Rad54 dissociates homologous recombination intermediates by branch migration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-07-29

AUTHORS

Dmitry V Bugreev, Fumio Hanaoka, Alexander V Mazin

ABSTRACT

Double-strand DNA breaks (DSBs) cause cell death and genome instability. Homologous recombination is a major DSB repair pathway that operates by forming joint molecules with homologous DNA sequences, which are used as templates to achieve accurate repair. In eukaryotes, Rad51 protein (RecA homolog) searches for homologous sequences and catalyzes the formation of joint molecules (D-loops). Once joint molecules have been formed, DNA polymerase extends the 3′ single-stranded DNA tails of the broken chromosome, restoring the lost information. How joint molecules subsequently dissociate is unknown. We reconstituted DSB repair in vitro using purified human homologous recombination proteins and DNA polymerase η. We found that Rad54 protein, owing to its ATP-dependent branch-migration activity, can cause dissociation of joint molecules. These results suggest a previously uncharacterized mechanism of DSB repair in which Rad54 branch-migration activity plays an important role. More... »

PAGES

746-753

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1268

DOI

http://dx.doi.org/10.1038/nsmb1268

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053231242

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17660833


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Breaks, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rad51 Recombinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombination, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, 630090, Novosibirsk, Russia", 
          "id": "http://www.grid.ac/institutes/grid.415877.8", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA", 
            "Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, 630090, Novosibirsk, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bugreev", 
        "givenName": "Dmitry V", 
        "id": "sg:person.016320146527.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016320146527.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Frontier Biosciences, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 1-3 Yamada-oka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Graduate School of Frontier Biosciences, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 1-3 Yamada-oka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanaoka", 
        "givenName": "Fumio", 
        "id": "sg:person.01177247732.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177247732.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA", 
          "id": "http://www.grid.ac/institutes/grid.166341.7", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazin", 
        "givenName": "Alexander V", 
        "id": "sg:person.01153722604.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153722604.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nsmb919", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007211500", 
          "https://doi.org/10.1038/nsmb919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017140008", 
          "https://doi.org/10.1038/nrm1502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009545445", 
          "https://doi.org/10.1038/nsb901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028183793", 
          "https://doi.org/10.1038/nature02253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/30037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051441726", 
          "https://doi.org/10.1038/30037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017349042", 
          "https://doi.org/10.1038/nature04889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000968951", 
          "https://doi.org/10.1038/nrm2008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006173489", 
          "https://doi.org/10.1038/nrc1012"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-07-29", 
    "datePublishedReg": "2007-07-29", 
    "description": "Double-strand DNA breaks (DSBs) cause cell death and genome instability. Homologous recombination is a major DSB repair pathway that operates by forming joint molecules with homologous DNA sequences, which are used as templates to achieve accurate repair. In eukaryotes, Rad51 protein (RecA homolog) searches for homologous sequences and catalyzes the formation of joint molecules (D-loops). Once joint molecules have been formed, DNA polymerase extends the 3\u2032 single-stranded DNA tails of the broken chromosome, restoring the lost information. How joint molecules subsequently dissociate is unknown. We reconstituted DSB repair in vitro using purified human homologous recombination proteins and DNA polymerase \u03b7. We found that Rad54 protein, owing to its ATP-dependent branch-migration activity, can cause dissociation of joint molecules. These results suggest a previously uncharacterized mechanism of DSB repair in which Rad54 branch-migration activity plays an important role.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nsmb1268", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2666959", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2476727", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "double-strand DNA breaks", 
      "branch migration activity", 
      "joint molecules", 
      "DSB repair", 
      "homologous recombination", 
      "major DSB repair pathways", 
      "homologous recombination proteins", 
      "homologous DNA sequences", 
      "DSB repair pathways", 
      "Rad54 protein", 
      "recombination proteins", 
      "genome instability", 
      "broken chromosomes", 
      "uncharacterized mechanism", 
      "repair pathways", 
      "DNA sequences", 
      "DNA breaks", 
      "homologous sequences", 
      "DNA tail", 
      "accurate repair", 
      "DNA polymerase \u03b7", 
      "cell death", 
      "branch migration", 
      "protein search", 
      "DNA polymerase", 
      "polymerase \u03b7", 
      "protein", 
      "recombination", 
      "sequence", 
      "eukaryotes", 
      "Rad54", 
      "important role", 
      "molecules", 
      "chromosomes", 
      "polymerase", 
      "repair", 
      "pathway", 
      "activity", 
      "vitro", 
      "tail", 
      "migration", 
      "breaks", 
      "mechanism", 
      "role", 
      "formation", 
      "dissociation", 
      "death", 
      "template", 
      "results", 
      "instability", 
      "information", 
      "search", 
      "Rad51 protein (RecA homolog) searches", 
      "human homologous recombination proteins", 
      "ATP-dependent branch-migration activity", 
      "Rad54 branch-migration activity"
    ], 
    "name": "Rad54 dissociates homologous recombination intermediates by branch migration", 
    "pagination": "746-753", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053231242"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb1268"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17660833"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb1268", 
      "https://app.dimensions.ai/details/publication/pub.1053231242"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nsmb1268"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb1268'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb1268'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb1268'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb1268'


 

This table displays all metadata directly associated to this object as RDF triples.

