Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Paul Erbel, Nikolaus Schiering, Allan D'Arcy, Martin Renatus, Markus Kroemer, Siew Pheng Lim, Zheng Yin, Thomas H Keller, Subhash G Vasudevan, Ulrich Hommel

ABSTRACT

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation. More... »

PAGES

372-373

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1073

DOI

http://dx.doi.org/10.1038/nsmb1073

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052049654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16532006


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dengue Virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrogen Bonding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macromolecular Substances", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protease Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serine Endopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Nonstructural Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "West Nile virus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Novartis (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erbel", 
        "givenName": "Paul", 
        "id": "sg:person.012517331127.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012517331127.58"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Schiering", 
        "givenName": "Nikolaus", 
        "id": "sg:person.01007441325.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007441325.22"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "D'Arcy", 
        "givenName": "Allan", 
        "id": "sg:person.01104435336.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104435336.77"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Renatus", 
        "givenName": "Martin", 
        "id": "sg:person.0750356163.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750356163.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kroemer", 
        "givenName": "Markus", 
        "id": "sg:person.0715351377.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715351377.01"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lim", 
        "givenName": "Siew Pheng", 
        "id": "sg:person.0610631630.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610631630.28"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Yin", 
        "givenName": "Zheng", 
        "id": "sg:person.01236450746.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236450746.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Keller", 
        "givenName": "Thomas H", 
        "id": "sg:person.01015221706.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015221706.52"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Vasudevan", 
        "givenName": "Subhash G", 
        "id": "sg:person.01015306653.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015306653.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hommel", 
        "givenName": "Ulrich", 
        "id": "sg:person.01223331641.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223331641.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81350-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010755853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.14.9963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020441827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.9.5573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026117633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031742663", 
          "https://doi.org/10.1038/nature02099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031742663", 
          "https://doi.org/10.1038/nature02099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81351-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033096317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m406810200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038587075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2005.09.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042790848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2005.09.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042790848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m409931200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046465200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.mi.44.100190.003245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048592391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m107360200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048755027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.2000.3924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052887889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-80-5-1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060361218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082957603", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-04", 
    "datePublishedReg": "2006-04-01", 
    "description": "The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nsmb1073", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295033", 
        "issn": [
          "1545-9993", 
          "2331-365X"
        ], 
        "name": "Nature Structural & Molecular Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus", 
    "pagination": "372-373", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f7ee91ae753cb0b710815599f2884cb488341e9cf858db80ad3ebadb17bd143f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16532006"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101186374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nsmb1073"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052049654"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nsmb1073", 
      "https://app.dimensions.ai/details/publication/pub.1052049654"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_54003_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nsmb/journal/v13/n4/full/nsmb1073.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb1073'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb1073'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb1073'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb1073'


 

This table displays all metadata directly associated to this object as RDF triples.

