Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Yu Chen, Yanhui Xu, Qing Bao, Yongna Xing, Zhu Li, Zheng Lin, Jeffry B Stock, Philip D Jeffrey, Yigong Shi

ABSTRACT

The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B' for the PP2A core enzyme. Consequently, ST does not efficiently displace B' from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes. More... »

PAGES

527-534

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1254

DOI

http://dx.doi.org/10.1038/nsmb1254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004835472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17529992


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Viral, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Polyacrylamide Gel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Structure, Tertiary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Subunits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian virus 40", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yu", 
        "id": "sg:person.01316646431.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316646431.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Yanhui", 
        "id": "sg:person.012037754077.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012037754077.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bao", 
        "givenName": "Qing", 
        "id": "sg:person.01263472517.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263472517.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xing", 
        "givenName": "Yongna", 
        "id": "sg:person.01167031023.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167031023.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zhu", 
        "id": "sg:person.0755604131.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755604131.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Zheng", 
        "id": "sg:person.0707470731.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707470731.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stock", 
        "givenName": "Jeffry B", 
        "id": "sg:person.010010754312.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010010754312.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeffrey", 
        "givenName": "Philip D", 
        "id": "sg:person.0732604444.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732604444.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princeton University", 
          "id": "https://www.grid.ac/institutes/grid.16750.35", 
          "name": [
            "Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Yigong", 
        "id": "sg:person.012705321277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.87.7.2521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000174874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(99)00074-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002618028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004818084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(97)76066-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004907170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.1.295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005126648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.8.4761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006499567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1993.tb17922.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008169915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.8.5257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008648486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0108767390010224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014210169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.3.1692", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014834661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889891004399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014885043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.11.4872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017244907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00026-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017377201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1993.1489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019247667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444998003254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.00899.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024378867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00027-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026207019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027078509", 
          "https://doi.org/10.1038/nature05351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027078509", 
          "https://doi.org/10.1038/nature05351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.11.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028113172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.4.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028215003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.4.1996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033226680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3530417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033284032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3530417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033284032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033723733", 
          "https://doi.org/10.1038/nmeth731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033723733", 
          "https://doi.org/10.1038/nmeth731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90726-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035355085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.14.4880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037417773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.12.4252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041821813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90533-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043750692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444905001617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044610818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(93)90005-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044945518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-419x(93)90005-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044945518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80963-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046345009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.09.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047119200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.7.2111-2123.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050612433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2004.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051323142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.52.35339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051691884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00397a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055173764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00455a010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055176938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00465a002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055177292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3530417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075047915", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075606545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075949631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082404014", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082627475", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082653927", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082723822", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082786184", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083359444", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-06", 
    "datePublishedReg": "2007-06-01", 
    "description": "The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B' for the PP2A core enzyme. Consequently, ST does not efficiently displace B' from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb1254", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2478954", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40", 
    "pagination": "527-534", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "170a9672d230f83115329ef157bb3965fcebd4c402e894c1ed673d7454b15f18"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17529992"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb1254"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004835472"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb1254", 
      "https://app.dimensions.ai/details/publication/pub.1004835472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nsmb1254"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb1254'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb1254'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb1254'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb1254'


 

This table displays all metadata directly associated to this object as RDF triples.

