cells induced MET and reduction of prometastatic miR-21, but caused an increase of the miR-200 family. These findings identify altered microRNA signatures as potent markers for ATCs that promote de-/transdifferentiation (EMT) and invasion of these neoplasias. Hence, TGFBR1 inhibition could have a significant potential for the treatment of ATCs and possibly other invasive tumors.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf Na58e539c877e41178b5eff7ef19b7b0d
33 Nf2f31b77a6844deea7d039bad2d24bde
34 sg:journal.1097543
35 schema:keywords Smad2
36 TGFBR1
37 TGFBR1 inhibition
38 TGFβ receptor 1
39 adjacent tissues
40 anaplastic thyroid carcinoma
41 carcinoma
42 cells
43 de
44 downregulation
45 downregulation of microRNA
46 epithelial thyroid cells
47 epithelial-mesenchymal transition
48 expression
49 expression of Smad2
50 factors
51 family
52 findings
53 follicular origin
54 follicular thyroid carcinoma
55 growth factor
56 increase
57 inhibition
58 invasion
59 invasive potential
60 invasive tumors
61 marker proteins
62 markers
63 members
64 mesenchymal-epithelial transition
65 miR-200
66 miR-200 family
67 miR-21
68 miR-30
69 microRNA patterns
70 microRNAs
71 neoplasia
72 normal thyroid tissue
73 origin
74 patterns
75 potent marker
76 potential
77 primary anaplastic thyroid carcinoma
78 protein
79 receptor 1
80 reduction
81 role
82 signatures
83 significant potential
84 thyroid carcinoma
85 thyroid cells
86 thyroid tissue
87 tissue
88 transition
89 treatment
90 treatment of ATC
91 tumors
92 schema:name Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
93 schema:pagination 4237-4244
94 schema:productId N1d5d339bfc2649699f654b45af36d5a6
95 N45196e05c9304d0eb2240c65de15e730
96 Ne235618c7eae449a9c4909eb8bd2218b
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038480751
98 https://doi.org/10.1038/onc.2010.169
99 schema:sdDatePublished 2022-09-02T15:54
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N7a98d1bf4819423d9ba361debb17a632
102 schema:url https://doi.org/10.1038/onc.2010.169
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N160f99e8de454955875a934f706d16f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Down-Regulation
108 rdf:type schema:DefinedTerm
109 N1d5d339bfc2649699f654b45af36d5a6 schema:name doi
110 schema:value 10.1038/onc.2010.169
111 rdf:type schema:PropertyValue
112 N2d3153d2fc514d96bafe6cb1d07ee62c rdf:first sg:person.0705662126.53
113 rdf:rest Na96de1df34a44ac497b760fe467270cd
114 N303751ef782b4ff6bc3226bfea9532f1 rdf:first sg:person.0761262105.04
115 rdf:rest N7729bc9ec769421286e0b795bee2ae86
116 N36ff990b4db6475faeb18da5df81e171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Repressor Proteins
118 rdf:type schema:DefinedTerm
119 N381d018c4a794673910693a38ebca41c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Homeodomain Proteins
121 rdf:type schema:DefinedTerm
122 N44899ce6db134033b044977397dfebb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Neoplasm Invasiveness
124 rdf:type schema:DefinedTerm
125 N45196e05c9304d0eb2240c65de15e730 schema:name dimensions_id
126 schema:value pub.1038480751
127 rdf:type schema:PropertyValue
128 N4724dcee082a42328862373f2b38a39b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Mesoderm
130 rdf:type schema:DefinedTerm
131 N6d4ffe9cde6e4bda8e2dc0fb8cc9a835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Epithelial Cells
133 rdf:type schema:DefinedTerm
134 N754ff16f3617454fb23f03e0e41f86b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N7729bc9ec769421286e0b795bee2ae86 rdf:first sg:person.01134707261.66
138 rdf:rest rdf:nil
139 N77d129eb6a134d5b9515b94b5733e903 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Smad2 Protein
141 rdf:type schema:DefinedTerm
142 N7a98d1bf4819423d9ba361debb17a632 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Na1e324b1bab847cda28a92c02a12f162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Thyroid Neoplasms
146 rdf:type schema:DefinedTerm
147 Na58e539c877e41178b5eff7ef19b7b0d schema:issueNumber 29
148 rdf:type schema:PublicationIssue
149 Na96de1df34a44ac497b760fe467270cd rdf:first sg:person.0617467150.16
