Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Yuanliang Zhai, Erchao Cheng, Hao Wu, Ningning Li, Philip Yuk Kwong Yung, Ning Gao, Bik-Kwoon Tye

ABSTRACT

The minichromosome maintenance complex (MCM) hexameric complex (Mcm2-7) forms the core of the eukaryotic replicative helicase. During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed loading mechanism remains unclear. Here we examine the structures of the yeast MCM hexamer and Cdt1-MCM heptamer from Saccharomyces cerevisiae. Both complexes form left-handed coil structures with a 10-15-Å gap between Mcm5 and Mcm2, and a central channel that is occluded by the C-terminal domain winged-helix motif of Mcm5. Cdt1 wraps around the N-terminal regions of Mcm2, Mcm6 and Mcm4 to stabilize the whole complex. The intrinsic coiled structures of the precursors provide insights into the DH formation, and suggest a spring-action model for the MCM during the initial origin melting and the subsequent DNA unwinding. More... »

PAGES

300-308

References to SciGraph publications

  • 2013-08. Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2011-04. The structural basis for MCM2–7 helicase activation by GINS and Cdc45 in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2016-03. Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012. MCM Structure and Mechanics: What We Have Learned from Archaeal MCM in THE EUKARYOTIC REPLISOME: A GUIDE TO PROTEIN STRUCTURE AND FUNCTION
  • 2013-06. Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM in NATURE METHODS
  • 2015-08. Structure of the eukaryotic MCM complex at 3.8 Å in NATURE
  • 2008-12. SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs in NATURE PROTOCOLS
  • 2004-08. Structural basis for inhibition of the replication licensing factor Cdt1 by geminin in NATURE
  • 2007-01. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast in NATURE
  • 2015-01. The I-TASSER Suite: protein structure and function prediction in NATURE METHODS
  • 2005. DNA Replication and Genomic Instability in GENOME INSTABILITY IN CANCER DEVELOPMENT
  • 2004-06. Structural analysis of a eukaryotic sliding DNA clamp–clamp loader complex in NATURE
  • 2013-03. ATPase-dependent quality control of DNA replication origin licensing in NATURE
  • 2015-03. Regulated eukaryotic DNA replication origin firing with purified proteins in NATURE
  • 2007-01. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast in NATURE
  • 2002-03. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase in NATURE CELL BIOLOGY
  • 2016-02-18. Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate in NATURE COMMUNICATIONS
  • 2015-02. Mechanistic insights into the recycling machine of the SNARE complex in NATURE
  • 2012. The RFC Clamp Loader: Structure and Function in THE EUKARYOTIC REPLISOME: A GUIDE TO PROTEIN STRUCTURE AND FUNCTION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.3374

