Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06

AUTHORS

Albert Weixlbaumer, Frank V. Murphy, Agnieszka Dziergowska, Andrzej Malkiewicz, Franck A. P. Vendeix, Paul F. Agris, V. Ramakrishnan

ABSTRACT

One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA. More... »

PAGES

498-502

References to SciGraph publications

  • 2004-12. The role of modifications in codon discrimination by tRNALysUUU in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2001-04-01. A universal mode of helix packing in RNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb1242

    DOI

    http://dx.doi.org/10.1038/nsmb1242

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010194852

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17496902


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anticodon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Pairing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Codon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crystallography", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Structure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Transfer, Val", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Uridine", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "MRC Laboratory of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weixlbaumer", 
            "givenName": "Albert", 
            "id": "sg:person.01247730704.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247730704.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC Laboratory of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murphy", 
            "givenName": "Frank V.", 
            "id": "sg:person.01255545751.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255545751.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lodz University of Technology", 
              "id": "https://www.grid.ac/institutes/grid.412284.9", 
              "name": [
                "Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego str.116, 90923 Lodz, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dziergowska", 
            "givenName": "Agnieszka", 
            "id": "sg:person.01255462726.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255462726.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lodz University of Technology", 
              "id": "https://www.grid.ac/institutes/grid.412284.9", 
              "name": [
                "Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego str.116, 90923 Lodz, Poland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Malkiewicz", 
            "givenName": "Andrzej", 
            "id": "sg:person.01117754165.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117754165.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "North Carolina State University", 
              "id": "https://www.grid.ac/institutes/grid.40803.3f", 
              "name": [
                "Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695-7622, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vendeix", 
            "givenName": "Franck A. P.", 
            "id": "sg:person.0632463131.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632463131.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "North Carolina State University", 
              "id": "https://www.grid.ac/institutes/grid.40803.3f", 
              "name": [
                "Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695-7622, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agris", 
            "givenName": "Paul F.", 
            "id": "sg:person.0620164703.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620164703.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "MRC Laboratory of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramakrishnan", 
            "givenName": "V.", 
            "id": "sg:person.012153760672.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153760672.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1060612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002395498"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1131127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003901838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0021-9673(00)94152-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005245543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(68)90392-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006985872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009433151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/86221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012669006", 
              "https://doi.org/10.1038/86221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1522-2675(20000119)83:1<152::aid-hlca152>3.0.co;2-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014642672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444998003254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019779527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444904019158", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020281098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biophys.35.040405.101950", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021378067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2005.08.076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022683204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2005.08.076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022683204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.1.395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023209178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/26.1.148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023830553"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1261/rna.7106404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024114474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444994003112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025573949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2006.11.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029098827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.70.1.415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029650829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2001.4778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035035606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/5.11.4451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044743773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045212970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444998007100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046332682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)01086-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049702328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.74.061903.155440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050517369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.10.4160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050707702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051708431", 
              "https://doi.org/10.1038/nsmb861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051708431", 
              "https://doi.org/10.1038/nsmb861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889893005588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053164838"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1355838200992082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054923551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1355838299991173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054924069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja048730k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055837815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja048730k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055837815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076884530", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079603951", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079939977", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-06", 
        "datePublishedReg": "2007-06-01", 
        "description": "One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nsmb1242", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2772610", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines", 
        "pagination": "498-502", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3091f4651d3f055c32c652c6e8796ecd78c434909a0db57c33560432febfcc23"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "17496902"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101186374"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb1242"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010194852"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb1242", 
          "https://app.dimensions.ai/details/publication/pub.1010194852"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nsmb1242"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb1242'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb1242'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb1242'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb1242'


     

    This table displays all metadata directly associated to this object as RDF triples.

