Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Wen Song, Jia Wang, Zhifu Han, Yifan Zhang, Heqiao Zhang, Weiguang Wang, Junbiao Chang, Bingshu Xia, Shilong Fan, Dekai Zhang, Jiawei Wang, Hong-Wei Wang, Jijie Chai

ABSTRACT

Toll-like receptors (TLRs) have crucial roles in innate immunity, functioning as pattern-recognition receptors. TLR13 recognizes a conserved sequence from bacterial 23S rRNA and then triggers an immune response. Here we report the crystal structure of the mouse TLR13 ectodomain bound by a 13-nt single-stranded (ss) RNA derived from 23S rRNA. The ssRNA induces TLR13 dimerization but assumes a stem-loop-like structure that is completely different from that in the bacterial ribosome but nevertheless is crucial for TLR13 recognition. Most of the RNA nucleotides are splayed out to make base-specific contacts with the concave surface of TLR13, and RNA-specific interactions are important to allow TLR13 to distinguish RNA from DNA. Interestingly, a viral-derived 16-nt ssRNA predicted to form a similar stem-loop-like structure also induces TLR13 activation. Together, our results reveal the structural mechanism of TLR13's sequence- and conformation-specific recognition of ssRNA. More... »

PAGES

782-787

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.3080

DOI

http://dx.doi.org/10.1038/nsmb.3080

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003444514

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26323037


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