    DOI

    http://dx.doi.org/10.1038/nsmb.3374

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083801556

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28191894


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenylyl Imidodiphosphate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Motifs", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cryoelectron Microscopy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Minichromosome Maintenance Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Domains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Multimerization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Structure, Secondary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Subunits", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Saccharomyces cerevisiae Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Zinc Fingers", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hong Kong University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.24515.37", 
              "name": [
                "Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.", 
                "Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhai", 
            "givenName": "Yuanliang", 
            "id": "sg:person.01024542635.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024542635.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cheng", 
            "givenName": "Erchao", 
            "id": "sg:person.01233624267.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233624267.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Hao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Peking University", 
              "id": "https://www.grid.ac/institutes/grid.11135.37", 
              "name": [
                "Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Ningning", 
            "id": "sg:person.01114032156.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114032156.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hong Kong University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.24515.37", 
              "name": [
                "Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yung", 
            "givenName": "Philip Yuk Kwong", 
            "id": "sg:person.0742306365.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742306365.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tsinghua University", 
              "id": "https://www.grid.ac/institutes/grid.12527.33", 
              "name": [
                "Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gao", 
            "givenName": "Ning", 
            "id": "sg:person.01126704766.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126704766.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cornell University", 
              "id": "https://www.grid.ac/institutes/grid.5386.8", 
              "name": [
                "Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.", 
                "Department of Molecular Biology and Genetics, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tye", 
            "givenName": "Bik-Kwoon", 
            "id": "sg:person.0677741301.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677741301.33"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.sbi.2013.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000985943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.03433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002193907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11920", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003048912", 
              "https://doi.org/10.1038/nature11920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003189182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444912001308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005539810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcdb.2014.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007020671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007234009", 
              "https://doi.org/10.1038/nature14285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2013.03.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007887819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2008.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008212112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.20084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008225564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.094169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.242313.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012908774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.01993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013205061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0905281106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014393677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014449249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-052610-094414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014884421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a010108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015092742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.2011511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017069821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017369330", 
              "https://doi.org/10.1038/nsmb.2629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr1118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017498005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017905987", 
              "https://doi.org/10.1038/nature05432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017905987", 
              "https://doi.org/10.1038/nature05432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/1-4020-3764-3_9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018806499", 
              "https://doi.org/10.1007/1-4020-3764-3_9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2012.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019988217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-4572-8_14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020442851", 
              "https://doi.org/10.1007/978-94-007-4572-8_14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0907444909052925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/305497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021300168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.06.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021878467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1209406109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021992511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022060714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2006.07.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022179585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2011.11.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022627276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024121020", 
              "https://doi.org/10.1038/ncomms10708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.115.186452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024855559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.115.186452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024855559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.075333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025248109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025683200", 
              "https://doi.org/10.1038/nature02813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025683200", 
              "https://doi.org/10.1038/nature02813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026949821", 
              "https://doi.org/10.1038/nmeth.3213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027378388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027378388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027770287", 
              "https://doi.org/10.1038/nature14148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2008.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028150318", 
              "https://doi.org/10.1038/nprot.2008.156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.68.1.649", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028935381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201593552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031154978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a012807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031215402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2004.11.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032128252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032237738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.06.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032478305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/emboj.2011.394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034090777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1933010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035610853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848481", 
              "https://doi.org/10.1038/ncb757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848481", 
              "https://doi.org/10.1038/ncb757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1883410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036815090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038111337", 
              "https://doi.org/10.1038/nsmb.2004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a010371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039462025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mmbr.00019-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039632404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039721868", 
              "https://doi.org/10.1038/nature14685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040200713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.242404.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041205054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042319022", 
              "https://doi.org/10.1038/nature05465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042319022", 
              "https://doi.org/10.1038/nature05465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2008.05.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042577158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-007-4572-8_6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043067409", 
              "https://doi.org/10.1007/978-94-007-4572-8_6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043106179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043106179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043603800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1596807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043604805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.03273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044177281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0911500106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044523994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.06.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044927218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046186049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00069-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046234181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1047-8477(03)00069-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046234181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1759609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049980699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050203089", 
              "https://doi.org/10.1038/nmeth.2472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2011.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050985160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051033134", 
              "https://doi.org/10.1038/nature02585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051033134", 
              "https://doi.org/10.1038/nature02585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051947060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.07.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052894008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.030539597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052994185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.3170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053369012", 
              "https://doi.org/10.1038/nsmb.3170"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-03", 
        "datePublishedReg": "2017-03-01", 
        "description": "The minichromosome maintenance complex (MCM) hexameric complex (Mcm2-7) forms the core of the eukaryotic replicative helicase. During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed loading mechanism remains unclear. Here we examine the structures of the yeast MCM hexamer and Cdt1-MCM heptamer from Saccharomyces cerevisiae. Both complexes form left-handed coil structures with a 10-15-\u00c5 gap between Mcm5 and Mcm2, and a central channel that is occluded by the C-terminal domain winged-helix motif of Mcm5. Cdt1 wraps around the N-terminal regions of Mcm2, Mcm6 and Mcm4 to stabilize the whole complex. The intrinsic coiled structures of the precursors provide insights into the DH formation, and suggest a spring-action model for the MCM during the initial origin melting and the subsequent DNA unwinding.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nsmb.3374", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7435980", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7429718", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7429702", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7429721", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "name": "Open-ringed structure of the Cdt1\u2013Mcm2\u20137 complex as a precursor of the MCM double hexamer", 
        "pagination": "300-308", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4fd67e481cda06ed6675b3e1bee90f53c9eefaf3bbd1836d7b06de9ca5019f76"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28191894"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101186374"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb.3374"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083801556"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb.3374", 
          "https://app.dimensions.ai/details/publication/pub.1083801556"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000427.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nsmb.3374"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3374'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3374'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3374'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3374'


