Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-09

AUTHORS

M Graff, K E North, K L Mohlke, L A Lange, J Luo, K M Harris, K L Young, A S Richardson, E M Lange, P Gordon-Larsen

ABSTRACT

OBJECTIVE: The contribution of genetic variants to body mass index (BMI) during adolescence across multiethnic samples is largely unknown. We selected genetic loci associated with BMI or obesity in European-descent samples and examined them in a multiethnic adolescent sample. DESIGN AND SAMPLE: In 5103 European American (EA), 1748 African American (AfA), 1304 Hispanic American (HA) and 439 Asian American (AsA) participants of the National Longitudinal Study of Adolescent Health (Add Health; ages 12-21 years, 47.5% male), we assessed the association between 41 established obesity-related single-nucleotide polymorphisms (SNPs) with BMI using additive genetic models, stratified by race/ethnicity, and in a pooled meta-analysis sample. We also compared the magnitude of effect for BMI-SNP associations in EA and AfA adolescents to comparable effect estimates from 11 861 EA and AfA adults in the Atherosclerosis Risk in Communities study (ages 45-64 years, 43.2% male). RESULTS: Thirty-five of 41 BMI-SNP associations were directionally consistent with published studies in European populations, 18 achieved nominal significance (P<0.05; effect sizes from 0.19 to 0.71 kg m(-2) increase in BMI per effect allele), while 4 (FTO, TMEM18, TFAP2B, MC4R) remained significant after Bonferroni correction (P<0.0015). Of 41 BMI-SNP associations in AfA, HA and AsA adolescents, nine, three and five, respectively, were directionally consistent and nominally significant. In the pooled meta-analysis, 36 of 41 effect estimates were directionally consistent and 21 of 36 were nominally significant. In EA adolescents, BMI effect estimates were larger (P<0.05) for variants near TMEM18, PTER and MC4R and smaller for variants near MTIF3 and NRXN3 compared with EA adults. CONCLUSION: Our findings suggest that obesity susceptibility loci may have a comparatively stronger role during adolescence than during adulthood, with variation across race/ethnic subpopulation. More... »

PAGES

e47

References to SciGraph publications

  • 2012-01. The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-03. Implication of European-derived adiposity loci in African Americans in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-02. Cellular cholesterol trafficking and compartmentalization in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2010-12. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies in NATURE GENETICS
  • 2009-02. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations in NATURE GENETICS
  • 2009-05. Combined effects of MC4R and FTO common genetic variants on obesity in European general populations in JOURNAL OF MOLECULAR MEDICINE
  • 2012-03. Meta-analysis identifies common variants associated with body mass index in east Asians in NATURE GENETICS
  • 2012-03. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations in NATURE GENETICS
  • 2009-06. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study in HUMAN GENETICS
  • 2012-04. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty in INTERNATIONAL JOURNAL OF OBESITY
  • 2010-02. An integrative approach to health in DEMOGRAPHY
  • 2009-01. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity in NATURE GENETICS
  • 2010-11. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index in NATURE GENETICS
  • 2009-09. Rank-Based Inverse Normal Transformations are Increasingly Used, But are They Merited? in BEHAVIOR GENETICS
  • 2009-01. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation in NATURE GENETICS
  • 2012-05. A genome-wide association meta-analysis identifies new childhood obesity loci in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nutd.2012.20

    DOI

    http://dx.doi.org/10.1038/nutd.2012.20

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051247083

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23168566


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