Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Julie A Clapperton, Isaac A Manke, Drew M Lowery, Timmy Ho, Lesley F Haire, Michael B Yaffe, Stephen J Smerdon

ABSTRACT

Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely obscure, many mutations are known to target the highly conserved C-terminal BRCT repeats that function as a phosphoserine/phosphothreonine-binding module. We report the X-ray crystal structure at a resolution of 1.85 A of the BRCA1 tandem BRCT domains in complex with a phosphorylated peptide representing the minimal interacting region of the DEAH-box helicase BACH1. The structure reveals the determinants of this novel class of BRCA1 binding events. We show that a subset of disease-linked mutations act through specific disruption of phospho-dependent BRCA1 interactions rather than through gross structural perturbation of the tandem BRCT domains. More... »

PAGES

512-518

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb775

DOI

http://dx.doi.org/10.1038/nsmb775

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053141408

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15133502


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "BRCA1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic-Leucine Zipper Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallography, X-Ray", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fanconi Anemia Complementation Group Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Francis Crick Institute", 
          "id": "https://www.grid.ac/institutes/grid.451388.3", 
          "name": [
            "National Institute for Medical Research, Division of Protein Structure, The Ridgeway, Mill Hill, London NW7 1AA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clapperton", 
        "givenName": "Julie A", 
        "id": "sg:person.0715104640.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715104640.53"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Manke", 
        "givenName": "Isaac A", 
        "id": "sg:person.01324554646.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324554646.21"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lowery", 
        "givenName": "Drew M", 
        "id": "sg:person.01366762462.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366762462.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ho", 
        "givenName": "Timmy", 
        "type": "Person"
      }, 
      {
        "familyName": "Haire", 
        "givenName": "Lesley F", 
        "id": "sg:person.0632641351.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632641351.65"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yaffe", 
        "givenName": "Michael B", 
        "id": "sg:person.01175115050.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175115050.08"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Smerdon", 
        "givenName": "Stephen J", 
        "id": "sg:person.010727525727.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727525727.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0955-0674(03)00042-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001093372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(03)00042-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001093372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00615-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003706567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005228794", 
          "https://doi.org/10.1038/sj.onc.1203334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005228794", 
          "https://doi.org/10.1038/sj.onc.1203334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008466971", 
          "https://doi.org/10.1038/87876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35044000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011057053", 
          "https://doi.org/10.1038/35044000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35044000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011057053", 
          "https://doi.org/10.1038/35044000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767390010224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014210169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35107009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020206735", 
          "https://doi.org/10.1038/35107009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35107009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020206735", 
          "https://doi.org/10.1038/35107009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(96)01312-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021526467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/10.4.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022573094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80276-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023606878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444994003112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025573949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026442022", 
          "https://doi.org/10.1038/sj.onc.1206678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026442022", 
          "https://doi.org/10.1038/sj.onc.1206678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0308717101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027639895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00725-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027657731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029264956", 
          "https://doi.org/10.1038/nsmb776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029264956", 
          "https://doi.org/10.1038/nsmb776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdg558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029793565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m210019200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033033649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.1.281-288.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035805910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c300407200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038447971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040868032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7545954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041365117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.1380080102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042426314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.1380080102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042426314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1001-838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042535267", 
