A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

Lina Vasiliauskaitė, Dimitrios Vitsios, Rebecca V Berrens, Claudia Carrieri, Wolf Reik, Anton J Enright, Dónal O'Carroll

ABSTRACT

In mice, the pathway involving PIWI and PIWI-interacting RNA (PIWI-piRNA) is essential to re-establish transposon silencing during male-germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2's binding to piRNA and its nuclear localization are proposed to be dependent upon MILI function. Here, we demonstrate the existence of a piRNA biogenesis pathway that sustains partial MIWI2 function and reprogramming activity in the absence of MILI. More... »

PAGES

604-606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.3413

DOI

http://dx.doi.org/10.1038/nsmb.3413

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085460565

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28530707


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