210 TRIPLES      21 PREDICATES      54 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nsmb1073 schema:about N0fd94059475c4bbe8df70c6078e22435
2 N1d5d3d40fb1148db8de97b8234d042cf
3 N1e78ac798e8244a281f4cd5d327ea223
4 N2609fda4595a45a8bcf06a57e24e96c9
5 N2a1b0c06cf434960bd77814ce455a9f1
6 N5c45a0186d564dd88cd1a8426f09fe63
7 N8e94d48e128147d097049f060039c641
8 Na521c37cd4ef4a6fbc63b106ecf7cffe
9 Nab54fcc55b414cbf893a75e6207a4693
10 Nb49680c70f3a46a681df6a6d3acd1bb9
11 Nc2d2dfbb0ebe469db376cde80481352c
12 Nd3a4de51f36e4c858e2811232eac4143
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author N6ac217e1b9cd457394f88ac09f28d300
16 schema:citation sg:pub.10.1038/nature02099
17 https://app.dimensions.ai/details/publication/pub.1082957603
18 https://doi.org/10.1006/jmbi.2000.3924
19 https://doi.org/10.1016/j.bmcl.2005.09.049
20 https://doi.org/10.1016/s0092-8674(00)81350-1
21 https://doi.org/10.1016/s0092-8674(00)81351-3
22 https://doi.org/10.1074/jbc.274.9.5573
23 https://doi.org/10.1074/jbc.275.14.9963
24 https://doi.org/10.1074/jbc.m107360200
25 https://doi.org/10.1074/jbc.m406810200
26 https://doi.org/10.1074/jbc.m409931200
27 https://doi.org/10.1099/0022-1317-80-5-1167
28 https://doi.org/10.1146/annurev.mi.44.100190.003245
29 schema:datePublished 2006-04
30 schema:datePublishedReg 2006-04-01
31 schema:description The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N67051ca0e3ed4459b6d9eb5605e73d82
36 N8c6c4e29e0454f7891556dfa8873aa31
37 sg:journal.1295033
38 schema:name Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
39 schema:pagination 372-373
40 schema:productId N21fb1f0a127c46608798fd968e68eea6
41 N43d76026fe4c4239a92fb8aaaaa803fc
42 N59f1a854ce6c402ab3422ec14a84b317
43 Nd400007fb4714e3ca53805cc21202852
44 Nf0e28957866d4285b2f86878a22ee583
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052049654
46 https://doi.org/10.1038/nsmb1073
47 schema:sdDatePublished 2019-04-11T12:14
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N4d33f864a61542c0b4b3ce843d108d0c
50 schema:url http://www.nature.com/nsmb/journal/v13/n4/full/nsmb1073.html
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N0fd94059475c4bbe8df70c6078e22435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name West Nile virus
56 rdf:type schema:DefinedTerm
57 N14875e37b3734658af900c1b04a6ba9a rdf:first sg:person.01236450746.66
58 rdf:rest Na7744f14cf964594b78143c02bdb9f6c
59 N1d5d3d40fb1148db8de97b8234d042cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Protease Inhibitors
61 rdf:type schema:DefinedTerm
62 N1e78ac798e8244a281f4cd5d327ea223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name RNA Helicases
64 rdf:type schema:DefinedTerm
65 N21fb1f0a127c46608798fd968e68eea6 schema:name doi
66 schema:value 10.1038/nsmb1073
67 rdf:type schema:PropertyValue
68 N2609fda4595a45a8bcf06a57e24e96c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Models, Molecular
70 rdf:type schema:DefinedTerm
71 N2a1b0c06cf434960bd77814ce455a9f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Oligopeptides
73 rdf:type schema:DefinedTerm
74 N43d76026fe4c4239a92fb8aaaaa803fc schema:name pubmed_id
75 schema:value 16532006
76 rdf:type schema:PropertyValue
77 N4d33f864a61542c0b4b3ce843d108d0c schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N59f1a854ce6c402ab3422ec14a84b317 schema:name dimensions_id
80 schema:value pub.1052049654
81 rdf:type schema:PropertyValue
82 N5c45a0186d564dd88cd1a8426f09fe63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Enzyme Activation
84 rdf:type schema:DefinedTerm
85 N67051ca0e3ed4459b6d9eb5605e73d82 schema:volumeNumber 13
86 rdf:type schema:PublicationVolume
87 N6ac217e1b9cd457394f88ac09f28d300 rdf:first sg:person.012517331127.58
88 rdf:rest Nf29d9990c6d04d6188c510f7459cda9f
89 N77ce27e213104b13b6f1ce3adc714647 rdf:first sg:person.0610631630.28
90 rdf:rest N14875e37b3734658af900c1b04a6ba9a
91 N8c6c4e29e0454f7891556dfa8873aa31 schema:issueNumber 4
92 rdf:type schema:PublicationIssue
93 N8e94d48e128147d097049f060039c641 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Hydrogen Bonding
95 rdf:type schema:DefinedTerm
96 Na521c37cd4ef4a6fbc63b106ecf7cffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Serine Endopeptidases
98 rdf:type schema:DefinedTerm
99 Na7744f14cf964594b78143c02bdb9f6c rdf:first sg:person.01015221706.52
100 rdf:rest Nec6a5027472f4b608274528d67440fdf
101 Nab54fcc55b414cbf893a75e6207a4693 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Binding Sites
103 rdf:type schema:DefinedTerm
104 Nb49680c70f3a46a681df6a6d3acd1bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Dengue Virus
106 rdf:type schema:DefinedTerm
107 Nb54f6e8e69304414a7d13733d21b7561 rdf:first sg:person.01104435336.77
108 rdf:rest Ncce302d13ad84e1a8e0924339d14c6e7
109 Nc2d2dfbb0ebe469db376cde80481352c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Macromolecular Substances
111 rdf:type schema:DefinedTerm
112 Nc63350caa2e4402aab701596b23a1290 rdf:first sg:person.01223331641.64
113 rdf:rest rdf:nil
114 Ncce302d13ad84e1a8e0924339d14c6e7 rdf:first sg:person.0750356163.12