     

    This table displays all metadata directly associated to this object as RDF triples.

    426 TRIPLES      21 PREDICATES      117 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb.3374 schema:about N043f5cb3a8dc401cbd70f3d8a3ba3f73
    2 N1789d53c9104438ba460add65ab400e6
    3 N2b2bf89efca947e3b5bc0868c1f39a27
    4 N4f61d65fc8f94bb79a62c423d7c04094
    5 N5bf7ea0ff32c4fdab13cdfefd8e27c1d
    6 N741ee1c9f4bf43e3995f4c9aa6a56bb6
    7 N78483005f679497e98287eccaea8dd57
    8 N898d35983b484a9387a4622636e227d8
    9 N9a6119ddff3747bdb08688c08bc6f300
    10 N9e2425bae76f4d5e9608d00a415711e1
    11 Nab99d9b9bfda436989012689980707a6
    12 Nc591cc8b07b441428ba7c5476f130897
    13 Nf327f462aa854eb781826dd801aa3675
    14 Nfe10a84700ba49bba36cacbd2f7938c6
    15 anzsrc-for:06
    16 anzsrc-for:0601
    17 schema:author Nc3dc6fb92a7d4e3d88f47d8a7cb949e4
    18 schema:citation sg:pub.10.1007/1-4020-3764-3_9
    19 sg:pub.10.1007/978-94-007-4572-8_14
    20 sg:pub.10.1007/978-94-007-4572-8_6
    21 sg:pub.10.1038/nature02585
    22 sg:pub.10.1038/nature02813
    23 sg:pub.10.1038/nature05432
    24 sg:pub.10.1038/nature05465
    25 sg:pub.10.1038/nature11920
    26 sg:pub.10.1038/nature14148
    27 sg:pub.10.1038/nature14285
    28 sg:pub.10.1038/nature14685
    29 sg:pub.10.1038/ncb757
    30 sg:pub.10.1038/ncomms10708
    31 sg:pub.10.1038/nmeth.2472
    32 sg:pub.10.1038/nmeth.3213
    33 sg:pub.10.1038/nprot.2008.156
    34 sg:pub.10.1038/nsmb.2004
    35 sg:pub.10.1038/nsmb.2629
    36 sg:pub.10.1038/nsmb.3170
    37 https://doi.org/10.1002/jcc.20084
    38 https://doi.org/10.1002/pro.236
    39 https://doi.org/10.1016/j.cell.2009.10.015
    40 https://doi.org/10.1016/j.cell.2011.06.012
    41 https://doi.org/10.1016/j.cell.2011.07.045
    42 https://doi.org/10.1016/j.cell.2012.09.014
    43 https://doi.org/10.1016/j.cell.2013.03.006
    44 https://doi.org/10.1016/j.cell.2015.03.012
    45 https://doi.org/10.1016/j.celrep.2014.02.022
    46 https://doi.org/10.1016/j.cub.2011.11.038
    47 https://doi.org/10.1016/j.jsb.2012.09.006
    48 https://doi.org/10.1016/j.molcel.2004.11.038
    49 https://doi.org/10.1016/j.molcel.2006.07.033
    50 https://doi.org/10.1016/j.molcel.2008.05.020
    51 https://doi.org/10.1016/j.molcel.2013.03.026
    52 https://doi.org/10.1016/j.molcel.2014.06.033
    53 https://doi.org/10.1016/j.molcel.2014.06.034
    54 https://doi.org/10.1016/j.molcel.2015.12.005
    55 https://doi.org/10.1016/j.sbi.2008.01.007
    56 https://doi.org/10.1016/j.sbi.2011.01.002
    57 https://doi.org/10.1016/j.sbi.2013.11.006
    58 https://doi.org/10.1016/j.semcdb.2014.03.008
    59 https://doi.org/10.1016/s1047-8477(03)00069-8
    60 https://doi.org/10.1038/emboj.2011.394
    61 https://doi.org/10.1073/pnas.030539597
    62 https://doi.org/10.1073/pnas.0905281106
    63 https://doi.org/10.1073/pnas.0911500106
    64 https://doi.org/10.1073/pnas.1209406109
    65 https://doi.org/10.1074/jbc.m109.075333
    66 https://doi.org/10.1093/nar/gkr1118
    67 https://doi.org/10.1093/nar/gkt1148
    68 https://doi.org/10.1093/nar/gkt381
    69 https://doi.org/10.1093/nar/gkv120
    70 https://doi.org/10.1101/cshperspect.a010108
    71 https://doi.org/10.1101/cshperspect.a010371
    72 https://doi.org/10.1101/cshperspect.a012807
    73 https://doi.org/10.1101/gad.1596807
    74 https://doi.org/10.1101/gad.1759609
    75 https://doi.org/10.1101/gad.1883410
    76 https://doi.org/10.1101/gad.1933010
    77 https://doi.org/10.1101/gad.2011511
    78 https://doi.org/10.1101/gad.242313.114
    79 https://doi.org/10.1101/gad.242404.114
    80 https://doi.org/10.1107/s0907444909052925
    81 https://doi.org/10.1107/s0907444912001308
    82 https://doi.org/10.1128/mmbr.00019-09
    83 https://doi.org/10.1146/annurev-biochem-052610-094414
    84 https://doi.org/10.1146/annurev.biochem.68.1.649
    85 https://doi.org/10.1155/2015/305497
    86 https://doi.org/10.1242/jcs.094169
    87 https://doi.org/10.15252/embj.201593552
    88 https://doi.org/10.1534/genetics.115.186452
    89 https://doi.org/10.7554/elife.01993
    90 https://doi.org/10.7554/elife.03273
    91 https://doi.org/10.7554/elife.03433
    92 schema:datePublished 2017-03
    93 schema:datePublishedReg 2017-03-01
    94 schema:description The minichromosome maintenance complex (MCM) hexameric complex (Mcm2-7) forms the core of the eukaryotic replicative helicase. During G1 phase, two Cdt1-Mcm2-7 heptamers are loaded onto each replication origin by the origin-recognition complex (ORC) and Cdc6 to form an inactive MCM double hexamer (DH), but the detailed loading mechanism remains unclear. Here we examine the structures of the yeast MCM hexamer and Cdt1-MCM heptamer from Saccharomyces cerevisiae. Both complexes form left-handed coil structures with a 10-15-Å gap between Mcm5 and Mcm2, and a central channel that is occluded by the C-terminal domain winged-helix motif of Mcm5. Cdt1 wraps around the N-terminal regions of Mcm2, Mcm6 and Mcm4 to stabilize the whole complex. The intrinsic coiled structures of the precursors provide insights into the DH formation, and suggest a spring-action model for the MCM during the initial origin melting and the subsequent DNA unwinding.
