Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12-29

AUTHORS

Marjorie Brand, Jeffrey A Ranish, Nicolas T Kummer, Joan Hamilton, Kazuhiko Igarashi, Claire Francastel, Tian H Chi, Gerald R Crabtree, Ruedi Aebersold, Mark Groudine

ABSTRACT

During erythroid differentiation, β-globin gene expression is regulated by the locus control region (LCR). The transcription factor NF-E2p18/MafK binds within this region and is essential for β-globin expression in murine erythroleukemia (MEL) cells. Here we use the isotope-coded affinity tag (ICAT) technique of quantitative mass spectrometry to compare proteins interacting with NF-E2p18/MafK during differentiation. Our results define MafK as a 'dual-function' molecule that shifts from a repressive to an activating mode during erythroid differentiation. The exchange of MafK dimerization partner from Bach1 to NF-E2p45 is a key step in the switch from the repressed to the active state. This shift is associated with changes in the interaction of MafK with co-repressors and co-activators. Thus, our results suggest that in addition to its role as a cis-acting activator of β-globin gene expression in differentiated erythroid cells, the LCR also promotes an active repression of β-globin transcription in committed cells before terminal differentiation. More... »

PAGES

73-80

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb713

DOI

http://dx.doi.org/10.1038/nsmb713

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031228962

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14718926


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythroid-Specific DNA-Binding Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Erythropoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MafK Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brand", 
        "givenName": "Marjorie", 
        "id": "sg:person.0725574274.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574274.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Systems Biology, 98103, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.64212.33", 
          "name": [
            "Institute for Systems Biology, 98103, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ranish", 
        "givenName": "Jeffrey A", 
        "id": "sg:person.010125731727.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125731727.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kummer", 
        "givenName": "Nicolas T", 
        "id": "sg:person.0701761205.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701761205.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.270240.3", 
          "name": [
            "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamilton", 
        "givenName": "Joan", 
        "id": "sg:person.0670140767.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670140767.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, 734-8551, Hiroshima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, 734-8551, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Igarashi", 
        "givenName": "Kazuhiko", 
        "id": "sg:person.01133436765.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133436765.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U474, Institut Cochin de G\u00e9n\u00e9tique Mol\u00e9culaire, 75014, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462098.1", 
          "name": [
            "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA", 
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U474, Institut Cochin de G\u00e9n\u00e9tique Mol\u00e9culaire, 75014, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Francastel", 
        "givenName": "Claire", 
        "id": "sg:person.01237541660.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237541660.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chi", 
        "givenName": "Tian H", 
        "id": "sg:person.0720062672.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720062672.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crabtree", 
        "givenName": "Gerald R", 
        "id": "sg:person.012126676102.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012126676102.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Systems Biology, 98103, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.64212.33", 
          "name": [
            "Institute for Systems Biology, 98103, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aebersold", 
        "givenName": "Ruedi", 
        "id": "sg:person.015313356237.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015313356237.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiation Oncology, University of Washington School of Medicine, 98104, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA", 
            "Department of Radiation Oncology, University of Washington School of Medicine, 98104, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groudine", 
        "givenName": "Mark", 
        "id": "sg:person.01306214770.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306214770.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.leu.2400552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034604693", 
          "https://doi.org/10.1038/sj.leu.2400552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013295796", 
