Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07

AUTHORS

M Walter, S Liang, S Ghosh, P J Hornsby, R Li

ABSTRACT

Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated. Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model. Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs. The cofilin-1-dependent pathway affects the production of interleukin 6 (IL-6) in ASCs. Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells. Thus, our study uncovers a link between a cytoskeleton-based pathway in ASCs and the stromal impact on breast cancer cells. More... »

PAGES

2745

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2009.130

DOI

http://dx.doi.org/10.1038/onc.2009.130

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028079634

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19483720


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cofilin 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "rho-Associated Kinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walter", 
        "givenName": "M", 
        "id": "sg:person.01173621766.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173621766.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liang", 
        "givenName": "S", 
        "id": "sg:person.01142061447.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142061447.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghosh", 
        "givenName": "S", 
        "id": "sg:person.0616533213.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616533213.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hornsby", 
        "givenName": "P J", 
        "id": "sg:person.01100501132.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100501132.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "R", 
        "id": "sg:person.0655145177.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655145177.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ncb1658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000085767", 
          "https://doi.org/10.1038/ncb1658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1593/neo.07205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000867335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.10142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003945011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.57.3.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006439440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-78818-0_6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007051896", 
          "https://doi.org/10.1007/978-0-387-78818-0_6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecl.2008.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009862696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-0528.2006.01021.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009927364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-8832com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010378421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-789x.2006.00261.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011787175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-1479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012859886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.03017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013902079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018025966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022872842", 
          "https://doi.org/10.1038/bjc.1997.73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022872842", 
          "https://doi.org/10.1038/bjc.1997.73"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-005-9056-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024902592", 
          "https://doi.org/10.1007/s11010-005-9056-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-005-9056-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024902592", 
          "https://doi.org/10.1007/s11010-005-9056-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024966960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suc.2005.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025022345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suc.2005.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025022345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2005.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026522829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000265074.83288.09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026893896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000265074.83288.09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026893896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cps.2005.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028110914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2008.07.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028672325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-0613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028973265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-0436.2002.700907.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030326974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-2946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030621353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031584740", 
          "https://doi.org/10.1038/nrc2148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032130529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00242.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032202073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032921962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-789x.2007.00410.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033074066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00120-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033457179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2007.01852.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038801363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m500030-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041713740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2007.05.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041737000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10565-005-0002-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043707305", 
          "https://doi.org/10.1007/s10565-005-0002-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10565-005-0002-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043707305", 
          "https://doi.org/10.1007/s10565-005-0002-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043984412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00145.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044218025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046203017", 
