The role of COX-2 in intestinal inflammation and colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-02

AUTHORS

D Wang, R N DuBois

ABSTRACT

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms: hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that genetic mutations, epigenetic changes, chronic inflammation, diet and lifestyle are the risk factors for CRC. As elevated cyclooxygenase-2 (COX-2) expression was found in most CRC tissue and is associated with worse survival among CRC patients, investigators have sought to evaluate the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors (COXIBs) on CRC. The epidemiological studies, clinical trials and animal experiments indicate that NSAIDs are among the most promising chemopreventive agents for this disease. NSAIDs exert their anti-inflammatory and antitumor effects primarily by reducing prostaglandin production by inhibition of COX-2 activity. In this review, we highlight breakthroughs in our understanding of the roles of COX-2 in CRC and inflammatory bowel disease. These recent data provide a rationale for re-evaluating COX-2 as both the prognostic and the predictive marker in a wide variety of malignancies and for renewing the interest in evaluating relative benefits and risk of COXIBs in appropriately selected patients for cancer prevention and treatment. More... »

PAGES

onc2009421

References to SciGraph publications

  • 1971-06. Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs in NATURE
  • 2007-02. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage in NATURE MEDICINE
  • 2007-12. Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial in BMC CANCER
  • 2006-02. Gemcitabine plus celecoxib (GECO) in advanced pancreatic cancer: a phase II trial in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2001-09. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice in NATURE MEDICINE
  • 2008-09. Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1992-09. APC mutations occur early during colorectal tumorigenesis in NATURE
  • 2006-02. The Gastrointestinal Safety and Effect on Disease Activity of Etoricoxib, a Selective Cox-2 Inhibitor in Inflammatory Bowel Diseases in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2000-08. Effects of nonsteroidal antiinflammatory drugs on inflammatory bowel disease: a case-control study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-04. Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung in INFLAMMOPHARMACOLOGY
  • 2009-06. Neoplasms escape selective COX-2 inhibition in an animal model of breast cancer in IRISH JOURNAL OF MEDICAL SCIENCE
  • 2007-10. Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats in INFLAMMOPHARMACOLOGY
  • 2003-07. Cyclo-oxygenase 2 inhibitors: emerging roles in the gut in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2005-12. Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands in BMC CANCER
  • 2009-02. Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis in INFLAMMATION RESEARCH
  • 2002-04. Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2001-10. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2009.421

    DOI

    http://dx.doi.org/10.1038/onc.2009.421

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019137863

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19946329


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