The SWI/SNF complex and cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-04

AUTHORS

D Reisman, S Glaros, E A Thompson

ABSTRACT

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1). More... »

PAGES

onc20094

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/onc.2009.4

    DOI

    http://dx.doi.org/10.1038/onc.2009.4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031157394

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19234488


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