Lactase non-persistence is directed by DNA variation-dependent epigenetic aging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05-09

AUTHORS

Viviane Labrie, Orion J Buske, Edward Oh, Richie Jeremian, Carolyn Ptak, Giedrius Gasiūnas, Almantas Maleckas, Rūta Petereit, Aida Žvirbliene, Kęstutis Adamonis, Edita Kriukienė, Karolis Koncevičius, Juozas Gordevičius, Akhil Nair, Aiping Zhang, Sasha Ebrahimi, Gabriel Oh, Virginijus Šikšnys, Limas Kupčinskas, Michael Brudno, Arturas Petronis

ABSTRACT

The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. It is not known how the lactase gene is dramatically downregulated with age in most individuals but remains active in some individuals. We performed a comprehensive epigenetic study of human and mouse small intestines, by using chromosome-wide DNA-modification profiling and targeted bisulfite sequencing. Epigenetically controlled regulatory elements accounted for the differences in lactase mRNA levels among individuals, intestinal cell types and species. We confirmed the importance of these regulatory elements in modulating lactase mRNA levels by using CRISPR-Cas9-induced deletions. Genetic factors contribute to epigenetic changes occurring with age at the regulatory elements, because lactase-persistence and lactase-nonpersistence DNA haplotypes demonstrated markedly different epigenetic aging. Thus, genetic factors enable a gradual accumulation of epigenetic changes with age, thereby influencing phenotypic outcome. More... »

PAGES

566-573

References to SciGraph publications

  • 2014-10-21. Genome flux and stasis in a five millennium transect of European prehistory in NATURE COMMUNICATIONS
  • 2011-02-15. The −14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity in HUMAN GENETICS
  • 2013-10-24. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 2014-03-25. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus in CELL RESEARCH
  • 2015-02-18. Intermediate DNA methylation is a conserved signature of genome regulation in NATURE COMMUNICATIONS
  • 2013-10-09. DNMT1-interacting RNAs block gene specific DNA methylation in NATURE
  • 2013-05-28. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus in GENOME BIOLOGY
  • 2015-04-06. Epigenome editing by a CRISPR/Cas9-based acetyltransferase activates genes from promoters and enhancers in NATURE BIOTECHNOLOGY
  • 2014-08-17. Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci in NATURE NEUROSCIENCE
  • 2013-07-23. DNA unmethylome profiling by covalent capture of CpG sites in NATURE COMMUNICATIONS
  • 2002-01-14. Identification of a variant associated with adult-type hypolactasia in NATURE GENETICS
  • 2015-12-16. Competition between DNA methylation and transcription factors determines binding of NRF1 in NATURE
  • 2012-01-19. The human lactase persistence-associated SNP −13910*T enables in vivo functional persistence of lactase promoter–reporter transgene expression in HUMAN GENETICS
  • 2014-03-11. CTCF: an architectural protein bridging genome topology and function in NATURE REVIEWS GENETICS
  • 2015-02-18. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2010-10-13. The NIH Roadmap Epigenomics Mapping Consortium in NATURE BIOTECHNOLOGY
  • 2014-03-30. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype in NATURE BIOTECHNOLOGY
  • 2006-12-10. Convergent adaptation of human lactase persistence in Africa and Europe in NATURE GENETICS
  • 2013-10-21. DNA methylation age of human tissues and cell types in GENOME BIOLOGY
  • 2012-09-05. An Integrated Encyclopedia of DNA Elements in the Human Genome in NATURE
  • 2008-11-26. Lactose digestion and the evolutionary genetics of lactase persistence in HUMAN GENETICS
  • 2012-02-05. Library-free Methylation Sequencing with Bisulfite Padlock Probes in NATURE METHODS
  • 2012-10-31. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2015-03-05. Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer in SCIENTIFIC REPORTS
  • 2007-06-07. An efficient pseudomedian filter for tiling microrrays in BMC BIOINFORMATICS
  • 2015-02-18. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nsmb.3227

