RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-01

AUTHORS

Andrea Újvári, Donal S Luse

ABSTRACT

Structural studies of RNA polymerase II have suggested two possible exit paths for the nascent RNA: groove 1, which points toward the subcomplex of subunits Rpb4 and Rpb7, and groove 2, which points toward Rpb8. These alternatives could not be distinguished previously because less than 10 nucleotides (nt) of transcript were resolved in the structures. We have approached this question by UV cross-linking nascent RNA to components of the transcription complex through uridine analogs located within the first six nucleotides of the RNA. We find that the emerging transcript cross-links to the Rpb7 subunit of RNA polymerase II in various complexes containing 26- to 32-nt transcripts. This interaction is greatly reduced in complexes with 41- or 43-nt RNAs and absent when the transcript is 125 nt. Our results are consistent with groove 1 being the exit path for nascent RNA. More... »

PAGES

49-54

References to SciGraph publications

  • 2000-01-01. Intron recognition comes of AGe in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2002-04. An extensive network of coupling among gene expression machines in NATURE
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    http://scigraph.springernature.com/pub.10.1038/nsmb1026

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    http://dx.doi.org/10.1038/nsmb1026

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16327806


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