    258 TRIPLES      21 PREDICATES      72 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb1242 schema:about N0e44aa0e48054b95b66f421fdb264e4c
    2 N4d8a4b722be94a9f9c9bacbaae6a129b
    3 N636f1a1d26c94802915fa323ba402fe8
    4 N839c1437cbd6459d9362d0c15ddc8b8c
    5 Nb19b4580cdeb4e0aabcee978c616e18b
    6 Nbdaeaadbc84b4b429535b42a944f8d85
    7 Nbf289af0079946aba164192485e68b76
    8 Nc4ece774db9b41f4aca62eaf7ab61d2d
    9 Ne4bacb60308e4944b9c882829917ea56
    10 Ne510aeae74844b2aa9b527431e92f02b
    11 Nf6b0466d2544473389e54c93394eaac8
    12 anzsrc-for:06
    13 anzsrc-for:0601
    14 schema:author Nf17dfb9708a4487daf93f3bd5eca2f09
    15 schema:citation sg:pub.10.1038/86221
    16 sg:pub.10.1038/nsmb861
    17 https://app.dimensions.ai/details/publication/pub.1076884530
    18 https://app.dimensions.ai/details/publication/pub.1079603951
    19 https://app.dimensions.ai/details/publication/pub.1079939977
    20 https://doi.org/10.1002/(sici)1522-2675(20000119)83:1<152::aid-hlca152>3.0.co;2-1
    21 https://doi.org/10.1006/jmbi.2001.4778
    22 https://doi.org/10.1016/0022-2836(68)90392-6
    23 https://doi.org/10.1016/j.jmb.2005.08.076
    24 https://doi.org/10.1016/j.jmb.2006.11.046
    25 https://doi.org/10.1016/j.molcel.2006.11.014
    26 https://doi.org/10.1016/s0021-9673(00)94152-9
    27 https://doi.org/10.1016/s0092-8674(02)01086-3
    28 https://doi.org/10.1017/s1355838200992082
    29 https://doi.org/10.1017/s1355838299991173
    30 https://doi.org/10.1021/ja048730k
    31 https://doi.org/10.1073/pnas.91.10.4160
    32 https://doi.org/10.1093/nar/26.1.148
    33 https://doi.org/10.1093/nar/30.1.395
    34 https://doi.org/10.1093/nar/5.11.4451
    35 https://doi.org/10.1093/nar/gkg680
    36 https://doi.org/10.1107/s0021889893005588
    37 https://doi.org/10.1107/s0907444904019158
    38 https://doi.org/10.1107/s0907444994003112
    39 https://doi.org/10.1107/s0907444998003254
    40 https://doi.org/10.1107/s0907444998007100
    41 https://doi.org/10.1126/science.1060612
    42 https://doi.org/10.1126/science.1131127
    43 https://doi.org/10.1146/annurev.biochem.70.1.415
    44 https://doi.org/10.1146/annurev.biochem.74.061903.155440
    45 https://doi.org/10.1146/annurev.biophys.35.040405.101950
    46 https://doi.org/10.1261/rna.7106404
    47 schema:datePublished 2007-06
    48 schema:datePublishedReg 2007-06-01
    49 schema:description One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA.
    50 schema:genre research_article
    51 schema:inLanguage en
    52 schema:isAccessibleForFree true
    53 schema:isPartOf N0e0c9f01e1444d6897c718aa5e363da6
    54 Nee147c970b8a421cb4c5a38975cc52df
    55 sg:journal.1295033
    56 schema:name Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines
    57 schema:pagination 498-502
    58 schema:productId N415c58f3276c489ba7e7be0e572ce026
    59 N416e60c519284c69b4ef2ec8ceb31064
    60 N49631f82839a409083d361b210e4d3f8
    61 N8f993967ce2041db936c7e305d763e5b
    62 Nc0b962be348148d38b10dd2ba2aaca78
    63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010194852
    64 https://doi.org/10.1038/nsmb1242
    65 schema:sdDatePublished 2019-04-11T00:54
    66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    67 schema:sdPublisher N42124c7ce47c4cb19963c43f5693b7f9
    68 schema:url http://www.nature.com/articles/nsmb1242
    69 sgo:license sg:explorer/license/
    70 sgo:sdDataset articles
    71 rdf:type schema:ScholarlyArticle
    72 N02f407f1508647f0bb013dc97a1733b1 rdf:first sg:person.0632463131.74
    73 rdf:rest N97c3d4e1155748fbbd266616cb4eaea8
    74 N0e0c9f01e1444d6897c718aa5e363da6 schema:volumeNumber 14
    75 rdf:type schema:PublicationVolume
    76 N0e44aa0e48054b95b66f421fdb264e4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name RNA, Transfer, Val
    78 rdf:type schema:DefinedTerm
    79 N415c58f3276c489ba7e7be0e572ce026 schema:name pubmed_id
    80 schema:value 17496902
    81 rdf:type schema:PropertyValue
    82 N416e60c519284c69b4ef2ec8ceb31064 schema:name readcube_id
    83 schema:value 3091f4651d3f055c32c652c6e8796ecd78c434909a0db57c33560432febfcc23
    84 rdf:type schema:PropertyValue
    85 N42124c7ce47c4cb19963c43f5693b7f9 schema:name Springer Nature - SN SciGraph project
    86 rdf:type schema:Organization
    87 N42c4aaa44917481f8f43258698035106 rdf:first sg:person.01117754165.20
    88 rdf:rest N02f407f1508647f0bb013dc97a1733b1
    89 N49631f82839a409083d361b210e4d3f8 schema:name dimensions_id
    90 schema:value pub.1010194852
    91 rdf:type schema:PropertyValue
    92 N4d8a4b722be94a9f9c9bacbaae6a129b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Molecular Structure
    94 rdf:type schema:DefinedTerm