    DOI

    http://dx.doi.org/10.1038/nsmb.3227

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032633409

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27159559


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CRISPR-Cas Systems", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Methylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Jejunum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lactase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lactose Intolerance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA", 
              "id": "http://www.grid.ac/institutes/grid.251017.0", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
                "Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada", 
                "Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labrie", 
            "givenName": "Viviane", 
            "id": "sg:person.01326346763.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326346763.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Department of Computer Science, University of Toronto, Toronto, Ontario, Canada", 
                "Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buske", 
            "givenName": "Orion J", 
            "id": "sg:person.01104055172.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104055172.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oh", 
            "givenName": "Edward", 
            "id": "sg:person.0604257653.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604257653.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jeremian", 
            "givenName": "Richie", 
            "id": "sg:person.01372422110.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372422110.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ptak", 
            "givenName": "Carolyn", 
            "id": "sg:person.0730131573.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730131573.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.6441.7", 
              "name": [
                "Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gasi\u016bnas", 
            "givenName": "Giedrius", 
            "id": "sg:person.01110433005.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110433005.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.45083.3a", 
              "name": [
                "Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maleckas", 
            "givenName": "Almantas", 
            "id": "sg:person.01100220265.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100220265.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.45083.3a", 
              "name": [
                "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petereit", 
            "givenName": "R\u016bta", 
            "id": "sg:person.0655712140.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655712140.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.45083.3a", 
              "name": [
                "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
                "Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "\u017dvirbliene", 
            "givenName": "Aida", 
            "id": "sg:person.01256045100.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256045100.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.45083.3a", 
              "name": [
                "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adamonis", 
            "givenName": "K\u0119stutis", 
            "id": "sg:person.01217276453.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217276453.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biological DNA Modification, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.6441.7", 
              "name": [
                "Department of Biological DNA Modification, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kriukien\u0117", 
            "givenName": "Edita", 
            "id": "sg:person.01021271127.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021271127.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.6441.7", 
              "name": [
                "Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koncevi\u010dius", 
            "givenName": "Karolis", 
            "id": "sg:person.0737311330.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737311330.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.6441.7", 
              "name": [
                "Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gordevi\u010dius", 
            "givenName": "Juozas", 
            "id": "sg:person.01050165757.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050165757.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nair", 
            "givenName": "Akhil", 
            "id": "sg:person.07765613145.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07765613145.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Aiping", 
            "id": "sg:person.01262643107.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262643107.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ebrahimi", 
            "givenName": "Sasha", 
            "id": "sg:person.01100301307.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100301307.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.155956.b", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oh", 
            "givenName": "Gabriel", 
            "id": "sg:person.0621414054.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621414054.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.6441.7", 
              "name": [
                "Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "\u0160ik\u0161nys", 
            "givenName": "Virginijus", 
            "id": "sg:person.01264100412.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264100412.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
              "id": "http://www.grid.ac/institutes/grid.45083.3a", 
              "name": [
                "Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania", 
                "Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kup\u010dinskas", 
            "givenName": "Limas", 
            "id": "sg:person.0634342064.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634342064.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.42327.30", 
              "name": [
                "Department of Computer Science, University of Toronto, Toronto, Ontario, Canada", 
                "Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brudno", 
            "givenName": "Michael", 
            "id": "sg:person.01253563237.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253563237.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada", 
              "id": "http://www.grid.ac/institutes/grid.17063.33", 
              "name": [
                "Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada", 
                "Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petronis", 
            "givenName": "Arturas", 
            "id": "sg:person.013300210647.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013300210647.59"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00439-011-0966-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017105909", 
              "https://doi.org/10.1007/s00439-011-0966-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011531387", 