215 TRIPLES      22 PREDICATES      100 URIs      83 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb1268 schema:about N0c81ee147d4441058eda8dd3b37b38a5
2 N33468b4ae6dc410ab1c24cdb21b816cc
3 N43ceb474454249ec93e942347023656b
4 N77704d8158b94b6ab84a0a3473e37473
5 N78202628a3ff479b9b76219e2b06cf8e
6 N8911825aa7ce4c7fbadfbdebde2e5c89
7 Nae2b0f46e7004590a3c2652898bcfb9a
8 Nc0f306d8c11e49c3944699a8111c5d0c
9 Nf0ff88d902fd4451b5ac5bae3f9770fa
10 anzsrc-for:06
11 anzsrc-for:0601
12 anzsrc-for:0604
13 schema:author N2323053e2ff543dc8715e19371a19318
14 schema:citation sg:pub.10.1038/30037
15 sg:pub.10.1038/nature02253
16 sg:pub.10.1038/nature04889
17 sg:pub.10.1038/nrc1012
18 sg:pub.10.1038/nrm1502
19 sg:pub.10.1038/nrm2008
20 sg:pub.10.1038/nsb901
21 sg:pub.10.1038/nsmb919
22 schema:datePublished 2007-07-29
23 schema:datePublishedReg 2007-07-29
24 schema:description Double-strand DNA breaks (DSBs) cause cell death and genome instability. Homologous recombination is a major DSB repair pathway that operates by forming joint molecules with homologous DNA sequences, which are used as templates to achieve accurate repair. In eukaryotes, Rad51 protein (RecA homolog) searches for homologous sequences and catalyzes the formation of joint molecules (D-loops). Once joint molecules have been formed, DNA polymerase extends the 3′ single-stranded DNA tails of the broken chromosome, restoring the lost information. How joint molecules subsequently dissociate is unknown. We reconstituted DSB repair in vitro using purified human homologous recombination proteins and DNA polymerase η. We found that Rad54 protein, owing to its ATP-dependent branch-migration activity, can cause dissociation of joint molecules. These results suggest a previously uncharacterized mechanism of DSB repair in which Rad54 branch-migration activity plays an important role.
25 schema:genre article
26 schema:inLanguage en
27 schema:isAccessibleForFree false
28 schema:isPartOf N881b741c04414c4fb49aeb66ab072c2b
29 N9aa8084c2a2c44ccbfad9790c29f1708
30 sg:journal.1295033
31 schema:keywords ATP-dependent branch-migration activity
32 DNA breaks
33 DNA polymerase
34 DNA polymerase η
35 DNA sequences
36 DNA tail
37 DSB repair
38 DSB repair pathways
39 Rad51 protein (RecA homolog) searches
40 Rad54
41 Rad54 branch-migration activity
42 Rad54 protein
43 accurate repair
44 activity
45 branch migration
46 branch migration activity
47 breaks
48 broken chromosomes
49 cell death
50 chromosomes
51 death
52 dissociation
53 double-strand DNA breaks
54 eukaryotes
55 formation
56 genome instability
57 homologous DNA sequences
58 homologous recombination
59 homologous recombination proteins
60 homologous sequences
61 human homologous recombination proteins
62 important role
63 information
64 instability
65 joint molecules
66 major DSB repair pathways
67 mechanism
68 migration
69 molecules
70 pathway
71 polymerase
72 polymerase η
73 protein
74 protein search
75 recombination
76 recombination proteins
77 repair
78 repair pathways
79 results
80 role
81 search
82 sequence
83 tail
84 template
85 uncharacterized mechanism
86 vitro
87 schema:name Rad54 dissociates homologous recombination intermediates by branch migration
88 schema:pagination 746-753
89 schema:productId N29e0ccdeafed447db348e3ffb3c29d78
90 N4270d7e29f184edc9258ededb8e1c178
91 Nbc8d32dc1271437b8fb90a2894b87f63
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053231242
93 https://doi.org/10.1038/nsmb1268
94 schema:sdDatePublished 2022-01-01T18:16
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher Nf262c7047eec48c28e08af42ce7811c1
97 schema:url https://doi.org/10.1038/nsmb1268
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0c81ee147d4441058eda8dd3b37b38a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name DNA Repair
103 rdf:type schema:DefinedTerm
104 N0f872c57871b409bb8271b15189c9fb8 rdf:first sg:person.01153722604.28
105 rdf:rest rdf:nil
106 N2323053e2ff543dc8715e19371a19318 rdf:first sg:person.016320146527.61
107 rdf:rest N6cbcbef890ff45cca09aae917308b941
108 N29e0ccdeafed447db348e3ffb3c29d78 schema:name pubmed_id
109 schema:value 17660833
110 rdf:type schema:PropertyValue
111 N33468b4ae6dc410ab1c24cdb21b816cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name DNA Helicases
113 rdf:type schema:DefinedTerm
114 N4270d7e29f184edc9258ededb8e1c178 schema:name dimensions_id
115 schema:value pub.1053231242
116 rdf:type schema:PropertyValue
117 N43ceb474454249ec93e942347023656b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N6cbcbef890ff45cca09aae917308b941 rdf:first sg:person.01177247732.44
121 rdf:rest N0f872c57871b409bb8271b15189c9fb8
122 N77704d8158b94b6ab84a0a3473e37473 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Rad51 Recombinase
124 rdf:type schema:DefinedTerm