          "https://doi.org/10.1038/nature06188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046336396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9328-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046580238", 
          "https://doi.org/10.1007/s10549-006-9328-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-006-9328-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046580238", 
          "https://doi.org/10.1007/s10549-006-9328-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crvi.2005.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046648325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047374084", 
          "https://doi.org/10.1038/nature06902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047850175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047850175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1043-2760(02)00567-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049972082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200709082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050728755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpendmet0456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052069549", 
          "https://doi.org/10.1038/ncpendmet0456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053351550", 
          "https://doi.org/10.1038/nrm1714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053351550", 
          "https://doi.org/10.1038/nrm1714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1156232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci31871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076838003", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/153537020422901107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076971482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/153537020422901107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076971482"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-07", 
    "datePublishedReg": "2009-07-01", 
    "description": "Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated. Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model. Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs. The cofilin-1-dependent pathway affects the production of interleukin 6 (IL-6) in ASCs. Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells. Thus, our study uncovers a link between a cytoskeleton-based pathway in ASCs and the stromal impact on breast cancer cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2009.130", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7135282", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2475774", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "30", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells", 
    "pagination": "2745", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "85c35ba8a5604befb66bdcd02bf897c7b4df501e32811a09de7bf63e2427d5d0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19483720"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2009.130"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028079634"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2009.130", 
      "https://app.dimensions.ai/details/publication/pub.1028079634"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000339_0000000339/records_109521_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2009130"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2009.130'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2009.130'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2009.130'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2009.130'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      95 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2009.130 schema:about N0ac2d48378b14368b1a2924b71f8fcdb
2 N28ee9bfd61754356805a308266b9a79c
3 N30e355ac24a24e4baa6606220ec1e3fb
4 N45fd0d135a114488b2e94e091c01a8f2
5 N53cd037a56cd43d494d796e957136c98
6 N5bfa40c671e94895bec58c034d592531
7 N8842f98baa7f48e48456e8d08d2fefe8
8 N8b23ab1e51334f86b61a7a80d204ec3b
9 N92a8e319e0b54ff0b9977e58802ec37c
10 N95bae7a85e034f8b981348562e282d6e
11 N9ea371bbfeea4f109f5758b06efc34e9
12 Naf53254fe32a472c9feb6fb4d3f68a5b
13 Nb08f1717d9f84cd5a551148a83ffe1f7
14 Nb10e9fd07e3f4925ac0cc4d26c1ad86f
15 Nd5ea367241b5473691f98ae9a02bfc19
16 Ndbdf5db51f634053943b9405d53b6afb
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N9a93854cfea64995b6976a336650bd08
20 schema:citation sg:pub.10.1007/978-0-387-78818-0_6
21 sg:pub.10.1007/s10549-006-9328-3
22 sg:pub.10.1007/s10565-005-0002-z
23 sg:pub.10.1007/s11010-005-9056-8
24 sg:pub.10.1038/bjc.1997.73
25 sg:pub.10.1038/nature06188
26 sg:pub.10.1038/nature06902
27 sg:pub.10.1038/ncb1658
28 sg:pub.10.1038/ncpendmet0456
29 sg:pub.10.1038/nrc2148
30 sg:pub.10.1038/nrm1714
31 https://app.dimensions.ai/details/publication/pub.1076838003
32 https://doi.org/10.1002/cncr.22999
33 https://doi.org/10.1002/jcp.10142
34 https://doi.org/10.1002/jcp.21068
35 https://doi.org/10.1002/path.1430
36 https://doi.org/10.1016/j.canlet.2007.05.013
37 https://doi.org/10.1016/j.cell.2005.02.034
38 https://doi.org/10.1016/j.cellsig.2005.03.001
39 https://doi.org/10.1016/j.cps.2005.08.004
40 https://doi.org/10.1016/j.crvi.2005.12.012
41 https://doi.org/10.1016/j.ecl.2008.06.004
42 https://doi.org/10.1016/j.suc.2005.04.006
43 https://doi.org/10.1016/j.yexcr.2008.07.028
44 https://doi.org/10.1016/s0092-8674(03)00120-x
45 https://doi.org/10.1016/s1043-2760(02)00567-2
46 https://doi.org/10.1046/j.1432-0436.2002.700907.x
47 https://doi.org/10.1074/mcp.m500030-mcp200
48 https://doi.org/10.1083/jcb.200709082
49 https://doi.org/10.1096/fj.07-8832com
50 https://doi.org/10.1111/j.1365-2796.2007.01852.x
51 https://doi.org/10.1111/j.1467-789x.2006.00261.x
52 https://doi.org/10.1111/j.1467-789x.2007.00410.x
53 https://doi.org/10.1111/j.1471-0528.2006.01021.x
54 https://doi.org/10.1124/pr.57.3.6
55 https://doi.org/10.1126/science.1156232
56 https://doi.org/10.1152/ajpendo.00242.2006
57 https://doi.org/10.1152/ajpgi.00145.2006
58 https://doi.org/10.1158/0008-5472.can-06-3452
59 https://doi.org/10.1158/0008-5472.can-07-2946
60 https://doi.org/10.1158/0008-5472.can-08-0613
61 https://doi.org/10.1158/1055-9965.epi-05-0106
62 https://doi.org/10.1158/1078-0432.ccr-07-1479
63 https://doi.org/10.1161/01.res.0000265074.83288.09
64 https://doi.org/10.1172/jci31871
65 https://doi.org/10.1172/jci32533
66 https://doi.org/10.1177/153537020422901107
67 https://doi.org/10.1242/jcs.03017
68 https://doi.org/10.1593/neo.07205
69 https://doi.org/10.1634/stemcells.2004-0021
70 schema:datePublished 2009-07
71 schema:datePublishedReg 2009-07-01