              "https://doi.org/10.1038/nbt.2884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044246673", 
              "https://doi.org/10.1038/nmeth.1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037762791", 
              "https://doi.org/10.1038/nn.3786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028915007", 
              "https://doi.org/10.1038/nature14252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1010-1045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048301228", 
              "https://doi.org/10.1038/nbt1010-1045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-012-1140-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009608299", 
              "https://doi.org/10.1007/s00439-012-1140-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014903556", 
              "https://doi.org/10.1038/nature16462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038595944", 
              "https://doi.org/10.1038/nature12598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037347132", 
              "https://doi.org/10.1038/ncomms6257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng826", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051591016", 
              "https://doi.org/10.1038/ng826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043156128", 
              "https://doi.org/10.1038/ncomms7363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049876798", 
              "https://doi.org/10.1038/ncomms3190"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031836937", 
              "https://doi.org/10.1038/nature14248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-008-0593-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015747323", 
              "https://doi.org/10.1007/s00439-008-0593-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.3199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031267114", 
              "https://doi.org/10.1038/nbt.3199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2014.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032435968", 
              "https://doi.org/10.1038/cr.2014.35"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-5-r50", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048852188", 
              "https://doi.org/10.1186/gb-2013-14-5-r50"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep08790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023008305", 
              "https://doi.org/10.1038/srep08790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000661742", 
              "https://doi.org/10.1038/nature11632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-10-r115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012339256", 
              "https://doi.org/10.1186/gb-2013-14-10-r115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-8-186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028169738", 
              "https://doi.org/10.1186/1471-2105-8-186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017831086", 
              "https://doi.org/10.1038/nrg3663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1946", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014224859", 
              "https://doi.org/10.1038/ng1946"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-05-09", 
        "datePublishedReg": "2016-05-09", 
        "description": "The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. It is not known how the lactase gene is dramatically downregulated with age in most individuals but remains active in some individuals. We performed a comprehensive epigenetic study of human and mouse small intestines, by using chromosome-wide DNA-modification profiling and targeted bisulfite sequencing. Epigenetically controlled regulatory elements accounted for the differences in lactase mRNA levels among individuals, intestinal cell types and species. We confirmed the importance of these regulatory elements in modulating lactase mRNA levels by using CRISPR-Cas9-induced deletions. Genetic factors contribute to epigenetic changes occurring with age at the regulatory elements, because lactase-persistence and lactase-nonpersistence DNA haplotypes demonstrated markedly different epigenetic aging. Thus, genetic factors enable a gradual accumulation of epigenetic changes with age, thereby influencing phenotypic outcome.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nsmb.3227", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2355455", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2552144", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1295033", 
            "issn": [
              "1545-9993", 
              "2331-365X"
            ], 
            "name": "Nature Structural & Molecular Biology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "23"
          }
        ], 
        "keywords": [
          "regulatory elements", 
          "epigenetic changes", 
          "lactase mRNA levels", 
          "epigenetic aging", 
          "intestinal cell types", 
          "DNA haplotypes", 
          "mRNA levels", 
          "bisulfite sequencing", 
          "epigenetic studies", 
          "phenotypic outcomes", 
          "certain human populations", 
          "genetic factors", 
          "cell types", 
          "lactase persistence", 
          "adult mammals", 
          "mouse small intestine", 
          "human populations", 
          "common traits", 
          "lactase gene", 
          "gradual accumulation", 
          "mammals", 
          "genes", 
          "traits", 
          "species", 
          "sequencing", 
          "deletion", 
          "haplotypes", 
          "most individuals", 
          "profiling", 
          "accumulation", 
          "aging", 
          "small intestine", 
          "lactase nonpersistence", 
          "individuals", 
          "humans", 
          "persistence", 
          "levels", 
          "population", 
          "elements", 
          "intestine", 
          "factors", 
          "changes", 
          "inability", 
          "importance", 
          "lactose", 
          "types", 
          "study", 
          "differences", 
          "age", 
          "nonpersistence", 
          "outcomes", 
          "comprehensive epigenetic study", 
          "chromosome-wide DNA-modification profiling", 
          "DNA-modification profiling", 
          "CRISPR-Cas9-induced deletions", 
          "lactase-nonpersistence DNA haplotypes", 
          "different epigenetic aging", 
          "DNA variation-dependent epigenetic aging", 
          "variation-dependent epigenetic aging"
        ], 
        "name": "Lactase non-persistence is directed by DNA variation-dependent epigenetic aging", 
        "pagination": "566-573", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032633409"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nsmb.3227"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27159559"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nsmb.3227", 
          "https://app.dimensions.ai/details/publication/pub.1032633409"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_689.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nsmb.3227"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3227'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3227'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3227'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nsmb.3227'


