Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

M Walter, S Liang, S Ghosh, P J Hornsby, R Li

ABSTRACT

Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated. Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model. Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs. The cofilin-1-dependent pathway affects the production of interleukin 6 (IL-6) in ASCs. Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells. Thus, our study uncovers a link between a cytoskeleton-based pathway in ASCs and the stromal impact on breast cancer cells. More... »

PAGES

2745

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2009.130

DOI

http://dx.doi.org/10.1038/onc.2009.130

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028079634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19483720


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