Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Adam T McGeoch, Michael A Trakselis, Ronald A Laskey, Stephen D Bell

ABSTRACT

The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric eukaryotic complex. Here we investigate the organization and orientation of the MCM complex of the hyperthermophilic archaeon Sulfolobus solfataricus (Sso) on model DNA substrates. Sso MCM binds as a hexamer and slides on the end of a 3'-extended single-stranded DNA tail of a Y-shaped substrate; binding is oriented so that the motor domain of the protein faces duplex DNA. Two candidate beta-hairpin motifs within the MCM monomer have partially redundant roles in DNA binding. Notably, however, conserved basic residues within these motifs have nonequivalent roles in the helicase activity of MCM. On the basis of these findings, we propose a model for the mechanism of the helicase activity of MCM and note parallels with SV40 T antigen. More... »

PAGES

756-762

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb974

DOI

http://dx.doi.org/10.1038/nsmb974

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034811191

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16116441


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Archaeal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minichromosome Maintenance 1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiprotein Complexes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Subunits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solutions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfolobus solfataricus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McGeoch", 
        "givenName": "Adam T", 
        "id": "sg:person.01344117505.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344117505.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trakselis", 
        "givenName": "Michael A", 
        "id": "sg:person.01204241377.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204241377.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laskey", 
        "givenName": "Ronald A", 
        "id": "sg:person.01315612264.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315612264.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bell", 
        "givenName": "Stephen D", 
        "id": "sg:person.014417710737.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014417710737.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2004.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003376060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2004.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004922349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)01734-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008209687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(95)46015-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013307174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m001118200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017849673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.39.24508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021633429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.embor706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023585786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.98.1.54", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023634277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308599200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025110773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(59)90090-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025255654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2958.2003.03369.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026522726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026897971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2003.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028892343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.06.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029971427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m000398200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032233553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035997182", 
          "https://doi.org/10.1038/nsb893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035997182", 
          "https://doi.org/10.1038/nsb893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036037235", 
          "https://doi.org/10.1038/nature01691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036037235", 
          "https://doi.org/10.1038/nature01691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.12.8003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037565716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108519200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040349421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2004.11.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041012301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1220104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041608796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.26.14783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041808243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(02)01330-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042108864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(02)01330-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042108864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042604955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046316637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/embo-reports/kvf160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049572444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050355989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308074200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052321764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.030539597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052994185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00616a032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055182820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9520747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi9520747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210905"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-09", 
    "datePublishedReg": "2005-09-01", 
    "description": "The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric eukaryotic complex. Here we investigate the organization and orientation of the MCM complex of the hyperthermophilic archaeon Sulfolobus solfataricus (Sso) on model DNA substrates. Sso MCM binds as a hexamer and slides on the end of a 3'-extended single-stranded DNA tail of a Y-shaped substrate; binding is oriented so that the motor domain of the protein faces duplex DNA. Two candidate beta-hairpin motifs within the MCM monomer have partially redundant roles in DNA binding. Notably, however, conserved basic residues within these motifs have nonequivalent roles in the helicase activity of MCM. On the basis of these findings, we propose a model for the mechanism of the helicase activity of MCM and note parallels with SV40 T antigen.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb974", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism", 
    "pagination": "756-762", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a5d3c1c634ecf05dd4e96f95ae4eb7e310e3d732901a62e62e68f9e89f500d5c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16116441"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb974"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034811191"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb974", 
      "https://app.dimensions.ai/details/publication/pub.1034811191"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53987_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nsmb974"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb974'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb974'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb974'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb974'


 

This table displays all metadata directly associated to this object as RDF triples.