     

    This table displays all metadata directly associated to this object as RDF triples.

    468 TRIPLES      22 PREDICATES      129 URIs      95 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nsmb.3227 schema:about N0fc051a129bc4db4ad807bbd5edefbc8
    2 N1a9b5d785f8b40da98451e3bd17ad389
    3 N2e4230f0f36547e3b1f0eea72139fd43
    4 N37ebaa96714d4285b14de56e77c6143d
    5 N59108aeebca64a5ba1ced49eebd3863e
    6 N59bf774862db4181b83d3a9d2ab98d15
    7 N6aac2b70cf9f4b5fbba06e0f23b0b159
    8 N7b896eedd35d42f589ec7a9b449a93e8
    9 N7eec9d33a442402fae7e6a7c6f333f92
    10 N9874241083c24f03a4725a376a09f946
    11 N98e432ac0e794f89a89fd2c4cea138c2
    12 N9b9d2fb160aa416baf8887e35144dbec
    13 Nbcbe1229eef94a3299c2096a0061b16e
    14 Nbf713d3f17f6448889158f60e45e4fe6
    15 Nc73005037c644ba08a2948f9b35f7a88
    16 Nd969d2d3381648bfbd4182a2c2f8d34d
    17 Ne8a24082f1ea4bccad52b3c17dc15e83
    18 Nfc913db5808240bb85748e12835d5817
    19 anzsrc-for:06
    20 anzsrc-for:0604
    21 schema:author N5b8593f925fe428b821c4a9c5eb2d8e5
    22 schema:citation sg:pub.10.1007/s00439-008-0593-6
    23 sg:pub.10.1007/s00439-011-0966-0
    24 sg:pub.10.1007/s00439-012-1140-z
    25 sg:pub.10.1038/cr.2014.35
    26 sg:pub.10.1038/nature11247
    27 sg:pub.10.1038/nature11632
    28 sg:pub.10.1038/nature12598
    29 sg:pub.10.1038/nature14248
    30 sg:pub.10.1038/nature14252
    31 sg:pub.10.1038/nature16462
    32 sg:pub.10.1038/nbt.2884
    33 sg:pub.10.1038/nbt.3199
    34 sg:pub.10.1038/nbt1010-1045
    35 sg:pub.10.1038/ncomms3190
    36 sg:pub.10.1038/ncomms6257
    37 sg:pub.10.1038/ncomms7363
    38 sg:pub.10.1038/ng1946
    39 sg:pub.10.1038/ng826
    40 sg:pub.10.1038/nmeth.1871
    41 sg:pub.10.1038/nn.3786
    42 sg:pub.10.1038/nprot.2013.143
    43 sg:pub.10.1038/nrg3663
    44 sg:pub.10.1038/srep08790
    45 sg:pub.10.1186/1471-2105-8-186
    46 sg:pub.10.1186/gb-2013-14-10-r115
    47 sg:pub.10.1186/gb-2013-14-5-r50
    48 schema:datePublished 2016-05-09
    49 schema:datePublishedReg 2016-05-09
    50 schema:description The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. It is not known how the lactase gene is dramatically downregulated with age in most individuals but remains active in some individuals. We performed a comprehensive epigenetic study of human and mouse small intestines, by using chromosome-wide DNA-modification profiling and targeted bisulfite sequencing. Epigenetically controlled regulatory elements accounted for the differences in lactase mRNA levels among individuals, intestinal cell types and species. We confirmed the importance of these regulatory elements in modulating lactase mRNA levels by using CRISPR-Cas9-induced deletions. Genetic factors contribute to epigenetic changes occurring with age at the regulatory elements, because lactase-persistence and lactase-nonpersistence DNA haplotypes demonstrated markedly different epigenetic aging. Thus, genetic factors enable a gradual accumulation of epigenetic changes with age, thereby influencing phenotypic outcome.
    51 schema:genre article
    52 schema:inLanguage en
    53 schema:isAccessibleForFree true
    54 schema:isPartOf N343b6cd53afb446aafa2e44f52787f65
    55 N99a953de57d0403480601b94bb8f6dd2
    56 sg:journal.1295033
    57 schema:keywords CRISPR-Cas9-induced deletions
    58 DNA haplotypes
    59 DNA variation-dependent epigenetic aging
    60 DNA-modification profiling
    61 accumulation
    62 adult mammals
    63 age
    64 aging
    65 bisulfite sequencing
    66 cell types
    67 certain human populations
    68 changes
    69 chromosome-wide DNA-modification profiling
    70 common traits
    71 comprehensive epigenetic study
    72 deletion
    73 differences
    74 different epigenetic aging
    75 elements
    76 epigenetic aging
    77 epigenetic changes
    78 epigenetic studies
    79 factors
    80 genes
    81 genetic factors
    82 gradual accumulation
    83 haplotypes
    84 human populations
    85 humans
    86 importance
    87 inability
    88 individuals
    89 intestinal cell types
    90 intestine
    91 lactase gene
    92 lactase mRNA levels
    93 lactase nonpersistence
    94 lactase persistence
    95 lactase-nonpersistence DNA haplotypes
    96 lactose
    97 levels
    98 mRNA levels
    99 mammals
    100 most individuals
    101 mouse small intestine
    102 nonpersistence
    103 outcomes
    104 persistence
    105 phenotypic outcomes
    106 population
    107 profiling
    108 regulatory elements
    109 sequencing
    110 small intestine
    111 species
    112 study
    113 traits
    114 types
    115 variation-dependent epigenetic aging
    116 schema:name Lactase non-persistence is directed by DNA variation-dependent epigenetic aging
    117 schema:pagination 566-573
