Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

H-H Woo, Y Zhou, X Yi, C L David, W Zheng, M Gilmore-Hebert, H M Kluger, E C Ulukus, T Baker, J B Stoffer, S K Chambers

ABSTRACT

The role of RNA-binding proteins in cancer biology is recognized increasingly. The nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer-related target mRNAs. The proto-oncogene c-fms, whose 3'untranslated region (3'UTR) is not AU-rich, is associated with poor prognosis in breast cancer. Using a large breast-cancer tissue array (N=670), we found nuclear HuR expression to be associated with nodal metastasis and independently with poor survival (P=0.03, RR 1.45), as well as to be co-expressed with c-fms in the breast tumors (P=0.0007). We described c-fms mRNA as a direct target of HuR in vivo, and that HuR bound specifically to a 69-nt region containing 'CUU' motifs in 3'UTR c-fms RNA. Overexpressing or silencing HuR significantly up- or down-regulated c-fms RNA expression, respectively. We also found that known glucocorticoid stimulation of c-fms RNA and protein is largely dependent on the presence of HuR. HuR, by binding to the 69-nt wild type, but not mutant, c-fms sequence can regulate reporter gene expression post-transcriptionally. We are the first to describe that HuR can regulate gene expression by binding non-AU-rich sequences in 3'UTR c-fms RNA. Collectively, our findings suggest that HuR plays a supportive role for c-fms in breast cancer progression by binding a 69-nt element in its 3'UTR, thus regulating its expression. More... »