258 TRIPLES      21 PREDICATES      77 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb974 schema:about N08e578c6297b45aea33cd51f0c5b3d4f
2 N15938ef522974956af6ef746ba840774
3 N20e7b323b96c4aba85cce30ef8d67f6c
4 N347a5f70d6ba482ba12086c35b0467a6
5 N564549c45d634e538314841c01ae8953
6 N73fd86522a12446e85a23364dbef34d4
7 N789ebba7c9d94f5593652f453a989c0d
8 N7c8eb14270ff4b749e1d40a34da30d81
9 N9170fb5bd1a54b598e29880d76ffb18a
10 N97bbe466a6db49e89a89c6f5ba09e471
11 Nb7ca0c5b400b42d6a4794fec2a841b43
12 Nc3247be96b3f4686815a64143030e1b2
13 Nc5935a5c420545fda9e71f208c42f14c
14 Nc75f71ab7c4e4071b02a1ae6cdc05028
15 Nd6b4f38c6254457d9bf118c61b0b9dd7
16 Ne48ad7e97e6e4a43b349fdcbda8be4ae
17 Nf543f7e9c49f40c8911dd8008c178edc
18 anzsrc-for:06
19 anzsrc-for:0604
20 schema:author Na03ac1fe0fa44a3895cf8be6ef3e0b16
21 schema:citation sg:pub.10.1038/nature01691
22 sg:pub.10.1038/nsb893
23 https://doi.org/10.1016/0003-9861(59)90090-6
24 https://doi.org/10.1016/0076-6879(95)46015-2
25 https://doi.org/10.1016/j.cell.2004.09.017
26 https://doi.org/10.1016/j.cell.2004.12.010
27 https://doi.org/10.1016/j.jmb.2004.11.076
28 https://doi.org/10.1016/j.jsb.2003.10.010
29 https://doi.org/10.1016/j.molcel.2004.06.039
30 https://doi.org/10.1016/s0022-2836(02)01330-x
31 https://doi.org/10.1016/s0968-0004(00)01734-5
32 https://doi.org/10.1021/bi00616a032
33 https://doi.org/10.1021/bi9520747
34 https://doi.org/10.1038/sj.embor.7400010
35 https://doi.org/10.1038/sj.embor.embor706
36 https://doi.org/10.1046/j.1365-2958.2003.03369.x
37 https://doi.org/10.1073/pnas.030539597
38 https://doi.org/10.1073/pnas.96.26.14783
39 https://doi.org/10.1073/pnas.98.1.54
40 https://doi.org/10.1074/jbc.272.39.24508
41 https://doi.org/10.1074/jbc.m000398200
42 https://doi.org/10.1074/jbc.m001118200
43 https://doi.org/10.1074/jbc.m108519200
44 https://doi.org/10.1074/jbc.m308074200
45 https://doi.org/10.1074/jbc.m308599200
46 https://doi.org/10.1093/embo-reports/kvf160
47 https://doi.org/10.1093/nar/gkg395
48 https://doi.org/10.1093/nar/gkg520
49 https://doi.org/10.1093/nar/gkg662
50 https://doi.org/10.1101/gad.1220104
51 https://doi.org/10.1128/mcb.19.12.8003
52 schema:datePublished 2005-09
53 schema:datePublishedReg 2005-09-01
54 schema:description The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric eukaryotic complex. Here we investigate the organization and orientation of the MCM complex of the hyperthermophilic archaeon Sulfolobus solfataricus (Sso) on model DNA substrates. Sso MCM binds as a hexamer and slides on the end of a 3'-extended single-stranded DNA tail of a Y-shaped substrate; binding is oriented so that the motor domain of the protein faces duplex DNA. Two candidate beta-hairpin motifs within the MCM monomer have partially redundant roles in DNA binding. Notably, however, conserved basic residues within these motifs have nonequivalent roles in the helicase activity of MCM. On the basis of these findings, we propose a model for the mechanism of the helicase activity of MCM and note parallels with SV40 T antigen.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N21319c7ea1784570880209e71d37ff9c
59 Ne8ba24e0492a46508762ee4f8ba9ac09
60 sg:journal.1295033
61 schema:name Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism
62 schema:pagination 756-762
63 schema:productId N15bedcfa7636489891ed0ef41d1c53aa
64 N220eb669a45641c7be84ef9ee901c89b
65 N3df44bdf2ff24cdf9be95b52611fdfb8
66 N47de88e6f993464fb510981d4c50a037
67 Nc04b6c3532fe40b5bd9d8a85582c0c5e
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034811191
69 https://doi.org/10.1038/nsmb974
70 schema:sdDatePublished 2019-04-11T12:12
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N3f3aeae5272746fd9879bcef7754c2b6
73 schema:url http://www.nature.com/articles/nsmb974
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N08e578c6297b45aea33cd51f0c5b3d4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Protein Binding
79 rdf:type schema:DefinedTerm
80 N14f6f77ed0514347addf84d3e3d81f63 rdf:first sg:person.01204241377.44
81 rdf:rest N15ebd66c8682441e96f4f6e84f46ac10
82 N15938ef522974956af6ef746ba840774 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name DNA Helicases
84 rdf:type schema:DefinedTerm
85 N15bedcfa7636489891ed0ef41d1c53aa schema:name doi
86 schema:value 10.1038/nsmb974
87 rdf:type schema:PropertyValue
88 N15ebd66c8682441e96f4f6e84f46ac10 rdf:first sg:person.01315612264.01
89 rdf:rest N2969cdf4af2b40b0ab4a3b6dd32e1f10
90 N20e7b323b96c4aba85cce30ef8d67f6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name DNA