150 rdf:rest N303751ef782b4ff6bc3226bfea9532f1
151 Na977deccc5764ad5ba78cfbb8400055c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Carcinoma
153 rdf:type schema:DefinedTerm
154 Nb0e6e86f2cd34ca1bdcdcf1f94e50821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name MicroRNAs
156 rdf:type schema:DefinedTerm
157 Nb41b62ac331042d18816dacfbfae9309 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Zinc Finger E-box Binding Homeobox 2
159 rdf:type schema:DefinedTerm
160 Nc565a90838df44ed8e2f465d0fab183d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Receptor, Transforming Growth Factor-beta Type I
162 rdf:type schema:DefinedTerm
163 Nd081a17cf0fa414d96d7c66fe221ed9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Transforming Growth Factor beta
165 rdf:type schema:DefinedTerm
166 Nde1aed97062c4f9e8ab7763d8ad8cf1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Protein Serine-Threonine Kinases
168 rdf:type schema:DefinedTerm
169 Ne235618c7eae449a9c4909eb8bd2218b schema:name pubmed_id
170 schema:value 20498632
171 rdf:type schema:PropertyValue
172 Nee16c04e205449e7a4e1ecbd8ed5448b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Receptors, Transforming Growth Factor beta
174 rdf:type schema:DefinedTerm
175 Nf2f31b77a6844deea7d039bad2d24bde schema:volumeNumber 29
176 rdf:type schema:PublicationVolume
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
181 schema:name Clinical Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
184 schema:name Oncology and Carcinogenesis
185 rdf:type schema:DefinedTerm
186 sg:grant.7970328 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2010.169
187 rdf:type schema:MonetaryGrant
188 sg:journal.1097543 schema:issn 0950-9232
189 1476-5594
190 schema:name Oncogene
191 schema:publisher Springer Nature
192 rdf:type schema:Periodical
193 sg:person.01134707261.66 schema:affiliation grid-institutes:grid.9018.0
194 schema:familyName Hüttelmaier
195 schema:givenName S
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134707261.66
197 rdf:type schema:Person
198 sg:person.0617467150.16 schema:affiliation grid-institutes:grid.9018.0
199 schema:familyName Hoang-Vu
200 schema:givenName C
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617467150.16
202 rdf:type schema:Person
203 sg:person.0705662126.53 schema:affiliation grid-institutes:grid.9018.0
204 schema:familyName Braun
205 schema:givenName J
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705662126.53
207 rdf:type schema:Person
208 sg:person.0761262105.04 schema:affiliation grid-institutes:grid.9018.0
209 schema:familyName Dralle
210 schema:givenName H
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761262105.04
212 rdf:type schema:Person
213 sg:pub.10.1038/cr.2008.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034356455
214 https://doi.org/10.1038/cr.2008.24
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nature07086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032756706
217 https://doi.org/10.1038/nature07086
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ncb1722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047429448
220 https://doi.org/10.1038/ncb1722
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nrc1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043526861
223 https://doi.org/10.1038/nrc1836
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.onc.1210046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013368231
226 https://doi.org/10.1038/sj.onc.1210046
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/sj.onc.1210564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047663958
229 https://doi.org/10.1038/sj.onc.1210564
230 rdf:type schema:CreativeWork
231 grid-institutes:grid.9018.0 schema:alternateName Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany
232 Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany
233 schema:name Department of General, Visceral and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany
234 Department of Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Halle, Germany
235 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...