PAGES

1176

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/onc.2008.469

DOI

http://dx.doi.org/10.1038/onc.2008.469

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036165013

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19151756


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3' Untranslated Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ELAV Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ELAV-Like Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, fms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woo", 
        "givenName": "H-H", 
        "id": "sg:person.0575464327.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575464327.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Y", 
        "id": "sg:person.0724371077.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724371077.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yi", 
        "givenName": "X", 
        "id": "sg:person.01040617477.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040617477.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "David", 
        "givenName": "C L", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zheng", 
        "givenName": "W", 
        "id": "sg:person.0673355213.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673355213.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Pathology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gilmore-Hebert", 
        "givenName": "M", 
        "id": "sg:person.056346446.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056346446.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Internal Medicine/Oncology, Yale University School of Medicine, New Haven, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kluger", 
        "givenName": "H M", 
        "id": "sg:person.01336750727.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336750727.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dokuz Eyl\u00fcl University", 
          "id": "https://www.grid.ac/institutes/grid.21200.31", 
          "name": [
            "Dokuz Eylul Universitesi, Izmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ulukus", 
        "givenName": "E C", 
        "id": "sg:person.01301162342.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301162342.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "T", 
        "id": "sg:person.01026141327.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026141327.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoffer", 
        "givenName": "J B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "Arizona Cancer Center, University of Arizona, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chambers", 
        "givenName": "S K", 
        "id": "sg:person.01215615165.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215615165.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-0070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003182340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005909438", 
          "https://doi.org/10.1038/sj.onc.1206862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005909438", 
          "https://doi.org/10.1038/sj.onc.1206862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006873135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00645-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013158546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2004.01.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013559935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0699-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013751146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.2257606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014012599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.12.3448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014507737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.200400219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016880030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.20.7268-7278.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019167781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.9.2.769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019697803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.193.6.727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021607618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.222537099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023008955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/320277a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023325656", 
          "https://doi.org/10.1038/320277a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0039-128x(94)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024572009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-005-0718-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026793924", 
          "https://doi.org/10.1007/s10585-005-0718-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-005-0718-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026793924", 
          "https://doi.org/10.1007/s10585-005-0718-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027874769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/pl00000854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028800681", 
          "https://doi.org/10.1007/pl00000854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030091957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007434200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030427666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.12.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034038962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.11.5937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034099348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.12.3461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034671773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0306453101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036834811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1033.2003.03396.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042994076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045483645", 
          "https://doi.org/10.1038/nprot.2006.82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.82", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045483645", 
          "https://doi.org/10.1038/nprot.2006.82"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045657100", 
          "https://doi.org/10.1038/labinvest.3780204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045657100", 