          "https://doi.org/10.1038/nsb1001-838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.959202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043669387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(02)00478-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044527505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80238-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044836649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80202-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047827768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00304-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048892237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0921-8777(00)00034-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049313417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.21.7926-7936.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050145128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80503-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050205530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0962-8924(98)01382-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052062034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/301749", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058609356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1088753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1088877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062448502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074630046", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-06", 
    "datePublishedReg": "2004-06-01", 
    "description": "Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely obscure, many mutations are known to target the highly conserved C-terminal BRCT repeats that function as a phosphoserine/phosphothreonine-binding module. We report the X-ray crystal structure at a resolution of 1.85 A of the BRCA1 tandem BRCT domains in complex with a phosphorylated peptide representing the minimal interacting region of the DEAH-box helicase BACH1. The structure reveals the determinants of this novel class of BRCA1 binding events. We show that a subset of disease-linked mutations act through specific disruption of phospho-dependent BRCA1 interactions rather than through gross structural perturbation of the tandem BRCT domains.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb775", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2516443", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer", 
    "pagination": "512-518", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fd1fe1b9862621cb6e619c6e19503a2e68d2d910163b7bedd17a16fde2297544"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15133502"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb775"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053141408"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb775", 
      "https://app.dimensions.ai/details/publication/pub.1053141408"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000360_0000000360/records_118339_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nsmb/journal/v11/n6/full/nsmb775.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb775'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb775'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb775'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb775'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      83 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb775 schema:about N0c3890b7ad01422c8b7841c141e55bdb
2 N0d4f4838a74243c4a856eb46af61a2b3
3 N4142187ffd53491794af4ce285e7221c
4 N45901b90cae64127bc3c065b8c7de23b
5 N5f4601e0056c48738a6597731530202f
6 N66004a021dd440008d622740614b15ec
7 N6ef21b6606974fc38cdf7093c87a80ec
8 N95352752026c4758ba519aabb2677b5d
9 N9a058a0dd79043d8a2e1e4972d5f62d6
10 Naa92183828a8484d960021a109e24c6a
11 Nb61f6f4f7cbe4393a267eaaf41f03f89
12 Nc0a1185553024f4399144349d0705659
13 Nd36b90f434af4ea9a4583f7a60c0ef9d
14 Ne026ef0f872d4b6abf7d7dfebbbd7edc
15 Ne27a122859b24b60adc6db2612f58abd
16 Ne2e2a70c89e44bb68b3a217820f48224
17 Nf67e53d860744227bbfd63c7a360f857
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N57c9400f88794badb380f0ae36efd7b4
21 schema:citation sg:pub.10.1038/35044000
22 sg:pub.10.1038/35107009
23 sg:pub.10.1038/87876
24 sg:pub.10.1038/nsb1001-838
25 sg:pub.10.1038/nsmb776
26 sg:pub.10.1038/sj.onc.1203334
27 sg:pub.10.1038/sj.onc.1206678
28 https://app.dimensions.ai/details/publication/pub.1074630046
29 https://doi.org/10.1002/humu.1380080102
30 https://doi.org/10.1016/s0014-5793(96)01312-9
31 https://doi.org/10.1016/s0022-2836(02)00478-3
32 https://doi.org/10.1016/s0076-6879(97)76066-x
33 https://doi.org/10.1016/s0092-8674(00)80503-6
34 https://doi.org/10.1016/s0092-8674(01)00304-x
35 https://doi.org/10.1016/s0092-8674(02)00615-3
36 https://doi.org/10.1016/s0092-8674(03)00725-6
37 https://doi.org/10.1016/s0921-8777(00)00034-3
38 https://doi.org/10.1016/s0955-0674(03)00042-5
39 https://doi.org/10.1016/s0962-8924(98)01382-8
40 https://doi.org/10.1016/s1097-2765(00)80202-6
41 https://doi.org/10.1016/s1097-2765(00)80238-5
42 https://doi.org/10.1016/s1097-2765(00)80276-2
43 https://doi.org/10.1073/pnas.0308717101
44 https://doi.org/10.1074/jbc.c300407200
45 https://doi.org/10.1074/jbc.m210019200
46 https://doi.org/10.1086/301749
47 https://doi.org/10.1093/emboj/cdf383
48 https://doi.org/10.1093/emboj/cdg558
49 https://doi.org/10.1093/hmg/10.4.353
50 https://doi.org/10.1101/gad.959202
51 https://doi.org/10.1107/s0108767390010224
52 https://doi.org/10.1107/s0907444994003112
53 https://doi.org/10.1126/science.1088753
54 https://doi.org/10.1126/science.1088877
55 https://doi.org/10.1126/science.7545954
56 https://doi.org/10.1128/mcb.21.1.281-288.2001
