Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02-09

AUTHORS

M G M Wolfs, N Gruben, S S Rensen, F J Verdam, J W Greve, A Driessen, C Wijmenga, W A Buurman, L Franke, L Scheja, D P Y Koonen, R Shiri-Sverdlov, T W van Haeften, M H Hofker, J Fu

ABSTRACT

Objectives:Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose tissues can be related to the development of specific characteristics of NAFLD, such as steatosis and inflammation. We aimed to address this question by simultaneously examining the adipokine expression in three tissue types in obese individuals.Methods:We enrolled 93 severely obese individuals with NAFLD, varying from simple steatosis to severe non-alcoholic steatohepatitis. Their expression of 48 adipokines in the liver, visceral and subcutaneous adipose tissue (SAT) was correlated to their phenotypic features of NAFLD. We further determined whether the correlations were tissue specific and/or independent of covariates, including age, sex, obesity, insulin resistance and type 2 diabetes (T2D).Results:The expression of adipokines showed a liver- and adipose tissue-specific pattern. We identified that the expression of leptin, angiopoietin 2 (ANGPT2) and chemerin in visceral adipose tissue (VAT) was associated with different NAFLD features, including steatosis, ballooning, portal and lobular inflammation. In addition, the expression of tumor necrosis factor (TNF), plasminogen activator inhibitor type 1 (PAI-1), insulin-like growth factor 1 (somatomedin C) (IGF1) and chemokine (C-X-C motif) ligand 10 (CXCL10) in the liver tissue and the expression of interleukin 1 receptor antagonist (IL1RN) in both the liver and SAT were associated with NAFLD features. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates.Conclusions:Our results suggest that in obese individuals, VAT-derived leptin and chemerin, and hepatic expression of TNF, IGF1, IL1RN and PAI-1 are involved in the development of NAFLD features. Further, functional studies are warranted to establish a causal relationship. More... »

PAGES

e146-e146

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nutd.2014.43

DOI

http://dx.doi.org/10.1038/nutd.2014.43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020368195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25664838


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolfs", 
        "givenName": "M G M", 
        "id": "sg:person.012661354367.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012661354367.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gruben", 
        "givenName": "N", 
        "id": "sg:person.01335046322.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335046322.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rensen", 
        "givenName": "S S", 
        "id": "sg:person.014072420547.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014072420547.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verdam", 
        "givenName": "F J", 
        "id": "sg:person.01020717221.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020717221.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.412966.e", 
          "name": [
            "Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greve", 
        "givenName": "J W", 
        "id": "sg:person.012637711072.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637711072.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University Hospital Antwerp, Edegem, Belgium", 
          "id": "http://www.grid.ac/institutes/grid.411414.5", 
          "name": [
            "Department of Pathology, Maastricht University Medical Centre, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands", 
            "Department of Pathology, University Hospital Antwerp, Edegem, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Driessen", 
        "givenName": "A", 
        "id": "sg:person.01301766345.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301766345.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wijmenga", 
        "givenName": "C", 
        "id": "sg:person.010754476744.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010754476744.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5012.6", 
          "name": [
            "School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buurman", 
        "givenName": "W A", 
        "id": "sg:person.01266401472.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266401472.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.4868.2", 
          "name": [
            "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
            "Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franke", 
        "givenName": "L", 
        "id": "sg:person.013152053532.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013152053532.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scheja", 
        "givenName": "L", 
        "id": "sg:person.0720577040.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720577040.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koonen", 
        "givenName": "D P Y", 