          "https://doi.org/10.1038/labinvest.3780204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00881-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046189169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m202883200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047746271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1071-5576(01)00092-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054678901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00239a030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055166621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1064693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074792790", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075262311", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076602069", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077611854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080245338", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532979", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082773516", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083020399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083310008", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083347246", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-03", 
    "datePublishedReg": "2009-03-01", 
    "description": "The role of RNA-binding proteins in cancer biology is recognized increasingly. The nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer-related target mRNAs. The proto-oncogene c-fms, whose 3'untranslated region (3'UTR) is not AU-rich, is associated with poor prognosis in breast cancer. Using a large breast-cancer tissue array (N=670), we found nuclear HuR expression to be associated with nodal metastasis and independently with poor survival (P=0.03, RR 1.45), as well as to be co-expressed with c-fms in the breast tumors (P=0.0007). We described c-fms mRNA as a direct target of HuR in vivo, and that HuR bound specifically to a 69-nt region containing 'CUU' motifs in 3'UTR c-fms RNA. Overexpressing or silencing HuR significantly up- or down-regulated c-fms RNA expression, respectively. We also found that known glucocorticoid stimulation of c-fms RNA and protein is largely dependent on the presence of HuR. HuR, by binding to the 69-nt wild type, but not mutant, c-fms sequence can regulate reporter gene expression post-transcriptionally. We are the first to describe that HuR can regulate gene expression by binding non-AU-rich sequences in 3'UTR c-fms RNA. Collectively, our findings suggest that HuR plays a supportive role for c-fms in breast cancer progression by binding a 69-nt element in its 3'UTR, thus regulating its expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/onc.2008.469", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7133812", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1097543", 
        "issn": [
          "0950-9232", 
          "1476-5594"
        ], 
        "name": "Oncogene", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer", 
    "pagination": "1176", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac46c3e869e5440e904d4fd3d34fe576b04ada58c90ac224b87efc5c2b28581b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19151756"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8711562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/onc.2008.469"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036165013"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/onc.2008.469", 
      "https://app.dimensions.ai/details/publication/pub.1036165013"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/onc2008469"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/onc.2008.469'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/onc.2008.469'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/onc.2008.469'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/onc.2008.469'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      21 PREDICATES      86 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/onc.2008.469 schema:about N041fdd5c8e574dabb99237cf018226dd
2 N13e4006659114b11bdd6f0a8a4791129
3 N3492649860cb437fa62f5e90ad38abfd
4 N489642e321624236aa4ba5f08f44a692
5 N53dc27a9d23042a3b9e8a4342d5a9071
6 Na57130868ed54d72a9232c850eca5294
7 Na981c33b8cfd40ac8549978ba8d10770
8 Nb327bcbaac704d079d1a2b7e0c00fbae
9 Nb56cb6f9a11e481282a0305b6c5e61c2
10 Nbb1ef011315b4a48949175ffd3fba6aa
11 Nc04572c4d62b4d15ad1263c92ac24280
12 Ndc27278b6e0146f68d8255ce5441e09e
13 Ne2750e18068042abb3659109ae335a48
14 Neadaa14f875049e2a72fb670504965df
15 Neee5714980744e91affcb7b85e248a87
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N9206810cfdf545eca7a538e2d4ec10d9
19 schema:citation sg:pub.10.1007/pl00000854
20 sg:pub.10.1007/s10585-005-0718-4
21 sg:pub.10.1038/320277a0
22 sg:pub.10.1038/labinvest.3780204
23 sg:pub.10.1038/nprot.2006.82
24 sg:pub.10.1038/sj.onc.1206862
25 https://app.dimensions.ai/details/publication/pub.1074792790
26 https://app.dimensions.ai/details/publication/pub.1075262311
27 https://app.dimensions.ai/details/publication/pub.1076602069
28 https://app.dimensions.ai/details/publication/pub.1077611854
29 https://app.dimensions.ai/details/publication/pub.1080245338
30 https://app.dimensions.ai/details/publication/pub.1082532979
31 https://app.dimensions.ai/details/publication/pub.1082773516
32 https://app.dimensions.ai/details/publication/pub.1083020399
33 https://app.dimensions.ai/details/publication/pub.1083310008
34 https://app.dimensions.ai/details/publication/pub.1083347246
35 https://doi.org/10.1002/cbic.200400219
36 https://doi.org/10.1016/0039-128x(94)90069-8
37 https://doi.org/10.1016/j.ajog.2004.01.021
38 https://doi.org/10.1016/j.molcel.2007.01.011
39 https://doi.org/10.1016/s0092-8674(02)00645-1
40 https://doi.org/10.1016/s1071-5576(01)00092-2
41 https://doi.org/10.1021/bi00239a030
42 https://doi.org/10.1038/sj.emboj.7600305
43 https://doi.org/10.1046/j.1432-1033.2003.03396.x
44 https://doi.org/10.1053/j.gastro.2006.12.031
45 https://doi.org/10.1073/pnas.0306453101
46 https://doi.org/10.1073/pnas.222537099
47 https://doi.org/10.1074/jbc.m007434200
48 https://doi.org/10.1074/jbc.m202883200
49 https://doi.org/10.1084/jem.193.6.727
50 https://doi.org/10.1093/emboj/17.12.3448
51 https://doi.org/10.1093/emboj/17.12.3461
52 https://doi.org/10.1126/science.1064693
53 https://doi.org/10.1128/mcb.00881-07
54 https://doi.org/10.1128/mcb.10.11.5937
55 https://doi.org/10.1128/mcb.22.20.7268-7278.2002
56 https://doi.org/10.1128/mcb.9.2.769
57 https://doi.org/10.1158/0008-5472.can-04-3765
58 https://doi.org/10.1158/1078-0432.ccr-04-0070
59 https://doi.org/10.1158/1078-0432.ccr-0699-3
60 https://doi.org/10.1261/rna.2257606
61 schema:datePublished 2009-03
62 schema:datePublishedReg 2009-03-01
63 schema:description The role of RNA-binding proteins in cancer biology is recognized increasingly. The nucleocytoplasmic shuttling and AU-rich RNA-binding protein HuR stabilizes several cancer-related target mRNAs. The proto-oncogene c-fms, whose 3'untranslated region (3'UTR) is not AU-rich, is associated with poor prognosis in breast cancer. Using a large breast-cancer tissue array (N=670), we found nuclear HuR expression to be associated with nodal metastasis and independently with poor survival (P=0.03, RR 1.45), as well as to be co-expressed with c-fms in the breast tumors (P=0.0007). We described c-fms mRNA as a direct target of HuR in vivo, and that HuR bound specifically to a 69-nt region containing 'CUU' motifs in 3'UTR c-fms RNA. Overexpressing or silencing HuR significantly up- or down-regulated c-fms RNA expression, respectively. We also found that known glucocorticoid stimulation of c-fms RNA and protein is largely dependent on the presence of HuR. HuR, by binding to the 69-nt wild type, but not mutant, c-fms sequence can regulate reporter gene expression post-transcriptionally. We are the first to describe that HuR can regulate gene expression by binding non-AU-rich sequences in 3'UTR c-fms RNA. Collectively, our findings suggest that HuR plays a supportive role for c-fms in breast cancer progression by binding a 69-nt element in its 3'UTR, thus regulating its expression.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N3b8253821ec14bb4b03150f9ef7a44bb