    95 N5799eb43e09a4800804243031f14972e rdf:first sg:person.012153760672.38
    96 rdf:rest rdf:nil
    97 N6174c9ef848e496fb692e8da703bd6f4 rdf:first sg:person.01255462726.05
    98 rdf:rest N42c4aaa44917481f8f43258698035106
    99 N636f1a1d26c94802915fa323ba402fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Codon
    101 rdf:type schema:DefinedTerm
    102 N839c1437cbd6459d9362d0c15ddc8b8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Uridine
    104 rdf:type schema:DefinedTerm
    105 N8f993967ce2041db936c7e305d763e5b schema:name doi
    106 schema:value 10.1038/nsmb1242
    107 rdf:type schema:PropertyValue
    108 N97c3d4e1155748fbbd266616cb4eaea8 rdf:first sg:person.0620164703.41
    109 rdf:rest N5799eb43e09a4800804243031f14972e
    110 Nb19b4580cdeb4e0aabcee978c616e18b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Crystallography
    112 rdf:type schema:DefinedTerm
    113 Nbdaeaadbc84b4b429535b42a944f8d85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Base Pairing
    115 rdf:type schema:DefinedTerm
    116 Nbf289af0079946aba164192485e68b76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Molecular Sequence Data
    118 rdf:type schema:DefinedTerm
    119 Nc0b962be348148d38b10dd2ba2aaca78 schema:name nlm_unique_id
    120 schema:value 101186374
    121 rdf:type schema:PropertyValue
    122 Nc4ece774db9b41f4aca62eaf7ab61d2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Anticodon
    124 rdf:type schema:DefinedTerm
    125 Nd8ffff524f124ecba05183c31e10fbaf rdf:first sg:person.01255545751.65
    126 rdf:rest N6174c9ef848e496fb692e8da703bd6f4
    127 Ne4bacb60308e4944b9c882829917ea56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Amino Acid Sequence
    129 rdf:type schema:DefinedTerm
    130 Ne510aeae74844b2aa9b527431e92f02b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Models, Molecular
    132 rdf:type schema:DefinedTerm
    133 Nee147c970b8a421cb4c5a38975cc52df schema:issueNumber 6
    134 rdf:type schema:PublicationIssue
    135 Nf17dfb9708a4487daf93f3bd5eca2f09 rdf:first sg:person.01247730704.66
    136 rdf:rest Nd8ffff524f124ecba05183c31e10fbaf
    137 Nf6b0466d2544473389e54c93394eaac8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Base Sequence
    139 rdf:type schema:DefinedTerm
    140 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Biological Sciences
    142 rdf:type schema:DefinedTerm
    143 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    144 schema:name Biochemistry and Cell Biology
    145 rdf:type schema:DefinedTerm
    146 sg:grant.2772610 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb1242
    147 rdf:type schema:MonetaryGrant
    148 sg:journal.1295033 schema:issn 1545-9993
    149 2331-365X
    150 schema:name Nature Structural & Molecular Biology
    151 rdf:type schema:Periodical
    152 sg:person.01117754165.20 schema:affiliation https://www.grid.ac/institutes/grid.412284.9
    153 schema:familyName Malkiewicz
    154 schema:givenName Andrzej
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117754165.20
    156 rdf:type schema:Person
    157 sg:person.012153760672.38 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
    158 schema:familyName Ramakrishnan
    159 schema:givenName V.
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012153760672.38
    161 rdf:type schema:Person
    162 sg:person.01247730704.66 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
    163 schema:familyName Weixlbaumer
    164 schema:givenName Albert
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247730704.66
    166 rdf:type schema:Person
    167 sg:person.01255462726.05 schema:affiliation https://www.grid.ac/institutes/grid.412284.9
    168 schema:familyName Dziergowska
    169 schema:givenName Agnieszka
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255462726.05
    171 rdf:type schema:Person
    172 sg:person.01255545751.65 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
    173 schema:familyName Murphy
    174 schema:givenName Frank V.
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255545751.65
    176 rdf:type schema:Person
    177 sg:person.0620164703.41 schema:affiliation https://www.grid.ac/institutes/grid.40803.3f
    178 schema:familyName Agris
    179 schema:givenName Paul F.
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620164703.41
    181 rdf:type schema:Person
    182 sg:person.0632463131.74 schema:affiliation https://www.grid.ac/institutes/grid.40803.3f
    183 schema:familyName Vendeix
    184 schema:givenName Franck A. P.
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632463131.74
    186 rdf:type schema:Person
    187 sg:pub.10.1038/86221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012669006
    188 https://doi.org/10.1038/86221