309 TRIPLES      21 PREDICATES      88 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb1254 schema:about N0ad97b6bd4c0463196cfe20c066adbcf
2 N10fac0692ebb4174b7cf41539303b43a
3 N263ac9b1e9c5407391ec0952b38dce40
4 N327fa70beb2845f9b6c21697675c7489
5 N7e1867f517514b1391d3cbef8d7a71bc
6 N8114703930ce4071833ed587d0ea0937
7 N8383aeebaa8f4818b623e9903aaa4a6c
8 N88cc21360ac140928634954c38ba6187
9 Na73d4c2059d947c19393788b456b533f
10 Nb4d0387c38954e5db4a1ea08b0cd2d0f
11 Nc45ca854e4074f14a8d6be7a1fc62d6d
12 Nefc4ada8c37e49ab8110bd752320bb20
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N5bc35e5d0eff4d67a1d5f98d4e7e2b21
16 schema:citation sg:pub.10.1038/nature05351
17 sg:pub.10.1038/nmeth731
18 https://app.dimensions.ai/details/publication/pub.1075047915
19 https://app.dimensions.ai/details/publication/pub.1075606545
20 https://app.dimensions.ai/details/publication/pub.1075949631
21 https://app.dimensions.ai/details/publication/pub.1082404014
22 https://app.dimensions.ai/details/publication/pub.1082627475
23 https://app.dimensions.ai/details/publication/pub.1082653927
24 https://app.dimensions.ai/details/publication/pub.1082723822
25 https://app.dimensions.ai/details/publication/pub.1082786184
26 https://app.dimensions.ai/details/publication/pub.1083359444
27 https://doi.org/10.1006/jmbi.1993.1489
28 https://doi.org/10.1016/0092-8674(90)90726-u
29 https://doi.org/10.1016/0092-8674(93)90533-v
30 https://doi.org/10.1016/0304-419x(93)90005-w
31 https://doi.org/10.1016/j.cell.2006.09.025
32 https://doi.org/10.1016/j.cell.2006.11.033
33 https://doi.org/10.1016/j.gde.2004.12.004
34 https://doi.org/10.1016/j.molcel.2006.07.027
35 https://doi.org/10.1016/s0076-6879(97)76066-x
36 https://doi.org/10.1016/s0092-8674(00)80963-0
37 https://doi.org/10.1016/s0955-0674(99)00074-5
38 https://doi.org/10.1016/s1535-6108(04)00026-1
39 https://doi.org/10.1016/s1535-6108(04)00027-3
40 https://doi.org/10.1021/bi00397a003
41 https://doi.org/10.1021/bi00455a010
42 https://doi.org/10.1021/bi00465a002
43 https://doi.org/10.1042/0264-6021:3530417
44 https://doi.org/10.1042/bj3530417
45 https://doi.org/10.1073/pnas.84.14.4880
46 https://doi.org/10.1073/pnas.85.12.4252
47 https://doi.org/10.1073/pnas.87.7.2521
48 https://doi.org/10.1074/jbc.273.52.35339
49 https://doi.org/10.1074/jbc.275.8.5257
50 https://doi.org/10.1093/emboj/20.1.295
51 https://doi.org/10.1107/s0021889891004399
52 https://doi.org/10.1107/s0108767390010224
53 https://doi.org/10.1107/s0907444905001617
54 https://doi.org/10.1107/s0907444998003254
55 https://doi.org/10.1111/j.1432-1033.1993.tb17922.x
56 https://doi.org/10.1111/j.1432-1033.1994.00899.x
57 https://doi.org/10.1128/mcb.11.4.1988
58 https://doi.org/10.1128/mcb.11.4.1996
59 https://doi.org/10.1128/mcb.12.11.4872
60 https://doi.org/10.1128/mcb.17.3.1692
61 https://doi.org/10.1128/mcb.17.8.4761
62 https://doi.org/10.1128/mcb.22.7.2111-2123.2002
63 schema:datePublished 2007-06
64 schema:datePublishedReg 2007-06-01
65 schema:description The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism. The crystal structure of the core domain of SV40 ST bound to the scaffolding subunit of human PP2A reveals that the ST core domain has a novel zinc-binding fold and interacts with the conserved ridge of HEAT repeats 3-6, which overlaps with the binding site for the B' (also called PR61 or B56) regulatory subunit. ST has a lower binding affinity than B' for the PP2A core enzyme. Consequently, ST does not efficiently displace B' from PP2A holoenzymes in vitro. Notably, ST inhibits PP2A phosphatase activity through its N-terminal J domain. These findings suggest that ST may function mainly by inhibiting the phosphatase activity of the PP2A core enzyme, and to a lesser extent by modulating assembly of the PP2A holoenzymes.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree false
69 schema:isPartOf N5ae684ad6d664062b682faf6cc75b3ab
70 Naa850a7bd62948cbb245f7882b2df010
71 sg:journal.1295033
72 schema:name Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
73 schema:pagination 527-534
74 schema:productId N187703956ca84fe387745abf9deb3cb9
75 N3c8ce96153e84f1691cd015bb22b52d3
76 N3f2d620cbee142998d832440fcfe6c6c
77 N5599a4c4313d48cab4e9d28436847137
78 Nab0a0411fba242d5be7b9a92fa31a37c
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004835472
80 https://doi.org/10.1038/nsmb1254
81 schema:sdDatePublished 2019-04-10T22:19
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N8196c4c40d664e54949e35739c17bb34
84 schema:url http://www.nature.com/articles/nsmb1254
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N0ad97b6bd4c0463196cfe20c066adbcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Humans
90 rdf:type schema:DefinedTerm
91 N0d56111c4ab541ecaab784916eab915b rdf:first sg:person.0755604131.07
92 rdf:rest Nfa33b954ab994621a68644a1d07d9275
93 N10fac0692ebb4174b7cf41539303b43a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Crystallization
95 rdf:type schema:DefinedTerm
96 N187703956ca84fe387745abf9deb3cb9 schema:name readcube_id
97 schema:value 170a9672d230f83115329ef157bb3965fcebd4c402e894c1ed673d7454b15f18
98 rdf:type schema:PropertyValue
99 N1a2f19ad7164446f87b2f7fe3d883736 rdf:first sg:person.012705321277.28
100 rdf:rest rdf:nil
101 N263ac9b1e9c5407391ec0952b38dce40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Simian virus 40
103 rdf:type schema:DefinedTerm
104 N327fa70beb2845f9b6c21697675c7489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Protein Structure, Tertiary
