Transcriptional noise and the fidelity of initiation by RNA polymerase II View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-02

AUTHORS

Kevin Struhl

ABSTRACT

Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that 90% of Pol II initiation events in yeast represent transcriptional noise, and that the specificity of initiation is comparable to that of DNA-binding proteins and other biological processes. This emphasizes the need to develop criteria that distinguish transcriptional noise from transcription with a biological function. More... »

PAGES

103-105

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb0207-103

DOI

http://dx.doi.org/10.1038/nsmb0207-103

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042141499

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17277804


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