92 rdf:type schema:DefinedTerm
93 N21319c7ea1784570880209e71d37ff9c schema:issueNumber 9
94 rdf:type schema:PublicationIssue
95 N220eb669a45641c7be84ef9ee901c89b schema:name pubmed_id
96 schema:value 16116441
97 rdf:type schema:PropertyValue
98 N2969cdf4af2b40b0ab4a3b6dd32e1f10 rdf:first sg:person.014417710737.07
99 rdf:rest rdf:nil
100 N347a5f70d6ba482ba12086c35b0467a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Multiprotein Complexes
102 rdf:type schema:DefinedTerm
103 N3df44bdf2ff24cdf9be95b52611fdfb8 schema:name nlm_unique_id
104 schema:value 101186374
105 rdf:type schema:PropertyValue
106 N3f3aeae5272746fd9879bcef7754c2b6 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N47de88e6f993464fb510981d4c50a037 schema:name dimensions_id
109 schema:value pub.1034811191
110 rdf:type schema:PropertyValue
111 N564549c45d634e538314841c01ae8953 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Nuclear Proteins
113 rdf:type schema:DefinedTerm
114 N73fd86522a12446e85a23364dbef34d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Models, Molecular
116 rdf:type schema:DefinedTerm
117 N789ebba7c9d94f5593652f453a989c0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Archaeal Proteins
119 rdf:type schema:DefinedTerm
120 N7c8eb14270ff4b749e1d40a34da30d81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Adenosine Triphosphatases
122 rdf:type schema:DefinedTerm
123 N9170fb5bd1a54b598e29880d76ffb18a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Solutions
125 rdf:type schema:DefinedTerm
126 N97bbe466a6db49e89a89c6f5ba09e471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Minichromosome Maintenance 1 Protein
128 rdf:type schema:DefinedTerm
129 N9a9f12bcfbe14d5d86a489223ce53905 schema:name MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK.
130 rdf:type schema:Organization
131 Na03ac1fe0fa44a3895cf8be6ef3e0b16 rdf:first sg:person.01344117505.28
132 rdf:rest N14f6f77ed0514347addf84d3e3d81f63
133 Nb7ca0c5b400b42d6a4794fec2a841b43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 Nc04b6c3532fe40b5bd9d8a85582c0c5e schema:name readcube_id
137 schema:value a5d3c1c634ecf05dd4e96f95ae4eb7e310e3d732901a62e62e68f9e89f500d5c
138 rdf:type schema:PropertyValue
139 Nc3247be96b3f4686815a64143030e1b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Sequence Alignment
141 rdf:type schema:DefinedTerm
142 Nc5935a5c420545fda9e71f208c42f14c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name DNA-Binding Proteins
144 rdf:type schema:DefinedTerm
145 Nc75f71ab7c4e4071b02a1ae6cdc05028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Sulfolobus solfataricus
147 rdf:type schema:DefinedTerm
148 Ncc527db078b247af858da7e6976b424b schema:name MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK.
149 rdf:type schema:Organization
150 Nd6b4f38c6254457d9bf118c61b0b9dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Protein Subunits
152 rdf:type schema:DefinedTerm
153 Ne48ad7e97e6e4a43b349fdcbda8be4ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Amino Acid Sequence
155 rdf:type schema:DefinedTerm
156 Ne8ba24e0492a46508762ee4f8ba9ac09 schema:volumeNumber 12
157 rdf:type schema:PublicationVolume
158 Nea1f45956834423ea662605cf085343e schema:name MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK.
159 rdf:type schema:Organization
160 Nea56d5be6e644a8eae4467432789de18 schema:name MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 2XZ, UK.
161 rdf:type schema:Organization
162 Nf543f7e9c49f40c8911dd8008c178edc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Molecular Sequence Data
164 rdf:type schema:DefinedTerm
165 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
166 schema:name Biological Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
169 schema:name Genetics
170 rdf:type schema:DefinedTerm
171 sg:journal.1295033 schema:issn 1545-9993
172 2331-365X
173 schema:name Nature Structural & Molecular Biology
174 rdf:type schema:Periodical
175 sg:person.01204241377.44 schema:affiliation Nea56d5be6e644a8eae4467432789de18
176 schema:familyName Trakselis
177 schema:givenName Michael A
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204241377.44
179 rdf:type schema:Person
180 sg:person.01315612264.01 schema:affiliation Ncc527db078b247af858da7e6976b424b
181 schema:familyName Laskey
182 schema:givenName Ronald A
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315612264.01
184 rdf:type schema:Person
185 sg:person.01344117505.28 schema:affiliation N9a9f12bcfbe14d5d86a489223ce53905
186 schema:familyName McGeoch
187 schema:givenName Adam T
