m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

Huiqing Zhou, Isaac J Kimsey, Evgenia N Nikolova, Bharathwaj Sathyamoorthy, Gianmarc Grazioli, James McSally, Tianyu Bai, Christoph H Wunderlich, Christoph Kreutz, Ioan Andricioaei, Hashim M Al-Hashimi

ABSTRACT

The B-DNA double helix can dynamically accommodate G-C and A-T base pairs in either Watson-Crick or Hoogsteen configurations. Here, we show that G-C(+) (in which + indicates protonation) and A-U Hoogsteen base pairs are strongly disfavored in A-RNA. As a result,N(1)-methyladenosine and N(1)-methylguanosine, which occur in DNA as a form of alkylation damage and in RNA as post-transcriptional modifications, have dramatically different consequences. Whereas they create G-C(+) and A-T Hoogsteen base pairs in duplex DNA, thereby maintaining the structural integrity of the double helix, they block base-pairing and induce local duplex melting in RNA. These observations provide a mechanism for disrupting RNA structure through post-transcriptional modifications. The different propensities to form Hoogsteen base pairs in B-DNA and A-RNA may help cells meet the opposing requirements of maintaining genome stability, on the one hand, and of dynamically modulating the structure of the epitranscriptome, on the other. More... »

PAGES

803

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.3270

    DOI

    http://dx.doi.org/10.1038/nsmb.3270

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008986533

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27478929


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