Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Paul Erbel, Nikolaus Schiering, Allan D'Arcy, Martin Renatus, Markus Kroemer, Siew Pheng Lim, Zheng Yin, Thomas H Keller, Subhash G Vasudevan, Ulrich Hommel

ABSTRACT

The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation. More... »

PAGES

372-373

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb1073

DOI

http://dx.doi.org/10.1038/nsmb1073

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052049654

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16532006


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