    95 schema:genre research_article
    96 schema:inLanguage en
    97 schema:isAccessibleForFree false
    98 schema:isPartOf N3d1b14e80cbe48e085f88ab735d71a77
    99 Nc6e2d80de7c947f3b4fad4c4736fbc8c
    100 sg:journal.1295033
    101 schema:name Open-ringed structure of the Cdt1–Mcm2–7 complex as a precursor of the MCM double hexamer
    102 schema:pagination 300-308
    103 schema:productId N24cd2a1a314042f4b4f90ce3b8e81159
    104 N659e4e1a7d034a59a95e13a296f392a7
    105 N6ce7fd7dbf8f4ad0813524bc041d2591
    106 Na8e288ca28904c9eae3a0cca52c1fc8a
    107 Nfefff367e5c846059c05e6e00ba52409
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083801556
    109 https://doi.org/10.1038/nsmb.3374
    110 schema:sdDatePublished 2019-04-10T13:00
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N3b299ed1f1384ceca39000853df76f2b
    113 schema:url http://www.nature.com/articles/nsmb.3374
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N043f5cb3a8dc401cbd70f3d8a3ba3f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Models, Molecular
    119 rdf:type schema:DefinedTerm
    120 N1789d53c9104438ba460add65ab400e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Saccharomyces cerevisiae Proteins
    122 rdf:type schema:DefinedTerm
    123 N24cd2a1a314042f4b4f90ce3b8e81159 schema:name doi
    124 schema:value 10.1038/nsmb.3374
    125 rdf:type schema:PropertyValue
    126 N2b2bf89efca947e3b5bc0868c1f39a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name DNA-Binding Proteins
    128 rdf:type schema:DefinedTerm
    129 N3b299ed1f1384ceca39000853df76f2b schema:name Springer Nature - SN SciGraph project
    130 rdf:type schema:Organization
    131 N3d1b14e80cbe48e085f88ab735d71a77 schema:issueNumber 3
    132 rdf:type schema:PublicationIssue
    133 N4b0f0043b79b4cadbb0cc616aff1461c rdf:first sg:person.01114032156.13
    134 rdf:rest Nb91808b38a8946a8ac001ea0370a5593
    135 N4f61d65fc8f94bb79a62c423d7c04094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Minichromosome Maintenance Proteins
    137 rdf:type schema:DefinedTerm
    138 N5626c82827b5435092b9e23469ba0fa1 rdf:first Nba6c2d9dc0a640a9a455908d2993d34c
    139 rdf:rest N4b0f0043b79b4cadbb0cc616aff1461c
    140 N5bf7ea0ff32c4fdab13cdfefd8e27c1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Protein Subunits
    142 rdf:type schema:DefinedTerm
    143 N6134609667984815b9d686e338b3ebba rdf:first sg:person.01126704766.30
    144 rdf:rest N715345c773274e6aa88fc4c411940957
    145 N659e4e1a7d034a59a95e13a296f392a7 schema:name nlm_unique_id
    146 schema:value 101186374
    147 rdf:type schema:PropertyValue
    148 N6ce7fd7dbf8f4ad0813524bc041d2591 schema:name readcube_id
    149 schema:value 4fd67e481cda06ed6675b3e1bee90f53c9eefaf3bbd1836d7b06de9ca5019f76
    150 rdf:type schema:PropertyValue
    151 N715345c773274e6aa88fc4c411940957 rdf:first sg:person.0677741301.33
    152 rdf:rest rdf:nil
    153 N741ee1c9f4bf43e3995f4c9aa6a56bb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Saccharomyces cerevisiae
    155 rdf:type schema:DefinedTerm
    156 N78483005f679497e98287eccaea8dd57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Cell Cycle Proteins
    158 rdf:type schema:DefinedTerm
    159 N898d35983b484a9387a4622636e227d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Protein Domains
    161 rdf:type schema:DefinedTerm
    162 N9a6119ddff3747bdb08688c08bc6f300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Adenylyl Imidodiphosphate
    164 rdf:type schema:DefinedTerm
    165 N9e2425bae76f4d5e9608d00a415711e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Cryoelectron Microscopy
    167 rdf:type schema:DefinedTerm
    168 Na8e288ca28904c9eae3a0cca52c1fc8a schema:name dimensions_id
    169 schema:value pub.1083801556
    170 rdf:type schema:PropertyValue
    171 Nab99d9b9bfda436989012689980707a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Protein Multimerization
    173 rdf:type schema:DefinedTerm
    174 Nb91808b38a8946a8ac001ea0370a5593 rdf:first sg:person.0742306365.99
    175 rdf:rest N6134609667984815b9d686e338b3ebba
    176 Nba6c2d9dc0a640a9a455908d2993d34c schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    177 schema:familyName Wu
    178 schema:givenName Hao
    179 rdf:type schema:Person
    180 Nc3dc6fb92a7d4e3d88f47d8a7cb949e4 rdf:first sg:person.01024542635.29
    181 rdf:rest Ne1af2cd298134850baf91d625c8c3b52
    182 Nc591cc8b07b441428ba7c5476f130897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Zinc Fingers