57 https://doi.org/10.1128/mcb.23.21.7926-7936.2003
58 schema:datePublished 2004-06
59 schema:datePublishedReg 2004-06-01
60 schema:description Germline mutations in the BRCA1 tumor suppressor gene often result in a significant increase in susceptibility to breast and ovarian cancers. Although the molecular basis of their effects remains largely obscure, many mutations are known to target the highly conserved C-terminal BRCT repeats that function as a phosphoserine/phosphothreonine-binding module. We report the X-ray crystal structure at a resolution of 1.85 A of the BRCA1 tandem BRCT domains in complex with a phosphorylated peptide representing the minimal interacting region of the DEAH-box helicase BACH1. The structure reveals the determinants of this novel class of BRCA1 binding events. We show that a subset of disease-linked mutations act through specific disruption of phospho-dependent BRCA1 interactions rather than through gross structural perturbation of the tandem BRCT domains.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N1989fbb7c0c44b9094da47961aadc3b0
65 Nfdc3e20d0be1400cbcc605cbb177dee6
66 sg:journal.1295033
67 schema:name Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
68 schema:pagination 512-518
69 schema:productId N09e3d6daf6314fa2b538494031b37c6b
70 N1056230227544499b7de29d02373ec27
71 N397ee1c9ab7646b6a8ac9343c2d7d6d0
72 N3c05a6c11773479485660ec2e786b90c
73 Ndc40a917fec54d58ac063e9140d3dab6
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053141408
75 https://doi.org/10.1038/nsmb775
76 schema:sdDatePublished 2019-04-11T12:06
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Ne326567ee2a044f5ae98ac6ff09b8f9d
79 schema:url http://www.nature.com/nsmb/journal/v11/n6/full/nsmb775.html
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N09e3d6daf6314fa2b538494031b37c6b schema:name readcube_id
84 schema:value fd1fe1b9862621cb6e619c6e19503a2e68d2d910163b7bedd17a16fde2297544
85 rdf:type schema:PropertyValue
86 N0c3890b7ad01422c8b7841c141e55bdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Protein Binding
88 rdf:type schema:DefinedTerm
89 N0d4f4838a74243c4a856eb46af61a2b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Fanconi Anemia Complementation Group Proteins
91 rdf:type schema:DefinedTerm
92 N1056230227544499b7de29d02373ec27 schema:name dimensions_id
93 schema:value pub.1053141408
94 rdf:type schema:PropertyValue
95 N129a36c2cd1a4b629baedabc0e232e87 rdf:first sg:person.010727525727.84
96 rdf:rest rdf:nil
97 N1989fbb7c0c44b9094da47961aadc3b0 schema:volumeNumber 11
98 rdf:type schema:PublicationVolume
99 N1d0a21161de8478db26f823fadd33c95 rdf:first sg:person.01324554646.21
100 rdf:rest N75f8dc01d6534f3b8b364e070d5094ef
101 N25597ec1abd44af4b473093292a7132e rdf:first N393504d71a8b41f6a384de0d5ccdbc6c
102 rdf:rest Nf24bc2747e0b42a18db1c352b81ae542
103 N393504d71a8b41f6a384de0d5ccdbc6c schema:familyName Ho
104 schema:givenName Timmy
105 rdf:type schema:Person
106 N397ee1c9ab7646b6a8ac9343c2d7d6d0 schema:name nlm_unique_id
107 schema:value 101186374
108 rdf:type schema:PropertyValue
109 N3a7e0972998b4b829be7bbd5d16ff624 rdf:first sg:person.01175115050.08
110 rdf:rest N129a36c2cd1a4b629baedabc0e232e87
111 N3c05a6c11773479485660ec2e786b90c schema:name doi
112 schema:value 10.1038/nsmb775
113 rdf:type schema:PropertyValue
114 N4142187ffd53491794af4ce285e7221c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Phosphopeptides
116 rdf:type schema:DefinedTerm
117 N45901b90cae64127bc3c065b8c7de23b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Basic-Leucine Zipper Transcription Factors
119 rdf:type schema:DefinedTerm
120 N57c9400f88794badb380f0ae36efd7b4 rdf:first sg:person.0715104640.53
121 rdf:rest N1d0a21161de8478db26f823fadd33c95
122 N5f4601e0056c48738a6597731530202f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Transcription Factors
124 rdf:type schema:DefinedTerm
125 N66004a021dd440008d622740614b15ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Female
127 rdf:type schema:DefinedTerm
128 N6ef21b6606974fc38cdf7093c87a80ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Protein Structure, Tertiary
130 rdf:type schema:DefinedTerm
131 N75f8dc01d6534f3b8b364e070d5094ef rdf:first sg:person.01366762462.20
132 rdf:rest N25597ec1abd44af4b473093292a7132e
133 N95352752026c4758ba519aabb2677b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Crystallography, X-Ray
135 rdf:type schema:DefinedTerm
136 N9a058a0dd79043d8a2e1e4972d5f62d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Humans
138 rdf:type schema:DefinedTerm
139 Naa92183828a8484d960021a109e24c6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mutation
141 rdf:type schema:DefinedTerm
142 Nb61f6f4f7cbe4393a267eaaf41f03f89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Transfection
144 rdf:type schema:DefinedTerm
145 Nc0a1185553024f4399144349d0705659 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name BRCA1 Protein
147 rdf:type schema:DefinedTerm
148 Nd36b90f434af4ea9a4583f7a60c0ef9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Breast Neoplasms
150 rdf:type schema:DefinedTerm
151 Ndc40a917fec54d58ac063e9140d3dab6 schema:name pubmed_id
152 schema:value 15133502
153 rdf:type schema:PropertyValue
154 Ne026ef0f872d4b6abf7d7dfebbbd7edc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Nuclear Proteins
156 rdf:type schema:DefinedTerm
157 Ne27a122859b24b60adc6db2612f58abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Nucleus
159 rdf:type schema:DefinedTerm
160 Ne2e2a70c89e44bb68b3a217820f48224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Microscopy, Fluorescence
162 rdf:type schema:DefinedTerm
163 Ne326567ee2a044f5ae98ac6ff09b8f9d schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nf24bc2747e0b42a18db1c352b81ae542 rdf:first sg:person.0632641351.65
166 rdf:rest N3a7e0972998b4b829be7bbd5d16ff624
167 Nf67e53d860744227bbfd63c7a360f857 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Cell Line, Tumor
169 rdf:type schema:DefinedTerm
170 Nfdc3e20d0be1400cbcc605cbb177dee6 schema:issueNumber 6
171 rdf:type schema:PublicationIssue
172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biological Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
176 schema:name Biochemistry and Cell Biology
177 rdf:type schema:DefinedTerm
178 sg:grant.2516443 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb775