72 schema:description Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive breast cancer, the estrogen-independent impact of adipose tissue on tumor invasion and progression needs to be elucidated. Here, we show that adipose stromal cells (ASCs) significantly stimulate migration and invasion of ER-negative breast cancer cells in vitro and tumor invasion in a co-transplant xenograft mouse model. Our study also identifies cofilin-1, a known regulator of actin dynamics, as a determinant of the tumor-promoting activity of ASCs. The cofilin-1-dependent pathway affects the production of interleukin 6 (IL-6) in ASCs. Depletion of IL-6 from the ASC-conditioned medium abrogated the stimulatory effect of ASCs on the migration and invasion of breast tumor cells. Thus, our study uncovers a link between a cytoskeleton-based pathway in ASCs and the stromal impact on breast cancer cells.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N0f7fda079a2c4fe082df0cb6bb2db305
77 Nad34426a086f4dc4972d70a790f65a51
78 sg:journal.1097543
79 schema:name Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
80 schema:pagination 2745
81 schema:productId N37e3f3f9f0b945e18c51866d025561e8
82 N56b9a465aac14fc69513b3f43719554f
83 N62e2bf4bd468477091aa74ba227bc5ab
84 Na2e0c04005bc41c1ad4aca1d9db3bce0
85 Na8127497643c4623ba0afc3c53514632
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028079634
87 https://doi.org/10.1038/onc.2009.130
88 schema:sdDatePublished 2019-04-11T09:20
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N123dfd4b97fb4d09bf9838b6c44a516b
91 schema:url https://www.nature.com/articles/onc2009130
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0ac2d48378b14368b1a2924b71f8fcdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Breast Neoplasms
97 rdf:type schema:DefinedTerm
98 N0f7fda079a2c4fe082df0cb6bb2db305 schema:issueNumber 30
99 rdf:type schema:PublicationIssue
100 N123dfd4b97fb4d09bf9838b6c44a516b schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N28ee9bfd61754356805a308266b9a79c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cofilin 1
104 rdf:type schema:DefinedTerm
105 N30e355ac24a24e4baa6606220ec1e3fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N37e3f3f9f0b945e18c51866d025561e8 schema:name nlm_unique_id
109 schema:value 8711562
110 rdf:type schema:PropertyValue
111 N45fd0d135a114488b2e94e091c01a8f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Cell Movement
113 rdf:type schema:DefinedTerm
114 N4ec27a7f0cf64a54a3ee782182260f27 rdf:first sg:person.0655145177.65
115 rdf:rest rdf:nil
116 N53cd037a56cd43d494d796e957136c98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adipocytes
118 rdf:type schema:DefinedTerm
119 N56b9a465aac14fc69513b3f43719554f schema:name readcube_id
120 schema:value 85c35ba8a5604befb66bdcd02bf897c7b4df501e32811a09de7bf63e2427d5d0
121 rdf:type schema:PropertyValue
122 N5bfa40c671e94895bec58c034d592531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Male
124 rdf:type schema:DefinedTerm
125 N62e2bf4bd468477091aa74ba227bc5ab schema:name dimensions_id
126 schema:value pub.1028079634
127 rdf:type schema:PropertyValue
128 N694f8ef217d44f978fc2f13962876f4a rdf:first sg:person.01142061447.51
129 rdf:rest Nd390d04173ff4e9dac65fe7585845c43
130 N84b737441f2b4671866e75a91a9d41a2 rdf:first sg:person.01100501132.19
131 rdf:rest N4ec27a7f0cf64a54a3ee782182260f27
132 N8842f98baa7f48e48456e8d08d2fefe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Interleukin-6
134 rdf:type schema:DefinedTerm
135 N8b23ab1e51334f86b61a7a80d204ec3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Cell Line, Tumor
137 rdf:type schema:DefinedTerm
138 N92a8e319e0b54ff0b9977e58802ec37c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Transplantation, Heterologous
140 rdf:type schema:DefinedTerm
141 N95bae7a85e034f8b981348562e282d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neoplasm Transplantation
143 rdf:type schema:DefinedTerm
144 N9a93854cfea64995b6976a336650bd08 rdf:first sg:person.01173621766.79
145 rdf:rest N694f8ef217d44f978fc2f13962876f4a
146 N9ea371bbfeea4f109f5758b06efc34e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice
148 rdf:type schema:DefinedTerm
149 Na2e0c04005bc41c1ad4aca1d9db3bce0 schema:name doi
150 schema:value 10.1038/onc.2009.130
151 rdf:type schema:PropertyValue
152 Na8127497643c4623ba0afc3c53514632 schema:name pubmed_id
153 schema:value 19483720
154 rdf:type schema:PropertyValue
155 Nad34426a086f4dc4972d70a790f65a51 schema:volumeNumber 28
156 rdf:type schema:PublicationVolume
157 Naf53254fe32a472c9feb6fb4d3f68a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name rho-Associated Kinases
159 rdf:type schema:DefinedTerm
160 Nb08f1717d9f84cd5a551148a83ffe1f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Stromal Cells
162 rdf:type schema:DefinedTerm
163 Nb10e9fd07e3f4925ac0cc4d26c1ad86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Humans
165 rdf:type schema:DefinedTerm
166 Nd390d04173ff4e9dac65fe7585845c43 rdf:first sg:person.0616533213.31
167 rdf:rest N84b737441f2b4671866e75a91a9d41a2
168 Nd5ea367241b5473691f98ae9a02bfc19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Invasiveness
170 rdf:type schema:DefinedTerm
171 Ndbdf5db51f634053943b9405d53b6afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Animals
173 rdf:type schema:DefinedTerm
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
178 schema:name Oncology and Carcinogenesis
179 rdf:type schema:DefinedTerm
180 sg:grant.2475774 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2009.130
181 rdf:type schema:MonetaryGrant
182 sg:grant.7135282 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2009.130
183 rdf:type schema:MonetaryGrant
184 sg:journal.1097543 schema:issn 0950-9232
185 1476-5594
186 schema:name Oncogene
187 rdf:type schema:Periodical
188 sg:person.01100501132.19 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
189 schema:familyName Hornsby
190 schema:givenName P J
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100501132.19
192 rdf:type schema:Person
193 sg:person.01142061447.51 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
194 schema:familyName Liang
195 schema:givenName S
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142061447.51
197 rdf:type schema:Person
198 sg:person.01173621766.79 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
199 schema:familyName Walter
200 schema:givenName M
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173621766.79
202 rdf:type schema:Person
203 sg:person.0616533213.31 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
204 schema:familyName Ghosh
205 schema:givenName S
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616533213.31
207 rdf:type schema:Person
208 sg:person.0655145177.65 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
209 schema:familyName Li
210 schema:givenName R
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655145177.65
212 rdf:type schema:Person
213 sg:pub.10.1007/978-0-387-78818-0_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007051896
214 https://doi.org/10.1007/978-0-387-78818-0_6
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s10549-006-9328-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046580238
217 https://doi.org/10.1007/s10549-006-9328-3