106 rdf:type schema:DefinedTerm
107 N3c8ce96153e84f1691cd015bb22b52d3 schema:name pubmed_id
108 schema:value 17529992
109 rdf:type schema:PropertyValue
110 N3f2d620cbee142998d832440fcfe6c6c schema:name nlm_unique_id
111 schema:value 101186374
112 rdf:type schema:PropertyValue
113 N5599a4c4313d48cab4e9d28436847137 schema:name dimensions_id
114 schema:value pub.1004835472
115 rdf:type schema:PropertyValue
116 N5ae684ad6d664062b682faf6cc75b3ab schema:issueNumber 6
117 rdf:type schema:PublicationIssue
118 N5bc35e5d0eff4d67a1d5f98d4e7e2b21 rdf:first sg:person.01316646431.77
119 rdf:rest Ncd5dd76ce29d4fefbe0adc6f7cfae549
120 N7e1867f517514b1391d3cbef8d7a71bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cell Transformation, Viral
122 rdf:type schema:DefinedTerm
123 N8114703930ce4071833ed587d0ea0937 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Antigens, Viral, Tumor
125 rdf:type schema:DefinedTerm
126 N8196c4c40d664e54949e35739c17bb34 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N8383aeebaa8f4818b623e9903aaa4a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Electrophoresis, Polyacrylamide Gel
130 rdf:type schema:DefinedTerm
131 N88cc21360ac140928634954c38ba6187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Amino Acid Sequence
133 rdf:type schema:DefinedTerm
134 Na73d4c2059d947c19393788b456b533f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Protein Phosphatase 2
136 rdf:type schema:DefinedTerm
137 Naa850a7bd62948cbb245f7882b2df010 schema:volumeNumber 14
138 rdf:type schema:PublicationVolume
139 Nab0a0411fba242d5be7b9a92fa31a37c schema:name doi
140 schema:value 10.1038/nsmb1254
141 rdf:type schema:PropertyValue
142 Nb4d0387c38954e5db4a1ea08b0cd2d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Models, Molecular
144 rdf:type schema:DefinedTerm
145 Nc45ca854e4074f14a8d6be7a1fc62d6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Protein Subunits
147 rdf:type schema:DefinedTerm
148 Nc498f6e867e746a59a0811e7bc33d177 rdf:first sg:person.01167031023.54
149 rdf:rest N0d56111c4ab541ecaab784916eab915b
150 Ncd5dd76ce29d4fefbe0adc6f7cfae549 rdf:first sg:person.012037754077.80
151 rdf:rest Ne27f3207d0c84e6a86e0b6e74ff960f6
152 Nd651fe0fbc88492db7ee58e3f4bc63cf rdf:first sg:person.0732604444.84
153 rdf:rest N1a2f19ad7164446f87b2f7fe3d883736
154 Ne27f3207d0c84e6a86e0b6e74ff960f6 rdf:first sg:person.01263472517.82
155 rdf:rest Nc498f6e867e746a59a0811e7bc33d177
156 Ne9755bf920dd42c4ae89f5c03e151641 rdf:first sg:person.010010754312.30
157 rdf:rest Nd651fe0fbc88492db7ee58e3f4bc63cf
158 Nefc4ada8c37e49ab8110bd752320bb20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Molecular Sequence Data
160 rdf:type schema:DefinedTerm
161 Nfa33b954ab994621a68644a1d07d9275 rdf:first sg:person.0707470731.03
162 rdf:rest Ne9755bf920dd42c4ae89f5c03e151641
163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biological Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biochemistry and Cell Biology
168 rdf:type schema:DefinedTerm
169 sg:grant.2478954 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb1254
170 rdf:type schema:MonetaryGrant
171 sg:journal.1295033 schema:issn 1545-9993
172 2331-365X
173 schema:name Nature Structural & Molecular Biology
174 rdf:type schema:Periodical
175 sg:person.010010754312.30 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
176 schema:familyName Stock
177 schema:givenName Jeffry B
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010010754312.30
179 rdf:type schema:Person
180 sg:person.01167031023.54 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
181 schema:familyName Xing
182 schema:givenName Yongna
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167031023.54
184 rdf:type schema:Person
185 sg:person.012037754077.80 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
186 schema:familyName Xu
187 schema:givenName Yanhui
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012037754077.80
189 rdf:type schema:Person
190 sg:person.01263472517.82 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
191 schema:familyName Bao
192 schema:givenName Qing
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263472517.82
194 rdf:type schema:Person
195 sg:person.012705321277.28 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
196 schema:familyName Shi
197 schema:givenName Yigong
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28
199 rdf:type schema:Person
200 sg:person.01316646431.77 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
201 schema:familyName Chen
202 schema:givenName Yu
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316646431.77
204 rdf:type schema:Person
205 sg:person.0707470731.03 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
206 schema:familyName Lin
207 schema:givenName Zheng
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707470731.03
209 rdf:type schema:Person
210 sg:person.0732604444.84 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
211 schema:familyName Jeffrey
212 schema:givenName Philip D
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732604444.84
214 rdf:type schema:Person
215 sg:person.0755604131.07 schema:affiliation https://www.grid.ac/institutes/grid.16750.35
216 schema:familyName Li
217 schema:givenName Zhu
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755604131.07
219 rdf:type schema:Person
220 sg:pub.10.1038/nature05351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027078509
221 https://doi.org/10.1038/nature05351