          "https://doi.org/10.1038/nature00876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/1044-0305(94)80016-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018629105", 
          "https://doi.org/10.1016/1044-0305(94)80016-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/367568a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046201766", 
          "https://doi.org/10.1038/367568a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029022565", 
          "https://doi.org/10.1038/13690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020526163", 
          "https://doi.org/10.1038/35065132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-55747-7_10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033098849", 
          "https://doi.org/10.1007/978-3-642-55747-7_10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1001-946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029399357", 
          "https://doi.org/10.1038/nbt1001-946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002213324", 
          "https://doi.org/10.1038/ng1101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362722a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012325889", 
          "https://doi.org/10.1038/362722a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366170a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019735918", 
          "https://doi.org/10.1038/366170a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-12-29", 
    "datePublishedReg": "2003-12-29", 
    "description": "During erythroid differentiation, \u03b2-globin gene expression is regulated by the locus control region (LCR). The transcription factor NF-E2p18/MafK binds within this region and is essential for \u03b2-globin expression in murine erythroleukemia (MEL) cells. Here we use the isotope-coded affinity tag (ICAT) technique of quantitative mass spectrometry to compare proteins interacting with NF-E2p18/MafK during differentiation. Our results define MafK as a 'dual-function' molecule that shifts from a repressive to an activating mode during erythroid differentiation. The exchange of MafK dimerization partner from Bach1 to NF-E2p45 is a key step in the switch from the repressed to the active state. This shift is associated with changes in the interaction of MafK with co-repressors and co-activators. Thus, our results suggest that in addition to its role as a cis-acting activator of \u03b2-globin gene expression in differentiated erythroid cells, the LCR also promotes an active repression of \u03b2-globin transcription in committed cells before terminal differentiation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nsmb713", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2634796", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2431409", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2494624", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2535749", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "locus control region", 
      "globin gene expression", 
      "erythroid differentiation", 
      "cis-acting activators", 
      "gene expression", 
      "isotope-coded affinity tag (ICAT) technique", 
      "NF-E2p45", 
      "transcription factor complex", 
      "quantitative mass spectrometry", 
      "murine erythroleukemia cells", 
      "MafK binds", 
      "transcription factor NF", 
      "globin transcription", 
      "active repression", 
      "dimerization partner", 
      "globin expression", 
      "control region", 
      "factor complex", 
      "quantitative proteomics", 
      "erythroid cells", 
      "erythroleukemia cells", 
      "terminal differentiation", 
      "MafK", 
      "factor NF", 
      "differentiation", 
      "tag technique", 
      "active state", 
      "expression", 
      "cells", 
      "transcription", 
      "dynamic changes", 
      "mass spectrometry", 
      "Bach1", 
      "repression", 
      "proteomics", 
      "repressive", 
      "protein", 
      "key step", 
      "binds", 
      "activator", 
      "region", 
      "complexes", 
      "NF", 
      "molecules", 
      "role", 
      "switch", 
      "changes", 
      "interaction", 
      "partners", 
      "spectrometry", 
      "step", 
      "addition", 
      "exchange", 
      "shift", 
      "results", 
      "mode", 
      "state", 
      "technique", 
      "affinity tag (ICAT) technique", 
      "NF-E2p18/MafK", 
      "MafK dimerization partner", 
      "interaction of MafK"
    ], 
    "name": "Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics", 
    "pagination": "73-80", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031228962"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb713"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14718926"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb713", 
      "https://app.dimensions.ai/details/publication/pub.1031228962"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_373.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nsmb713"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb713'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb713'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb713'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb713'