        "id": "sg:person.0620601147.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620601147.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.5012.6", 
          "name": [
            "Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shiri-Sverdlov", 
        "givenName": "R", 
        "id": "sg:person.0652115365.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652115365.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.7692.a", 
          "name": [
            "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
            "Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Haeften", 
        "givenName": "T W", 
        "id": "sg:person.0613067077.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613067077.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hofker", 
        "givenName": "M H", 
        "id": "sg:person.01117120547.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117120547.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fu", 
        "givenName": "J", 
        "id": "sg:person.01316140701.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.ijo.0802987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016472146", 
          "https://doi.org/10.1038/sj.ijo.0802987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2003.08767.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048094221", 
          "https://doi.org/10.1111/j.1572-0241.2003.08767.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1755-8794-3-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045358656", 
          "https://doi.org/10.1186/1755-8794-3-34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-009-9814-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013464941", 
          "https://doi.org/10.1007/s11695-009-9814-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2007.01709.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034837134", 
          "https://doi.org/10.1111/j.1572-0241.2007.01709.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2000.03297.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046274404", 
          "https://doi.org/10.1111/j.1572-0241.2000.03297.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/27376", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048314480", 
          "https://doi.org/10.1038/27376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-008-0585-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047694281", 
          "https://doi.org/10.1007/s10620-008-0585-3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-02-09", 
    "datePublishedReg": "2015-02-09", 
    "description": "Objectives:Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose tissues can be related to the development of specific characteristics of NAFLD, such as steatosis and inflammation. We aimed to address this question by simultaneously examining the adipokine expression in three tissue types in obese individuals.Methods:We enrolled 93 severely obese individuals with NAFLD, varying from simple steatosis to severe non-alcoholic steatohepatitis. Their expression of 48 adipokines in the liver, visceral and subcutaneous adipose tissue (SAT) was correlated to their phenotypic features of NAFLD. We further determined whether the correlations were tissue specific and/or independent of covariates, including age, sex, obesity, insulin resistance and type 2 diabetes (T2D).Results:The expression of adipokines showed a liver- and adipose tissue-specific pattern. We identified that the expression of leptin, angiopoietin 2 (ANGPT2) and chemerin in visceral adipose tissue (VAT) was associated with different NAFLD features, including steatosis, ballooning, portal and lobular inflammation. In addition, the expression of tumor necrosis factor (TNF), plasminogen activator inhibitor type 1 (PAI-1), insulin-like growth factor 1 (somatomedin C) (IGF1) and chemokine (C-X-C motif) ligand 10 (CXCL10) in the liver tissue and the expression of interleukin 1 receptor antagonist (IL1RN) in both the liver and SAT were associated with NAFLD features. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates.Conclusions:Our results suggest that in obese individuals, VAT-derived leptin and chemerin, and hepatic expression of TNF, IGF1, IL1RN and PAI-1 are involved in the development of NAFLD features. Further, functional studies are warranted to establish a causal relationship.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nutd.2014.43", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4124477", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4700213", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045540", 
        "issn": [
          "2044-4052"
        ], 
        "name": "Nutrition & Diabetes", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "non-alcoholic fatty liver disease", 
      "tumor necrosis factor", 
      "subcutaneous adipose tissue", 
      "NAFLD features", 
      "fatty liver disease", 
      "visceral adipose tissue", 
      "obese individuals", 
      "angiopoietin-2", 
      "adipose tissue", 
      "liver disease", 
      "insulin resistance", 
      "adipokine expression", 
      "development of NAFLD", 
      "severe non-alcoholic steatohepatitis", 
