p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-11-18

AUTHORS

Shravanti Rampalli, LiFang Li, Esther Mak, Kai Ge, Marjorie Brand, Stephen J Tapscott, F Jeffrey Dilworth

ABSTRACT

Cell-specific patterns of gene expression are established through the antagonistic functions of trithorax group (TrxG) and Polycomb group (PcG) proteins. Several muscle-specific genes have previously been shown to be epigenetically marked for repression by PcG proteins in muscle progenitor cells. Here we demonstrate that these developmentally regulated genes become epigenetically marked for gene expression (trimethylated on histone H3 Lys4, H3K4me3) during muscle differentiation through specific recruitment of Ash2L-containing methyltransferase complexes. Targeting of Ash2L to specific genes is mediated by the transcriptional regulator Mef2d. Furthermore, this interaction is modulated during differentiation through activation of the p38 MAPK signaling pathway via phosphorylation of Mef2d. Thus, we provide evidence that signaling pathways regulate the targeting of TrxG-mediated epigenetic modifications at specific promoters during cellular differentiation. More... »

PAGES

1150-1156

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1316

DOI

http://dx.doi.org/10.1038/nsmb1316

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020559439

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18026121


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