179 rdf:type schema:MonetaryGrant
180 sg:journal.1295033 schema:issn 1545-9993
181 2331-365X
182 schema:name Nature Structural & Molecular Biology
183 rdf:type schema:Periodical
184 sg:person.010727525727.84 schema:familyName Smerdon
185 schema:givenName Stephen J
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010727525727.84
187 rdf:type schema:Person
188 sg:person.01175115050.08 schema:familyName Yaffe
189 schema:givenName Michael B
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175115050.08
191 rdf:type schema:Person
192 sg:person.01324554646.21 schema:familyName Manke
193 schema:givenName Isaac A
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324554646.21
195 rdf:type schema:Person
196 sg:person.01366762462.20 schema:familyName Lowery
197 schema:givenName Drew M
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366762462.20
199 rdf:type schema:Person
200 sg:person.0632641351.65 schema:familyName Haire
201 schema:givenName Lesley F
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632641351.65
203 rdf:type schema:Person
204 sg:person.0715104640.53 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
205 schema:familyName Clapperton
206 schema:givenName Julie A
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715104640.53
208 rdf:type schema:Person
209 sg:pub.10.1038/35044000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011057053
210 https://doi.org/10.1038/35044000
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/35107009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020206735
213 https://doi.org/10.1038/35107009
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/87876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008466971
216 https://doi.org/10.1038/87876
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nsb1001-838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042535267
219 https://doi.org/10.1038/nsb1001-838
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nsmb776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029264956
222 https://doi.org/10.1038/nsmb776
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.onc.1203334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005228794
225 https://doi.org/10.1038/sj.onc.1203334
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/sj.onc.1206678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026442022
228 https://doi.org/10.1038/sj.onc.1206678
229 rdf:type schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1074630046 schema:CreativeWork
231 https://doi.org/10.1002/humu.1380080102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042426314
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0014-5793(96)01312-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021526467
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0022-2836(02)00478-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044527505
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0092-8674(00)80503-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050205530
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0092-8674(01)00304-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048892237
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0092-8674(02)00615-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003706567
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0092-8674(03)00725-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027657731
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0921-8777(00)00034-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049313417
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s0955-0674(03)00042-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001093372
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0962-8924(98)01382-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052062034
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s1097-2765(00)80202-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047827768
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s1097-2765(00)80238-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044836649
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s1097-2765(00)80276-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023606878
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1073/pnas.0308717101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027639895
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1074/jbc.c300407200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038447971
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1074/jbc.m210019200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033033649
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1086/301749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058609356
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/emboj/cdf383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040868032
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/emboj/cdg558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029793565
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/hmg/10.4.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022573094
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1101/gad.959202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043669387
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1126/science.1088753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448490
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1126/science.1088877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062448502
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1126/science.7545954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041365117
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1128/mcb.21.1.281-288.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035805910
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1128/mcb.23.21.7926-7936.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050145128
288 rdf:type schema:CreativeWork
289 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
290 schema:name National Institute for Medical Research, Division of Protein Structure, The Ridgeway, Mill Hill, London NW7 1AA, UK.
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...