68 Nd3a99a6a0b51433da2964f4429a19287
69 sg:journal.1097543
70 schema:name Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer
71 schema:pagination 1176
72 schema:productId N9462a32a06494c579fb53737190082f4
73 N960b90db14a148a68e5e6044898a5c7a
74 Nb374e90576d2435c8110ff0cdae17a14
75 Nd2906d7e5829458c9ee2c863dacd43e7
76 Nf1394217f7ce469da4aad4d56b531fc1
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036165013
78 https://doi.org/10.1038/onc.2008.469
79 schema:sdDatePublished 2019-04-11T00:55
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N14408446dd724a2491b0a532c41c494e
82 schema:url https://www.nature.com/articles/onc2008469
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N041fdd5c8e574dabb99237cf018226dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Genes, fms
88 rdf:type schema:DefinedTerm
89 N10b30cfcce3743efa5c20ab0b6f92073 rdf:first sg:person.0673355213.26
90 rdf:rest N56f29d22e57d49969c268ed0814a9dab
91 N13e4006659114b11bdd6f0a8a4791129 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Gene Expression Regulation, Neoplastic
93 rdf:type schema:DefinedTerm
94 N14408446dd724a2491b0a532c41c494e schema:name Springer Nature - SN SciGraph project
95 rdf:type schema:Organization
96 N24f19ed15a27462ebb8aa50af942dd33 rdf:first sg:person.0724371077.72
97 rdf:rest N8bd125f9a9364d27b9226224fb506e45
98 N3492649860cb437fa62f5e90ad38abfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name RNA-Binding Proteins
100 rdf:type schema:DefinedTerm
101 N3702203b0de64e88b5c157d866eb6ce2 rdf:first sg:person.01301162342.37
102 rdf:rest Nbd0d9c9371964f85ac4c3a5de657609e
103 N3b8253821ec14bb4b03150f9ef7a44bb schema:volumeNumber 28
104 rdf:type schema:PublicationVolume
105 N40472e2682724fda9f5d46a6cca699b5 rdf:first N581c42ac779a475eb3f28e46570b7061
106 rdf:rest N10b30cfcce3743efa5c20ab0b6f92073
107 N42eff5efff61467bb98f3703ea40989a rdf:first N4334c8ff2a4d48f48fab2ea99507a1e2
108 rdf:rest Nf1228acfad4447c3848910e67754f31d
109 N4334c8ff2a4d48f48fab2ea99507a1e2 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
110 schema:familyName Stoffer
111 schema:givenName J B
112 rdf:type schema:Person
113 N489642e321624236aa4ba5f08f44a692 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name 3' Untranslated Regions
115 rdf:type schema:DefinedTerm
116 N53dc27a9d23042a3b9e8a4342d5a9071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Down-Regulation
118 rdf:type schema:DefinedTerm
119 N56f29d22e57d49969c268ed0814a9dab rdf:first sg:person.056346446.77
120 rdf:rest N8ef9ba6c4edd49b8ac3b34644a474e32
121 N581c42ac779a475eb3f28e46570b7061 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
122 schema:familyName David
123 schema:givenName C L
124 rdf:type schema:Person
125 N8bd125f9a9364d27b9226224fb506e45 rdf:first sg:person.01040617477.34
126 rdf:rest N40472e2682724fda9f5d46a6cca699b5
127 N8ef9ba6c4edd49b8ac3b34644a474e32 rdf:first sg:person.01336750727.45
128 rdf:rest N3702203b0de64e88b5c157d866eb6ce2
129 N9206810cfdf545eca7a538e2d4ec10d9 rdf:first sg:person.0575464327.75
130 rdf:rest N24f19ed15a27462ebb8aa50af942dd33
131 N9462a32a06494c579fb53737190082f4 schema:name doi
132 schema:value 10.1038/onc.2008.469
133 rdf:type schema:PropertyValue
134 N960b90db14a148a68e5e6044898a5c7a schema:name readcube_id
135 schema:value ac46c3e869e5440e904d4fd3d34fe576b04ada58c90ac224b87efc5c2b28581b
136 rdf:type schema:PropertyValue
137 Na57130868ed54d72a9232c850eca5294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name ELAV Proteins
139 rdf:type schema:DefinedTerm
140 Na981c33b8cfd40ac8549978ba8d10770 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Breast Neoplasms
142 rdf:type schema:DefinedTerm
143 Nb327bcbaac704d079d1a2b7e0c00fbae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Base Sequence
145 rdf:type schema:DefinedTerm
146 Nb374e90576d2435c8110ff0cdae17a14 schema:name nlm_unique_id
147 schema:value 8711562
148 rdf:type schema:PropertyValue
149 Nb56cb6f9a11e481282a0305b6c5e61c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Humans
151 rdf:type schema:DefinedTerm
152 Nbb1ef011315b4a48949175ffd3fba6aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cohort Studies
154 rdf:type schema:DefinedTerm
155 Nbd0d9c9371964f85ac4c3a5de657609e rdf:first sg:person.01026141327.10
156 rdf:rest N42eff5efff61467bb98f3703ea40989a
157 Nc04572c4d62b4d15ad1263c92ac24280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Immunohistochemistry
159 rdf:type schema:DefinedTerm
160 Nd2906d7e5829458c9ee2c863dacd43e7 schema:name pubmed_id
161 schema:value 19151756
162 rdf:type schema:PropertyValue
163 Nd3a99a6a0b51433da2964f4429a19287 schema:issueNumber 9
164 rdf:type schema:PublicationIssue
165 Ndc27278b6e0146f68d8255ce5441e09e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name RNA, Messenger
167 rdf:type schema:DefinedTerm
168 Ne2750e18068042abb3659109ae335a48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Survival Analysis
170 rdf:type schema:DefinedTerm
171 Neadaa14f875049e2a72fb670504965df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Antigens, Surface
173 rdf:type schema:DefinedTerm
174 Neee5714980744e91affcb7b85e248a87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name ELAV-Like Protein 1
176 rdf:type schema:DefinedTerm
177 Nf1228acfad4447c3848910e67754f31d rdf:first sg:person.01215615165.47
178 rdf:rest rdf:nil
179 Nf1394217f7ce469da4aad4d56b531fc1 schema:name dimensions_id
180 schema:value pub.1036165013
181 rdf:type schema:PropertyValue
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
186 schema:name Oncology and Carcinogenesis
187 rdf:type schema:DefinedTerm
188 sg:grant.7133812 http://pending.schema.org/fundedItem sg:pub.10.1038/onc.2008.469
189 rdf:type schema:MonetaryGrant
190 sg:journal.1097543 schema:issn 0950-9232
191 1476-5594
192 schema:name Oncogene
193 rdf:type schema:Periodical
194 sg:person.01026141327.10 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
195 schema:familyName Baker
196 schema:givenName T
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026141327.10
198 rdf:type schema:Person
199 sg:person.01040617477.34 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
200 schema:familyName Yi
201 schema:givenName X
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040617477.34
203 rdf:type schema:Person
204 sg:person.01215615165.47 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
205 schema:familyName Chambers
206 schema:givenName S K
