A 'loop recapture' mechanism for ACF-dependent nucleosome remodeling View Full Text


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Article Info

DATE

2005-08

AUTHORS

Ralf Strohner, Malte Wachsmuth, Karoline Dachauer, Jacek Mazurkiewicz, Julia Hochstatter, Karsten Rippe, Gernot Längst

ABSTRACT

The ATPase ISWI is the molecular motor of several nucleosome remodeling complexes including ACF. We analyzed the ACF-nucleosome interactions and determined the characteristics of ACF-dependent nucleosome remodeling. In contrast to ISWI, ACF interacts symmetrically with DNA entry sites of the nucleosome. Two-color fluorescence cross-correlation spectroscopy measurements show that ACF can bind four DNA duplexes simultaneously in a complex that contains two Acf1 and ISWI molecules. Using bead-bound nucleosomal substrates, nucleosome movement by mechanisms involving DNA twisting was excluded. Furthermore, an ACF-dependent local detachment of DNA from the nucleosome was demonstrated in a novel assay based on the preferred intercalation of ethidium bromide to free DNA. The findings suggest a loop recapture mechanism in which ACF introduces a DNA loop at the nucleosomal entry site that propagates over the histone octamer surface and leads to nucleosome repositioning. More... »

PAGES

683-690

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb966

DOI

http://dx.doi.org/10.1038/nsmb966

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030208615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16025127


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