    118 schema:productId N1916a555eedd47b89d21cdebd0b5f76a
    119 N3cdc7d9be57046a9896486baeb57e3ce
    120 Nb7a190feffb84a6fa904f76e8ab6691f
    121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032633409
    122 https://doi.org/10.1038/nsmb.3227
    123 schema:sdDatePublished 2021-11-01T18:26
    124 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    125 schema:sdPublisher N83f9392d91134cb08a4f03ff326db896
    126 schema:url https://doi.org/10.1038/nsmb.3227
    127 sgo:license sg:explorer/license/
    128 sgo:sdDataset articles
    129 rdf:type schema:ScholarlyArticle
    130 N08789ea2d7144a25929ded83f8252739 rdf:first sg:person.0737311330.22
    131 rdf:rest Ndc5fcdc4623747b59b00bdf9d148c0fc
    132 N0fc051a129bc4db4ad807bbd5edefbc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Chromosomes
    134 rdf:type schema:DefinedTerm
    135 N1916a555eedd47b89d21cdebd0b5f76a schema:name doi
    136 schema:value 10.1038/nsmb.3227
    137 rdf:type schema:PropertyValue
    138 N1a9b5d785f8b40da98451e3bd17ad389 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Adult
    140 rdf:type schema:DefinedTerm
    141 N2e4230f0f36547e3b1f0eea72139fd43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name DNA Methylation
    143 rdf:type schema:DefinedTerm
    144 N343b6cd53afb446aafa2e44f52787f65 schema:volumeNumber 23
    145 rdf:type schema:PublicationVolume
    146 N3644779c00234e30ace5d71f9d00db45 rdf:first sg:person.01100220265.17
    147 rdf:rest N4106ce6ff2d147e989727a9194e0b9e8
    148 N37ebaa96714d4285b14de56e77c6143d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Animals
    150 rdf:type schema:DefinedTerm
    151 N3cdc7d9be57046a9896486baeb57e3ce schema:name pubmed_id
    152 schema:value 27159559
    153 rdf:type schema:PropertyValue
    154 N3f97ede7a72a4079a8a5106daf0f8806 rdf:first sg:person.01110433005.26
    155 rdf:rest N3644779c00234e30ace5d71f9d00db45
    156 N4106ce6ff2d147e989727a9194e0b9e8 rdf:first sg:person.0655712140.02
    157 rdf:rest N615290c40fec4bad9acae7a5011acc7c
    158 N581f3fbd7238460384f34a8a05eeff8d rdf:first sg:person.01372422110.70
    159 rdf:rest N999c76a4352a4d00a8700ec0880fa7f8
    160 N59108aeebca64a5ba1ced49eebd3863e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Aged
    162 rdf:type schema:DefinedTerm
    163 N59bf774862db4181b83d3a9d2ab98d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Promoter Regions, Genetic
    165 rdf:type schema:DefinedTerm
    166 N5a870614382a45dd9cf9e82f6aecf784 rdf:first sg:person.0621414054.40
    167 rdf:rest N8636f2ea480c4f898ec156c691ff0768
    168 N5b8593f925fe428b821c4a9c5eb2d8e5 rdf:first sg:person.01326346763.15
    169 rdf:rest Ncfa0f790812a44c39a73ecb1ede17acd
    170 N615290c40fec4bad9acae7a5011acc7c rdf:first sg:person.01256045100.58
    171 rdf:rest N7c51c08aa4eb42ce8e0ff6a6a8eeb2f1
    172 N62792bbeb6af447b92f10f6f077bcedd rdf:first sg:person.0604257653.59
    173 rdf:rest N581f3fbd7238460384f34a8a05eeff8d
    174 N6aac2b70cf9f4b5fbba06e0f23b0b159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Jejunum
    176 rdf:type schema:DefinedTerm
    177 N6f853b57086c40e69e99207ad3951a72 rdf:first sg:person.0634342064.30
    178 rdf:rest Nc2f4b8d8e1404b76b4fb6ca962c9a252
    179 N71cc20f5d48d4858a6e8d863733759d3 rdf:first sg:person.01262643107.01
    180 rdf:rest Nee8ca8eb1c1a47c2a6522973aede721e
    181 N7b896eedd35d42f589ec7a9b449a93e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Middle Aged
    183 rdf:type schema:DefinedTerm
    184 N7c51c08aa4eb42ce8e0ff6a6a8eeb2f1 rdf:first sg:person.01217276453.78
    185 rdf:rest N9dfd073d069d41f2b23f12ec40b71978
    186 N7eec9d33a442402fae7e6a7c6f333f92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Young Adult
    188 rdf:type schema:DefinedTerm
    189 N83f9392d91134cb08a4f03ff326db896 schema:name Springer Nature - SN SciGraph project
    190 rdf:type schema:Organization
    191 N8636f2ea480c4f898ec156c691ff0768 rdf:first sg:person.01264100412.83
    192 rdf:rest N6f853b57086c40e69e99207ad3951a72
    193 N905d3c560082405399f7602757baa3f7 rdf:first sg:person.07765613145.11
    194 rdf:rest N71cc20f5d48d4858a6e8d863733759d3
    195 N9874241083c24f03a4725a376a09f946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Epigenesis, Genetic
    197 rdf:type schema:DefinedTerm
    198 N98e432ac0e794f89a89fd2c4cea138c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name RNA, Messenger
    200 rdf:type schema:DefinedTerm
    201 N999c76a4352a4d00a8700ec0880fa7f8 rdf:first sg:person.0730131573.53
    202 rdf:rest N3f97ede7a72a4079a8a5106daf0f8806
    203 N99a953de57d0403480601b94bb8f6dd2 schema:issueNumber 6
    204 rdf:type schema:PublicationIssue
    205 N9b9d2fb160aa416baf8887e35144dbec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Humans
