Ontology type: schema:ScholarlyArticle
2005-08
AUTHORSJana Sticht, Michael Humbert, Stuart Findlow, Jochen Bodem, Barbara Müller, Ursula Dietrich, Jörn Werner, Hans-Georg Kräusslich
ABSTRACTFormation of infectious HIV-1 involves assembly of Gag polyproteins into immature particles and subsequent assembly of mature capsids after proteolytic disassembly of the Gag shell. We report a 12-mer peptide, capsid assembly inhibitor (CAI), that binds the capsid (CA) domain of Gag and inhibits assembly of immature- and mature-like capsid particles in vitro. CAI was identified by phage display screening among a group of peptides with similar sequences that bind to a single reactive site in CA. Its binding site was mapped to CA residues 169-191, with an additional contribution from the last helix of CA. This result was confirmed by a separate X-ray structure analysis showing that CAI inserts into a conserved hydrophobic groove and alters the CA dimer interface. The CAI binding site is a new target for antiviral development, and CAI is the first known inhibitor directed against assembly of immature HIV-1. More... »
PAGES671-677
http://scigraph.springernature.com/pub.10.1038/nsmb964
DOIhttp://dx.doi.org/10.1038/nsmb964
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/16041387
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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb964'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb964'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb964'
This table displays all metadata directly associated to this object as RDF triples.
319 TRIPLES
21 PREDICATES
88 URIs
36 LITERALS
24 BLANK NODES