      "interleukin-1 receptor antagonist", 
      "insulin-like growth factor-1", 
      "non-alcoholic steatohepatitis", 
      "plasminogen activator inhibitor type 1", 
      "type 2 diabetes", 
      "obesity-associated diseases", 
      "chemokine ligand 10", 
      "activator inhibitor type 1", 
      "expression of leptin", 
      "expression of adipokines", 
      "growth factor-1", 
      "phenotypic features", 
      "inhibitor type 1", 
      "lobular inflammation", 
      "simple steatosis", 
      "receptor antagonist", 
      "necrosis factor", 
      "hepatic expression", 
      "adipokines", 
      "ligand 10", 
      "PAI-1", 
      "liver tissue", 
      "type 1", 
      "steatosis", 
      "liver", 
      "disease", 
      "factor 1", 
      "chemerin", 
      "obesity", 
      "inflammation", 
      "leptin", 
      "tissue", 
      "multiple tissues", 
      "expression", 
      "covariates", 
      "functional studies", 
      "individuals", 
      "steatohepatitis", 
      "CXCL10", 
      "T2D", 
      "diabetes", 
      "tissue-specific patterns", 
      "causal relationship", 
      "antagonist", 
      "IL1RN", 
      "tissue types", 
      "IGF1", 
      "age", 
      "ballooning", 
      "sex", 
      "correlation", 
      "association", 
      "resistance", 
      "development", 
      "features", 
      "factors", 
      "genes", 
      "study", 
      "specific characteristics", 
      "patterns", 
      "addition", 
      "relationship", 
      "types", 
      "results", 
      "characteristics", 
      "questions"
    ], 
    "name": "Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity", 
    "pagination": "e146-e146", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020368195"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nutd.2014.43"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25664838"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nutd.2014.43", 
      "https://app.dimensions.ai/details/publication/pub.1020368195"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_670.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nutd.2014.43"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nutd.2014.43'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nutd.2014.43'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nutd.2014.43'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nutd.2014.43'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      113 URIs      97 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nutd.2014.43 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N66f257cf9b364d3eb6861751db31528e
4 schema:citation sg:pub.10.1007/s10620-008-0585-3
5 sg:pub.10.1007/s11695-009-9814-x
6 sg:pub.10.1038/27376
7 sg:pub.10.1038/sj.ijo.0802987
8 sg:pub.10.1111/j.1572-0241.2000.03297.x
9 sg:pub.10.1111/j.1572-0241.2003.08767.x
10 sg:pub.10.1111/j.1572-0241.2007.01709.x
11 sg:pub.10.1186/1755-8794-3-34
12 schema:datePublished 2015-02-09
13 schema:datePublishedReg 2015-02-09
14 schema:description Objectives:Non-alcoholic fatty liver disease (NAFLD) is an obesity-associated disease, and in obesity adipokines are believed to be involved in the development of NAFLD. However, it is still not clear whether adipokines in the liver and/or adipose tissues can be related to the development of specific characteristics of NAFLD, such as steatosis and inflammation. We aimed to address this question by simultaneously examining the adipokine expression in three tissue types in obese individuals.Methods:We enrolled 93 severely obese individuals with NAFLD, varying from simple steatosis to severe non-alcoholic steatohepatitis. Their expression of 48 adipokines in the liver, visceral and subcutaneous adipose tissue (SAT) was correlated to their phenotypic features of NAFLD. We further determined whether the correlations were tissue specific and/or independent of covariates, including age, sex, obesity, insulin resistance and type 2 diabetes (T2D).Results:The expression of adipokines showed a liver- and adipose tissue-specific pattern. We identified that the expression of leptin, angiopoietin 2 (ANGPT2) and chemerin in visceral adipose tissue (VAT) was associated with different NAFLD features, including steatosis, ballooning, portal and lobular inflammation. In addition, the expression of tumor necrosis factor (TNF), plasminogen activator inhibitor type 1 (PAI-1), insulin-like growth factor 1 (somatomedin C) (IGF1) and chemokine (C-X-C motif) ligand 10 (CXCL10) in the liver tissue and the expression of interleukin 1 receptor antagonist (IL1RN) in both the liver and SAT were associated with NAFLD features. The correlations between ANGPT2 and CXCL10, and NAFLD features were dependent on insulin resistance and T2D, but for the other genes the correlation with at least one NAFLD feature remained significant after correcting for the covariates.Conclusions:Our results suggest that in obese individuals, VAT-derived leptin and chemerin, and hepatic expression of TNF, IGF1, IL1RN and PAI-1 are involved in the development of NAFLD features. Further, functional studies are warranted to establish a causal relationship.
