Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Yury S Polikanov, Sergey V Melnikov, Dieter Söll, Thomas A Steitz

ABSTRACT

We report crystal structures of the Thermus thermophilus ribosome at 2.3- to 2.5-Å resolution, which have enabled modeling of rRNA modifications. The structures reveal contacts of modified nucleotides with mRNA and tRNAs or protein pY, and contacts within the ribosome interior stabilizing the functional fold of rRNA. Our work provides a resource to explore the roles of rRNA modifications and yields a more comprehensive atomic model of a bacterial ribosome. More... »

PAGES

342-344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nsmb.2992

DOI

http://dx.doi.org/10.1038/nsmb.2992

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018986616

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25775268


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