    207 rdf:type schema:DefinedTerm
    208 N9dfd073d069d41f2b23f12ec40b71978 rdf:first sg:person.01021271127.21
    209 rdf:rest N08789ea2d7144a25929ded83f8252739
    210 Nb4ec6d4154484afd8b66c4068024f46d rdf:first sg:person.013300210647.59
    211 rdf:rest rdf:nil
    212 Nb7a190feffb84a6fa904f76e8ab6691f schema:name dimensions_id
    213 schema:value pub.1032633409
    214 rdf:type schema:PropertyValue
    215 Nbcbe1229eef94a3299c2096a0061b16e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Lactose Intolerance
    217 rdf:type schema:DefinedTerm
    218 Nbf713d3f17f6448889158f60e45e4fe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Mice
    220 rdf:type schema:DefinedTerm
    221 Nc2f4b8d8e1404b76b4fb6ca962c9a252 rdf:first sg:person.01253563237.25
    222 rdf:rest Nb4ec6d4154484afd8b66c4068024f46d
    223 Nc73005037c644ba08a2948f9b35f7a88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Mice, Inbred C57BL
    225 rdf:type schema:DefinedTerm
    226 Ncfa0f790812a44c39a73ecb1ede17acd rdf:first sg:person.01104055172.55
    227 rdf:rest N62792bbeb6af447b92f10f6f077bcedd
    228 Nd969d2d3381648bfbd4182a2c2f8d34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name CRISPR-Cas Systems
    230 rdf:type schema:DefinedTerm
    231 Ndc5fcdc4623747b59b00bdf9d148c0fc rdf:first sg:person.01050165757.56
    232 rdf:rest N905d3c560082405399f7602757baa3f7
    233 Ne8a24082f1ea4bccad52b3c17dc15e83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Aging
    235 rdf:type schema:DefinedTerm
    236 Nee8ca8eb1c1a47c2a6522973aede721e rdf:first sg:person.01100301307.15
    237 rdf:rest N5a870614382a45dd9cf9e82f6aecf784
    238 Nfc913db5808240bb85748e12835d5817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Lactase
    240 rdf:type schema:DefinedTerm
    241 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    242 schema:name Biological Sciences
    243 rdf:type schema:DefinedTerm
    244 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    245 schema:name Genetics
    246 rdf:type schema:DefinedTerm
    247 sg:grant.2355455 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3227
    248 rdf:type schema:MonetaryGrant
    249 sg:grant.2552144 http://pending.schema.org/fundedItem sg:pub.10.1038/nsmb.3227
    250 rdf:type schema:MonetaryGrant
    251 sg:journal.1295033 schema:issn 1545-9993
    252 2331-365X
    253 schema:name Nature Structural & Molecular Biology
    254 schema:publisher Springer Nature
    255 rdf:type schema:Periodical
    256 sg:person.01021271127.21 schema:affiliation grid-institutes:grid.6441.7
    257 schema:familyName Kriukienė
    258 schema:givenName Edita
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021271127.21
    260 rdf:type schema:Person
    261 sg:person.01050165757.56 schema:affiliation grid-institutes:grid.6441.7
    262 schema:familyName Gordevičius
    263 schema:givenName Juozas
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050165757.56
    265 rdf:type schema:Person
    266 sg:person.01100220265.17 schema:affiliation grid-institutes:grid.45083.3a
    267 schema:familyName Maleckas
    268 schema:givenName Almantas
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100220265.17
    270 rdf:type schema:Person
    271 sg:person.01100301307.15 schema:affiliation grid-institutes:grid.155956.b
    272 schema:familyName Ebrahimi
    273 schema:givenName Sasha
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100301307.15
    275 rdf:type schema:Person
    276 sg:person.01104055172.55 schema:affiliation grid-institutes:grid.42327.30
    277 schema:familyName Buske
    278 schema:givenName Orion J
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104055172.55
    280 rdf:type schema:Person
    281 sg:person.01110433005.26 schema:affiliation grid-institutes:grid.6441.7
    282 schema:familyName Gasiūnas
    283 schema:givenName Giedrius
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110433005.26
    285 rdf:type schema:Person
    286 sg:person.01217276453.78 schema:affiliation grid-institutes:grid.45083.3a
    287 schema:familyName Adamonis
    288 schema:givenName Kęstutis
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217276453.78
    290 rdf:type schema:Person
    291 sg:person.01253563237.25 schema:affiliation grid-institutes:grid.42327.30
    292 schema:familyName Brudno
    293 schema:givenName Michael
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253563237.25
    295 rdf:type schema:Person
    296 sg:person.01256045100.58 schema:affiliation grid-institutes:grid.45083.3a
    297 schema:familyName Žvirbliene
    298 schema:givenName Aida
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256045100.58
    300 rdf:type schema:Person
    301 sg:person.01262643107.01 schema:affiliation grid-institutes:grid.155956.b