    184 rdf:type schema:DefinedTerm
    185 Nc6e2d80de7c947f3b4fad4c4736fbc8c schema:volumeNumber 24
    186 rdf:type schema:PublicationVolume
    187 Ne1af2cd298134850baf91d625c8c3b52 rdf:first sg:person.01233624267.15
    188 rdf:rest N5626c82827b5435092b9e23469ba0fa1
    189 Nf327f462aa854eb781826dd801aa3675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Amino Acid Motifs
    191 rdf:type schema:DefinedTerm
    192 Nfe10a84700ba49bba36cacbd2f7938c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Protein Structure, Secondary
    194 rdf:type schema:DefinedTerm
    195 Nfefff367e5c846059c05e6e00ba52409 schema:name pubmed_id
    196 schema:value 28191894
    197 rdf:type schema:PropertyValue
    198 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Biological Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Biochemistry and Cell Biology
    203 rdf:type schema:DefinedTerm
    204 sg:grant.7429702 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3374
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.7429718 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3374
    207 rdf:type schema:MonetaryGrant
    208 sg:grant.7429721 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3374
    209 rdf:type schema:MonetaryGrant
    210 sg:grant.7435980 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3374
    211 rdf:type schema:MonetaryGrant
    212 sg:journal.1295033 schema:issn 1545-9993
    213 2331-365X
    214 schema:name Nature Structural & Molecular Biology
    215 rdf:type schema:Periodical
    216 sg:person.01024542635.29 schema:affiliation https://www.grid.ac/institutes/grid.24515.37
    217 schema:familyName Zhai
    218 schema:givenName Yuanliang
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024542635.29
    220 rdf:type schema:Person
    221 sg:person.01114032156.13 schema:affiliation https://www.grid.ac/institutes/grid.11135.37
    222 schema:familyName Li
    223 schema:givenName Ningning
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114032156.13
    225 rdf:type schema:Person
    226 sg:person.01126704766.30 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    227 schema:familyName Gao
    228 schema:givenName Ning
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126704766.30
    230 rdf:type schema:Person
    231 sg:person.01233624267.15 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
    232 schema:familyName Cheng
    233 schema:givenName Erchao
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233624267.15
    235 rdf:type schema:Person
    236 sg:person.0677741301.33 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
    237 schema:familyName Tye
    238 schema:givenName Bik-Kwoon
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677741301.33
    240 rdf:type schema:Person
    241 sg:person.0742306365.99 schema:affiliation https://www.grid.ac/institutes/grid.24515.37
    242 schema:familyName Yung
    243 schema:givenName Philip Yuk Kwong
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742306365.99
    245 rdf:type schema:Person
    246 sg:pub.10.1007/1-4020-3764-3_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018806499
    247 https://doi.org/10.1007/1-4020-3764-3_9
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/978-94-007-4572-8_14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020442851
    250 https://doi.org/10.1007/978-94-007-4572-8_14
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/978-94-007-4572-8_6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043067409
    253 https://doi.org/10.1007/978-94-007-4572-8_6
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nature02585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051033134
    256 https://doi.org/10.1038/nature02585
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/nature02813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025683200
    259 https://doi.org/10.1038/nature02813
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/nature05432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017905987
    262 https://doi.org/10.1038/nature05432
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nature05465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042319022
    265 https://doi.org/10.1038/nature05465
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/nature11920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003048912
    268 https://doi.org/10.1038/nature11920
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nature14148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027770287
    271 https://doi.org/10.1038/nature14148
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nature14285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007234009
    274 https://doi.org/10.1038/nature14285