115 rdf:rest Neb1d79e572de4044806998df659403a7
116 Nd3a4de51f36e4c858e2811232eac4143 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Viral Nonstructural Proteins
118 rdf:type schema:DefinedTerm
119 Nd400007fb4714e3ca53805cc21202852 schema:name nlm_unique_id
120 schema:value 101186374
121 rdf:type schema:PropertyValue
122 Neb1d79e572de4044806998df659403a7 rdf:first sg:person.0715351377.01
123 rdf:rest N77ce27e213104b13b6f1ce3adc714647
124 Nec6a5027472f4b608274528d67440fdf rdf:first sg:person.01015306653.11
125 rdf:rest Nc63350caa2e4402aab701596b23a1290
126 Nf0e28957866d4285b2f86878a22ee583 schema:name readcube_id
127 schema:value f7ee91ae753cb0b710815599f2884cb488341e9cf858db80ad3ebadb17bd143f
128 rdf:type schema:PropertyValue
129 Nf29d9990c6d04d6188c510f7459cda9f rdf:first sg:person.01007441325.22
130 rdf:rest Nb54f6e8e69304414a7d13733d21b7561
131 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biological Sciences
133 rdf:type schema:DefinedTerm
134 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
135 schema:name Biochemistry and Cell Biology
136 rdf:type schema:DefinedTerm
137 sg:journal.1295033 schema:issn 1545-9993
138 2331-365X
139 schema:name Nature Structural & Molecular Biology
140 rdf:type schema:Periodical
141 sg:person.01007441325.22 schema:familyName Schiering
142 schema:givenName Nikolaus
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007441325.22
144 rdf:type schema:Person
145 sg:person.01015221706.52 schema:familyName Keller
146 schema:givenName Thomas H
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015221706.52
148 rdf:type schema:Person
149 sg:person.01015306653.11 schema:familyName Vasudevan
150 schema:givenName Subhash G
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015306653.11
152 rdf:type schema:Person
153 sg:person.01104435336.77 schema:familyName D'Arcy
154 schema:givenName Allan
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104435336.77
156 rdf:type schema:Person
157 sg:person.01223331641.64 schema:familyName Hommel
158 schema:givenName Ulrich
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223331641.64
160 rdf:type schema:Person
161 sg:person.01236450746.66 schema:familyName Yin
162 schema:givenName Zheng
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236450746.66
164 rdf:type schema:Person
165 sg:person.012517331127.58 schema:affiliation https://www.grid.ac/institutes/grid.419481.1
166 schema:familyName Erbel
167 schema:givenName Paul
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012517331127.58
169 rdf:type schema:Person
170 sg:person.0610631630.28 schema:familyName Lim
171 schema:givenName Siew Pheng
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610631630.28
173 rdf:type schema:Person
174 sg:person.0715351377.01 schema:familyName Kroemer
175 schema:givenName Markus
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715351377.01
177 rdf:type schema:Person
178 sg:person.0750356163.12 schema:familyName Renatus
179 schema:givenName Martin
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750356163.12
181 rdf:type schema:Person
182 sg:pub.10.1038/nature02099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031742663
183 https://doi.org/10.1038/nature02099
184 rdf:type schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1082957603 schema:CreativeWork
186 https://doi.org/10.1006/jmbi.2000.3924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052887889
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.bmcl.2005.09.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042790848
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0092-8674(00)81350-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010755853
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0092-8674(00)81351-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033096317
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1074/jbc.274.9.5573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026117633
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1074/jbc.275.14.9963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020441827
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1074/jbc.m107360200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048755027
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1074/jbc.m406810200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038587075
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1074/jbc.m409931200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046465200
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1099/0022-1317-80-5-1167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060361218
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1146/annurev.mi.44.100190.003245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048592391
207 rdf:type schema:CreativeWork
208 https://www.grid.ac/institutes/grid.419481.1 schema:alternateName Novartis (Switzerland)
209 schema:name Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland.
210 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...