Regulation of MLL1 H3K4 methyltransferase activity by its core components View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-08

AUTHORS

Yali Dou, Thomas A Milne, Alexander J Ruthenburg, Seunghee Lee, Jae Woon Lee, Gregory L Verdine, C David Allis, Robert G Roeder

ABSTRACT

Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4 methyltransferase complexes is the presence of three structural components (RbBP5, Ash2L and WDR5) and a catalytic subunit containing a SET domain. Here we report the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex. This reconstitution, combined with in vivo assays, allows direct analysis of the contribution of each component to MLL1 enzymatic activity and their roles in transcriptional regulation. Moreover, taking clues from a crystal structure analysis, we demonstrate that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate. Mechanistic insights gained from this study can be generalized to the whole family of SET1-like histone methyltransferases in mammals. More... »

PAGES

713-719

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1128

DOI

http://dx.doi.org/10.1038/nsmb1128

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047968845

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16878130


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