15 schema:genre article
16 schema:isAccessibleForFree true
17 schema:isPartOf Nd0be843765ed4f2687ada54fc317be49
18 Nf12f4a818a1d4de8914870800211bcf1
19 sg:journal.1045540
20 schema:keywords CXCL10
21 IGF1
22 IL1RN
23 NAFLD features
24 PAI-1
25 T2D
26 activator inhibitor type 1
27 addition
28 adipokine expression
29 adipokines
30 adipose tissue
31 age
32 angiopoietin-2
33 antagonist
34 association
35 ballooning
36 causal relationship
37 characteristics
38 chemerin
39 chemokine ligand 10
40 correlation
41 covariates
42 development
43 development of NAFLD
44 diabetes
45 disease
46 expression
47 expression of adipokines
48 expression of leptin
49 factor 1
50 factors
51 fatty liver disease
52 features
53 functional studies
54 genes
55 growth factor-1
56 hepatic expression
57 individuals
58 inflammation
59 inhibitor type 1
60 insulin resistance
61 insulin-like growth factor-1
62 interleukin-1 receptor antagonist
63 leptin
64 ligand 10
65 liver
66 liver disease
67 liver tissue
68 lobular inflammation
69 multiple tissues
70 necrosis factor
71 non-alcoholic fatty liver disease
72 non-alcoholic steatohepatitis
73 obese individuals
74 obesity
75 obesity-associated diseases
76 patterns
77 phenotypic features
78 plasminogen activator inhibitor type 1
79 questions
80 receptor antagonist
81 relationship
82 resistance
83 results
84 severe non-alcoholic steatohepatitis
85 sex
86 simple steatosis
87 specific characteristics
88 steatohepatitis
89 steatosis
90 study
91 subcutaneous adipose tissue
92 tissue
93 tissue types
94 tissue-specific patterns
95 tumor necrosis factor
96 type 1
97 type 2 diabetes
98 types
99 visceral adipose tissue
100 schema:name Determining the association between adipokine expression in multiple tissues and phenotypic features of non-alcoholic fatty liver disease in obesity
101 schema:pagination e146-e146
102 schema:productId N8f2de20adfe94431a7ba709cb73083b0
103 Nc40c472837cc4f72814278d4cb1d1304
104 Ne1c20a79893c466b8fde652916a07c85
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020368195
106 https://doi.org/10.1038/nutd.2014.43
107 schema:sdDatePublished 2022-09-02T15:59
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N91d9b94288a4497d89baf148b723cbce
110 schema:url https://doi.org/10.1038/nutd.2014.43
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N05b1f5c94cac42a291395767b2d7f5be rdf:first sg:person.010754476744.69
115 rdf:rest Na0e88f07d7df415da1471235cec38b01
116 N0bd9394eca1d4ee1864fe9f907a9e61c rdf:first sg:person.0652115365.70
117 rdf:rest N7928354eb42f47059418568b9f246625
118 N0e681b84ad0f481987f0853912385a2c rdf:first sg:person.01117120547.62
119 rdf:rest Nc3a810be6e074713ae62ec880a4c06b6
120 N15084cc8628b4c3b9fe61acd84358458 rdf:first sg:person.01335046322.93
121 rdf:rest N39d0fd2a92a14eefbb0dcc2df673cff8
122 N30b315c56e5745be84bf78682758cb5c rdf:first sg:person.012637711072.24
123 rdf:rest N9eecfb7643494bd7ac4796d520d7fcd9
124 N39d0fd2a92a14eefbb0dcc2df673cff8 rdf:first sg:person.014072420547.86
125 rdf:rest Ne5e9363a71b247c492ef9b37ed9f8ae8
126 N40c23551180d4f8ebd382e3f96bb4394 rdf:first sg:person.0720577040.99
127 rdf:rest Nedda92bcdb484b9ca9013840f6536308
128 N66f257cf9b364d3eb6861751db31528e rdf:first sg:person.012661354367.81
129 rdf:rest N15084cc8628b4c3b9fe61acd84358458
130 N7928354eb42f47059418568b9f246625 rdf:first sg:person.0613067077.22
131 rdf:rest N0e681b84ad0f481987f0853912385a2c
132 N8f2de20adfe94431a7ba709cb73083b0 schema:name pubmed_id
133 schema:value 25664838
134 rdf:type schema:PropertyValue
135 N91d9b94288a4497d89baf148b723cbce schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N9eecfb7643494bd7ac4796d520d7fcd9 rdf:first sg:person.01301766345.96
138 rdf:rest N05b1f5c94cac42a291395767b2d7f5be
139 Na0e88f07d7df415da1471235cec38b01 rdf:first sg:person.01266401472.01
140 rdf:rest Na900570eb04c4555b24d1ec22146acad
141 Na900570eb04c4555b24d1ec22146acad rdf:first sg:person.013152053532.46
142 rdf:rest N40c23551180d4f8ebd382e3f96bb4394
143 Nc3a810be6e074713ae62ec880a4c06b6 rdf:first sg:person.01316140701.98
