Mechanism for expanding the decoding capacity of transfer RNAs by modification of uridines View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-06

AUTHORS

Albert Weixlbaumer, Frank V. Murphy, Agnieszka Dziergowska, Andrzej Malkiewicz, Franck A. P. Vendeix, Paul F. Agris, V. Ramakrishnan

ABSTRACT

One of the most prevalent base modifications involved in decoding is uridine 5-oxyacetic acid at the wobble position of tRNA. It has been known for several decades that this modification enables a single tRNA to decode all four codons in a degenerate codon box. We have determined structures of an anticodon stem-loop of tRNA(Val) containing the modified uridine with all four valine codons in the decoding site of the 30S ribosomal subunit. An intramolecular hydrogen bond involving the modification helps to prestructure the anticodon loop. We found unusual base pairs with the three noncomplementary codon bases, including a G.U base pair in standard Watson-Crick geometry, which presumably involves an enol form for the uridine. These structures suggest how a modification in the uridine at the wobble position can expand the decoding capability of a tRNA. More... »

PAGES

498-502

References to SciGraph publications

  • 2004-12. The role of modifications in codon discrimination by tRNALysUUU in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2001-04-01. A universal mode of helix packing in RNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb1242

    DOI

    http://dx.doi.org/10.1038/nsmb1242

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17496902


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