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/nature14685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039721868
    277 https://doi.org/10.1038/nature14685
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/ncb757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035848481
    280 https://doi.org/10.1038/ncb757
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/ncomms10708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024121020
    283 https://doi.org/10.1038/ncomms10708
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/nmeth.2472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050203089
    286 https://doi.org/10.1038/nmeth.2472
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/nmeth.3213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026949821
    289 https://doi.org/10.1038/nmeth.3213
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nprot.2008.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028150318
    292 https://doi.org/10.1038/nprot.2008.156
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/nsmb.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038111337
    295 https://doi.org/10.1038/nsmb.2004
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/nsmb.2629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017369330
    298 https://doi.org/10.1038/nsmb.2629
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/nsmb.3170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053369012
    301 https://doi.org/10.1038/nsmb.3170
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1002/pro.236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043106179
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.cell.2009.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014449249
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.cell.2011.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044927218
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/j.cell.2011.07.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052894008
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.cell.2012.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003189182
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.cell.2013.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040200713
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cell.2015.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027378388
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.celrep.2014.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032237738
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.cub.2011.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022627276
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.jsb.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019988217
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.molcel.2004.11.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032128252
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.molcel.2006.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022179585
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.molcel.2008.05.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042577158
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.molcel.2013.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007887819
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.molcel.2014.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021878467
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/j.molcel.2014.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032478305
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/j.molcel.2015.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022060714
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/j.sbi.2008.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008212112
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/j.sbi.2011.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050985160
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/j.sbi.2013.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000985943
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/j.semcdb.2014.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007020671
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s1047-8477(03)00069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046234181
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1038/emboj.2011.394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034090777
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1073/pnas.030539597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052994185
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1073/pnas.0905281106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014393677
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1073/pnas.0911500106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044523994