125 N78202628a3ff479b9b76219e2b06cf8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Recombination, Genetic
127 rdf:type schema:DefinedTerm
128 N881b741c04414c4fb49aeb66ab072c2b schema:issueNumber 8
129 rdf:type schema:PublicationIssue
130 N8911825aa7ce4c7fbadfbdebde2e5c89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name DNA
132 rdf:type schema:DefinedTerm
133 N9aa8084c2a2c44ccbfad9790c29f1708 schema:volumeNumber 14
134 rdf:type schema:PublicationVolume
135 Nae2b0f46e7004590a3c2652898bcfb9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name DNA-Binding Proteins
137 rdf:type schema:DefinedTerm
138 Nbc8d32dc1271437b8fb90a2894b87f63 schema:name doi
139 schema:value 10.1038/nsmb1268
140 rdf:type schema:PropertyValue
141 Nc0f306d8c11e49c3944699a8111c5d0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name DNA Breaks, Double-Stranded
143 rdf:type schema:DefinedTerm
144 Nf0ff88d902fd4451b5ac5bae3f9770fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Nuclear Proteins
146 rdf:type schema:DefinedTerm
147 Nf262c7047eec48c28e08af42ce7811c1 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
150 schema:name Biological Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
153 schema:name Biochemistry and Cell Biology
154 rdf:type schema:DefinedTerm
155 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
156 schema:name Genetics
157 rdf:type schema:DefinedTerm
158 sg:grant.2476727 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb1268
159 rdf:type schema:MonetaryGrant
160 sg:grant.2666959 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb1268
161 rdf:type schema:MonetaryGrant
162 sg:journal.1295033 schema:issn 1545-9993
163 2331-365X
164 schema:name Nature Structural & Molecular Biology
165 schema:publisher Springer Nature
166 rdf:type schema:Periodical
167 sg:person.01153722604.28 schema:affiliation grid-institutes:grid.166341.7
168 schema:familyName Mazin
169 schema:givenName Alexander V
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153722604.28
171 rdf:type schema:Person
172 sg:person.01177247732.44 schema:affiliation grid-institutes:grid.419082.6
173 schema:familyName Hanaoka
174 schema:givenName Fumio
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177247732.44
176 rdf:type schema:Person
177 sg:person.016320146527.61 schema:affiliation grid-institutes:grid.415877.8
178 schema:familyName Bugreev
179 schema:givenName Dmitry V
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016320146527.61
181 rdf:type schema:Person
182 sg:pub.10.1038/30037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051441726
183 https://doi.org/10.1038/30037
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nature02253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028183793
186 https://doi.org/10.1038/nature02253
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/nature04889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017349042
189 https://doi.org/10.1038/nature04889
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/nrc1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006173489
192 https://doi.org/10.1038/nrc1012
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/nrm1502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017140008
195 https://doi.org/10.1038/nrm1502
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/nrm2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000968951
198 https://doi.org/10.1038/nrm2008
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nsb901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009545445
201 https://doi.org/10.1038/nsb901
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nsmb919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007211500
204 https://doi.org/10.1038/nsmb919
205 rdf:type schema:CreativeWork
206 grid-institutes:grid.166341.7 schema:alternateName Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA
207 schema:name Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA
208 rdf:type schema:Organization
209 grid-institutes:grid.415877.8 schema:alternateName Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, 630090, Novosibirsk, Russia
210 schema:name Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 19102-1192, Philadelphia, Pennsylvania, USA
211 Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Science, 630090, Novosibirsk, Russia
212 rdf:type schema:Organization
213 grid-institutes:grid.419082.6 schema:alternateName Graduate School of Frontier Biosciences, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 1-3 Yamada-oka, 565-0871, Suita, Osaka, Japan
214 schema:name Graduate School of Frontier Biosciences, Osaka University and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, 1-3 Yamada-oka, 565-0871, Suita, Osaka, Japan
215 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...