 

This table displays all metadata directly associated to this object as RDF triples.

320 TRIPLES      22 PREDICATES      115 URIs      96 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb713 schema:about N25569800f4624a28a86627253e8405d5
2 N2ece7a74f82f4f84876d87d32fa2c1a0
3 N393902a478dc4184b91337817ddee5d0
4 N3ea5373d278a4d4697178daa02f3f972
5 N3ffa4243c0064628a27af6ec023702a9
6 N43f103c3846a4b8996231e3ba70d58e5
7 N5a26a72b6e284d24b84802729640b018
8 N6c7e144274de4132a4aca6820269ea8f
9 N9f59a209f74f4b9baf84189e710ef6f6
10 Na5fc913effaa4b95b5272fcbf4512471
11 Nc768d5320ae2463b83d2b3e7783a305e
12 Ndb2d772ac36343989ac9d998da2c0e8d
13 Ne0f865bedc824586850734d02ccfff19
14 Nee910ef03f4345cf90508e1c4e9c0b63
15 Nfc89f0eeaa65422ba2e47ebb514ba89a
16 Nff452d5530ac40719b73e2ab8ae805e1
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N56586d15b2014914a49ff8e9f5dce420
20 schema:citation sg:pub.10.1007/978-3-642-55747-7_10
21 sg:pub.10.1016/1044-0305(94)80016-2
22 sg:pub.10.1038/13690
23 sg:pub.10.1038/35065132
24 sg:pub.10.1038/362722a0
25 sg:pub.10.1038/366170a0
26 sg:pub.10.1038/367568a0
27 sg:pub.10.1038/nature00876
28 sg:pub.10.1038/nbt1001-946
29 sg:pub.10.1038/ng1101
30 sg:pub.10.1038/sj.leu.2400552
31 schema:datePublished 2003-12-29
32 schema:datePublishedReg 2003-12-29
33 schema:description During erythroid differentiation, β-globin gene expression is regulated by the locus control region (LCR). The transcription factor NF-E2p18/MafK binds within this region and is essential for β-globin expression in murine erythroleukemia (MEL) cells. Here we use the isotope-coded affinity tag (ICAT) technique of quantitative mass spectrometry to compare proteins interacting with NF-E2p18/MafK during differentiation. Our results define MafK as a 'dual-function' molecule that shifts from a repressive to an activating mode during erythroid differentiation. The exchange of MafK dimerization partner from Bach1 to NF-E2p45 is a key step in the switch from the repressed to the active state. This shift is associated with changes in the interaction of MafK with co-repressors and co-activators. Thus, our results suggest that in addition to its role as a cis-acting activator of β-globin gene expression in differentiated erythroid cells, the LCR also promotes an active repression of β-globin transcription in committed cells before terminal differentiation.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf N09c00b13b93b407a838183e23ebe5e4e
38 N8ffdf71f659948ef880a1ba8a4e35bb4
39 sg:journal.1295033
40 schema:keywords Bach1
41 MafK
42 MafK binds
43 MafK dimerization partner
44 NF
45 NF-E2p18/MafK
46 NF-E2p45
47 activator
48 active repression
49 active state
50 addition
51 affinity tag (ICAT) technique
52 binds
53 cells
54 changes
55 cis-acting activators
56 complexes
57 control region
58 differentiation
59 dimerization partner
60 dynamic changes
61 erythroid cells
62 erythroid differentiation
63 erythroleukemia cells
64 exchange
65 expression
66 factor NF
67 factor complex
68 gene expression
69 globin expression
70 globin gene expression
71 globin transcription
72 interaction
73 interaction of MafK
74 isotope-coded affinity tag (ICAT) technique
75 key step
76 locus control region
77 mass spectrometry
78 mode
79 molecules
80 murine erythroleukemia cells
81 partners
82 protein
83 proteomics
84 quantitative mass spectrometry
85 quantitative proteomics
86 region
87 repression
88 repressive
89 results
90 role
91 shift
92 spectrometry
93 state
94 step
95 switch
96 tag technique
97 technique
98 terminal differentiation
99 transcription
100 transcription factor NF
101 transcription factor complex
102 schema:name Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics
103 schema:pagination 73-80
104 schema:productId N397742ad46064fea9cda63d8d8c7db66
105 Na063c1e805a9417ead9dec95723631c3
106 Nd77d4ca3d76440978442220582fcabc9
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031228962
108 https://doi.org/10.1038/nsmb713
109 schema:sdDatePublished 2021-12-01T19:15
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher Nbbfae885fe4141ccaca97c12b9b222cd
112 schema:url https://doi.org/10.1038/nsmb713
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N09c00b13b93b407a838183e23ebe5e4e schema:volumeNumber 11
117 rdf:type schema:PublicationVolume
118 N25569800f4624a28a86627253e8405d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Animals
120 rdf:type schema:DefinedTerm
121 N2ece7a74f82f4f84876d87d32fa2c1a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Erythrocytes
123 rdf:type schema:DefinedTerm
124 N393902a478dc4184b91337817ddee5d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Models, Biological
126 rdf:type schema:DefinedTerm
127 N397742ad46064fea9cda63d8d8c7db66 schema:name doi
128 schema:value 10.1038/nsmb713
129 rdf:type schema:PropertyValue
130 N3ea5373d278a4d4697178daa02f3f972 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Macromolecular Substances
132 rdf:type schema:DefinedTerm
133 N3ffa4243c0064628a27af6ec023702a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Line