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1073/pnas.1209406109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021992511
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1074/jbc.m109.075333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025248109
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1093/nar/gkr1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017498005
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1093/nar/gkt1148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046186049
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1093/nar/gkt381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051947060
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1093/nar/gkv120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043603800
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1101/cshperspect.a010108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015092742
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1101/cshperspect.a010371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039462025
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1101/cshperspect.a012807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031215402
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1101/gad.1596807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043604805
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1101/gad.1759609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049980699
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1101/gad.1883410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036815090
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1101/gad.1933010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035610853
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1101/gad.2011511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017069821
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1101/gad.242313.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012908774
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1101/gad.242404.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041205054
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1107/s0907444909052925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777046
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1107/s0907444912001308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005539810
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1128/mmbr.00019-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039632404
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1146/annurev-biochem-052610-094414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014884421
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1146/annurev.biochem.68.1.649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028935381
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1155/2015/305497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021300168
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1242/jcs.094169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010153340
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.15252/embj.201593552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031154978
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1534/genetics.115.186452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024855559
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.7554/elife.01993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013205061
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.7554/elife.03273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044177281
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.7554/elife.03433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002193907
    412 rdf:type schema:CreativeWork
    413 https://www.grid.ac/institutes/grid.11135.37 schema:alternateName Peking University
    414 schema:name Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University, Beijing, China.
    415 rdf:type schema:Organization
    416 https://www.grid.ac/institutes/grid.12527.33 schema:alternateName Tsinghua University
    417 schema:name Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
    418 rdf:type schema:Organization
    419 https://www.grid.ac/institutes/grid.24515.37 schema:alternateName Hong Kong University of Science and Technology
    420 schema:name Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
    421 Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
    422 rdf:type schema:Organization
    423 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
    424 schema:name Department of Molecular Biology and Genetics, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA.
    425 Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
    426 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...