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s10565-005-0002-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043707305
220 https://doi.org/10.1007/s10565-005-0002-z
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s11010-005-9056-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024902592
223 https://doi.org/10.1007/s11010-005-9056-8
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/bjc.1997.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022872842
226 https://doi.org/10.1038/bjc.1997.73
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature06188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046203017
229 https://doi.org/10.1038/nature06188
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nature06902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047374084
232 https://doi.org/10.1038/nature06902
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ncb1658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000085767
235 https://doi.org/10.1038/ncb1658
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ncpendmet0456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052069549
238 https://doi.org/10.1038/ncpendmet0456
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nrc2148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031584740
241 https://doi.org/10.1038/nrc2148
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nrm1714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053351550
244 https://doi.org/10.1038/nrm1714
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1076838003 schema:CreativeWork
247 https://doi.org/10.1002/cncr.22999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046336396
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/jcp.10142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003945011
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/jcp.21068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921962
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/path.1430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043984412
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.canlet.2007.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041737000
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.cell.2005.02.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047850175
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cellsig.2005.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026522829
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.cps.2005.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028110914
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.crvi.2005.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046648325
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ecl.2008.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009862696
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.suc.2005.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025022345
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.yexcr.2008.07.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028672325
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0092-8674(03)00120-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033457179
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s1043-2760(02)00567-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049972082
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1046/j.1432-0436.2002.700907.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030326974
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1074/mcp.m500030-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041713740
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1083/jcb.200709082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050728755
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1096/fj.07-8832com schema:sameAs https://app.dimensions.ai/details/publication/pub.1010378421
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1365-2796.2007.01852.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038801363
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1111/j.1467-789x.2006.00261.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011787175
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1111/j.1467-789x.2007.00410.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033074066
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1111/j.1471-0528.2006.01021.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009927364
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1124/pr.57.3.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006439440
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1126/science.1156232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457633
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/ajpendo.00242.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032202073
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1152/ajpgi.00145.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044218025
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1158/0008-5472.can-06-3452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018025966
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1158/0008-5472.can-07-2946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030621353
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1158/0008-5472.can-08-0613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028973265
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1158/1055-9965.epi-05-0106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024966960
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1158/1078-0432.ccr-07-1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012859886
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1161/01.res.0000265074.83288.09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026893896
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1172/jci31871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416953
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1172/jci32533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416991
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1177/153537020422901107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076971482
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1242/jcs.03017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013902079
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1593/neo.07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000867335
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1634/stemcells.2004-0021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032130529
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.267309.9 schema:alternateName The University of Texas Health Science Center at San Antonio
324 schema:name Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
325 Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...