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nmeth731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033723733
224 https://doi.org/10.1038/nmeth731
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1075047915 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1075606545 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1075949631 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1082404014 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1082627475 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1082653927 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1082723822 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082786184 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1083359444 schema:CreativeWork
235 https://doi.org/10.1006/jmbi.1993.1489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019247667
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0092-8674(90)90726-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1035355085
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0092-8674(93)90533-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1043750692
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0304-419x(93)90005-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1044945518
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.cell.2006.09.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047119200
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.cell.2006.11.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028113172
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.gde.2004.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051323142
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.molcel.2006.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004818084
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0076-6879(97)76066-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004907170
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0092-8674(00)80963-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046345009
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0955-0674(99)00074-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002618028
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s1535-6108(04)00026-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017377201
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s1535-6108(04)00027-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026207019
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1021/bi00397a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055173764
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1021/bi00455a010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055176938
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1021/bi00465a002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055177292
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1042/0264-6021:3530417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715265
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1042/bj3530417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033284032
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1073/pnas.84.14.4880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037417773
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1073/pnas.85.12.4252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041821813
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1073/pnas.87.7.2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000174874
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1074/jbc.273.52.35339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051691884
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1074/jbc.275.8.5257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008648486
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/emboj/20.1.295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005126648
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1107/s0021889891004399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014885043
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1107/s0907444905001617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044610818
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1432-1033.1993.tb17922.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008169915
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/j.1432-1033.1994.00899.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024378867
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1128/mcb.11.4.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028215003
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1128/mcb.11.4.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033226680
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1128/mcb.12.11.4872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017244907
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1128/mcb.17.3.1692 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014834661
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1128/mcb.17.8.4761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006499567
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/mcb.22.7.2111-2123.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050612433
306 rdf:type schema:CreativeWork
307 https://www.grid.ac/institutes/grid.16750.35 schema:alternateName Princeton University
308 schema:name Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA.
309 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...