144 rdf:rest rdf:nil
145 Nc40c472837cc4f72814278d4cb1d1304 schema:name dimensions_id
146 schema:value pub.1020368195
147 rdf:type schema:PropertyValue
148 Nd0be843765ed4f2687ada54fc317be49 schema:issueNumber 2
149 rdf:type schema:PublicationIssue
150 Ne1c20a79893c466b8fde652916a07c85 schema:name doi
151 schema:value 10.1038/nutd.2014.43
152 rdf:type schema:PropertyValue
153 Ne5e9363a71b247c492ef9b37ed9f8ae8 rdf:first sg:person.01020717221.40
154 rdf:rest N30b315c56e5745be84bf78682758cb5c
155 Nedda92bcdb484b9ca9013840f6536308 rdf:first sg:person.0620601147.92
156 rdf:rest N0bd9394eca1d4ee1864fe9f907a9e61c
157 Nf12f4a818a1d4de8914870800211bcf1 schema:volumeNumber 5
158 rdf:type schema:PublicationVolume
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
163 schema:name Clinical Sciences
164 rdf:type schema:DefinedTerm
165 sg:grant.4124477 http://pending.schema.org/fundedItem sg:pub.10.1038/nutd.2014.43
166 rdf:type schema:MonetaryGrant
167 sg:grant.4700213 http://pending.schema.org/fundedItem sg:pub.10.1038/nutd.2014.43
168 rdf:type schema:MonetaryGrant
169 sg:journal.1045540 schema:issn 2044-4052
170 schema:name Nutrition & Diabetes
171 schema:publisher Springer Nature
172 rdf:type schema:Periodical
173 sg:person.01020717221.40 schema:affiliation grid-institutes:grid.412966.e
174 schema:familyName Verdam
175 schema:givenName F J
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020717221.40
177 rdf:type schema:Person
178 sg:person.010754476744.69 schema:affiliation grid-institutes:grid.4494.d
179 schema:familyName Wijmenga
180 schema:givenName C
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010754476744.69
182 rdf:type schema:Person
183 sg:person.01117120547.62 schema:affiliation grid-institutes:grid.4494.d
184 schema:familyName Hofker
185 schema:givenName M H
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117120547.62
187 rdf:type schema:Person
188 sg:person.012637711072.24 schema:affiliation grid-institutes:grid.412966.e
189 schema:familyName Greve
190 schema:givenName J W
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012637711072.24
192 rdf:type schema:Person
193 sg:person.012661354367.81 schema:affiliation grid-institutes:grid.4494.d
194 schema:familyName Wolfs
195 schema:givenName M G M
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012661354367.81
197 rdf:type schema:Person
198 sg:person.01266401472.01 schema:affiliation grid-institutes:grid.5012.6
199 schema:familyName Buurman
200 schema:givenName W A
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266401472.01
202 rdf:type schema:Person
203 sg:person.01301766345.96 schema:affiliation grid-institutes:grid.411414.5
204 schema:familyName Driessen
205 schema:givenName A
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301766345.96
207 rdf:type schema:Person
208 sg:person.013152053532.46 schema:affiliation grid-institutes:grid.4868.2
209 schema:familyName Franke
210 schema:givenName L
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013152053532.46
212 rdf:type schema:Person
213 sg:person.01316140701.98 schema:affiliation grid-institutes:grid.4494.d
214 schema:familyName Fu
215 schema:givenName J
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316140701.98
217 rdf:type schema:Person
218 sg:person.01335046322.93 schema:affiliation grid-institutes:grid.4494.d
219 schema:familyName Gruben
220 schema:givenName N
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335046322.93
222 rdf:type schema:Person
223 sg:person.014072420547.86 schema:affiliation grid-institutes:grid.412966.e
224 schema:familyName Rensen
225 schema:givenName S S
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014072420547.86
227 rdf:type schema:Person
228 sg:person.0613067077.22 schema:affiliation grid-institutes:grid.7692.a
229 schema:familyName van Haeften
230 schema:givenName T W
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613067077.22
232 rdf:type schema:Person
233 sg:person.0620601147.92 schema:affiliation grid-institutes:grid.4494.d
234 schema:familyName Koonen