    302 schema:familyName Zhang
    303 schema:givenName Aiping
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262643107.01
    305 rdf:type schema:Person
    306 sg:person.01264100412.83 schema:affiliation grid-institutes:grid.6441.7
    307 schema:familyName Šikšnys
    308 schema:givenName Virginijus
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264100412.83
    310 rdf:type schema:Person
    311 sg:person.01326346763.15 schema:affiliation grid-institutes:grid.251017.0
    312 schema:familyName Labrie
    313 schema:givenName Viviane
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326346763.15
    315 rdf:type schema:Person
    316 sg:person.013300210647.59 schema:affiliation grid-institutes:grid.17063.33
    317 schema:familyName Petronis
    318 schema:givenName Arturas
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013300210647.59
    320 rdf:type schema:Person
    321 sg:person.01372422110.70 schema:affiliation grid-institutes:grid.155956.b
    322 schema:familyName Jeremian
    323 schema:givenName Richie
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372422110.70
    325 rdf:type schema:Person
    326 sg:person.0604257653.59 schema:affiliation grid-institutes:grid.155956.b
    327 schema:familyName Oh
    328 schema:givenName Edward
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604257653.59
    330 rdf:type schema:Person
    331 sg:person.0621414054.40 schema:affiliation grid-institutes:grid.155956.b
    332 schema:familyName Oh
    333 schema:givenName Gabriel
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621414054.40
    335 rdf:type schema:Person
    336 sg:person.0634342064.30 schema:affiliation grid-institutes:grid.45083.3a
    337 schema:familyName Kupčinskas
    338 schema:givenName Limas
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634342064.30
    340 rdf:type schema:Person
    341 sg:person.0655712140.02 schema:affiliation grid-institutes:grid.45083.3a
    342 schema:familyName Petereit
    343 schema:givenName Rūta
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655712140.02
    345 rdf:type schema:Person
    346 sg:person.0730131573.53 schema:affiliation grid-institutes:grid.155956.b
    347 schema:familyName Ptak
    348 schema:givenName Carolyn
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730131573.53
    350 rdf:type schema:Person
    351 sg:person.0737311330.22 schema:affiliation grid-institutes:grid.6441.7
    352 schema:familyName Koncevičius
    353 schema:givenName Karolis
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737311330.22
    355 rdf:type schema:Person
    356 sg:person.07765613145.11 schema:affiliation grid-institutes:grid.155956.b
    357 schema:familyName Nair
    358 schema:givenName Akhil
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07765613145.11
    360 rdf:type schema:Person
    361 sg:pub.10.1007/s00439-008-0593-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015747323
    362 https://doi.org/10.1007/s00439-008-0593-6
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1007/s00439-011-0966-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017105909
    365 https://doi.org/10.1007/s00439-011-0966-0
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1007/s00439-012-1140-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1009608299
    368 https://doi.org/10.1007/s00439-012-1140-z
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1038/cr.2014.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032435968
    371 https://doi.org/10.1038/cr.2014.35
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    374 https://doi.org/10.1038/nature11247
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/nature11632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000661742
    377 https://doi.org/10.1038/nature11632
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/nature12598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038595944
    380 https://doi.org/10.1038/nature12598
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/nature14248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031836937
    383 https://doi.org/10.1038/nature14248
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/nature14252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028915007
    386 https://doi.org/10.1038/nature14252
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/nature16462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014903556
    389 https://doi.org/10.1038/nature16462
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/nbt.2884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011531387
    392 https://doi.org/10.1038/nbt.2884
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/nbt.3199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031267114