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215615165.47
208 rdf:type schema:Person
209 sg:person.01301162342.37 schema:affiliation https://www.grid.ac/institutes/grid.21200.31
210 schema:familyName Ulukus
211 schema:givenName E C
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301162342.37
213 rdf:type schema:Person
214 sg:person.01336750727.45 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
215 schema:familyName Kluger
216 schema:givenName H M
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336750727.45
218 rdf:type schema:Person
219 sg:person.056346446.77 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
220 schema:familyName Gilmore-Hebert
221 schema:givenName M
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.056346446.77
223 rdf:type schema:Person
224 sg:person.0575464327.75 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
225 schema:familyName Woo
226 schema:givenName H-H
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575464327.75
228 rdf:type schema:Person
229 sg:person.0673355213.26 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
230 schema:familyName Zheng
231 schema:givenName W
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673355213.26
233 rdf:type schema:Person
234 sg:person.0724371077.72 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
235 schema:familyName Zhou
236 schema:givenName Y
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724371077.72
238 rdf:type schema:Person
239 sg:pub.10.1007/pl00000854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028800681
240 https://doi.org/10.1007/pl00000854
241 rdf:type schema:CreativeWork
242 sg:pub.10.1007/s10585-005-0718-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026793924
243 https://doi.org/10.1007/s10585-005-0718-4
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/320277a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023325656
246 https://doi.org/10.1038/320277a0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/labinvest.3780204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045657100
249 https://doi.org/10.1038/labinvest.3780204
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nprot.2006.82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045483645
252 https://doi.org/10.1038/nprot.2006.82
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/sj.onc.1206862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005909438
255 https://doi.org/10.1038/sj.onc.1206862
256 rdf:type schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1074792790 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1075262311 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1076602069 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1077611854 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1080245338 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082532979 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1082773516 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083020399 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1083310008 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083347246 schema:CreativeWork
267 https://doi.org/10.1002/cbic.200400219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016880030
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0039-128x(94)90069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024572009
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ajog.2004.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013559935
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.molcel.2007.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030091957
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0092-8674(02)00645-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013158546
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s1071-5576(01)00092-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054678901
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1021/bi00239a030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055166621
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1038/sj.emboj.7600305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006873135
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1046/j.1432-1033.2003.03396.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042994076
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1053/j.gastro.2006.12.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034038962
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1073/pnas.0306453101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036834811
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1073/pnas.222537099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023008955
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1074/jbc.m007434200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030427666
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1074/jbc.m202883200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047746271
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1084/jem.193.6.727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021607618
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1093/emboj/17.12.3448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014507737
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1093/emboj/17.12.3461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034671773
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.1064693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445438
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/mcb.00881-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046189169
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/mcb.10.11.5937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034099348
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1128/mcb.22.20.7268-7278.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019167781
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/mcb.9.2.769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019697803
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1158/0008-5472.can-04-3765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027874769
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1158/1078-0432.ccr-04-0070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003182340
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1158/1078-0432.ccr-0699-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013751146
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1261/rna.2257606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014012599
318 rdf:type schema:CreativeWork
319 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
320 schema:name Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.21200.31 schema:alternateName Dokuz Eylül University
323 schema:name Dokuz Eylul Universitesi, Izmir, Turkey
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
326 schema:name Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
327 Internal Medicine/Oncology, Yale University School of Medicine, New Haven, CT, USA
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...