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344117505.28
189 rdf:type schema:Person
190 sg:person.014417710737.07 schema:affiliation Nea1f45956834423ea662605cf085343e
191 schema:familyName Bell
192 schema:givenName Stephen D
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014417710737.07
194 rdf:type schema:Person
195 sg:pub.10.1038/nature01691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036037235
196 https://doi.org/10.1038/nature01691
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nsb893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035997182
199 https://doi.org/10.1038/nsb893
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/0003-9861(59)90090-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025255654
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0076-6879(95)46015-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013307174
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.cell.2004.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004922349
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.cell.2004.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003376060
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.jmb.2004.11.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041012301
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jsb.2003.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028892343
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.molcel.2004.06.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029971427
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0022-2836(02)01330-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042108864
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0968-0004(00)01734-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008209687
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1021/bi00616a032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055182820
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1021/bi9520747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055210905
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1038/sj.embor.7400010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026897971
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1038/sj.embor.embor706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023585786
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1046/j.1365-2958.2003.03369.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026522726
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1073/pnas.030539597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052994185
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.96.26.14783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041808243
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1073/pnas.98.1.54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023634277
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1074/jbc.272.39.24508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021633429
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1074/jbc.m000398200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032233553
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1074/jbc.m001118200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017849673
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1074/jbc.m108519200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040349421
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1074/jbc.m308074200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052321764
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.m308599200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025110773
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/embo-reports/kvf160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049572444
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1093/nar/gkg395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042604955
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1093/nar/gkg520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050355989
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1093/nar/gkg662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046316637
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1101/gad.1220104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041608796
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1128/mcb.19.12.8003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037565716
258 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...