    395 https://doi.org/10.1038/nbt.3199
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/nbt1010-1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048301228
    398 https://doi.org/10.1038/nbt1010-1045
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/ncomms3190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049876798
    401 https://doi.org/10.1038/ncomms3190
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/ncomms6257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037347132
    404 https://doi.org/10.1038/ncomms6257
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/ncomms7363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043156128
    407 https://doi.org/10.1038/ncomms7363
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/ng1946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014224859
    410 https://doi.org/10.1038/ng1946
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/ng826 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051591016
    413 https://doi.org/10.1038/ng826
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/nmeth.1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044246673
    416 https://doi.org/10.1038/nmeth.1871
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/nn.3786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037762791
    419 https://doi.org/10.1038/nn.3786
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    422 https://doi.org/10.1038/nprot.2013.143
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/nrg3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017831086
    425 https://doi.org/10.1038/nrg3663
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/srep08790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023008305
    428 https://doi.org/10.1038/srep08790
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1186/1471-2105-8-186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028169738
    431 https://doi.org/10.1186/1471-2105-8-186
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1186/gb-2013-14-10-r115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012339256
    434 https://doi.org/10.1186/gb-2013-14-10-r115
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1186/gb-2013-14-5-r50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048852188
    437 https://doi.org/10.1186/gb-2013-14-5-r50
    438 rdf:type schema:CreativeWork
    439 grid-institutes:grid.155956.b schema:alternateName Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    440 schema:name Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    441 rdf:type schema:Organization
    442 grid-institutes:grid.17063.33 schema:alternateName Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    443 schema:name Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    444 Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    445 rdf:type schema:Organization
    446 grid-institutes:grid.251017.0 schema:alternateName Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA
    447 schema:name Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA
    448 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
    449 Krembil Family Epigenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    450 rdf:type schema:Organization
    451 grid-institutes:grid.42327.30 schema:alternateName Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    452 schema:name Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    453 Department of Computer Science, University of Toronto, Toronto, Ontario, Canada
    454 rdf:type schema:Organization
    455 grid-institutes:grid.45083.3a schema:alternateName Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
    456 Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
    457 Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
    458 schema:name Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania
    459 Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania
    460 Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania
    461 rdf:type schema:Organization
    462 grid-institutes:grid.6441.7 schema:alternateName Department of Biological DNA Modification, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
    463 Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
    464 Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania
    465 schema:name Department of Biological DNA Modification, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
    466 Department of Protein-DNA Interactions, Institute of Biotechnology, Vilnius University, Vilnius, Lithuania
    467 Institute of Mathematics and Informatics, Vilnius University, Vilnius, Lithuania
    468 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...