135 rdf:type schema:DefinedTerm
136 N422346c04a1049578e37449bc5052a8f rdf:first sg:person.010125731727.05
137 rdf:rest Neb9bd117e1334c169c074ee4325ef2e4
138 N43f103c3846a4b8996231e3ba70d58e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Erythroid-Specific DNA-Binding Factors
140 rdf:type schema:DefinedTerm
141 N56586d15b2014914a49ff8e9f5dce420 rdf:first sg:person.0725574274.51
142 rdf:rest N422346c04a1049578e37449bc5052a8f
143 N5a26a72b6e284d24b84802729640b018 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Erythropoiesis
145 rdf:type schema:DefinedTerm
146 N5b7a0b4a543c48e8bf6511d27945ceed rdf:first sg:person.015313356237.76
147 rdf:rest N634ff56c1ee1497bb2d53a4e333cb739
148 N634ff56c1ee1497bb2d53a4e333cb739 rdf:first sg:person.01306214770.12
149 rdf:rest rdf:nil
150 N680d79d69ea14c29baadc5ec38303c82 rdf:first sg:person.0720062672.59
151 rdf:rest Nec8ac595c1aa46b39b3e29da4e718a40
152 N6c7e144274de4132a4aca6820269ea8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Mice
154 rdf:type schema:DefinedTerm
155 N8ffdf71f659948ef880a1ba8a4e35bb4 schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 N9582ba5a1c544e95aac4e603f013df4b rdf:first sg:person.01133436765.75
158 rdf:rest Ne8118762aa3149f1b2f4e1e32e7edec6
159 N9f59a209f74f4b9baf84189e710ef6f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Gene Expression Regulation, Developmental
161 rdf:type schema:DefinedTerm
162 Na063c1e805a9417ead9dec95723631c3 schema:name pubmed_id
163 schema:value 14718926
164 rdf:type schema:PropertyValue
165 Na5fc913effaa4b95b5272fcbf4512471 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Transcription Factors
167 rdf:type schema:DefinedTerm
168 Nbbfae885fe4141ccaca97c12b9b222cd schema:name Springer Nature - SN SciGraph project
169 rdf:type schema:Organization
170 Nc768d5320ae2463b83d2b3e7783a305e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name MafK Transcription Factor
172 rdf:type schema:DefinedTerm
173 Nd238b970c01d4a16aafe319a401dbbe5 rdf:first sg:person.0670140767.90
174 rdf:rest N9582ba5a1c544e95aac4e603f013df4b
175 Nd77d4ca3d76440978442220582fcabc9 schema:name dimensions_id
176 schema:value pub.1031228962
177 rdf:type schema:PropertyValue
178 Ndb2d772ac36343989ac9d998da2c0e8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Globins
180 rdf:type schema:DefinedTerm
181 Ne0f865bedc824586850734d02ccfff19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name DNA-Binding Proteins
183 rdf:type schema:DefinedTerm
184 Ne8118762aa3149f1b2f4e1e32e7edec6 rdf:first sg:person.01237541660.41
185 rdf:rest N680d79d69ea14c29baadc5ec38303c82
186 Neb9bd117e1334c169c074ee4325ef2e4 rdf:first sg:person.0701761205.47
187 rdf:rest Nd238b970c01d4a16aafe319a401dbbe5
188 Nec8ac595c1aa46b39b3e29da4e718a40 rdf:first sg:person.012126676102.17
189 rdf:rest N5b7a0b4a543c48e8bf6511d27945ceed
190 Nee910ef03f4345cf90508e1c4e9c0b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Cell Differentiation
192 rdf:type schema:DefinedTerm
193 Nfc89f0eeaa65422ba2e47ebb514ba89a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Proteomics
195 rdf:type schema:DefinedTerm
196 Nff452d5530ac40719b73e2ab8ae805e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Nuclear Proteins
198 rdf:type schema:DefinedTerm
199 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
200 schema:name Biological Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
203 schema:name Biochemistry and Cell Biology
204 rdf:type schema:DefinedTerm
205 sg:grant.2431409 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb713
206 rdf:type schema:MonetaryGrant
207 sg:grant.2494624 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb713
208 rdf:type schema:MonetaryGrant
209 sg:grant.2535749 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb713
210 rdf:type schema:MonetaryGrant
211 sg:grant.2634796 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb713
212 rdf:type schema:MonetaryGrant
213 sg:journal.1295033 schema:issn 1545-9993
214 2331-365X
215 schema:name Nature Structural & Molecular Biology
216 schema:publisher Springer Nature
217 rdf:type schema:Periodical
218 sg:person.010125731727.05 schema:affiliation grid-institutes:grid.64212.33
219 schema:familyName Ranish
220 schema:givenName Jeffrey A
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010125731727.05
222 rdf:type schema:Person
223 sg:person.01133436765.75 schema:affiliation grid-institutes:grid.257022.0
224 schema:familyName Igarashi
225 schema:givenName Kazuhiko
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133436765.75
227 rdf:type schema:Person
228 sg:person.012126676102.17 schema:affiliation grid-institutes:grid.168010.e
229 schema:familyName Crabtree
230 schema:givenName Gerald R
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012126676102.17
232 rdf:type schema:Person
233 sg:person.01237541660.41 schema:affiliation grid-institutes:grid.462098.1
234 schema:familyName Francastel
235 schema:givenName Claire
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237541660.41
237 rdf:type schema:Person