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nsmb861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051708431
    191 https://doi.org/10.1038/nsmb861
    192 rdf:type schema:CreativeWork
    193 https://app.dimensions.ai/details/publication/pub.1076884530 schema:CreativeWork
    194 https://app.dimensions.ai/details/publication/pub.1079603951 schema:CreativeWork
    195 https://app.dimensions.ai/details/publication/pub.1079939977 schema:CreativeWork
    196 https://doi.org/10.1002/(sici)1522-2675(20000119)83:1<152::aid-hlca152>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014642672
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1006/jmbi.2001.4778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035035606
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/0022-2836(68)90392-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006985872
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.jmb.2005.08.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022683204
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.jmb.2006.11.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029098827
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.molcel.2006.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009433151
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/s0021-9673(00)94152-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005245543
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/s0092-8674(02)01086-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049702328
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1017/s1355838200992082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923551
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1017/s1355838299991173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054924069
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1021/ja048730k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055837815
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1073/pnas.91.10.4160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050707702
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1093/nar/26.1.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023830553
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1093/nar/30.1.395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023209178
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1093/nar/5.11.4451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044743773
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1093/nar/gkg680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045212970
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1107/s0021889893005588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053164838
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1107/s0907444994003112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025573949
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1107/s0907444998003254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779527
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1107/s0907444998007100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046332682
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1126/science.1060612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002395498
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1126/science.1131127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003901838
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1146/annurev.biochem.70.1.415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029650829
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1146/annurev.biochem.74.061903.155440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050517369
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1146/annurev.biophys.35.040405.101950 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021378067
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1261/rna.7106404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024114474
    249 rdf:type schema:CreativeWork
    250 https://www.grid.ac/institutes/grid.40803.3f schema:alternateName North Carolina State University
    251 schema:name Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695-7622, USA
    252 rdf:type schema:Organization
    253 https://www.grid.ac/institutes/grid.412284.9 schema:alternateName Lodz University of Technology
    254 schema:name Institute of Organic Chemistry, Technical University of Lodz, Zeromskiego str.116, 90923 Lodz, Poland
    255 rdf:type schema:Organization
    256 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
    257 schema:name MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    258 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...