235 schema:givenName D P Y
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620601147.92
237 rdf:type schema:Person
238 sg:person.0652115365.70 schema:affiliation grid-institutes:grid.5012.6
239 schema:familyName Shiri-Sverdlov
240 schema:givenName R
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652115365.70
242 rdf:type schema:Person
243 sg:person.0720577040.99 schema:affiliation grid-institutes:grid.13648.38
244 schema:familyName Scheja
245 schema:givenName L
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720577040.99
247 rdf:type schema:Person
248 sg:pub.10.1007/s10620-008-0585-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047694281
249 https://doi.org/10.1007/s10620-008-0585-3
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s11695-009-9814-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013464941
252 https://doi.org/10.1007/s11695-009-9814-x
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/27376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048314480
255 https://doi.org/10.1038/27376
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/sj.ijo.0802987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016472146
258 https://doi.org/10.1038/sj.ijo.0802987
259 rdf:type schema:CreativeWork
260 sg:pub.10.1111/j.1572-0241.2000.03297.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046274404
261 https://doi.org/10.1111/j.1572-0241.2000.03297.x
262 rdf:type schema:CreativeWork
263 sg:pub.10.1111/j.1572-0241.2003.08767.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048094221
264 https://doi.org/10.1111/j.1572-0241.2003.08767.x
265 rdf:type schema:CreativeWork
266 sg:pub.10.1111/j.1572-0241.2007.01709.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034837134
267 https://doi.org/10.1111/j.1572-0241.2007.01709.x
268 rdf:type schema:CreativeWork
269 sg:pub.10.1186/1755-8794-3-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045358656
270 https://doi.org/10.1186/1755-8794-3-34
271 rdf:type schema:CreativeWork
272 grid-institutes:grid.13648.38 schema:alternateName Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
273 schema:name Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
274 rdf:type schema:Organization
275 grid-institutes:grid.411414.5 schema:alternateName Department of Pathology, University Hospital Antwerp, Edegem, Belgium
276 schema:name Department of Pathology, Maastricht University Medical Centre, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
277 Department of Pathology, University Hospital Antwerp, Edegem, Belgium
278 rdf:type schema:Organization
279 grid-institutes:grid.412966.e schema:alternateName Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
280 schema:name Department of General Surgery, Maastricht University Medical Center, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, The Netherlands
281 rdf:type schema:Organization
282 grid-institutes:grid.4494.d schema:alternateName Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
283 Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
284 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
285 Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
286 rdf:type schema:Organization
287 grid-institutes:grid.4868.2 schema:alternateName Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK
288 schema:name Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
289 Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, UK
290 rdf:type schema:Organization
291 grid-institutes:grid.5012.6 schema:alternateName Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
292 School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
293 schema:name Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands
294 School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
295 rdf:type schema:Organization
296 grid-institutes:grid.7692.a schema:alternateName Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
297 schema:name Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
298 Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...