238 sg:person.01306214770.12 schema:affiliation grid-institutes:grid.34477.33
239 schema:familyName Groudine
240 schema:givenName Mark
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306214770.12
242 rdf:type schema:Person
243 sg:person.015313356237.76 schema:affiliation grid-institutes:grid.64212.33
244 schema:familyName Aebersold
245 schema:givenName Ruedi
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015313356237.76
247 rdf:type schema:Person
248 sg:person.0670140767.90 schema:affiliation grid-institutes:grid.270240.3
249 schema:familyName Hamilton
250 schema:givenName Joan
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670140767.90
252 rdf:type schema:Person
253 sg:person.0701761205.47 schema:affiliation grid-institutes:grid.270240.3
254 schema:familyName Kummer
255 schema:givenName Nicolas T
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701761205.47
257 rdf:type schema:Person
258 sg:person.0720062672.59 schema:affiliation grid-institutes:grid.168010.e
259 schema:familyName Chi
260 schema:givenName Tian H
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720062672.59
262 rdf:type schema:Person
263 sg:person.0725574274.51 schema:affiliation grid-institutes:grid.270240.3
264 schema:familyName Brand
265 schema:givenName Marjorie
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725574274.51
267 rdf:type schema:Person
268 sg:pub.10.1007/978-3-642-55747-7_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033098849
269 https://doi.org/10.1007/978-3-642-55747-7_10
270 rdf:type schema:CreativeWork
271 sg:pub.10.1016/1044-0305(94)80016-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018629105
272 https://doi.org/10.1016/1044-0305(94)80016-2
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/13690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029022565
275 https://doi.org/10.1038/13690
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/35065132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020526163
278 https://doi.org/10.1038/35065132
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/362722a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012325889
281 https://doi.org/10.1038/362722a0
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/366170a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019735918
284 https://doi.org/10.1038/366170a0
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/367568a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046201766
287 https://doi.org/10.1038/367568a0
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/nature00876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013295796
290 https://doi.org/10.1038/nature00876
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nbt1001-946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029399357
293 https://doi.org/10.1038/nbt1001-946
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/ng1101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002213324
296 https://doi.org/10.1038/ng1101
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/sj.leu.2400552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034604693
299 https://doi.org/10.1038/sj.leu.2400552
300 rdf:type schema:CreativeWork
301 grid-institutes:grid.168010.e schema:alternateName Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA
302 schema:name Departments of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, 94305, Palo Alto, California, USA
303 rdf:type schema:Organization
304 grid-institutes:grid.257022.0 schema:alternateName Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, 734-8551, Hiroshima, Japan
305 schema:name Department of Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Kasumi 1-2-3, 734-8551, Hiroshima, Japan
306 rdf:type schema:Organization
307 grid-institutes:grid.270240.3 schema:alternateName Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA
308 schema:name Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA
309 rdf:type schema:Organization
310 grid-institutes:grid.34477.33 schema:alternateName Department of Radiation Oncology, University of Washington School of Medicine, 98104, Seattle, Washington, USA
311 schema:name Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA
312 Department of Radiation Oncology, University of Washington School of Medicine, 98104, Seattle, Washington, USA
313 rdf:type schema:Organization
314 grid-institutes:grid.462098.1 schema:alternateName Institut National de la Santé et de la Recherche Médicale U474, Institut Cochin de Génétique Moléculaire, 75014, Paris, France
315 schema:name Basic Sciences Division, Fred Hutchinson Cancer Research Center, 98109, Seattle, Washington, USA
316 Institut National de la Santé et de la Recherche Médicale U474, Institut Cochin de Génétique Moléculaire, 75014, Paris, France
317 rdf:type schema:Organization
318 grid-institutes:grid.64212.33 schema:alternateName Institute for Systems Biology, 98103, Seattle, Washington, USA
319 schema:name Institute for Systems Biology, 98103, Seattle, Washington, USA
320 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...